Cell Reports Medicine最新文献_第6页

Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential. 泛癌症γδTCR分析揭示了克隆型的多样性和预后潜力。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-04 DOI: 10.1016/j.xcrm.2024.101764

Xiaoqing Yu, Li Song, Ling Cen, Biwei Cao, Ranran Tao, Yuanyuan Shen, Daniel Abate-Daga, Paulo C Rodriguez, Jose R Conejo-Garcia, Xuefeng Wang

引用次数: 0

Advances and challenges in neuroimaging-based pain biomarkers. 基于神经影像的疼痛生物标记的进展与挑战。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-08 DOI: 10.1016/j.xcrm.2024.101784

Li-Bo Zhang, Yu-Xin Chen, Zhen-Jiang Li, Xin-Yi Geng, Xiang-Yue Zhao, Feng-Rui Zhang, Yan-Zhi Bi, Xue-Jing Lu, Li Hu

{"title":"Advances and challenges in neuroimaging-based pain biomarkers.","authors":"Li-Bo Zhang, Yu-Xin Chen, Zhen-Jiang Li, Xin-Yi Geng, Xiang-Yue Zhao, Feng-Rui Zhang, Yan-Zhi Bi, Xue-Jing Lu, Li Hu","doi":"10.1016/j.xcrm.2024.101784","DOIUrl":"10.1016/j.xcrm.2024.101784","url":null,"abstract":"Identifying neural biomarkers of pain has long been a central theme in pain neuroscience. Here, we review the state-of-the-art candidates for neural biomarkers of acute and chronic pain. We classify these potential neural biomarkers into five categories based on the nature of their target variables, including neural biomarkers of (1) within-individual perception, (2) between-individual sensitivity, and (3) discriminability for acute pain, as well as (4) assessment and (5) prospective neural biomarkers for chronic pain. For each category, we provide a synthesized review of candidate biomarkers developed using neuroimaging techniques including functional magnetic resonance imaging (fMRI), structural magnetic resonance imaging (sMRI), and electroencephalography (EEG). We also discuss the conceptual and practical challenges in developing neural biomarkers of pain. Addressing these challenges, optimal biomarkers of pain can be developed to deepen our understanding of how the brain represents pain and ultimately help alleviate patients' suffering and improve their well-being.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical pain management: Current practice and recent innovations in research. 临床疼痛管理：当前实践与最新研究创新。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-08 DOI: 10.1016/j.xcrm.2024.101786

Jing Wang, Lisa V Doan

引用次数: 0

Schwann cell-secreted frizzled-related protein 1 dictates neuroinflammation and peripheral nerve degeneration after neurotrauma. 许旺细胞分泌的frizzled相关蛋白1决定了神经创伤后的神经炎症和周围神经变性。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-14 DOI: 10.1016/j.xcrm.2024.101791

Xiangyun Yao, Lingchi Kong, Yi Qiao, David Brand, Juehong Li, Zhiwen Yan, Song Guo Zheng, Yun Qian, Cunyi Fan

{"title":"Schwann cell-secreted frizzled-related protein 1 dictates neuroinflammation and peripheral nerve degeneration after neurotrauma.","authors":"Xiangyun Yao, Lingchi Kong, Yi Qiao, David Brand, Juehong Li, Zhiwen Yan, Song Guo Zheng, Yun Qian, Cunyi Fan","doi":"10.1016/j.xcrm.2024.101791","DOIUrl":"https://doi.org/10.1016/j.xcrm.2024.101791","url":null,"abstract":"Neurotrauma in limbs can induce sustained neuroinflammation, resulting in persistent disruption of nerve tissue architecture and retardation of axon regrowth. Despite macrophage-mediated inflammation promoting the removal of necrotic neural components and stimulating neo-vessel ingrowth, detrimental shifts in macrophage phenotype exacerbate nerve degeneration. Herein, we find that peripheral nerve injuries (PNIs) result in abundant secreted frizzled-related protein 1 (sFRP1) expression, particularly by Schwann cells (SCs). Heat shock protein 90 (HSP90) in macrophages recognizes sFRP1 and triggers a dysregulated secretion of inflammatory mediators. Single-cell atlas of human injured peripheral nerves reveals the appearance of sFRP1-expressing SCs with mesenchymal traits and macrophages with a proinflammatory genetic profile. Deletion of either SC-specific sFRP1 or macrophage-specific HSP90 alleviates neuroinflammation and prevents the progression of nerve degeneration. Together, our findings implicate the response of macrophages to SC-derived sFRP1 in exacerbating nerve damage following PNIs.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EGFR-directed antibodies promote HER2 ADC internalization and efficacy. 表皮生长因子受体定向抗体可促进 HER2 ADC 的内化和疗效。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-11 DOI: 10.1016/j.xcrm.2024.101792

Avantika Gupta, Flavia Michelini, Hong Shao, Celine Yeh, Joshua Z Drago, Dazhi Liu, Eric Rosiek, Yevgeniy Romin, Negin Ghafourian, Sheeno Thyparambil, Sandra Misale, Wungki Park, Elisa de Stanchina, Yelena Y Janjigian, Rona Yaeger, Bob T Li, Sarat Chandarlapaty

{"title":"EGFR-directed antibodies promote HER2 ADC internalization and efficacy.","authors":"Avantika Gupta, Flavia Michelini, Hong Shao, Celine Yeh, Joshua Z Drago, Dazhi Liu, Eric Rosiek, Yevgeniy Romin, Negin Ghafourian, Sheeno Thyparambil, Sandra Misale, Wungki Park, Elisa de Stanchina, Yelena Y Janjigian, Rona Yaeger, Bob T Li, Sarat Chandarlapaty","doi":"10.1016/j.xcrm.2024.101792","DOIUrl":"https://doi.org/10.1016/j.xcrm.2024.101792","url":null,"abstract":"Trastuzumab deruxtecan (T-DXd) is a human epidermal growth factor receptor 2 (HER2)-targeting antibody drug conjugate that has remarkable activity in HER2-positive cancers. However, the degree of benefit of T-DXd is not uniform among solid tumors even with high levels of HER2. Despite high HER2 expression, the HER2/T-DXd complex may not always undergo internalization and payload release dependent on the receptor's conformation and context. We hypothesize that epidermal growth factor receptor (EGFR), a dimerization partner of HER2, can modulate HER2 trafficking through endocytic pathways and affect T-DXd uptake. We demonstrate that elevated EGFR expression levels can promote EGFR/HER2 heterodimer formation and suppress T-DXd internalization and efficacy. Knockdown of EGFR expression or pharmacologic stimulation of EGFR endocytosis with EGFR monoclonal antibodies restores T-DXd trafficking and antitumor activity in EGFR-overexpressing cancers in vivo. Our results reveal EGFR overexpression to be a potential mechanism of resistance to T-DXd, which can be overcome by combination therapy strategies targeting EGFR.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropeptide therapeutics to repress lateral septum neurons that disable sociability in an autism mouse model. 神经肽疗法抑制自闭症小鼠模型的外侧隔神经元，使其丧失社交能力。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-10 DOI: 10.1016/j.xcrm.2024.101781

Amélie M Borie, Yann Dromard, Prabahan Chakraborty, Pierre Fontanaud, Emilie M Andre, Amaury François, Pascal Colson, Françoise Muscatelli, Gilles Guillon, Michel G Desarménien, Freddy Jeanneteau

{"title":"Neuropeptide therapeutics to repress lateral septum neurons that disable sociability in an autism mouse model.","authors":"Amélie M Borie, Yann Dromard, Prabahan Chakraborty, Pierre Fontanaud, Emilie M Andre, Amaury François, Pascal Colson, Françoise Muscatelli, Gilles Guillon, Michel G Desarménien, Freddy Jeanneteau","doi":"10.1016/j.xcrm.2024.101781","DOIUrl":"https://doi.org/10.1016/j.xcrm.2024.101781","url":null,"abstract":"Confronting oxytocin and vasopressin deficits in autism spectrum disorders and rare syndromes brought promises and disappointments for the treatment of social disabilities. We searched downstream of oxytocin and vasopressin for targets alleviating social deficits in a mouse model of Prader-Willi syndrome and Schaaf-Yang syndrome, both associated with high prevalence of autism. We found a population of neurons in the lateral septum-activated on termination of social contacts-which oxytocin and vasopressin inhibit as per degree of peer affiliation. These are somatostatin neurons expressing oxytocin receptors coupled to GABA-B signaling, which are inhibited via GABA-A channels by vasopressin-excited GABA neurons. Loss of oxytocin or vasopressin signaling recapitulated the disease phenotype. By contrast, deactivation of somatostatin neurons or receptor signaling alleviated social deficits of disease models by increasing the duration of contacts with mates and strangers. These findings provide new insights into the treatment framework of social disabilities in neuropsychiatric disorders.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disrupting stroke-induced GAT-1-syntaxin1A interaction promotes functional recovery after stroke. 破坏中风诱导的 GAT-1-syntaxin1A 相互作用可促进中风后的功能恢复。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-10 DOI: 10.1016/j.xcrm.2024.101789

Yu-Hui Lin, Feng Wu, Ting-You Li, Long Lin, Fan Gao, Li-Juan Zhu, Xiu-Mei Xu, Ming-Yu Chen, Ya-Lan Hou, Chang-Jing Zhang, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Ya-Juan Qin, Dong-Ya Zhu

{"title":"Disrupting stroke-induced GAT-1-syntaxin1A interaction promotes functional recovery after stroke.","authors":"Yu-Hui Lin, Feng Wu, Ting-You Li, Long Lin, Fan Gao, Li-Juan Zhu, Xiu-Mei Xu, Ming-Yu Chen, Ya-Lan Hou, Chang-Jing Zhang, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Ya-Juan Qin, Dong-Ya Zhu","doi":"10.1016/j.xcrm.2024.101789","DOIUrl":"https://doi.org/10.1016/j.xcrm.2024.101789","url":null,"abstract":"Although stroke is a frequent cause of permanent disability, our ability to promote stroke recovery is limited. Here, we design a small-molecule stroke recovery promoting agent that works by dissociating γ-aminobutyric acid (GABA) transporter 1 (GAT-1) from syntaxin1A (Synt1A), a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein. Stroke induces an increase in GAT-1-Synt1A interaction in the subacute phase, a critical period for functional recovery. Uncoupling GAT-1-Synt1A reverses stroke-induced GAT-1 dysfunction and cortical excitability decline and enhances synaptic GABAergic inhibition and consequently cortical oscillations and network plasticity by facilitating the assembly of the SNARE complex at the synapse. Based on the molecular mechanism of GAT-1 binding to Synt1A, we design GAT-1-Synt1A blockers. Among them, ZLQ-3 exhibits the greatest potency. Intranasal use of ZLQ-3-1, a glycosylation product of ZLQ-3, substantially lessens impairments of sensorimotor and cognitive functions in rodent models. This compound, or its analogs, may serve as a promoting agent for stroke recovery.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The penetration of therapeutics across the blood-brain barrier: Classic case studies and clinical implications. 治疗药物穿越血脑屏障：经典案例研究与临床意义。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2024-10-03 DOI: 10.1016/j.xcrm.2024.101760

William A Banks, Elizabeth M Rhea, May J Reed, Michelle A Erickson

引用次数: 0

Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma 以 eIF4G1 为靶点重编程免疫抑制微环境，根除胰腺导管腺癌

IF 14.3 1区医学

Cell Reports Medicine Pub Date : 2024-09-19 DOI: 10.1016/j.xcrm.2024.101731

Lihong He, Xiaozhen Zhang, Fukang Shi, Hanjia Zhang, Yan Chen, Kang Sun, Hanshen Yang, Jiatao Shi, Zihao Lin, Qingsong Lu, Sicheng Wang, Linyue Liu, Xinyuan Liu, Qingbo Meng, Junmin Huang, Pinglong Xu, Xueli Bai, Tingbo Liang

{"title":"Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma","authors":"Lihong He, Xiaozhen Zhang, Fukang Shi, Hanjia Zhang, Yan Chen, Kang Sun, Hanshen Yang, Jiatao Shi, Zihao Lin, Qingsong Lu, Sicheng Wang, Linyue Liu, Xinyuan Liu, Qingbo Meng, Junmin Huang, Pinglong Xu, Xueli Bai, Tingbo Liang","doi":"10.1016/j.xcrm.2024.101731","DOIUrl":"https://doi.org/10.1016/j.xcrm.2024.101731","url":null,"abstract":"Current therapies against pancreatic ductal adenocarcinoma (PDAC) have limited clinical benefits owing to tumor heterogeneity and their unique immunosuppressive microenvironments. The eukaryotic initiation factor (eIF) 4F complex is involved in regulating translation and various downstream carcinogenic signaling pathways. We report that eIF4G1, one of the subunits of eIF4F, is overexpressed in cancer cells and cancer-associated fibroblasts, and this correlates with poor prognosis in patients with PDAC. In PDAC mice, eIF4G1 inhibition limits tumor progression and prolongs overall survival, especially when combined with PD1/PDL1 antagonists and gemcitabine. Mechanistically, eIF4G1 inhibition hinders the production of cytokines and chemokines that promote fibrosis and inhibit cytotoxic T cell chemotaxis. Moreover, eIF4G1 inhibition impairs integrinβ1 protein translation and exerts tumor suppression effects through the FAK-ERK/AKT signaling pathway. These findings highlight the effects of eIF4G1 on tumor immune dependence and independence and identify eIF4G1 as a promising therapeutic target for PDAC.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":null,"pages":null},"PeriodicalIF":14.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mining nucleic acid “omics” to boost liquid biopsy in cancer 挖掘核酸 "omics"，促进癌症液体活检

IF 14.3 1区医学

Cell Reports Medicine Pub Date : 2024-09-17 DOI: 10.1016/j.xcrm.2024.101736

Ann Tivey, Rebecca J. Lee, Alexandra Clipson, Steven M. Hill, Paul Lorigan, Dominic G. Rothwell, Caroline Dive, Florent Mouliere

引用次数: 0