Global, regional, and national burden of headache disorders, 1990-2021, with forecasts to 2050: A Global Burden of Disease study 2021.

IF 10.6 1区医学 Q1 CELL BIOLOGY

Cell Reports Medicine Pub Date : 2025-09-18 DOI:10.1016/j.xcrm.2025.102348

Tissa Wijeratne, Jiyeon Oh, Soeun Kim, Yesol Yim, Min Seo Kim, Jae Il Shin, Yun-Seo Oh, Raon Jung, Yun Seo Kim, Lee Smith, Hasan Aalruz, Rami Abd-Rabu, Deldar Morad Abdulah, Richard Gyan Aboagye, Meysam Abolmaali, Dariush Abtahi, Ahmed Abualhasan, Rufus Adesoji Adedoyin, Qorinah Estiningtyas Sakilah Adnani, Fatemeh Afrashteh, Navidha Aggarwal, Danish Ahmad, Ali Ahmadi, Negar Sadat Ahmadi, Amir Mahmoud Ahmadzade, Syed Anees Ahmed, Salah Al Awaidy, Sawsan Alabbad, Muaaz M Alajlani, Yazan Al-Ajlouni, Mohammed Usman Ali, Syed Shujait Ali, Waad Ali, Joseph Uy Almazan, Najim Z Alshahrani, Awais Altaf, Mohammad Al-Wardat, Karem H Alzoubi, Sohrab Amiri, Hubert Amu, Ganiyu Adeniyi Amusa, David B Anderson, Saleha Anwar, Demelash Areda, Mohammad Asghari-Jafarabadi, Sait Ashina, Javed Ashraf, Tahira Ashraf, Ali Azargoonjahromi, Yogesh Bahurupi, Atif Amin Baig, Soham Bandyopadhyay, Mainak Bardhan, Hiba Jawdat Barqawi, Azadeh Bashiri, Mohammad-Mahdi Bastan, Maryam Bemanalizadeh, Isabela M Bensenor, Alemshet Yirga Yirga Berhie, Akshaya Srikanth Bhagavathula, Sonu Bhaskar, Vivek Bhat, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti, Cem Bilgin, Atanu Biswas, Bruno Bizzozero-Peroni, Yasser Bustanji, Luis Alberto Cámera, Edoardo Caronna, Andre F Carvalho, Sandip Chakraborty, Patrick R Ching, Nikos Christodoulou, Dinh-Toi Chu, Hongyuan Chu, Natalia Cruz-Martins, Omid Dadras, Xiaochen Dai, Emanuele D'Amico, Amira Hamed Darwish, Sindhura Deekonda, Vinoth Gnana Chellaiyan Devanbu, Samath Dhamminda Dharmaratne, Adriana Dima, Temesgien Ergetie Dinkayehu, Huyen Do, Paul Narh Doku, Ojas Prakashbhai Doshi, Abdel Rahman E'mar, Negin Eissazade, Chadi Eltaha, Ayesha Fahim, Jawad Fares, Mohsen Farjoud Kouhanjani, Andre Faro, Patrick Fazeli, Seyed-Mohammad Fereshtehnejad, Pietro Ferrara, Nuno Ferreira, Florian Fischer, Arianna Fornari, Márió Gajdács, Miglas Welay Gebregergis, Delaram J Ghadimi, Amir Ghaffari Jolfayi, Elena V Gnedovskaya, Mahaveer Golechha, Enrique Gomez Figueroa, Mohammad Hashem Hashempur, Md Saquib Hasnain, Amr Hassan, Nageeb Hassan, Mahgol Sadat Hassan Zadeh Tabatabaei, Mohamed I Hegazy, Golnaz Heidari, Bartosz Helfer, Md Mahbub Hossain, Mowafa Househ, Chengxi Hu, Ivo Iavicoli, Olayinka Stephen Ilesanmi, Irena M Ilic, Muhana Fawwazy Ilyas, Salim Ilyasu, Nahlah Elkudssiah Ismail, Ali Jafari-Khounigh, Haitham Jahrami, Manthan Dilipkumar Janodia, Ruwan Duminda Jayasinghe, Bijay Mukesh Jeswani, Jost B Jonas, Nitin Joseph, Rizwan Kalani, Moien A B Khan, Sorour Khateri, Mahalaqua Nazli Khatib, Hamid Reza Khayat Kashani, Feriha Fatima Khidri, Moein Khormali, Sepehr Khosravi, Yun Jin Kim, Farzad Kompani, Karel Kostev, Kewal Krishan, Bindu Krishnan, Barthelemy Kuate Defo, Mohammed Kuddus, Mukhtar Kulimbet, Rakesh Kumar, Vijay Kumar, Ville Kytö, Savita Lasrado, Seung Won Lee, Jacopo Lenzi, Matilde Leonardi, Giancarlo Lucchetti, Alessandra Lugo, Irsa Fatima Makhdoom, Arashk Mallahzadeh, Vahid Mansouri, Roy Rillera Marzo, Yasith Mathangasinghe, Mahsa Mayeli, Asim Mehmood, Atte Meretoja, Tomislav Mestrovic, Sachith Mettananda, Giuseppe Minervini, Archana Mishra, Prasanna Mithra, Khabab Abbasher Hussien Mohamed Ahmed, Ibrahim Mohammadzadeh, Shafiu Mohammed, Lorenzo Monasta, Shane Douglas Morrison, Amin Nabavi, Zuhair S Natto, Javaid Nauman, Luciano Nieddu, Fred Nugen, Andrew T Olagunju, Arão Belitardo Oliveira, Welber Sousa Oliveira, Hany A Omar, Goran Latif Omer, Nikita Otstavnov, Mahesh P A, Leonidas D Panos, Romil R Parikh, Shankargouda Patil, Apurba Patra, Paolo Pedersini, Umberto Pensato, Prince Peprah, Mario F P Peres, Michael A Piradov, Patricia Pozo-Rosich, Jalandhar Pradhan, Sanjay Prakash, Akila Prashant, Jagadeesh Puvvula, Alireza Rafiei, Alberto Raggi, Amir Masoud Rahmani, Mahmoud Mohammed Ramadan, Devarajan Rathish, Ilari Rautalin, Salman Rawaf, Mohsen Rezaeian, Donya Rezazadeh Eidgahi, Taeho Gregory Rhee, Priyanka Roy, Adnan Saad Eddin, Cameron John Sabet, Basema Ahmad Saddik, Erfan Sadeghi, Umar Saeed, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Pragyan Monalisa Sahoo, Sohrab Salimi, Abdallah M Samy, Jennifer Saulam, Monika Sawhney, Yigit Can Senol, Subramanian Senthilkumaran, Yashendra Sethi, Homa Seyedmirzaei, Mahan Shafie, Anas Shamsi, Amin Sharifan, Hatem Samir Shehata, Rekha Raghuveer Shenoy, Farhad Shokraneh, Jaspreet Kaur Sidhu, Baljinder Singh, Harmanjit Singh, Jasvinder A Singh, Surjit Singh, Anna Aleksandrovna Skryabina, Farrukh Sobia, Bahadar S Srichawla, Vinay Suresh, Chandan Kumar Swain, Sree Sudha T Y, Payam Tabaee Damavandi, Celine Tabche, Mohammad Tabish, Manoj Tanwar, Mohamad-Hani Temsah, Masayuki Teramoto, Nghia Minh Tran, Thang Huu Tran, Aristidis Tsatsakis, Aniefiok John Udoakang, Jibrin Sammani Usman, Hande Uzunçıbuk, Jef Van den Eynde, Tommi Juhani Vasankari, Narayanaswamy Venketasubramanian, Jorge Hugo Villafañe, Lintao Wang, Xingxin Wang, Yuan-Pang Wang, Taweewat Wiangkham, Andrea Sylvia Winkler, Alemayehu Molla Wollie, Zheman Xiao, Yazachew Engida Engida Yismaw, Abdilahi Yousuf, Zhongyi Zhao, Magdalena Zielińska, Min Kyung Chu, Tae-Jin Song, Dong Keon Yon, Valery L Feigin

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Bahurupi, Atif Amin Baig, Soham Bandyopadhyay, Mainak Bardhan, Hiba Jawdat Barqawi, Azadeh Bashiri, Mohammad-Mahdi Bastan, Maryam Bemanalizadeh, Isabela M Bensenor, Alemshet Yirga Yirga Berhie, Akshaya Srikanth Bhagavathula, Sonu Bhaskar, Vivek Bhat, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti, Cem Bilgin, Atanu Biswas, Bruno Bizzozero-Peroni, Yasser Bustanji, Luis Alberto Cámera, Edoardo Caronna, Andre F Carvalho, Sandip Chakraborty, Patrick R Ching, Nikos Christodoulou, Dinh-Toi Chu, Hongyuan Chu, Natalia Cruz-Martins, Omid Dadras, Xiaochen Dai, Emanuele D'Amico, Amira Hamed Darwish, Sindhura Deekonda, Vinoth Gnana Chellaiyan Devanbu, Samath Dhamminda Dharmaratne, Adriana Dima, Temesgien Ergetie Dinkayehu, Huyen Do, Paul Narh Doku, Ojas Prakashbhai Doshi, Abdel Rahman E'mar, Negin Eissazade, Chadi Eltaha, Ayesha Fahim, Jawad Fares, Mohsen Farjoud Kouhanjani, Andre Faro, Patrick Fazeli, Seyed-Mohammad Fereshtehnejad, Pietro Ferrara, Nuno Ferreira, Florian Fischer, Arianna Fornari, Márió Gajdács, Miglas Welay Gebregergis, Delaram J Ghadimi, Amir Ghaffari Jolfayi, Elena V Gnedovskaya, Mahaveer Golechha, Enrique Gomez Figueroa, Mohammad Hashem Hashempur, Md Saquib Hasnain, Amr Hassan, Nageeb Hassan, Mahgol Sadat Hassan Zadeh Tabatabaei, Mohamed I Hegazy, Golnaz Heidari, Bartosz Helfer, Md Mahbub Hossain, Mowafa Househ, Chengxi Hu, Ivo Iavicoli, Olayinka Stephen Ilesanmi, Irena M Ilic, Muhana Fawwazy Ilyas, Salim Ilyasu, Nahlah Elkudssiah Ismail, Ali Jafari-Khounigh, Haitham Jahrami, Manthan Dilipkumar Janodia, Ruwan Duminda Jayasinghe, Bijay Mukesh Jeswani, Jost B Jonas, Nitin Joseph, Rizwan Kalani, Moien A B Khan, Sorour Khateri, Mahalaqua Nazli Khatib, Hamid Reza Khayat Kashani, Feriha Fatima Khidri, Moein Khormali, Sepehr Khosravi, Yun Jin Kim, Farzad Kompani, Karel Kostev, Kewal Krishan, Bindu Krishnan, Barthelemy Kuate Defo, Mohammed Kuddus, Mukhtar Kulimbet, Rakesh Kumar, Vijay Kumar, Ville Kytö, Savita Lasrado, Seung Won Lee, Jacopo Lenzi, Matilde Leonardi, Giancarlo Lucchetti, Alessandra Lugo, Irsa Fatima Makhdoom, Arashk Mallahzadeh, Vahid Mansouri, Roy Rillera Marzo, Yasith Mathangasinghe, Mahsa Mayeli, Asim Mehmood, Atte Meretoja, Tomislav Mestrovic, Sachith Mettananda, Giuseppe Minervini, Archana Mishra, Prasanna Mithra, Khabab Abbasher Hussien Mohamed Ahmed, Ibrahim Mohammadzadeh, Shafiu Mohammed, Lorenzo Monasta, Shane Douglas Morrison, Amin Nabavi, Zuhair S Natto, Javaid Nauman, Luciano Nieddu, Fred Nugen, Andrew T Olagunju, Arão Belitardo Oliveira, Welber Sousa Oliveira, Hany A Omar, Goran Latif Omer, Nikita Otstavnov, Mahesh P A, Leonidas D Panos, Romil R Parikh, Shankargouda Patil, Apurba Patra, Paolo Pedersini, Umberto Pensato, Prince Peprah, Mario F P Peres, Michael A Piradov, Patricia Pozo-Rosich, Jalandhar Pradhan, Sanjay Prakash, Akila Prashant, Jagadeesh Puvvula, Alireza Rafiei, Alberto Raggi, Amir Masoud Rahmani, Mahmoud Mohammed Ramadan, Devarajan Rathish, Ilari Rautalin, Salman Rawaf, Mohsen Rezaeian, Donya Rezazadeh 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引用次数: 0

Abstract

Headache disorders, especially migraines and tension-type headaches (TTHs), are major global public health concerns, as shown by the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. We provide updated global estimates of prevalence and years lived with disability (YLDs) from 1990 to 2021 across 204 countries and territories and forecasts through 2050. In 2021, there are 2.0 billion people with TTH and 1.2 billion with migraine. Although TTH is more prevalent, migraine causes higher disability. While crude prevalence and YLDs increased, age-standardized rates remained stable and are projected to continue this trend due to population growth. There is a disproportionately higher burden in women aged 30-44 and countries with higher Socio-demographic Index and Healthcare Access and Quality Index. Despite this, migraines remain underrecognized in health policies and funding. This study emphasizes the urgent need to prioritize headache disorders in global health agendas.

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1990-2021年全球、区域和国家头痛疾病负担，并预测到2050年：2021年全球疾病负担研究。

《2021年全球疾病、损伤和风险因素负担研究》（GBD）显示，头痛疾病，特别是偏头痛和紧张性头痛（TTHs），是全球主要的公共卫生问题。我们提供了从1990年到2021年全球204个国家和地区的残疾患病率和残疾生活年数（YLDs）的最新估计，以及到2050年的预测。到2021年，有20亿人患有TTH， 12亿人患有偏头痛。虽然TTH更普遍，但偏头痛会导致更高的残疾。虽然粗流行率和年平均寿命增加，但年龄标准化率保持稳定，预计由于人口增长，这一趋势将继续下去。30-44岁的妇女以及社会人口指数和医疗保健获得与质量指数较高的国家的负担过高。尽管如此，在卫生政策和资金方面，偏头痛仍未得到充分认识。这项研究强调迫切需要在全球卫生议程中优先考虑头痛疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.