镍-铝双金属催化三级 C(sp3)-H活化用于甲酰胺与炔烃的双 C-H 嵌合反应

IF 9.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

CCS Chemistry Pub Date : 2024-07-27 DOI:10.31635/ccschem.024.202404549

Yi Li, Yu-Peng Liu, Mengying Xu, Weiwei Xu, Feng-Ping Zhang, Mengchun Ye

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引用次数: 0

摘要

3d金属催化三级C（sp3）-H键活化一直是一项艰巨的挑战。在此，Ni-Al 双金属催化剂顺利活化了三级 C(sp3)-H 键，用于甲酰胺与炔烃的双 C-H 环化反应，产生了一系列具有季碳的δ-内酰胺，收率高达 98%。各种三级 C（sp3）-H 键（如非环、单环和桥环三级 C（sp3）-H 键）均可与该反应相容。

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Ni–Al Bimetal-Catalyzed Tertiary C(sp3)–H Activation for Dual C–H Annulation of Formamides with Alkynes

3d-Metal-catalyzed tertiary C(sp³)–H bond activation has been a formidable challenge. Herein, a tertiary C(sp³)–H bond is smoothly activated by Ni–Al bimetallic catalysts for dual C–H annulation of formamides with alkynes, delivering a series of δ-lactams with a quaternary carbon up to 98% yield. Various tertiary C(sp³)–H bonds such as noncyclic, monocyclic and bridged-ring tertiary C(sp³)–H bonds are all compatible with the reaction.

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来源期刊

CCS Chemistry Chemistry-General Chemistry

CiteScore

13.60

自引率

13.40%

发文量

475

审稿时长

10 weeks

期刊介绍： CCS Chemistry, the flagship publication of the Chinese Chemical Society, stands as a leading international chemistry journal based in China. With a commitment to global outreach in both contributions and readership, the journal operates on a fully Open Access model, eliminating subscription fees for contributing authors. Issued monthly, all articles are published online promptly upon reaching final publishable form. Additionally, authors have the option to expedite the posting process through Immediate Online Accepted Article posting, making a PDF of their accepted article available online upon journal acceptance.