Xiaojing Jia, Chunyan Hu, Yu Xu, Yue Yin, Hong Lin, Ruizhi Zheng, Mian Li, Min Xu, Tiange Wang, Zhiyun Zhao, Hong Qiao, Guijun Qin, Yingfen Qin, Xulei Tang, Zhen Ye, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Qin Wan, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, Li Chen, Xinguo Hou, Yanan Huo, Qiang Li, Yinfei Zhang, Tianshu Zeng, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Donghui Li, Shenghan Lai, Lulu Chen, Jiajun Zhao, Yiming Mu, Guang Ning, Yuhong Chen, Jieli Lu, Yufang Bi, Weiqing Wang
{"title":"重新审视中国成人心血管疾病和死亡风险的肥胖阈值：年龄和性别特异性见解","authors":"Xiaojing Jia, Chunyan Hu, Yu Xu, Yue Yin, Hong Lin, Ruizhi Zheng, Mian Li, Min Xu, Tiange Wang, Zhiyun Zhao, Hong Qiao, Guijun Qin, Yingfen Qin, Xulei Tang, Zhen Ye, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Qin Wan, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, Li Chen, Xinguo Hou, Yanan Huo, Qiang Li, Yinfei Zhang, Tianshu Zeng, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Donghui Li, Shenghan Lai, Lulu Chen, Jiajun Zhao, Yiming Mu, Guang Ning, Yuhong Chen, Jieli Lu, Yufang Bi, Weiqing Wang","doi":"10.1016/j.xcrm.2025.102309","DOIUrl":null,"url":null,"abstract":"<p><p>Current obesity classifications may not adequately reflect age- and gender-specific risks in diverse populations. In a prospective cohort study of 166,285 Chinese adults aged ≥40 years without prior cardiovascular disease (CVD) or cancer, we evaluate optimal thresholds of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) for predicting incident CVD and all-cause mortality. We observe monotonically increasing dose-response associations of BMI, WC, and WHR with CVD risk but U-shaped relationships with all-cause mortality. The optimal obesity thresholds based on all-cause mortality risk differ by gender, with the lowest mortality risks occurring at BMI 26.3 kg/m<sup>2</sup>, WC 88 cm, and WHR 0.90 in men and BMI 25.4 kg/m<sup>2</sup>, WC 83 cm, and WHR 0.85 in women. Moreover, higher adiposity appears protective in older adults. These findings highlight the need for population-specific obesity criteria to enhance clinical risk assessment and public health strategies.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102309"},"PeriodicalIF":10.6000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490207/pdf/","citationCount":"0","resultStr":"{\"title\":\"Revisiting obesity thresholds for cardiovascular disease and mortality risk in Chinese adults: Age- and gender-specific insights.\",\"authors\":\"Xiaojing Jia, Chunyan Hu, Yu Xu, Yue Yin, Hong Lin, Ruizhi Zheng, Mian Li, Min Xu, Tiange Wang, Zhiyun Zhao, Hong Qiao, Guijun Qin, Yingfen Qin, Xulei Tang, Zhen Ye, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Qin Wan, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, Li Chen, Xinguo Hou, Yanan Huo, Qiang Li, Yinfei Zhang, Tianshu Zeng, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Donghui Li, Shenghan Lai, Lulu Chen, Jiajun Zhao, Yiming Mu, Guang Ning, Yuhong Chen, Jieli Lu, Yufang Bi, Weiqing Wang\",\"doi\":\"10.1016/j.xcrm.2025.102309\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Current obesity classifications may not adequately reflect age- and gender-specific risks in diverse populations. 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Revisiting obesity thresholds for cardiovascular disease and mortality risk in Chinese adults: Age- and gender-specific insights.
Current obesity classifications may not adequately reflect age- and gender-specific risks in diverse populations. In a prospective cohort study of 166,285 Chinese adults aged ≥40 years without prior cardiovascular disease (CVD) or cancer, we evaluate optimal thresholds of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) for predicting incident CVD and all-cause mortality. We observe monotonically increasing dose-response associations of BMI, WC, and WHR with CVD risk but U-shaped relationships with all-cause mortality. The optimal obesity thresholds based on all-cause mortality risk differ by gender, with the lowest mortality risks occurring at BMI 26.3 kg/m2, WC 88 cm, and WHR 0.90 in men and BMI 25.4 kg/m2, WC 83 cm, and WHR 0.85 in women. Moreover, higher adiposity appears protective in older adults. These findings highlight the need for population-specific obesity criteria to enhance clinical risk assessment and public health strategies.
Cell Reports MedicineBiochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
15.00
自引率
1.40%
发文量
231
审稿时长
40 days
期刊介绍：
Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine.
Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.
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