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Twenty-Step Total Synthesis of (+)-Phorbol 二十步全合成 (+)-Phorbol
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-08-06 DOI: 10.31635/ccschem.024.202404505
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引用次数: 0
Efficient N-Trifluoromethylation of Amines with Carbon Disulfide and Silver Fluoride as Reagents 以二硫化碳和氟化银为试剂高效进行胺的 N-三氟甲基化反应
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-08-06 DOI: 10.31635/ccschem.024.202404432
Haixia Song, Qin Wang, Xiaoying Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu
{"title":"Efficient N-Trifluoromethylation of Amines with Carbon Disulfide and Silver Fluoride as Reagents","authors":"Haixia Song, Qin Wang, Xiaoying Wang, Yinbin Zhang, Xin-Hua Duan, Mingyou Hu","doi":"10.31635/ccschem.024.202404432","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404432","url":null,"abstract":"<p>The installation of a trifluoromethyl group onto a nitrogen atom can effectively modulate the basicity of amines owing to the strong electron-withdrawing effect of fluorine. Nevertheless, efficient and operationally simple methods for <i>N</i>-trifluoromethylation of amines are yet to be developed. This protocol involves the use of readily available secondary amines as starting materials, along with CS<sub>2</sub> and AgF as the <i>N</i>-trifluoromethylation reagents, enabling the target molecules to be synthesized in a single step. The versatility of our method was demonstrated by successfully synthesizing <i>N,N</i>-dialkyl and <i>N</i>-(hetero)aromatic <i>N</i>-CF<sub>3</sub>-containing compounds with various substituents. Moreover, this methodology has been successfully applied to the late-stage modification of complex bioactive molecules, facilitating the synthesis of <i>N</i>-CF<sub>3</sub> drug bioisosteres and <i>N</i>-CF<sub>3</sub>-tailored amino acids, which would broadly stimulate the drug discovery of <i>N</i>-CF<sub>3</sub> containing molecules.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"75 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Bowls Protecting Guests from Oxidation 保护客人免受氧化的分子碗
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-08-06 DOI: 10.31635/ccschem.024.202404512
Yating Wu, Yueyan Kuang, Shuai Fang, Chenqi Ge, Hua Tang, Jizeng Sun, Shaoying Huang, Simon Duttwyler, Xufeng Lin, Hao Li
{"title":"Molecular Bowls Protecting Guests from Oxidation","authors":"Yating Wu, Yueyan Kuang, Shuai Fang, Chenqi Ge, Hua Tang, Jizeng Sun, Shaoying Huang, Simon Duttwyler, Xufeng Lin, Hao Li","doi":"10.31635/ccschem.024.202404512","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404512","url":null,"abstract":"<p>Two structurally analogous self-assembled bowl-shaped hosts were obtained in close to quantitative yields via hydrazone condensation in acidic aqueous media, where the dynamic nature of hydrazone bonds was activated. Each bowl bears nine positive charges, endowing it with good water solubility. The bowls can thus take advantage of the hydrophobic effect and/or electrostatic forces to recognize neutral or anionic guests. Upon being accommodated within the host cavity, an anthracene derivative was protected from UV-stimulated oxidation.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"83 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Spotlight 作者聚焦
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-08-01 DOI: 10.31635/ccschem.024.202400720ed2
{"title":"Author Spotlight","authors":"","doi":"10.31635/ccschem.024.202400720ed2","DOIUrl":"https://doi.org/10.31635/ccschem.024.202400720ed2","url":null,"abstract":"CCS Chemistry, Volume 6, Issue 8, Page 1840-1843, August 2024.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"14 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141884706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isomer-Selective Generation of Cytidine Radicals via Wavelength-Regulated Photodissociation 通过波长调节光解离生成胞苷自由基的异构体选择性
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-07-27 DOI: 10.31635/ccschem.024.202404201
{"title":"Isomer-Selective Generation of Cytidine Radicals via Wavelength-Regulated Photodissociation","authors":"","doi":"10.31635/ccschem.024.202404201","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404201","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"25 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organic Mixed Ionic-Electronic Conductors for Solid-State Batteries 用于固态电池的有机混合离子电子导体
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-07-27 DOI: 10.31635/ccschem.024.202404284
{"title":"Organic Mixed Ionic-Electronic Conductors for Solid-State Batteries","authors":"","doi":"10.31635/ccschem.024.202404284","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404284","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"14 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Skeletons Modification Induces Distinctive Aggregation Behaviors and Boosts the Efficiency Over 19% in Organic Solar Cells 分子骨架修饰可诱导独特的聚集行为，并将有机太阳能电池的效率提高 19% 以上
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-07-27 DOI: 10.31635/ccschem.024.202404482
{"title":"Molecular Skeletons Modification Induces Distinctive Aggregation Behaviors and Boosts the Efficiency Over 19% in Organic Solar Cells","authors":"","doi":"10.31635/ccschem.024.202404482","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404482","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"58 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expansion Strategy-Driven Micron-Level Resolution Mass Spectrometry Imaging of Lipids in Mouse Brain Tissue 小鼠脑组织中脂类的微米级分辨率质谱成像扩展策略
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-07-27 DOI: 10.31635/ccschem.024.202404002
Yik Ling Winnie Hung, Chengyi Xie, Jianing Wang, Xin Diao, Ruxin Li, Xiaoxiao Wang, Shulan Qiu, Jiacheng Fang, Zongwei Cai
{"title":"Expansion Strategy-Driven Micron-Level Resolution Mass Spectrometry Imaging of Lipids in Mouse Brain Tissue","authors":"Yik Ling Winnie Hung, Chengyi Xie, Jianing Wang, Xin Diao, Ruxin Li, Xiaoxiao Wang, Shulan Qiu, Jiacheng Fang, Zongwei Cai","doi":"10.31635/ccschem.024.202404002","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404002","url":null,"abstract":"<p>A novel method for enhanced resolution, termed expansion mass spectrometry imaging, has been developed for lipid mass spectrometry imaging, utilizing existing commercially available mass spectrometers without necessitating modifications. This approach involves embedding tissue sections in a swellable polyelectrolyte gel, with the target biomolecules indirectly anchored to the gel network. By employing matrix-assisted laser desorption ionization mass spectrometry imaging, the method has realized an enhanced spatial resolution that surpasses the conventional resolution limits of commercial instruments by approximately 4.5 fold. This enhancement permits the detailed visualization of intricate structures within the mouse brain at a subcellular level, with a lateral resolution nearing 1 μm. As a physical technique for achieving resolution beyond standard capabilities, this readily adaptable approach presents a powerful tool for high-definition imaging in biological research.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"26 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cationic Conjugated Polymers with Enhanced Doped-State Planarity for n-Type Organic Thermoelectrics 用于 n 型有机热电的具有增强掺杂态平面性的阳离子共轭聚合物
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-07-27 DOI: 10.31635/ccschem.024.202404274
{"title":"Cationic Conjugated Polymers with Enhanced Doped-State Planarity for n-Type Organic Thermoelectrics","authors":"","doi":"10.31635/ccschem.024.202404274","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404274","url":null,"abstract":"CCS Chemistry, Ahead of Print.<br/>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"19 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ni–Al Bimetal-Catalyzed Tertiary C(sp3)–H Activation for Dual C–H Annulation of Formamides with Alkynes 镍-铝双金属催化三级 C(sp3)-H活化用于甲酰胺与炔烃的双 C-H 嵌合反应
IF 11.2 1区 化学
CCS Chemistry Pub Date : 2024-07-27 DOI: 10.31635/ccschem.024.202404549
Yi Li, Yu-Peng Liu, Mengying Xu, Weiwei Xu, Feng-Ping Zhang, Mengchun Ye
{"title":"Ni–Al Bimetal-Catalyzed Tertiary C(sp3)–H Activation for Dual C–H Annulation of Formamides with Alkynes","authors":"Yi Li, Yu-Peng Liu, Mengying Xu, Weiwei Xu, Feng-Ping Zhang, Mengchun Ye","doi":"10.31635/ccschem.024.202404549","DOIUrl":"https://doi.org/10.31635/ccschem.024.202404549","url":null,"abstract":"<p>3d-Metal-catalyzed tertiary C(sp<sup>3</sup>)–H bond activation has been a formidable challenge. Herein, a tertiary C(sp<sup>3</sup>)–H bond is smoothly activated by Ni–Al bimetallic catalysts for dual C–H annulation of formamides with alkynes, delivering a series of δ-lactams with a quaternary carbon up to 98% yield. Various tertiary C(sp<sup>3</sup>)–H bonds such as noncyclic, monocyclic and bridged-ring tertiary C(sp<sup>3</sup>)–H bonds are all compatible with the reaction.</p>","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"87 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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