CCS Chemistry最新文献

Helicene-Based Chiral Macrocycle: Efficient Synthesis, Spontaneous Chiral Resolution, and Strong Circularly Polarized Luminescence 螺旋烯基手性大环：高效合成、自发手性分辨和强圆偏振发光

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-28 DOI: 10.31635/ccschem.026.202607463

Peipei Liu, Meng-Ling Yu, Meng-Xiang Wu, Xiao-Li Zhao, Gui-Fei Huo, Xueliang Shi & Hai-Bo YangShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062

{"title":"Helicene-Based Chiral Macrocycle: Efficient Synthesis, Spontaneous Chiral Resolution, and Strong Circularly Polarized Luminescence","authors":"Peipei Liu, Meng-Ling Yu, Meng-Xiang Wu, Xiao-Li Zhao, Gui-Fei Huo, Xueliang Shi & Hai-Bo YangShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062","doi":"10.31635/ccschem.026.202607463","DOIUrl":"https://doi.org/10.31635/ccschem.026.202607463","url":null,"abstract":"CCS Chemistry, Ahead of Print. Herein, we report the synthesis of a novel helicene-based chiral macrocycle featuring distinctive conglomerate crystallization and markedly enhanced photophysical and chiroptical properties. Chiral macrocycle 1, consisting of three helicene moieties, is efficiently constructed via Yamamoto coupling of a newly synthesized dichloro-[5]helicene 2. Notably, 1 predominantly adopted the PPM/MMP conformation rather than the more stable PPP/MMM. The structures of both macrocycle 1 and its precursor helicene 2 were unambiguously confirmed by single-crystal X-ray diffraction (XRD). Interestingly, an unusual spontaneous chiral resolution phenomenon was observed upon crystallization of 1, resulting in enantiomerically pure chiral crystals of 1-PPM and 1-MMP. Compared with helicene 2, the absorption of macrocycle 1 was significantly redshifted, and its molar extinction coefficient (ε), as well as the fluorescence quantum efficiency (ΦF), were also remarkably enhanced. Notably, 1 exhibited a superior luminescent asymmetry factor (|glum| = 2.85 × 10−2) and a very high circularly polarized luminescence (CPL) brightness (Bcpl = 1514 M−1 cm−1), which represents one of the best CPL performances among chiral organic molecules. We believe this work provides valuable insights and new perspectives for exploring novel helicene-based macrocycles with multiple conformations, enhanced (chir)optical properties, as well as valuable electronic and optoelectronic applications.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"28 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral Copper Clusters as Artificial Light-Harvesting Antennas Enabling Sequential Circularly Polarized Förster Resonance Energy Transfer 手性铜簇作为人工光收集天线实现顺序圆极化Förster共振能量转移

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-28 DOI: 10.31635/ccschem.026.202607344

Tian-Li Gao, Qi-Xiang Cai, Xiao-Jie Xu, Shuai-Peng Chen, Li-Zhen Wang, Ying-Xue Yuan, & Shuang-Quan ZangHenan Key Laboratory of Crystalline Molecular Functional Materials, College of Chemistry, Zhengzhou University, Zhengzhou, 450001, Henan Province

{"title":"Chiral Copper Clusters as Artificial Light-Harvesting Antennas Enabling Sequential Circularly Polarized Förster Resonance Energy Transfer","authors":"Tian-Li Gao, Qi-Xiang Cai, Xiao-Jie Xu, Shuai-Peng Chen, Li-Zhen Wang, Ying-Xue Yuan, & Shuang-Quan ZangHenan Key Laboratory of Crystalline Molecular Functional Materials, College of Chemistry, Zhengzhou University, Zhengzhou, 450001, Henan Province","doi":"10.31635/ccschem.026.202607344","DOIUrl":"https://doi.org/10.31635/ccschem.026.202607344","url":null,"abstract":"CCS Chemistry, Ahead of Print. The continuous transmission and amplification of chirality is a fascinating feature in natural biological systems. However, achieving sequential transmission of circularly polarized luminescence (CPL) through multistep energy transfer remains a formidable challenge. Here, chiral N-heterocyclic carbene-protected Cu3 clusters (R/S-Cu3) were synthesized as light-harvesting antennas, self-assembling into blue-emitting nanospheres with considerable CPL-active. Coumarin 6 (C-6), a green emitter, was introduced as the key relay baton for both chirality and energy transmission. We constructed chiral light-harvesting systems (LHSs) through the coassembly of R/S-Cu3, C-6, and red-emitting Nile Red (NiR), enabling efficient two-step energy transfer with a maximum efficiency (ΦET, max) of 87.86%. Supramolecular engineering was employed to fabricate nanofiber bundles serving as film templates, which facilitated sequential CPL transmission from Cu3 to C-6 and subsequently to NiR. The sequential circularly polarized Förster resonance energy transfer (CP-FRET) was verified via CPL spectral comparisons, resulting in distinct amplification of the dissymmetry factor. This work develops metal cluster-driven sequential CPL and energy transmission in chiral LHSs and provides in-depth insights into CP-FRET mechanism.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"23 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic Strength Modulation Enables Diffusion-Controlled Slow Growth of CsPbX3 Perovskite Quantum Dots 离子强度调制使CsPbX3钙钛矿量子点的扩散控制缓慢生长

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-25 DOI: 10.31635/ccschem.026.202507290

Maoyi Zhang, Xiang Sun, Xinyang Huang, Linlin Gao, Qinquan Wang, Muhan Cao, Zeke Liu, Wanli Ma

引用次数: 0

ECNU-ChemGPT: A Large Language Model for Chemistry and Retrosynthesis Predictions ECNU-ChemGPT：用于化学和逆向合成预测的大型语言模型

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-24 DOI: 10.31635/ccschem.026.202607359

Yueqing Zhang, Wentao Liu, Yan Zhang, Danyang Xiong, Jihang Zhai, Hao Hao, Jiaxi Zhuang, Hui Wang, Yucheng Gu, Haibo Yang, Shuanhu Gao, Lianrui Hu, Aimin Zhou, Xiao He

{"title":"ECNU-ChemGPT: A Large Language Model for Chemistry and Retrosynthesis Predictions","authors":"Yueqing Zhang, Wentao Liu, Yan Zhang, Danyang Xiong, Jihang Zhai, Hao Hao, Jiaxi Zhuang, Hui Wang, Yucheng Gu, Haibo Yang, Shuanhu Gao, Lianrui Hu, Aimin Zhou, Xiao He","doi":"10.31635/ccschem.026.202607359","DOIUrl":"https://doi.org/10.31635/ccschem.026.202607359","url":null,"abstract":"Large language models (LLMs) have achieved impressive progress across a broad range of general-purpose tasks, but their effectiveness in chemistry remains limited due to scarce domain-specific datasets, and the demand for precise symbolic and structural reasoning. Here we introduce ECNU-ChemGPT (East China Normal University Chemistry GPT model), a chemistry-specialized LLM engineered for deep chemical knowledge understanding and accurate retrosynthetic route planning. Our approach is distinguished by four key strategies: structured prompt-based knowledge distillation from authoritative chemistry textbooks to construct a high-quality question-answering dataset; domain-specific prompt engineering using curated chemical keywords, combined with LLM APIs for data derivation and knowledge distillation; fine-tuning on a meticulously cleaned Pistachio reaction dataset to enhance retrosynthesis prediction accuracy; and integration of BrainGPT (a brain-inspired multi-model scheduling framework), a dynamic multi-model scheduling framework that enables task-specific invocation of multiple specialized models trained for diverse chemistryrelated tasks. ECNU-ChemGPT exhibits superior performance on chemistry questionanswering and retrosynthetic planning benchmarks, outperforming leading generalpurpose models-including DeepSeek-R1, Qwen-2.5, and GPT-4o. In retrosynthesis, it achieves a Top-1 accuracy of 68.3% on the USPTO-50K dataset and successfully reproduces seven complete drug synthesis routes reported in the literatures and patents. These results underscore the effectiveness of domain-adapted LLM fine-tuning combined with dynamic multi-model task scheduling, providing a scalable and robust solution for chemical knowledge question answering, and retrosynthetic planning.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"70 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-Component C-Glycosylation of Amino Acids and Peptides Enabled by Photoinduced Palladium Catalysis 光诱导钯催化下氨基酸和肽的三组分c -糖基化

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-24 DOI: 10.31635/ccschem.026.202607588

Peng Huang, Lvnan Jin, Minmin Zhu, Zichun Zhang, Sen Zhou, Haipeng Hu, Xiaoming Feng, Yangbin Liu

{"title":"Three-Component C-Glycosylation of Amino Acids and Peptides Enabled by Photoinduced Palladium Catalysis","authors":"Peng Huang, Lvnan Jin, Minmin Zhu, Zichun Zhang, Sen Zhou, Haipeng Hu, Xiaoming Feng, Yangbin Liu","doi":"10.31635/ccschem.026.202607588","DOIUrl":"https://doi.org/10.31635/ccschem.026.202607588","url":null,"abstract":"Glycosylation represents a powerful strategy for modulating the properties and functions of peptides and proteins, with significant implications for biochemical and medicinal research. Particularly, C-glycosyl peptides and proteins-structural mimics of native O/N-glycosides-exhibit superior metabolic stability, rendering them attractive candidates for therapeutic development. Despite impressive advances in glycosyl radical-based synthesis of C-Glycopeptides, current approaches largely depend on harnessing nucleophilic reactivity of glycosyl radicals and pre functionalizing amino acid substrates to introduce electrophilic sites. To explore more reactivity patterns of glycosyl radicals and eliminate additional prefunctionalization steps, we herein disclose a photoinduced palladium-catalyzed, three-component glycosylation strategy for the direct assembly of saccharides with non-preactivated amino acids and peptides using 1,3-dienes as versatile coupling linkers. Notably, this approach transforms nucleophilic glycosyl radicals into electrophilic π-allylpalladium species, representing a novel reactivity pattern in glycosyl radical chemistry. Featuring mild conditions and good functional group tolerance, this method provides a versatile and general platform for constructing structurally diverse C-glycoamino acids, peptides, and drug conjugates in good yields with high stereoselectivity.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"27 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-Doped Conical Molecular Carbon Nanotubes 氮掺杂锥形分子碳纳米管

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-24 DOI: 10.31635/ccschem.026.202607785

Guang-Di Zhou, Ming Xie, Shuo Tong, Qing-Hui Guo, Ruimao Hua, Mei-Xiang Wang

引用次数: 0

Fundamental Dynamics and Management of Triplet Excitons in Perovskite Light-Emitting Diodes 钙钛矿发光二极管中三重态激子的基本动力学和管理

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-22 DOI: 10.31635/ccschem.026.202506635

Jia-Cheng Li, Yan-Hui Lou, Zhao-Kui Wang

引用次数: 0

Implantable Organic Transistors: Architectures, Properties, and Applications 可植入有机晶体管：架构、特性和应用

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-22 DOI: 10.31635/ccschem.026.202507280

Tao Hai, Shen Zhang, Yunqi Liu, Derong Kong, Dacheng Wei

引用次数: 0

Dipole-Promoted Stable Radicals Enabling Red Circularly Polarized Room-Temperature Phosphorescence 偶极子促进的稳定自由基实现红色圆极化室温磷光

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-20 DOI: 10.31635/ccschem.026.202607619

Qihuan Li, Zhaopeng Fang, Xuewen Guo, Yuxiang Wang, Junsheng Zhang, Yixiang Cheng

{"title":"Dipole-Promoted Stable Radicals Enabling Red Circularly Polarized Room-Temperature Phosphorescence","authors":"Qihuan Li, Zhaopeng Fang, Xuewen Guo, Yuxiang Wang, Junsheng Zhang, Yixiang Cheng","doi":"10.31635/ccschem.026.202607619","DOIUrl":"https://doi.org/10.31635/ccschem.026.202607619","url":null,"abstract":"Open-shell organic radicals are well known to promote triplet exciton transitions in organic dyes, enabling efficient room-temperature phosphorescence (RTP). However, their inherent instability and high reactivity impose severe constraints on practical applications. To address this bottleneck, we report a novel strategy for radical stabilization via dipole-dipole interactions. A host-guest system was engineered using triazine derivatives as the hosts and pyrene-functionalized binaphthyl derivatives as phosphorescent guests/chiral inducers. Introduction of a cyanobiphenyl liquid crystalline moiety drives the system to co-assemble into a long-range ordered superhelical architecture, which not only amplifies the chiral signal, but also synergistically aligns microscopic dipoles into a macroscopically oriented strong dipole field, affording a stabilizing microenvironment for radicals photogenerated under UV excitation. The resulting system exhibits intense red circularly polarized room-temperature phosphorescence (CP-RTP) emission (635 nm, gem = 4.7 × 10−2). This work offers a versatile strategy toward high-performance red CP-RTP materials, while providing new insights for addressing the dual challenges of radical stabilization and chiral signal transmission.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"22 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Gated Dynamic Covalent Chemistry with Spirothiopyran for Spatiotemporal Control of Bond Formation and Exchange 光门控动态共价化学与螺比嘌呤键形成和交换的时空控制

IF 11.2 1区化学

CCS Chemistry Pub Date : 2026-04-19 DOI: 10.31635/ccschem.026.202607612

Shuailong Zhou, Hanbo Xu, Yingjie Liu, Jun Lin, Chuang Li

{"title":"Light-Gated Dynamic Covalent Chemistry with Spirothiopyran for Spatiotemporal Control of Bond Formation and Exchange","authors":"Shuailong Zhou, Hanbo Xu, Yingjie Liu, Jun Lin, Chuang Li","doi":"10.31635/ccschem.026.202607612","DOIUrl":"https://doi.org/10.31635/ccschem.026.202607612","url":null,"abstract":"Dynamic covalent chemistry (DCC) underpins the adaptive and stimuli-responsive properties of many advanced materials, yet achieving precise spatiotemporal control over bond formation and cleavage remains a significant challenge. The integration of molecular photoswitches with DCC offers a powerful strategy to address this limitation by enabling optical regulation. In this work, we report a light-regulated DCC platform operating through a radical-mediated pathway, utilizing photoswitchable spirothiopyran (STP) together with thiol/disulfide substrates. Under an identical light irradiation condition, STP reversibly isomerizes to its thiomerocyanine (TMC) form, unlocking latent ene functionality that engages in a subsequent thiol-ene “click” reaction with sulfur radicals photogenerated in situ from thiols or disulfides. This concurrent photoactivation and coupling yield dynamic photoadducts capable of undergoing thermally driven reversible C-S bond dissociation. Multiple cycles of C-S bond formation and cleavage are demonstrated by alternating light irradiation and thermal relaxation. Moreover, the resulting photoadducts exhibit reversible bond exchange in the presence of external thiols, highlighting their excellent dynamic covalent character. These properties can also be leveraged to label hydrogels in a thermally reversible and dynamically exchangeable manner. The developed photoswitchable DCC system offers a promising avenue for the development of dynamic networks, smart materials, and adaptive polymers with precisely controllable properties.","PeriodicalId":9810,"journal":{"name":"CCS Chemistry","volume":"15 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0