Cell Reports Medicine最新文献

{"title":"Global, regional, and national burden of headache disorders, 1990-2021, with forecasts to 2050: A Global Burden of Disease study 2021.","authors":"Tissa Wijeratne, Jiyeon Oh, Soeun Kim, Yesol Yim, Min Seo Kim, Jae Il Shin, Yun-Seo Oh, Raon Jung, Yun Seo Kim, Lee Smith, Hasan Aalruz, Rami Abd-Rabu, Deldar Morad Abdulah, Richard Gyan Aboagye, Meysam Abolmaali, Dariush Abtahi, Ahmed Abualhasan, Rufus Adesoji Adedoyin, Qorinah Estiningtyas Sakilah Adnani, Fatemeh Afrashteh, Navidha Aggarwal, Danish Ahmad, Ali Ahmadi, Negar Sadat Ahmadi, Amir Mahmoud Ahmadzade, Syed Anees Ahmed, Salah Al Awaidy, Sawsan Alabbad, Muaaz M Alajlani, Yazan Al-Ajlouni, Mohammed Usman Ali, Syed Shujait Ali, Waad Ali, Joseph Uy Almazan, Najim Z Alshahrani, Awais Altaf, Mohammad Al-Wardat, Karem H Alzoubi, Sohrab Amiri, Hubert Amu, Ganiyu Adeniyi Amusa, David B Anderson, Saleha Anwar, Demelash Areda, Mohammad Asghari-Jafarabadi, Sait Ashina, Javed Ashraf, Tahira Ashraf, Ali Azargoonjahromi, Yogesh Bahurupi, Atif Amin Baig, Soham Bandyopadhyay, Mainak Bardhan, Hiba Jawdat Barqawi, Azadeh Bashiri, Mohammad-Mahdi Bastan, Maryam Bemanalizadeh, Isabela M Bensenor, Alemshet Yirga Yirga Berhie, Akshaya Srikanth Bhagavathula, Sonu Bhaskar, Vivek Bhat, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti, Cem Bilgin, Atanu Biswas, Bruno Bizzozero-Peroni, Yasser Bustanji, Luis Alberto Cámera, Edoardo Caronna, Andre F Carvalho, Sandip Chakraborty, Patrick R Ching, Nikos Christodoulou, Dinh-Toi Chu, Hongyuan Chu, Natalia Cruz-Martins, Omid Dadras, Xiaochen Dai, Emanuele D'Amico, Amira Hamed Darwish, Sindhura Deekonda, Vinoth Gnana Chellaiyan Devanbu, Samath Dhamminda Dharmaratne, Adriana Dima, Temesgien Ergetie Dinkayehu, Huyen Do, Paul Narh Doku, Ojas Prakashbhai Doshi, Abdel Rahman E'mar, Negin Eissazade, Chadi Eltaha, Ayesha Fahim, Jawad Fares, Mohsen Farjoud Kouhanjani, Andre Faro, Patrick Fazeli, Seyed-Mohammad Fereshtehnejad, Pietro Ferrara, Nuno Ferreira, Florian Fischer, Arianna Fornari, Márió Gajdács, Miglas Welay Gebregergis, Delaram J Ghadimi, Amir Ghaffari Jolfayi, Elena V Gnedovskaya, Mahaveer Golechha, Enrique Gomez Figueroa, Mohammad Hashem Hashempur, Md Saquib Hasnain, Amr Hassan, Nageeb Hassan, Mahgol Sadat Hassan Zadeh Tabatabaei, Mohamed I Hegazy, Golnaz Heidari, Bartosz Helfer, Md Mahbub Hossain, Mowafa Househ, Chengxi Hu, Ivo Iavicoli, Olayinka Stephen Ilesanmi, Irena M Ilic, Muhana Fawwazy Ilyas, Salim Ilyasu, Nahlah Elkudssiah Ismail, Ali Jafari-Khounigh, Haitham Jahrami, Manthan Dilipkumar Janodia, Ruwan Duminda Jayasinghe, Bijay Mukesh Jeswani, Jost B Jonas, Nitin Joseph, Rizwan Kalani, Moien A B Khan, Sorour Khateri, Mahalaqua Nazli Khatib, Hamid Reza Khayat Kashani, Feriha Fatima Khidri, Moein Khormali, Sepehr Khosravi, Yun Jin Kim, Farzad Kompani, Karel Kostev, Kewal Krishan, Bindu Krishnan, Barthelemy Kuate Defo, Mohammed Kuddus, Mukhtar Kulimbet, Rakesh Kumar, Vijay Kumar, Ville Kytö, Savita Lasrado, Seung Won Lee, Jacopo Lenzi, Matilde Leonardi, Giancarlo Lucchetti, Alessandra Lugo, Irsa Fatima Makhdoom, Arashk Mallahzadeh, Vahid Mansouri, Roy Rillera Marzo, Yasith Mathangasinghe, Mahsa Mayeli, Asim Mehmood, Atte Meretoja, Tomislav Mestrovic, Sachith Mettananda, Giuseppe Minervini, Archana Mishra, Prasanna Mithra, Khabab Abbasher Hussien Mohamed Ahmed, Ibrahim Mohammadzadeh, Shafiu Mohammed, Lorenzo Monasta, Shane Douglas Morrison, Amin Nabavi, Zuhair S Natto, Javaid Nauman, Luciano Nieddu, Fred Nugen, Andrew T Olagunju, Arão Belitardo Oliveira, Welber Sousa Oliveira, Hany A Omar, Goran Latif Omer, Nikita Otstavnov, Mahesh P A, Leonidas D Panos, Romil R Parikh, Shankargouda Patil, Apurba Patra, Paolo Pedersini, Umberto Pensato, Prince Peprah, Mario F P Peres, Michael A Piradov, Patricia Pozo-Rosich, Jalandhar Pradhan, Sanjay Prakash, Akila Prashant, Jagadeesh Puvvula, Alireza Rafiei, Alberto Raggi, Amir Masoud Rahmani, Mahmoud Mohammed Ramadan, Devarajan Rathish, Ilari Rautalin, Salman Rawaf, Mohsen Rezaeian, Donya Rezazadeh Eidgahi, Taeho Gregory Rhee, Priyanka Roy, Adnan Saad Eddin, Cameron John Sabet, Basema Ahmad Saddik, Erfan Sadeghi, Umar Saeed, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Pragyan Monalisa Sahoo, Sohrab Salimi, Abdallah M Samy, Jennifer Saulam, Monika Sawhney, Yigit Can Senol, Subramanian Senthilkumaran, Yashendra Sethi, Homa Seyedmirzaei, Mahan Shafie, Anas Shamsi, Amin Sharifan, Hatem Samir Shehata, Rekha Raghuveer Shenoy, Farhad Shokraneh, Jaspreet Kaur Sidhu, Baljinder Singh, Harmanjit Singh, Jasvinder A Singh, Surjit Singh, Anna Aleksandrovna Skryabina, Farrukh Sobia, Bahadar S Srichawla, Vinay Suresh, Chandan Kumar Swain, Sree Sudha T Y, Payam Tabaee Damavandi, Celine Tabche, Mohammad Tabish, Manoj Tanwar, Mohamad-Hani Temsah, Masayuki Teramoto, Nghia Minh Tran, Thang Huu Tran, Aristidis Tsatsakis, Aniefiok John Udoakang, Jibrin Sammani Usman, Hande Uzunçıbuk, Jef Van den Eynde, Tommi Juhani Vasankari, Narayanaswamy Venketasubramanian, Jorge Hugo Villafañe, Lintao Wang, Xingxin Wang, Yuan-Pang Wang, Taweewat Wiangkham, Andrea Sylvia Winkler, Alemayehu Molla Wollie, Zheman Xiao, Yazachew Engida Engida Yismaw, Abdilahi Yousuf, Zhongyi Zhao, Magdalena Zielińska, Min Kyung Chu, Tae-Jin Song, Dong Keon Yon, Valery L Feigin","doi":"10.1016/j.xcrm.2025.102348","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102348","url":null,"abstract":"<p><p>Headache disorders, especially migraines and tension-type headaches (TTHs), are major global public health concerns, as shown by the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. We provide updated global estimates of prevalence and years lived with disability (YLDs) from 1990 to 2021 across 204 countries and territories and forecasts through 2050. In 2021, there are 2.0 billion people with TTH and 1.2 billion with migraine. Although TTH is more prevalent, migraine causes higher disability. While crude prevalence and YLDs increased, age-standardized rates remained stable and are projected to continue this trend due to population growth. There is a disproportionately higher burden in women aged 30-44 and countries with higher Socio-demographic Index and Healthcare Access and Quality Index. Despite this, migraines remain underrecognized in health policies and funding. This study emphasizes the urgent need to prioritize headache disorders in global health agendas.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102348"},"PeriodicalIF":10.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic T cells with 3-in-1 strategy for the treatment of biliary tract cancer.","authors":"Xueshuai Wan, Jie Zhao, Xiaobo Yang, Xianing Mou, Bing Liu, Bin Gao, Weiyue Gu, Haitao Zhao","doi":"10.1016/j.xcrm.2025.102349","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102349","url":null,"abstract":"<p><p>T cell therapy for tumors faces barriers like heterogeneous antigen expression, an unfriendly tumor microenvironment, and limited T cell expansion. We adopt a 3-in-1 strategy to produce super circulating TIL-like (tumor-infiltrating lymphocyte-like) cells (ScTILs): modifying PD-1-positive peripheral blood T cells with an enhance receptor (ER), a PD-1 and CD28 fusion protein to reverse inhibitory signal, and an anti-CD19 chimeric antigen receptor (CAR) for expansion (CFE). ScTILs kill tumor cells effectively in vitro and in vivo. Clinically, ten advanced biliary tract cancer (BTC) patients receive ScTILs treatment; post hoc analysis shows that ScTILs monotherapy yields a median overall survival (OS) of 18.3 months in appropriate dose or normal B cell groups (5/10), outperforming first-line BTC treatment (OS ∼12 months). It skips chemo-pre-treatment and interleukin-2 (IL-2), with better safety, no reliance on surgical materials, and a shorter production cycle. Overall, ScTILs are a promising therapy for future BTC treatment. This study is registered with ChiCTR (ChiCTR2000029738).</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102349"},"PeriodicalIF":10.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lentiviral vectors for hematopoietic stem cell gene therapy restore α-globin expression in α-thalassemia red blood cells.","authors":"Eva E R Segura, Kevyn Hart, Beatriz Campo Fernandez, Devin Brown, Kevin Tam, Andrea Gutierrez Garcia, Eva Seigneurbieux, Karen Li, Carol Mulumba, Emma Blakely, Katelyn Masiuk, Roshani Sinha, Devesh Sharma, John Everett, Matthew Hogenauer, M Kyle Cromer, Frederic Bushman, Tippi C MacKenzie, Donald B Kohn","doi":"10.1016/j.xcrm.2025.102362","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102362","url":null,"abstract":"<p><p>Alpha thalassemia major (ATM) is an inherited blood disorder caused by the absence of all four α-globin genes (HBA2/1), resulting in severe anemia and lifelong transfusion dependence. While allogeneic hematopoietic stem cell transplantation (HSCT) offers a potential cure, donor availability remains limited. We present a gene therapy approach for autologous HSCT using lentiviral vectors (LVs) to deliver HBA2 under the regulation of optimized β-globin locus control region (LCR) enhancers, restoring α-globin expression in red blood cells. The best-performing LVs, erythroid vector-alpha (EV-α) and EV-α-UV, achieved up to 100% transduction efficiency in human hematopoietic stem and progenitor cells (HSPCs), optimal vector copy numbers, and safe integration profiles. ATM-derived HSPCs from three donors treated with these LVs yielded α/β-globin mRNA and chain ratios within the therapeutic range (∼0.5+), and restored hemoglobin levels by 50%-100%. These findings establish the safety and clinical potential of EV-α and EV-α-UV as a promising autologous stem cell gene therapy for ATM.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102362"},"PeriodicalIF":10.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An age-related decrease in leptin contributes to CD8⁺ T cell aging in the tumor microenvironment.","authors":"Feixiang Wang, Rujuan Bao, Shuiyu Xu, Wenyan Li, Haiyan Huang, Runchang Li, Xinyu Ding, Yuerong Zhang, Xiaoyan Yu, Qiaoqiao Han, Xian Du, Jie Wan, Song Li, Yichuan Xiao, Ren Zhao, Xingang Cui, Youqiong Ye, Jiayuan Sun, Junke Zheng, Guo-Qiang Chen, Qiang Zou","doi":"10.1016/j.xcrm.2025.102310","DOIUrl":"10.1016/j.xcrm.2025.102310","url":null,"abstract":"<p><p>T cell dysfunction with age underlies an increased incidence of cancer in elderly individuals; however, how T cell aging is triggered in the tumor microenvironment is unclear. Here, we show that an age-associated reduction in adipocyte-derived leptin contributes to the accumulation of tumor-infiltrating senescent CD8⁺ T cells. Single-cell profiling of human and mouse cancer tissues reveals that the frequency of intratumoral senescent CD8⁺ T cells increases with age, leading to a weak antitumor effect. Moreover, decreased levels of adipocyte-derived leptin are an indispensable factor for CD8⁺ T cell aging. Leptin signaling prevents p38-dependent CD8⁺ T cell senescence. Furthermore, plasma leptin levels are negatively related to intratumoral CD8⁺ T cell senescence in cancer patients. Our findings identify an unappreciated interplay between metabolic perturbation and T cell aging and suggest that modulating adipocyte-derived leptin levels may be a promising therapeutic strategy for older cancer patients.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102310"},"PeriodicalIF":10.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in hepatocellular carcinoma after FOLFOX-HAIC therapy.","authors":"Rui Xing, Jie Mei, Zhijun Zuo, Hao Zou, Xingjuan Yu, Jing Xu, Rongping Guo, Wei Wei, Limin Zheng","doi":"10.1016/j.xcrm.2025.102298","DOIUrl":"10.1016/j.xcrm.2025.102298","url":null,"abstract":"<p><p>Tertiary lymphoid structures (TLSs) emerge as crucial determinants of anti-tumor immune responses and clinical outcomes. However, their clinical significance and formation mechanisms in hepatocellular carcinoma (HCC) remain unclear. Here, we demonstrate that hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin, leucovorin, and fluorouracil (FOLFOX) significantly enhances TLS formation in HCC tissues, correlating with improved therapeutic efficacy and prolonged progression-free survival in patients with HCC. Mechanistically, HAIC induces lymphotoxin β (LTβ)-expressing central memory T cell (T_CM)-like CD4⁺ T cells, which activate MMP2⁺ fibroblasts and FOLR2⁺CCL4⁺ macrophages via the LTβ-LTβR axis to drive TLS development. Furthermore, the CXCL12-CXCR4 axis acts as a critical mediator in recruiting these cells to HAIC-treated tumors, thereby facilitating TLS formation and enhancing anti-tumor immunity. These findings highlight the pivotal role of TLSs in HAIC-induced anti-tumor immunity and their significance as robust prognostic biomarkers, offering potential therapeutic targets to optimize clinical outcomes for patients with HCC.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102298"},"PeriodicalIF":10.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenized neural stem cell-derived exosomes: A neotype therapeutic agent for traumatic injuries of the central nervous system.","authors":"Wenjing Wang, Guihong Lu, Peilin Guo, Haochong Zhang, Yan Wang, Diwei Zheng, Chengliang Lyu, Dongfang Wang, Shang Li, Feng Li, Jiawei Zhao, Meng Qin, Weiping Li, Hui Tan, Guanghui Ma, Wei Wei","doi":"10.1016/j.xcrm.2025.102319","DOIUrl":"10.1016/j.xcrm.2025.102319","url":null,"abstract":"<p><p>Oxidative damage and neuroinflammation are the key features of central nervous system (CNS) injury. Inspired by the neuroprotective properties of neural stem cell-derived exosomes (NExo) and the reactive oxygen species (ROS) scavenging ability of selenium, we develop an advanced NExo bearing ultrasmall nano-selenium (∼3.5 nm) via lipid-mediated nucleation (SeNExo). In addition to maintaining the biological components of NExo, the resulting SeNExo exhibits a Se-O bond that dramatically enhances its ROS-scavenging performance. SeNExo penetrates the blood-brain barrier (BBB) via the apolipoprotein E and prolow-density lipoprotein receptor-related protein 1 (APOE_LRP-1) interaction. Through proteomics, microRNA (miRNA) omics, and single-nucleus RNA sequencing, we find that SeNExo can alleviate neuronal apoptosis, restore glia homeostasis, and remodel glia-neuron networks. Therefore, SeNExo confers potent therapeutic benefits, significantly reducing cerebral lesions in a murine traumatic brain injury model. Even extending to a murine spinal cord injury model, SeNExo promotes locomotory recovery, further supporting SeNExo as a neotype and a promising therapeutic agent for treating traumatic CNS injury.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102319"},"PeriodicalIF":10.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic modulation of BARD1 to enhance anti-VEGF therapy.","authors":"Emine Bayraktar, Cristian Rodriguez-Aguayo, Elaine Stur, Sudhir Kumar, Lingegowda S Mangala, Nicholas B Jennings, Nazende Nur Bayram, Sara Corvigno, Amma Asare, Cristina Ivan, Mark S Kim, Thanh Chung Vu, Pahul Hanjra, Sangbae Kim, Adrian Lankenau Ahumada, Weichem Wu, Sanghoon Lee, Anna Szymanowska, Hulya Oztatlici, Marcos R Estecio, Ju-Seog Lee, Abhinav K Jain, Nidhi Sahni, John P Hagan, Stephen Baylin, Jinsong Liu, Gabriel Lopez-Berestein, Sunila Pradeep, Anil K Sood","doi":"10.1016/j.xcrm.2025.102329","DOIUrl":"10.1016/j.xcrm.2025.102329","url":null,"abstract":"<p><p>Despite the clinical use of anti-vascular endothelial growth factor (VEGF) antibodies (AVAs) in cancer therapy, resistance frequently develops, leading to disease progression. To address this, we identify a previously unknown role for breast cancer type 1 susceptibility protein (BRCA1)-associated RING domain 1 (BARD1) in modulating AVA sensitivity. Epigenetic modulation-via global and targeted DNA methylation-reveals BARD1 as a key regulator of angiogenesis. Sequential treatment with azacytidine overcomes AVA resistance in vivo. To enable precise epigenetic reactivation, we develop a liposomal CRISPR-deactivated Cas9 (dCas9)-TET1 system guided by BARD1-targeting single-guide RNAs (sgRNAs). This platform achieves CpG-specific demethylation of the BARD1 promoter, restores expression, and enhances AVA response. Additionally, BARD1 restoration, through either dCas9-TET1 or small interfering RNA (siRNA), significantly reduces tumor growth in combination with AVA in ovarian cancer models. These findings uncover a previously unrecognized function of BARD1 in tumor angiogenesis and demonstrate the potential of gene-specific epigenetic targeting to overcome AVA resistance.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102329"},"PeriodicalIF":10.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic disease and cardio-oncology: Insights from iPSC models and tissue engineering.","authors":"Ana Kojic, Javid Moslehi, Bonnie Ky, Joseph C Wu","doi":"10.1016/j.xcrm.2025.102261","DOIUrl":"10.1016/j.xcrm.2025.102261","url":null,"abstract":"<p><p>Heart disease and cancer share common risk factors, genetic predispositions, and metabolic and inflammatory components. Metabolic reprogramming can drive disease progression in both, with cardiometabolic syndrome-marked by obesity, insulin resistance, dyslipidemia, and hypertension-contributing to cancer development. Studies link around 20% of cancer cases to obesity, while elevated glucose and triglyceride levels increase the risk of liver, thyroid, and respiratory cancers. Beyond treatment-related cardiotoxicity, cancer patients often have pre-existing cardiovascular disease (CVD) at diagnosis, highlighting their bidirectional relationship. Patient-specific induced pluripotent stem cells (iPSCs) offer a powerful platform to study these links at a personalized level. iPSC models help explore shared molecular mechanisms, metabolic dysregulation, inflammation, and cardiotoxicity. This review examines emerging themes in cardio-oncology and cardio-metabolism, emphasizing how iPSC-based approaches can reveal disease connections and inform new therapies.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102261"},"PeriodicalIF":10.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4⁺ T cells.","authors":"Hongbo Gao, Yuhao Li, Ritudwhaj Tiwari, Marilia Pinzone, Xiwen Qin, Kolin M Clark, Sara K Nicholson, Tony Yao, Kelly Rome, Michael Scaglione, Will Bailis, Rachel M Presti, Irini Sereti, Naresha Saligrama, Leyao Wang, Liang Shan","doi":"10.1016/j.xcrm.2025.102311","DOIUrl":"10.1016/j.xcrm.2025.102311","url":null,"abstract":"<p><p>Despite antiretroviral therapy, HIV-1 mainly persists in memory CD4⁺ T cells in people living with HIV-1. Most long-lived viral reservoir cells are infected by the virus near the time of therapy initiation. A better understanding of the early events in viral reservoir seeding presents opportunities for preventing latent reservoir formation. Here, we demonstrate that CD4⁺ T cells expressing CCR5, permissive to HIV-1 infection, are effector or terminally differentiated cells. BTB domain and CNC homolog 2 (BACH2) is expressed by a small subset of CCR5⁺ cells and reverses their terminal differentiation. BACH2-mediated memory differentiation is impeded due to heightened inflammation before treatment initiation. Mice with a BACH2-knockout human immune system have a reduced frequency of HIV-1 reservoir cells and do not experience virus rebound after treatment discontinuation. Our study reveals that BACH2 is essential to the seeding and establishment of long-lived HIV-1 reservoir in memory CD4⁺ T cells.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102311"},"PeriodicalIF":10.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can muscle avert GLP1R weight plateau and regain?","authors":"Dongdong Wang, Andre Djalalvandi, Christina T Saed, Katherine M Morrison, Gregory R Steinberg","doi":"10.1016/j.xcrm.2025.102308","DOIUrl":"10.1016/j.xcrm.2025.102308","url":null,"abstract":"<p><p>GLP1R-based obesity therapies can reduce lean muscle and energy expenditure via adaptive thermogenesis (also known as metabolic adaptation), leading to weight plateaus and regain. Defining the role of muscle energy expenditure in mediating these effects is critical to improving next-generation treatments and sustaining long-term weight loss.</p>","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":"6 9","pages":"102308"},"PeriodicalIF":10.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}