肌肉能避免GLP1R体重平稳和反弹吗？

IF 10.6 1区医学 Q1 CELL BIOLOGY

Cell Reports Medicine Pub Date : 2025-09-16 DOI:10.1016/j.xcrm.2025.102308

Dongdong Wang, Andre Djalalvandi, Christina T Saed, Katherine M Morrison, Gregory R Steinberg

引用次数: 0

摘要

基于glp1r的肥胖疗法可以通过适应性产热（也称为代谢适应）减少瘦肌肉和能量消耗，导致体重停滞和恢复。确定肌肉能量消耗在调节这些效应中的作用对于改进下一代治疗方法和维持长期体重减轻至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Can muscle avert GLP1R weight plateau and regain?

GLP1R-based obesity therapies can reduce lean muscle and energy expenditure via adaptive thermogenesis (also known as metabolic adaptation), leading to weight plateaus and regain. Defining the role of muscle energy expenditure in mediating these effects is critical to improving next-generation treatments and sustaining long-term weight loss.

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来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.