CCS ChemistryPub Date : 2024-08-06DOI: 10.31635/ccschem.024.202404417
Jie Li, Chenyang Yuan, Yang He, Zhen Xu, Haoyang Pan, Shuai Lu, Yudi Wang, Mingjun Zhong, Xin Li, Shimin Hou, Qian Shen, Kai Wu, Yajie Zhang, Song Gao, , YongFeng Wang
{"title":"Surface-Mediated Catalytic Dechlorination and Spin-State Modulation of ClFePc on Au(111)","authors":"Jie Li, Chenyang Yuan, Yang He, Zhen Xu, Haoyang Pan, Shuai Lu, Yudi Wang, Mingjun Zhong, Xin Li, Shimin Hou, Qian Shen, Kai Wu, Yajie Zhang, Song Gao, , YongFeng Wang","doi":"10.31635/ccschem.024.202404417","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404417","url":null,"abstract":"<p>Interactions between molecules and surfaces are crucial in modern surface science. In particular, surfaces catalyze molecular reactions and modulate molecular spin states. In this article, we investigate the adsorption behaviors and electronic structures of chloro-iron phthalocyanine (ClFePc) on Au(111). Combining ultrahigh vacuum scanning tunneling microscopy experiments with density functional theory calculations, we found indications of surface-catalyzed dechlorination. Our findings reveal that the adsorption behavior of ClFePc is determined by its adsorption direction. ClFePc in the Cl-up (Cl pointing to the vacuum) configuration exhibits stable adsorption on the Au(111) surface. Conversely, the Cl-down (Cl pointing to the substrate) configuration is unstable, resulting in the dissociation of the Cl–Fe bond due to interactions with the Au(111) surface. Through scanning tunneling spectroscopy analysis, we further investigate the Kondo resonance features and spin characteristics. Notably, following dechlorination, the spin-state transitions from <i>S</i> = 3/2 to 1. This study provides profound insights into the surface-molecule interaction and its application in modulating magnetic properties.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"21 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CCS ChemistryPub Date : 2024-08-06DOI: 10.31635/ccschem.024.202404180
{"title":"Leveraging Adsorption Kinetics and Thermodynamics in a Channel-Pore Interconnected Metal–Organic Framework for Stepwise Splitting Hexanes","authors":"","doi":"10.31635/ccschem.024.202404180","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404180","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"17 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CCS ChemistryPub Date : 2024-08-06DOI: 10.31635/ccschem.024.202404505
{"title":"Twenty-Step Total Synthesis of (+)-Phorbol","authors":"","doi":"10.31635/ccschem.024.202404505","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404505","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"38 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficient N-Trifluoromethylation of Amines with Carbon Disulfide and Silver Fluoride as Reagents","authors":"Haixia Song, Qin Wang, Xiaoying Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu","doi":"10.31635/ccschem.024.202404432","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404432","url":null,"abstract":"<p>The installation of a trifluoromethyl group onto a nitrogen atom can effectively modulate the basicity of amines owing to the strong electron-withdrawing effect of fluorine. Nevertheless, efficient and operationally simple methods for <i>N</i>-trifluoromethylation of amines are yet to be developed. This protocol involves the use of readily available secondary amines as starting materials, along with CS<sub>2</sub> and AgF as the <i>N</i>-trifluoromethylation reagents, enabling the target molecules to be synthesized in a single step. The versatility of our method was demonstrated by successfully synthesizing <i>N,N</i>-dialkyl and <i>N</i>-(hetero)aromatic <i>N</i>-CF<sub>3</sub>-containing compounds with various substituents. Moreover, this methodology has been successfully applied to the late-stage modification of complex bioactive molecules, facilitating the synthesis of <i>N</i>-CF<sub>3</sub> drug bioisosteres and <i>N</i>-CF<sub>3</sub>-tailored amino acids, which would broadly stimulate the drug discovery of <i>N</i>-CF<sub>3</sub> containing molecules.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"75 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CCS ChemistryPub Date : 2024-08-06DOI: 10.31635/ccschem.024.202404512
Yating Wu, Yueyan Kuang, Shuai Fang, Chenqi Ge, Hua Tang, Jizeng Sun, Shaoying Huang, Simon Duttwyler, Xufeng Lin, Hao Li
{"title":"Molecular Bowls Protecting Guests from Oxidation","authors":"Yating Wu, Yueyan Kuang, Shuai Fang, Chenqi Ge, Hua Tang, Jizeng Sun, Shaoying Huang, Simon Duttwyler, Xufeng Lin, Hao Li","doi":"10.31635/ccschem.024.202404512","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404512","url":null,"abstract":"<p>Two structurally analogous self-assembled bowl-shaped hosts were obtained in close to quantitative yields via hydrazone condensation in acidic aqueous media, where the dynamic nature of hydrazone bonds was activated. Each bowl bears nine positive charges, endowing it with good water solubility. The bowls can thus take advantage of the hydrophobic effect and/or electrostatic forces to recognize neutral or anionic guests. Upon being accommodated within the host cavity, an anthracene derivative was protected from UV-stimulated oxidation.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"83 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CCS ChemistryPub Date : 2024-07-27DOI: 10.31635/ccschem.024.202404201
{"title":"Isomer-Selective Generation of Cytidine Radicals via Wavelength-Regulated Photodissociation","authors":"","doi":"10.31635/ccschem.024.202404201","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404201","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"25 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CCS ChemistryPub Date : 2024-07-27DOI: 10.31635/ccschem.024.202404482
{"title":"Molecular Skeletons Modification Induces Distinctive Aggregation Behaviors and Boosts the Efficiency Over 19% in Organic Solar Cells","authors":"","doi":"10.31635/ccschem.024.202404482","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404482","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"58 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expansion Strategy-Driven Micron-Level Resolution Mass Spectrometry Imaging of Lipids in Mouse Brain Tissue","authors":"Yik Ling Winnie Hung, Chengyi Xie, Jianing Wang, Xin Diao, Ruxin Li, Xiaoxiao Wang, Shulan Qiu, Jiacheng Fang, Zongwei Cai","doi":"10.31635/ccschem.024.202404002","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404002","url":null,"abstract":"<p>A novel method for enhanced resolution, termed expansion mass spectrometry imaging, has been developed for lipid mass spectrometry imaging, utilizing existing commercially available mass spectrometers without necessitating modifications. This approach involves embedding tissue sections in a swellable polyelectrolyte gel, with the target biomolecules indirectly anchored to the gel network. By employing matrix-assisted laser desorption ionization mass spectrometry imaging, the method has realized an enhanced spatial resolution that surpasses the conventional resolution limits of commercial instruments by approximately 4.5 fold. This enhancement permits the detailed visualization of intricate structures within the mouse brain at a subcellular level, with a lateral resolution nearing 1 μm. As a physical technique for achieving resolution beyond standard capabilities, this readily adaptable approach presents a powerful tool for high-definition imaging in biological research.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"26 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}