Cell Reports Medicine最新文献_第3页

Arun Sharma. 阿伦沙玛。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.xcrm.2025.102048

Arun Sharma

引用次数: 0

Cooking methods affect advanced glycation end products and lipid profiles: A randomized cross-over study in healthy subjects. 烹饪方法影响晚期糖基化终产物和脂质谱：一项健康受试者的随机交叉研究

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.xcrm.2025.102091

Judith Wellens, Eva Vissers, Anaïs Dumoulin, Sien Hoekx, Julie Vanderstappen, Joke Verbeke, Roman Vangoitsenhoven, Muriel Derrien, Bram Verstockt, Marc Ferrante, Christophe Matthys, Jeroen Raes, Kristin Verbeke, Séverine Vermeire, João Sabino

{"title":"Cooking methods affect advanced glycation end products and lipid profiles: A randomized cross-over study in healthy subjects.","authors":"Judith Wellens, Eva Vissers, Anaïs Dumoulin, Sien Hoekx, Julie Vanderstappen, Joke Verbeke, Roman Vangoitsenhoven, Muriel Derrien, Bram Verstockt, Marc Ferrante, Christophe Matthys, Jeroen Raes, Kristin Verbeke, Séverine Vermeire, João Sabino","doi":"10.1016/j.xcrm.2025.102091","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102091","url":null,"abstract":"Thermal treatments used in ultra-processed foods (UPFs) lead to advanced glycation end products (AGEs). UPFs and serum AGEs are associated with cardiometabolic disease. We explore differential cooking methods as a mechanistic link between UPFs and detrimental health outcomes through a randomized cross-over cooking method trial in healthy subjects using identical ingredients and a deep profiling analysis. We show that low-AGE-generating cooking methods such as boiling and steaming decrease serum AGEs, improve lipid profiles, and increase serum protein 4E-BP1. In contrast, high-AGE-generating cooking methods such as grilling and baking increase fecal butyrate. In sum, this suggests that low-AGE-generating cooking methods should be considered in cardiovascular risk prevention. Since current dietary guidelines focus on ingredients, but not cooking methods, our results suggest that culinary techniques should be considered as an important factor in cardiometabolic preventive strategies and future dietary trial design. This study was registered at ClinicalTrials.gov (NCT06547190).","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102091"},"PeriodicalIF":11.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase 2 trial of perioperative chemo-immunotherapy for gastro-esophageal adenocarcinoma: The role of M2 macrophage landscape in predicting response. 胃食管腺癌围手术期化疗免疫治疗二期试验：M2巨噬细胞景观在预测反应中的作用。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.xcrm.2025.102045

Thierry Alcindor, James Tankel, Pierre-Olivier Fiset, Sanjima Pal, Touhid Opu, Michael Strasser, Mehrnoush Dehghani, Nicholas Bertos, Dongmei Zuo, Carmen Mueller, Jonathan Cools-Lartigue, Marc Hickeson, Victoria Marcus, Sophie Camilleri-Broet, Alan Spatz, Gertruda Evaristo, Mina Farag, Giovanni Artho, Arielle Elkrief, Ramy Saleh, Swneke Bailey, Morag Park, Sui Huang, Veena Sangwan, Lorenzo Ferri

{"title":"Phase 2 trial of perioperative chemo-immunotherapy for gastro-esophageal adenocarcinoma: The role of M2 macrophage landscape in predicting response.","authors":"Thierry Alcindor, James Tankel, Pierre-Olivier Fiset, Sanjima Pal, Touhid Opu, Michael Strasser, Mehrnoush Dehghani, Nicholas Bertos, Dongmei Zuo, Carmen Mueller, Jonathan Cools-Lartigue, Marc Hickeson, Victoria Marcus, Sophie Camilleri-Broet, Alan Spatz, Gertruda Evaristo, Mina Farag, Giovanni Artho, Arielle Elkrief, Ramy Saleh, Swneke Bailey, Morag Park, Sui Huang, Veena Sangwan, Lorenzo Ferri","doi":"10.1016/j.xcrm.2025.102045","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102045","url":null,"abstract":"We present the clinical results of a phase 2 trial combining neoadjuvant docetaxel, cisplatin, 5 Flourouracil, and the PD-L1 inhibitor avelumab in locally advanced gastro-esophageal adenocarcinoma (GEA). Fifty-one patients receive neoadjuvant therapy with 50 proceeding to surgery. Grade 3-4 adverse events occur in 40%; complete/major pathological response is found in 7/50 (14%) and 9/50 (18%), with 2-year disease-free survival of 67.5%. There is no correlation between tumor regression and PD-L1 or mismatch repair (MMR) status. Multiplex immunohistochemistry and longitudinal single-cell transcriptomic profiling reveal alterations in certain innate immune cell populations, particularly noting an M2-tumor-associated macrophage (M2-TAM) proliferation in non-responding tumors. These findings describe the effective nature of this treatment regimen for GEA and reveal associated features of the inflammatory milieux associated with response to chemo-immunotherapy. The specific character of the inflammatory environment in non-responders may, in the future, help personalize treatment. This study was registered at ClinicalTrials.gov (NCT03288350).","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":"6 4","pages":"102045"},"PeriodicalIF":11.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specific macrophage RhoA targeting CRISPR-Cas9 for mitigating osteoclastogenesis-induced joint damage in inflammatory arthritis. 靶向CRISPR-Cas9的特异性巨噬细胞RhoA减轻炎性关节炎中破骨细胞发生诱导的关节损伤。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.xcrm.2025.102046

Jianhai Chen, Jianwei Tan, Nannan Wang, Hui Li, Wenxiang Cheng, Jian Li, Benguo Wang, Adam C Sedgwick, Zhitong Chen, Guojun Chen, Peng Zhang, Wei Zheng, Chengbo Liu, Jingqin Chen

{"title":"Specific macrophage RhoA targeting CRISPR-Cas9 for mitigating osteoclastogenesis-induced joint damage in inflammatory arthritis.","authors":"Jianhai Chen, Jianwei Tan, Nannan Wang, Hui Li, Wenxiang Cheng, Jian Li, Benguo Wang, Adam C Sedgwick, Zhitong Chen, Guojun Chen, Peng Zhang, Wei Zheng, Chengbo Liu, Jingqin Chen","doi":"10.1016/j.xcrm.2025.102046","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102046","url":null,"abstract":"Rheumatoid arthritis (RA) is the most prevalent inflammatory arthritis with unknown etiology, characterized by synovial inflammation and articular bone erosion. Studies have highlighted that inhibiting macrophage-induced osteoclastogenesis holds promise in mitigating bone destruction. However, specifically halting this pathological cascade remains a challenge for the management of RA. Here, initially, we identify that Ras homolog gene family member A (RhoA) is a pivotal target in inducing osteoclastogenesis of macrophages. Subsequently, we develop a strategy termed specific macrophages RhoA targeting (SMART), in which phosphatidylserine (PS)-enriched macrophage membranes are engineered to deliver macrophage-specific promoter-containing CRISPR-Cas9 plasmids (SMART-Cas9), enabling targeted editing of RhoA in RA joint macrophages. Multiscale imaging techniques confirm the highly specific targeted effect of SMART-Cas9 on the macrophages of inflamed joints. SMART-Cas9 successfully reduces osteoclastogenesis by macrophages, thus mitigating bone erosion by modulating cytoskeletal dynamics and immune balance in inflammatory arthritis, representing a therapeutic avenue for RA and other inflammatory bone diseases.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":"6 4","pages":"102046"},"PeriodicalIF":11.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD47-blocking antibody confers metabolic benefits against obesity. cd47阻断抗体对肥胖具有代谢益处。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.xcrm.2025.102089

Yajuan Su, Jingyu Sun, Xiaobo Li, Feier Huang, Yunhui Kong, Zian Chen, Jingzhi Zhang, Duran Qin, Xiangyi Chen, Zhaoyue Wang, Yu Pei, Mengting Gong, Kaijiang Yang, Minglu Xu, Yu Dong, Qing He, Zhen-Ning Zhang, Zhejin Sheng, Qiaolin Deng, Hong Wang, Gaowei Wang, Ping Hu, Rongrong Le, Shaorong Gao, Weida Li

{"title":"CD47-blocking antibody confers metabolic benefits against obesity.","authors":"Yajuan Su, Jingyu Sun, Xiaobo Li, Feier Huang, Yunhui Kong, Zian Chen, Jingzhi Zhang, Duran Qin, Xiangyi Chen, Zhaoyue Wang, Yu Pei, Mengting Gong, Kaijiang Yang, Minglu Xu, Yu Dong, Qing He, Zhen-Ning Zhang, Zhejin Sheng, Qiaolin Deng, Hong Wang, Gaowei Wang, Ping Hu, Rongrong Le, Shaorong Gao, Weida Li","doi":"10.1016/j.xcrm.2025.102089","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102089","url":null,"abstract":"CD47-blocking antibody is a well-known potential antibody drug for tumor immunotherapy. However, it is unclear whether CD47-blocking antibody can protect against metabolic disorders. We report that high-fat diet (HFD)-induced obesity increases CD47 expression, while exercise downregulates it in skeletal muscle. Administration of CD47-blocking antibody in mice prevents HFD-induced weight gain and glucose intolerance, enhances exercise capacity, and improves body composition and skeletal muscle mitochondrial function. Mechanistically, the protective effects conferred by CD47-blocking antibody are mediated through activation of AMP-activated protein kinase (AMPK) in skeletal muscle. Consistently, muscle-specific CD47-knockout mice show similar metabolic improvements, indicating a direct muscle-specific role of CD47 in regulating AMPK activation in vivo. Furthermore, the CD47-blocking antibody reduces the phosphorylation of heat shock protein 90α (HSP90α) to activate AMPK in skeletal muscle. In conclusion, CD47-blocking antibody confers metabolic benefits by activating the AMPK pathway in skeletal muscle.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102089"},"PeriodicalIF":11.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and opportunities in microRNA-based cancer therapeutics. 基于微rna的癌症治疗的挑战和机遇。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.xcrm.2025.102057

Jingfang Ju

引用次数: 0

Celebrating 5 years of Cell Reports Medicine with authors: Past and future. 与作者一起庆祝《细胞报告医学》出版5周年：过去与未来。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-15 DOI: 10.1016/j.xcrm.2025.102082

Jun Yu, Jakob Nikolas Kather, Ti-Fei Yuan, Marina Sirota

引用次数: 0

A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes. 17q21.31 MAPT区域的结构单倍型与慢性创伤性脑病内表型的风险增加有关。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-09 DOI: 10.1016/j.xcrm.2025.102084

Xudong Han, Yichi Zhang, Jillian N Petrosky, Sarah Bald, Richard M Sherva, Adam Labadorf, Jonathan D Cherry, Jaeyoon Chung, Kurt Farrell, Bobak Abdolmohammadi, Shruti Durape, Brett M Martin, Joseph N Palmisano, John J Farrell, Victor E Alvarez, Bertrand R Huber, Brigid Dwyer, Daniel H Daneshvar, Kristen Dams-O'Connor, Gyungah R Jun, Kathryn L Lunetta, Lee E Goldstein, Douglas I Katz, Robert C Cantu, Martha E Shenton, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Michael L Alosco, Yorghos Tripodis, Lindsay A Farrer, Thor D Stein, John F Crary, Ann C McKee, Jesse Mez

{"title":"A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes.","authors":"Xudong Han, Yichi Zhang, Jillian N Petrosky, Sarah Bald, Richard M Sherva, Adam Labadorf, Jonathan D Cherry, Jaeyoon Chung, Kurt Farrell, Bobak Abdolmohammadi, Shruti Durape, Brett M Martin, Joseph N Palmisano, John J Farrell, Victor E Alvarez, Bertrand R Huber, Brigid Dwyer, Daniel H Daneshvar, Kristen Dams-O'Connor, Gyungah R Jun, Kathryn L Lunetta, Lee E Goldstein, Douglas I Katz, Robert C Cantu, Martha E Shenton, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Michael L Alosco, Yorghos Tripodis, Lindsay A Farrer, Thor D Stein, John F Crary, Ann C McKee, Jesse Mez","doi":"10.1016/j.xcrm.2025.102084","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102084","url":null,"abstract":"Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. Genetic variation in the 17q21.31 region, containing microtubule-associated protein tau (MAPT), has been implicated in tauopathies but has not been investigated in CTE. The region includes a megabase-long inversion (H1/H2) and copy-number variations, including α, β, and γ segments, which can be characterized as nine segregating structural haplotypes. We leveraged array SNP data and a reference panel across the 17q21.31 region to impute structural haplotypes and test their association with CTE endophenotypes in 447 European ancestry brain donors with RHI exposure. The H1β1γ1 haplotype was significantly associated with dementia and semi-quantitative tau burden in multiple cortical and medial temporal regions commonly affected in CTE. H1β1γ1 differential expression analyses in dorsolateral frontal cortex implicated cis-acting genes and inflammatory pathways. Taken together, the H1β1γ1 haplotype may help explain CTE heterogeneity among those with similar RHI exposure.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102084"},"PeriodicalIF":11.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring an intravenously injectable oncolytic virus for augmenting radiotherapy. 为增强放射治疗量身定制静脉注射溶瘤病毒。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-08 DOI: 10.1016/j.xcrm.2025.102078

Chen Xu, Liting Chen, Guangna Liu, Jiaqi Xu, Wei Lv, Xiaoyu Gao, Peijun Xu, Ming Tang, Yaohe Wang, Xiao Zhao, Guangjun Nie, Keman Cheng, Funan Liu

{"title":"Tailoring an intravenously injectable oncolytic virus for augmenting radiotherapy.","authors":"Chen Xu, Liting Chen, Guangna Liu, Jiaqi Xu, Wei Lv, Xiaoyu Gao, Peijun Xu, Ming Tang, Yaohe Wang, Xiao Zhao, Guangjun Nie, Keman Cheng, Funan Liu","doi":"10.1016/j.xcrm.2025.102078","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102078","url":null,"abstract":"Oncolytic viruses (OVs) combined with radiotherapy (RT) show promise but are limited by challenges such as poor intravenous delivery and insufficient RT-induced DNA damage. In this study, an oncolytic adenovirus (AD) formulation, RadioOnco (AD@PSSP), is developed to improve delivery, infectivity, immune response, and RT efficacy. The multifunctional polyethylenimine (PEI)-selenium-polyethylene glycol (PEG) (PSSP) enhances intravenous delivery, shields the virus from rapid clearance, and enables targeted delivery to tumor sites after RT. The exposed PEI enhances the infectivity of AD through electrostatic interactions, thereby increasing DNA damage after RT by inhibiting the expression of DNA repair proteins, such as CHEK1 and CDK1. Furthermore, AD-PEI captures and delivers RT-induced tumor-released antigens to lymph nodes, activating robust anti-tumor immune responses. Animal model data demonstrate that RadioOnco overcomes RT resistance, targets distant metastases, and promotes long-term immunity, addressing metastasis and recurrence. In summary, this intravenously injectable OV enhances RT synergy through surface modification with multifunctional materials.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102078"},"PeriodicalIF":11.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma. 联合靶向BMI1和MYC消除鳞状细胞癌中的肿瘤干细胞。

IF 11.7 1区医学

Cell Reports Medicine Pub Date : 2025-04-08 DOI: 10.1016/j.xcrm.2025.102077

Zhen Qin, Shuo Liu, Yunfei Zheng, Yujia Wang, Yiwen Chen, Xin Peng, Lingfei Jia

{"title":"Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma.","authors":"Zhen Qin, Shuo Liu, Yunfei Zheng, Yujia Wang, Yiwen Chen, Xin Peng, Lingfei Jia","doi":"10.1016/j.xcrm.2025.102077","DOIUrl":"https://doi.org/10.1016/j.xcrm.2025.102077","url":null,"abstract":"Bmi1+ tumor cells act as cancer stem cells (CSCs) driving relapse and therapy resistance in head and neck squamous cell carcinoma (HNSCC). Although BMI1 inhibitors reduce CSCs, combined cisplatin treatment targeting non-stem tumor cells is more effective in eliminating CSCs. Non-stem tumor cells may revert to CSCs post-treatment. However, in vivo evidence and underlying mechanisms remain unclear. Here, we demonstrate that BMI1 inhibitors induce temporary tumor regression followed by relapse. Lineage tracing reveals that keratin 16-marked non-stem tumor cells revert to Bmi1+ CSCs, which drive compensatory tumor growth after BMI1 targeting therapy. Mechanistically, BMI1 inhibitors activate DNA damage/nuclear factor κB (NF-κB) signaling and inflammatory cytokine secretion, subsequently stimulating myelocytomatosis viral oncogene homolog (MYC) expression in non-stem tumor cells to promote the reversion process. Genetic and pharmacological inhibition of MYC synergizes with BMI1 targeting, achieving sustained CSC eradication and relapse prevention. These findings provide insights into CSCs' plasticity and suggest dual BMI1/MYC blockade as an effective HNSCC treatment strategy.","PeriodicalId":9822,"journal":{"name":"Cell Reports Medicine","volume":" ","pages":"102077"},"PeriodicalIF":11.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0