Cell Reports Medicine最新文献_第7页

The temporal dynamics of the gut mycobiome and its association with cardiometabolic health in a nationwide cohort of 12,641 Chinese adults. 由 12,641 名中国成年人组成的全国性队列中肠道真菌生物群的时间动态及其与心脏代谢健康的关系。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-04 DOI: 10.1016/j.xcrm.2024.101775

Wanglong Gou, Huijun Wang, Chang Su, Yuanqing Fu, Xinyu Wang, Chang Gao, Menglei Shuai, Zelei Miao, Jiguo Zhang, Xiaofang Jia, Wenwen Du, Ke Zhang, Bing Zhang, Ju-Sheng Zheng

{"title":"The temporal dynamics of the gut mycobiome and its association with cardiometabolic health in a nationwide cohort of 12,641 Chinese adults.","authors":"Wanglong Gou, Huijun Wang, Chang Su, Yuanqing Fu, Xinyu Wang, Chang Gao, Menglei Shuai, Zelei Miao, Jiguo Zhang, Xiaofang Jia, Wenwen Du, Ke Zhang, Bing Zhang, Ju-Sheng Zheng","doi":"10.1016/j.xcrm.2024.101775","DOIUrl":"10.1016/j.xcrm.2024.101775","url":null,"abstract":"The dynamics of the gut mycobiome and its association with cardiometabolic health remain largely unexplored. Here, we employ internal transcribed spacer (ITS) sequencing to capture the gut mycobiome composition and dynamics within a nationwide human cohort of 12,641 Chinese participants, including 1,946 participants with repeated measurements across three years. We find that the gut mycobiome is associated with cardiometabolic diseases and related biomarkers in both cross-sectional and dynamic analyses. Fungal alpha diversity indices and 19 mycobiome genera are the major contributors to the mycobiome-cardiometabolic disease link. Particularly, Saccharomyces emerges as an effect modifier of traditional risk factors in promoting type 2 diabetes risk. Further integration of multi-omics data reveals key metabolites such as γ-linolenic acid and L-valine linking the gut mycobiome to type 2 diabetes. This study advances our understanding of the potential roles of the gut mycobiome in cardiometabolic health.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"101775"},"PeriodicalIF":11.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical-proteomic classification and precision treatment strategy of chordoma. 脊索瘤的临床-蛋白组学分类和精准治疗策略

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-04 DOI: 10.1016/j.xcrm.2024.101757

Huabin Yin, Jinbo Hu, Jianxuan Gao, Tong Su, Jiali Jin, Cong Jiang, Wenxuan Yin, Xiaowen Xu, Zhengyan Chang, Wei Sun, Zhengdong Cai, Wang Zhou, Ping Wang, Jun Lin, Dianwen Song, Tong Meng

{"title":"Clinical-proteomic classification and precision treatment strategy of chordoma.","authors":"Huabin Yin, Jinbo Hu, Jianxuan Gao, Tong Su, Jiali Jin, Cong Jiang, Wenxuan Yin, Xiaowen Xu, Zhengyan Chang, Wei Sun, Zhengdong Cai, Wang Zhou, Ping Wang, Jun Lin, Dianwen Song, Tong Meng","doi":"10.1016/j.xcrm.2024.101757","DOIUrl":"10.1016/j.xcrm.2024.101757","url":null,"abstract":"Chordoma is a rare and heterogeneous mesenchymal malignancy, with distinct clinical and biological behaviors. Till now, its comprehensive clinical-molecular characteristics and accurate molecular classification remain obscure. In this research, we enroll 102 patients with chordoma and describe their clinical, imageological, and histopathological features. Through tandem mass tag-based proteomic analysis and nonnegative matrix factorization clustering, we classify chordoma into three molecular subtypes: bone microenvironment-dominant, mesenchymal-derived, and mesenchymal-to-epithelial transition-mediated pattern. The three subtypes exhibit discrete clinical prognosis and distinct biological attributes of osteoclastogenesis and immunogenicity, oxidative phosphorylation, and receptor tyrosine kinase activation, suggesting targeted therapeutic strategies of denosumab, S-Gboxin, and anlotinib, respectively. Notably, these approaches demonstrate positive treatment outcomes for each subtype in vitro and in vivo. Altogether, this work sheds light on the clinical-proteomic characteristics of chordoma and provides a candidate precision treatment strategy for chordoma according to molecular classification, underscoring their potential for clinical application.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"101757"},"PeriodicalIF":11.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene therapy for chronic pain management. 用于慢性疼痛治疗的基因疗法。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-03 DOI: 10.1016/j.xcrm.2024.101756

Yi-Ze Li, Ru-Rong Ji

引用次数: 0

Modeling lung adenocarcinoma metastases using patient-derived organoids. 利用源自患者的器官组织建立肺腺癌转移模型

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 DOI: 10.1016/j.xcrm.2024.101777

Yuan Liu, Manendra Lankadasari, Joel Rosiene, Kofi E Johnson, Juan Zhou, Samhita Bapat, Lai-Fong L Chow-Tsang, Huasong Tian, Brooke Mastrogiacomo, Di He, James G Connolly, Harry B Lengel, Raul Caso, Elizabeth G Dunne, Cameron N Fick, Gaetano Rocco, Smita Sihag, James M Isbell, Mathew J Bott, Bob T Li, Piro Lito, Cameron W Brennan, Mark H Bilsky, Natasha Rekhtman, Prasad S Adusumilli, Marty W Mayo, Marcin Imielinski, David R Jones

{"title":"Modeling lung adenocarcinoma metastases using patient-derived organoids.","authors":"Yuan Liu, Manendra Lankadasari, Joel Rosiene, Kofi E Johnson, Juan Zhou, Samhita Bapat, Lai-Fong L Chow-Tsang, Huasong Tian, Brooke Mastrogiacomo, Di He, James G Connolly, Harry B Lengel, Raul Caso, Elizabeth G Dunne, Cameron N Fick, Gaetano Rocco, Smita Sihag, James M Isbell, Mathew J Bott, Bob T Li, Piro Lito, Cameron W Brennan, Mark H Bilsky, Natasha Rekhtman, Prasad S Adusumilli, Marty W Mayo, Marcin Imielinski, David R Jones","doi":"10.1016/j.xcrm.2024.101777","DOIUrl":"10.1016/j.xcrm.2024.101777","url":null,"abstract":"Approximately 50% of patients with surgically resected early-stage lung cancer develop distant metastasis. At present, there is no in vivo metastasis model to investigate the biology of human lung cancer metastases. Using well-characterized lung adenocarcinoma (LUAD) patient-derived organoids (PDOs), we establish an in vivo metastasis model that preserves the biologic features of human metastases. Results of whole-genome and RNA sequencing establish that our in vivo PDO metastasis model can be used to study clonality and tumor evolution and to identify biomarkers related to organotropism. Investigation of the response of KRASG12C PDOs to sotorasib demonstrates that the model can examine the efficacy of treatments to suppress metastasis and identify mechanisms of drug resistance. Finally, our PDO model cocultured with autologous peripheral blood mononuclear cells can potentially be used to determine the optimal immune-priming strategy for individual patients with LUAD.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":"5 10","pages":"101777"},"PeriodicalIF":11.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential. 泛癌症γδTCR分析揭示了克隆型的多样性和预后潜力。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-04 DOI: 10.1016/j.xcrm.2024.101764

Xiaoqing Yu, Li Song, Ling Cen, Biwei Cao, Ranran Tao, Yuanyuan Shen, Daniel Abate-Daga, Paulo C Rodriguez, Jose R Conejo-Garcia, Xuefeng Wang

引用次数: 0

Standardization of gut microbiome analysis in sports. 体育运动中肠道微生物组分析的标准化。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-04 DOI: 10.1016/j.xcrm.2024.101759

Laura Mancin, Antonio Paoli, Sara Berry, Javier T Gonzalez, Adam J Collins, Maria Antonia Lizarraga, Joao Felipe Mota, Segata Nicola, Ian Rollo

{"title":"Standardization of gut microbiome analysis in sports.","authors":"Laura Mancin, Antonio Paoli, Sara Berry, Javier T Gonzalez, Adam J Collins, Maria Antonia Lizarraga, Joao Felipe Mota, Segata Nicola, Ian Rollo","doi":"10.1016/j.xcrm.2024.101759","DOIUrl":"10.1016/j.xcrm.2024.101759","url":null,"abstract":"The gut microbiome plays a significant role in physiological functions such as nutrient processing, vitamin production, inflammatory response, and immune modulation, which, in turn, are important contributors to athlete health and performance. To date, the interpretation, discussion, and visualization of microbiome results of athletes are challenging, due to a lack of standard parameters and reference data for collection and comparison. The purpose of this perspective piece is to provide researchers with an easy-to-understand framework for the collection, analysis, and data management related to the gut microbiome with a specific focus on athletic populations. In the absence of a consensus on microbiome research in the sports field, we hope that these considerations serve as foundational \"best practice.\" Adherence to these standard operating procedures will accelerate the path toward improving the quality of data and ultimately our understanding of the influence of the gut microbiome in sport settings.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"101759"},"PeriodicalIF":11.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling high-risk Wilms tumors enables the discovery of therapeutic vulnerability. 对高风险 Wilms 肿瘤进行建模，有助于发现治疗漏洞。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-04 DOI: 10.1016/j.xcrm.2024.101770

Gui Ma, Ang Gao, Jiani Chen, Peng Liu, Rakesh Sarda, Jessica Gulliver, Yidan Wang, Carstyn Joiner, Mingshan Hu, Eui-Jun Kim, Herman Yeger, Hau D Le, Xiang Chen, Wan-Ju Li, Wei Xu

{"title":"Modeling high-risk Wilms tumors enables the discovery of therapeutic vulnerability.","authors":"Gui Ma, Ang Gao, Jiani Chen, Peng Liu, Rakesh Sarda, Jessica Gulliver, Yidan Wang, Carstyn Joiner, Mingshan Hu, Eui-Jun Kim, Herman Yeger, Hau D Le, Xiang Chen, Wan-Ju Li, Wei Xu","doi":"10.1016/j.xcrm.2024.101770","DOIUrl":"10.1016/j.xcrm.2024.101770","url":null,"abstract":"Wilms tumor (WT) is the most common pediatric kidney cancer treated with standard chemotherapy. However, less-differentiated blastemal type of WT often relapses. To model the high-risk WT for therapeutic intervention, we introduce pluripotency factors into WiT49, a mixed-type WT cell line, to generate partially reprogrammed cells, namely WiT49-PRCs. When implanted into the kidney capsule in mice, WiT49-PRCs form kidney tumors and develop both liver and lung metastases, whereas WiT49 tumors do not metastasize. Histological characterization and gene expression signatures demonstrate that WiT49-PRCs recapitulate blastemal-predominant WTs. Moreover, drug screening in isogeneic WiT49 and WiT49-PRCs leads to the identification of epithelial- or blastemal-predominant WT-sensitive drugs, whose selectivity is validated in patient-derived xenografts (PDXs). Histone deacetylase (HDAC) inhibitors (e.g., panobinostat and romidepsin) are found universally effective across different WT and more potent than doxorubicin in PDXs. Taken together, WiT49-PRCs serve as a blastemal-predominant WT model for therapeutic intervention to treat patients with high-risk WT.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"101770"},"PeriodicalIF":11.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A simplified and robust risk stratification model for stem cell transplantation in pediatric acute myeloid leukemia. 小儿急性髓性白血病干细胞移植的简化稳健风险分层模型。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-03 DOI: 10.1016/j.xcrm.2024.101762

Hua Yang, Yang Xun, Yali Shen, Hongtao Wang, Yu Tao, Huihan Wang, Xinyue Zhang, Rongqiu Liu, Huarong Yu, Li Wei, Jinsong Yan, Xiaoyu Zhu, Hua You

{"title":"A simplified and robust risk stratification model for stem cell transplantation in pediatric acute myeloid leukemia.","authors":"Hua Yang, Yang Xun, Yali Shen, Hongtao Wang, Yu Tao, Huihan Wang, Xinyue Zhang, Rongqiu Liu, Huarong Yu, Li Wei, Jinsong Yan, Xiaoyu Zhu, Hua You","doi":"10.1016/j.xcrm.2024.101762","DOIUrl":"10.1016/j.xcrm.2024.101762","url":null,"abstract":"The efficacy of stem cell transplantation (SCT) in pediatric acute myeloid leukemia (pAML) remains unsatisfactory due to the limitations of existing prognostic models in predicting efficacy and selecting suitable candidates. This study aims to develop a cytomolecular risk stratification-independent prognostic model for SCT in pAML patients at CR1 stage. The pAML SCT model, based on age, KMT2A rearrangement (KMT2A-r), and minimal residual disease at end of course 1 (MRD1), effectively classifies patients into low-, intermediate-, and high-risk groups. We validate the effectiveness in an internal validation cohort and in four external validation cohorts, consisting of different graft sources and donors. Moreover, by incorporating the FMS-like tyrosine kinase 3/internal tandem duplication (FLT3/ITD) allelic ratio, the pAML SCT model is refined, enhancing its ability to effectively select suitable candidates. We develop a simple and robust risk stratification model for pAML patients undergoing SCT, to aid in risk stratification and inform pretransplant decision-making at CR1 stage.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"101762"},"PeriodicalIF":11.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and challenges in neuroimaging-based pain biomarkers. 基于神经影像的疼痛生物标记的进展与挑战。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-08 DOI: 10.1016/j.xcrm.2024.101784

Li-Bo Zhang, Yu-Xin Chen, Zhen-Jiang Li, Xin-Yi Geng, Xiang-Yue Zhao, Feng-Rui Zhang, Yan-Zhi Bi, Xue-Jing Lu, Li Hu

{"title":"Advances and challenges in neuroimaging-based pain biomarkers.","authors":"Li-Bo Zhang, Yu-Xin Chen, Zhen-Jiang Li, Xin-Yi Geng, Xiang-Yue Zhao, Feng-Rui Zhang, Yan-Zhi Bi, Xue-Jing Lu, Li Hu","doi":"10.1016/j.xcrm.2024.101784","DOIUrl":"10.1016/j.xcrm.2024.101784","url":null,"abstract":"Identifying neural biomarkers of pain has long been a central theme in pain neuroscience. Here, we review the state-of-the-art candidates for neural biomarkers of acute and chronic pain. We classify these potential neural biomarkers into five categories based on the nature of their target variables, including neural biomarkers of (1) within-individual perception, (2) between-individual sensitivity, and (3) discriminability for acute pain, as well as (4) assessment and (5) prospective neural biomarkers for chronic pain. For each category, we provide a synthesized review of candidate biomarkers developed using neuroimaging techniques including functional magnetic resonance imaging (fMRI), structural magnetic resonance imaging (sMRI), and electroencephalography (EEG). We also discuss the conceptual and practical challenges in developing neural biomarkers of pain. Addressing these challenges, optimal biomarkers of pain can be developed to deepen our understanding of how the brain represents pain and ultimately help alleviate patients' suffering and improve their well-being.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"101784"},"PeriodicalIF":11.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical pain management: Current practice and recent innovations in research. 临床疼痛管理：当前实践与最新研究创新。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-08 DOI: 10.1016/j.xcrm.2024.101786

Jing Wang, Lisa V Doan

引用次数: 0