Cell Biology International最新文献_第2页

Role of Gut Microbiota in Immune Checkpoint Inhibitor Therapy 肠道微生物群在免疫检查点抑制剂治疗中的作用。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-03-02 DOI: 10.1002/cbin.70148

Yue-Chun Fu, Bing Pang, Shao-Bo Liang

引用次数: 0

Polydatin as a Multifunctional Anticancer Agent: Cellular Mechanisms, Therapeutic Potential and Future Clinical Perspectives 多柚素作为一种多功能抗癌药物：细胞机制、治疗潜力和未来临床前景。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-02-19 DOI: 10.1002/cbin.70145

Putri Cahaya Situmorang, Cheryl Grace Pratiwi Rumahorbo, Leo Jumadi Simanjuntak, Rony Abdi Syahputra, Javad Sharifi-Rad, Daniela Calina

{"title":"Polydatin as a Multifunctional Anticancer Agent: Cellular Mechanisms, Therapeutic Potential and Future Clinical Perspectives","authors":"Putri Cahaya Situmorang, Cheryl Grace Pratiwi Rumahorbo, Leo Jumadi Simanjuntak, Rony Abdi Syahputra, Javad Sharifi-Rad, Daniela Calina","doi":"10.1002/cbin.70145","DOIUrl":"10.1002/cbin.70145","url":null,"abstract":"<div>\u0000 \u0000 <p>Cancer remains one of the leading causes of death worldwide, with conventional treatments often facing limitations such as toxicity, drug resistance, and reduced effectiveness over time. Polydatin (PD), a natural glycosylated derivative of resveratrol, has emerged as a promising therapeutic compound due to its ability to induce apoptosis, regulate the cell cycle, modulate oxidative stress, and inhibit angiogenesis. Additionally, PD plays a key role in shaping the tumor microenvironment and enhancing immune responses, making it a strong candidate for use alongside chemotherapy and radiotherapy. This review examines PD's pharmacological potential, highlighting its anticancer mechanisms, therapeutic combinations, and clinical relevance. A systematic literature search was conducted using PubMed, Scopus and Web of Science to analyze preclinical and clinical studies published between 2010 and 2024. Findings suggest that PD enhances chemotherapy efficacy, increases tumor sensitivity to radiotherapy, and reduces drug resistance by targeting critical signaling pathways, including phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK). Beyond cancer treatment, PD has demonstrated cardioprotective, neuroprotective, and hepatoprotective properties, further supporting its clinical potential. Despite encouraging preclinical evidence, clinical studies on PD remain limited, emphasizing the need for further investigations into its pharmacokinetics, bioavailability, and safety. Moving forward, research should focus on improving drug delivery systems, conducting rigorous clinical trials, and exploring PD's role in precision medicine to maximize its therapeutic impact in oncology and beyond.</p>\u0000 </div>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"50 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PKMYT1/FOXM1/Snail Axis Promotes Metastasis in Clear Cell Renal Cell Carcinoma by Inducing Epithelial–mesenchymal Transition PKMYT1/FOXM1/蜗牛轴通过诱导上皮-间质转化促进透明细胞肾细胞癌的转移。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-02-16 DOI: 10.1002/cbin.70139

Jianzhi Su, Ren Xu, Bin Liu, Aili Zhang

{"title":"PKMYT1/FOXM1/Snail Axis Promotes Metastasis in Clear Cell Renal Cell Carcinoma by Inducing Epithelial–mesenchymal Transition","authors":"Jianzhi Su, Ren Xu, Bin Liu, Aili Zhang","doi":"10.1002/cbin.70139","DOIUrl":"10.1002/cbin.70139","url":null,"abstract":"<p>Clear cell renal cell carcinoma (ccRCC), the most prevalent subtype of renal cell carcinoma, exhibits high invasiveness and metastatic potential. Membrane-associated tyrosine/threonine 1 (PKMYT1) is linked to poor prognosis in ccRCC; however, its role in metastasis and the underlying molecular mechanisms remain unclear. Here, we analyzed <i>PKMYT1</i> expression and its correlation with clinicopathological features in ccRCC using The Cancer Genome Atlas (TCGA) dataset. Exogenously modulating PKMYT1 expression in ccRCC cells, we assessed changes in cell migration, invasion, and epithelial-mesenchymal transition (EMT) markers, and explored the involvement of the forkhead box M1 (FoxM1)/Snail axis. A mouse metastasis model was used to evaluate the impact of PKMYT1 and its downstream targets on metastasis. TCGA data showed <i>PKMYT1</i> was overexpressed in ccRCC, with high expression correlating with advanced tumor grade, metastasis, and poor survival. In vitro and in vivo assays demonstrated that PKMYT1 promoted ccRCC cell migration, invasion, and metastasis. Mechanistically, PKMYT1 directly activates Snail transcription by upregulating FoxM1, which in turn represses E-cadherin and activates vimentin expression, thereby inducing EMT in ccRCC cells. Inhibition of the FoxM1/Snail/EMT pathway reversed PKMYT1-induced metastasis in mice. Collectively, our findings identify the PKMYT1/FoxM1/Snail axis as a driver of ccRCC metastasis via EMT induction, highlighting PKMYT1 as a potential therapeutic target for ccRCC.</p>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"50 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin Relieves Neuropathic Pain and Depressive-Like Behaviors by Inhibiting the ERK/NF-κB/c-Fos Signaling Pathway in the Spinal Cord of Spared Nerve Injury Mice 褪黑素通过抑制神经损伤小鼠脊髓ERK/NF-κB/c-Fos信号通路减轻神经性疼痛和抑郁样行为。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-02-14 DOI: 10.1002/cbin.70144

Shuang Wang, Yuanxun Liu, Shaohui Chen, Lixin Yao, Chengchen Zeng, Qiqi Xia, Mengwei Zhang, Shuli Chen, Tao Zhang, Shuwei Hua, Ling Liu

{"title":"Melatonin Relieves Neuropathic Pain and Depressive-Like Behaviors by Inhibiting the ERK/NF-κB/c-Fos Signaling Pathway in the Spinal Cord of Spared Nerve Injury Mice","authors":"Shuang Wang, Yuanxun Liu, Shaohui Chen, Lixin Yao, Chengchen Zeng, Qiqi Xia, Mengwei Zhang, Shuli Chen, Tao Zhang, Shuwei Hua, Ling Liu","doi":"10.1002/cbin.70144","DOIUrl":"10.1002/cbin.70144","url":null,"abstract":"<div>\u0000 \u0000 <p>Neuropathic pain (NP) is marked by ongoing nociceptive signals and accompanied by symptoms resembling depression, which complicates treatment strategies. Melatonin (MT), a hormone known for its neuroprotective properties, has garnered attention for its potential in NP treatment, but its precise mechanisms remain incompletely understood. In this study, a spared nerve injury (SNI) model was established and MT was injected intraperitoneally. As a consequence, SNI mice displayed significantly reduced mechanical paw withdrawal thresholds (PWT) and thermal paw withdrawal latencies (PWL). Additionally, these mice demonstrated depressive-like symptoms, as evidenced by prolonged immobility durations in both the forced swim test (FST) and the tail suspension test (TST). Further analysis found that there is an increase in the activation of the NF-κB/ERK/c-Fos signaling pathway and NLRP3 inflammasome-related neuroinflammation. MT administration significantly increased PWT, prolonged PWL and reduced immobility time by inhibiting the NF-κB/ERK/c-Fos pathway and the subsequent formation of the NLRP3 inflammasome in SNI mice. This study highlights the dual therapeutic potential of MT through the modulation of the NF-κB/ERK/c-Fos signaling pathway, providing a novel potential target and strategy for the clinical treatment of NP with certain translational application value.</p></div>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"50 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESSION OF CONCERN: Rat Marrow-Derived Mesenchymal Stem Cells Developed in a Medium Supplemented With the Autologous Versus Bovine Serum 关注的表达：大鼠骨髓来源的间充质干细胞在补充了自体与牛血清的培养基中发育。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-02-10 DOI: 10.1002/cbin.70138

引用次数: 0

Brucine as a Natural Modulator of Cancer Signaling: Cellular Mechanisms, Therapeutic Potential, and Translational Perspectives 马钱子碱作为癌症信号的天然调节剂：细胞机制、治疗潜力和翻译观点。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-02-02 DOI: 10.1002/cbin.70143

Putri Cahaya Situmorang, Helen Helen, Rony Abdi Syahputra, Sony Eka Nugraha, Etti Sartina Siregar, Doni Aldo Samuel Siahaan, Zainab M. Almarhoon, William N. Setzer, Javad Sharifi-Rad

{"title":"Brucine as a Natural Modulator of Cancer Signaling: Cellular Mechanisms, Therapeutic Potential, and Translational Perspectives","authors":"Putri Cahaya Situmorang, Helen Helen, Rony Abdi Syahputra, Sony Eka Nugraha, Etti Sartina Siregar, Doni Aldo Samuel Siahaan, Zainab M. Almarhoon, William N. Setzer, Javad Sharifi-Rad","doi":"10.1002/cbin.70143","DOIUrl":"10.1002/cbin.70143","url":null,"abstract":"<div>\u0000 \u0000 <p>Brucine (BRU), a naturally occurring indole alkaloid primarily derived from <i>Strychnos nux-vomica</i>, has recently gained attention for its notable anticancer potential. Preclinical studies using both <i>in vitro</i> and <i>in vivo</i> models have demonstrated that BRU and its semi-synthetic derivatives exhibit significant inhibitory effects on tumor development across various cancer types, including cervical, breast, liver, skin, colon, and prostate cancers. This review explores the phytochemical properties of BRU, its chemical modifications, bioavailability, pharmacokinetics, mechanisms of anticancer activity, as well as findings from clinical research, toxicity profiles, and safety evaluations. Compared to conventional chemotherapeutic agents, BRU offers a promising alternative due to its broad-spectrum efficacy and natural origin, although its therapeutic application is limited by a narrow safety margin. Therefore, future research should focus on the development of optimized semi-synthetic derivatives and advanced drug delivery systems to enhance its pharmacological performance while minimizing toxicity, supporting its potential as a viable candidate in anticancer therapy.</p>\u0000 </div>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"50 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on the Antagonism of Aluminum-Induced Neurotoxicity by Ginsenosides 人参皂苷拮抗铝致神经毒性的研究进展。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-01-28 DOI: 10.1002/cbin.70141

Lu Zhihang, Lu Jiaxu, Ye Zhao, Feng Zhuonan, Yin Baishuang, Zhu Yanzhu

{"title":"Research Progress on the Antagonism of Aluminum-Induced Neurotoxicity by Ginsenosides","authors":"Lu Zhihang, Lu Jiaxu, Ye Zhao, Feng Zhuonan, Yin Baishuang, Zhu Yanzhu","doi":"10.1002/cbin.70141","DOIUrl":"10.1002/cbin.70141","url":null,"abstract":"<div>\u0000 \u0000 <p>Aluminum (Al) was a nonessential toxic metal in the environment. Al exposure had been widely demonstrated to cause cognitive impairment and neuronal damage. However, the neurotoxicology mechanism of Al was still not summarized through the oxidative stress, inflammation, apoptosis, and gut microbiota. Ginsenosides, natural active components derived from ginseng, had garnered significant attention due to its antioxidant and neuroprotective properties. Although the neurotoxic mechanisms of Al had been elucidated, the treatment of ginsenosides on Al exposure was elusive. This review explores the suppressive feasibility of ginsenosides on the Al-induced neurotoxicity through oxidative stress, inflammatory factors, apoptosis, and intestinal microbiota. Ginsenoside Rb1, Rk3, and Rg1 exhibits anti-inflammatory, anti-oxidative stress, anti-apoptosis, and refinement the gut microbiota composition. But the direct evidence is scarce in the Al-induce neuro disease. Compared with donepezil, ginsenosides exhibit a synergistic advantage encompassing pathological intervention—neuroprotection—metal clearance. Thus, ginsenosides may have potential therapeutic intervention to mitigate Al-induced neurotoxicity. However, the precise mechanisms underlying these effects warrant further investigation.</p>\u0000 </div>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"50 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of Micronuclear Epigenetic Signatures in Analyses of Toxicity and Genomic Instability 微核表观遗传特征在毒性和基因组不稳定性分析中的潜力。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-01-27 DOI: 10.1002/cbin.70142

Somnath Paul, Ankita Das, Apurba K. Bandyopadhyay, Ashok K. Giri

{"title":"Potential of Micronuclear Epigenetic Signatures in Analyses of Toxicity and Genomic Instability","authors":"Somnath Paul, Ankita Das, Apurba K. Bandyopadhyay, Ashok K. Giri","doi":"10.1002/cbin.70142","DOIUrl":"10.1002/cbin.70142","url":null,"abstract":"<div>\u0000 \u0000 <p>Micronuclei (MN) are small extranuclear chromosomal fragments that arise from genomic instability and serve as established biomarkers for genotoxicity and disease susceptibility. Once considered only markers of disease, they are now recognized as active, causative drivers of disease progression, driven by emerging evidence of epigenetic regulation within these structures. The micronucleus assay is recognized as a cost-effective and minimally invasive method for monitoring genotoxicity resulting from both chronic and early exposure to environmental factors such as arsenic and lead, as well as from genetic instability associated with cancer progression. This review critically examines the expanding role of MN beyond traditional cytogenetic endpoints, with particular emphasis on recent insights into their epigenetic landscape. Mass spectrometry-based studies have demonstrated that MN possess distinct histone posttranslational modification signatures compared to primary nuclei, including alterations in H3K27ac, H3K9ac, and H3K18ac. These modifications affect chromatin structure, gene expression, and DNA repair mechanisms. In the context of xenobiotic exposures, MN-associated epigenetic changes may function as early indicators of disease progression. Additionally, rupture of the MN envelope can activate innate immune responses through the cGAS–STING pathway or result in chromothripsis, both of which contribute to cancer progression. The concept of “Micronuclear Epigenetics” is highlighted, with its potential application in high-throughput diagnostic platforms, particularly liquid biopsy, discussed. This approach may enhance early detection and risk stratification in exposure-induced toxicity and diseases such as cancer.</p>\u0000 </div>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"50 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Antibacterial, Anti-Biofouling, and Corrosion-Resistant Surface Technologies 抗菌、抗生物污和耐腐蚀表面技术的研究进展。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-01-27 DOI: 10.1002/cbin.70140

Anca Mazare, Wolfgang H. Goldmann, Alexander B. Tesler

引用次数: 0

Orchestrating Microtubules: A Review of Kinase–Dependent Regulatory Mechanisms 调控微管：激酶依赖性调控机制综述。

IF 3.1 3区生物学

Cell Biology International Pub Date : 2026-01-24 DOI: 10.1002/cbin.70133

Yaqian Zhang, Shasha Hua, Kai Jiang

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