Cell Proliferation最新文献_第3页

Small molecule valproic acid enhances ventral patterning of human neural tube organoids by regulating Wnt and Shh signalling. 小分子丙戊酸通过调节Wnt和Shh信号增强人类神经管器官组织的腹侧模式。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2025-01-01 Epub Date: 2024-08-20 DOI: 10.1111/cpr.13737

Yuanyuan Zheng, Fangrong Zhang, Haifeng Nie, Xinyu Li, Jiali Xun, Jianping Fu, Lijun Wu

{"title":"Small molecule valproic acid enhances ventral patterning of human neural tube organoids by regulating Wnt and Shh signalling.","authors":"Yuanyuan Zheng, Fangrong Zhang, Haifeng Nie, Xinyu Li, Jiali Xun, Jianping Fu, Lijun Wu","doi":"10.1111/cpr.13737","DOIUrl":"10.1111/cpr.13737","url":null,"abstract":"Valproic acid (VPA), a clinically approved small molecule, has been reported to activate Wnt signalling that is critical for dorsal-ventral (DV) patterning of neural tube. However, little is known about the impact of VPA on DV patterning process. Here, we show that even though VPA has a negative impact on the early formation of human neural tube organoids (hNTOs), it significantly enhances the efficiency of ventrally patterned hNTOs, when VPA is added during the entire differentiation process. RNA sequencing and RT-qPCR analysis demonstrates VPA activates endogenous Wnt signalling in hNTOs. Surprisingly, transcriptome analysis also identifies upregulation of genes for degradation of GLI2 and GLI3 proteins, whose truncated fragment are transcriptional repressors of Shh signalling. The Western-blot analysis confirms the increase of GLI3R proteins after VPA treatment. Thus, VPA might enhance ventral patterning of hNTOs through both activating Wnt, which can antagonise Shh signalling by inducing GLI3 expression, and/or inhibiting Shh signalling by inducing GLI protein degradation. We further obtain results to show that VPA still increases patterning efficiency of hNTOs with a weak influence on their early formation when the initiation time of VPA is delayed and its duration is reduced. Taken together, this study demonstrates that VPA enhances the generation of more reproducible hNTOs with ventral patterning, opening the avenues for the applications of hNTOs in developmental biology and regenerative medicine.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13737"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel tetrahedral framework nucleic acid-derived chemodynamic therapy agent for effective glioblastoma treatment. 用于有效治疗胶质母细胞瘤的新型四面体框架核酸衍生化学动力疗法制剂。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2025-01-01 Epub Date: 2024-08-24 DOI: 10.1111/cpr.13736

Xiaodie Li, Lei Li, Xin Fu, Shiqian Huang, Yuhao Wang, Yuepeng Yang, Shuqin Zhou, Zhaowei Zou, Qing Peng, Chao Zhang

{"title":"A novel tetrahedral framework nucleic acid-derived chemodynamic therapy agent for effective glioblastoma treatment.","authors":"Xiaodie Li, Lei Li, Xin Fu, Shiqian Huang, Yuhao Wang, Yuepeng Yang, Shuqin Zhou, Zhaowei Zou, Qing Peng, Chao Zhang","doi":"10.1111/cpr.13736","DOIUrl":"10.1111/cpr.13736","url":null,"abstract":"Chemodynamic therapy (CDT) has garnered significant attention for treating diverse malignant tumours due to its minimally invasive nature, reduced damage to healthy tissues, and potential mitigation of side effects. However, its application in glioblastoma (GBM) is hindered by the diminished capacity of CDT agents to traverse the blood-brain barrier (BBB), inadequate tumour targeting efficiency, and restricted availability of H2O2 within the tumour microenvironment (TME). To address these challenges, we devised a novel CDT agent (Fe@tFNAs-ANG-3AT) based on a tetrahedral framework nucleic acids (tFNAs). Fe@tFNAs-ANG-3AT was constructed by anchoring iron ions (Fe3+) onto the dual appendages-modified tFNAs. Specifically, one appendage, Angiopep-2 (ANG, a penetrating peptide), facilitates Fe@tFNAs-ANG-3AT penetration across the BBB and selective targeting of tumour cells. Simultaneously, the second appendage, 3-Amino-1,2,4-triazole (3AT, a H2O2 enzyme inhibitor), augments the H2O2 levels required for effective CDT treatment. Upon tumour cell internalization, the loaded Fe3+ in Fe@tFNAs-ANG-3AT is reduced to Fe2+ by the overexpressed glutathione (GSH) in the TME, catalysing the generation of cytotoxic hydroxyl radicals (·OH) and inducing tumour cell death via elevated oxidative stress levels within tumour cells. It is anticipated that Fe@tFNAs-ANG-3AT holds promise as a transformative treatment strategy for GBM.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13736"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoid chrysin activates both TrkB and FGFR1 receptors while upregulates their endogenous ligands such as brain derived neurotrophic factor to promote human neurogenesis. 黄酮类化合物菊黄素可激活 TrkB 和 FGFR1 受体，同时上调它们的内源性配体，如脑源性神经营养因子，从而促进人类神经发生。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2025-01-01 Epub Date: 2024-09-27 DOI: 10.1111/cpr.13732

Xiaoxu Dong, Gang Pei, Zhuo Yang, Shichao Huang

{"title":"Flavonoid chrysin activates both TrkB and FGFR1 receptors while upregulates their endogenous ligands such as brain derived neurotrophic factor to promote human neurogenesis.","authors":"Xiaoxu Dong, Gang Pei, Zhuo Yang, Shichao Huang","doi":"10.1111/cpr.13732","DOIUrl":"10.1111/cpr.13732","url":null,"abstract":"Neurogenesis is the process of generating new neurons from neural stem cells (NSCs) and plays a crucial role in neurological diseases. The process involves a series of steps, including NSC proliferation, migration and differentiation, which are regulated by multiple pathways such as neurotrophic Trk and fibroblast growth factor receptors (FGFR) signalling. Despite the discovery of numerous compounds capable of modulating individual stages of neurogenesis, it remains challenging to identify an agent that can regulate multiple cellular processes of neurogenesis. Here, through screening of bioactive compounds in dietary functional foods, we identified a flavonoid chrysin that not only enhanced the human NSCs proliferation but also facilitated neuronal differentiation and neurite outgrowth. Further mechanistic study revealed the effect of chrysin was attenuated by inhibition of neurotrophic tropomyosin receptor kinase-B (TrkB) receptor. Consistently, chrysin activated TrkB and downstream ERK1/2 and AKT. Intriguingly, we found that the effect of chrysin was also reduced by FGFR1 blockade. Moreover, extended treatment of chrysin enhanced levels of brain-derived neurotrophic factor, as well as FGF1 and FGF8. Finally, chrysin was found to promote neurogenesis in human cerebral organoids by increasing the organoid expansion and folding, which was also mediated by TrkB and FGFR1 signalling. To conclude, our study indicates that activating both TrkB and FGFR1 signalling could be a promising avenue for therapeutic interventions in neurological diseases, and chrysin appears to be a potential candidate for the development of such treatments.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13732"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The chromatin accessibility landscape of mouse oocytes during configuration transition. 小鼠卵母细胞配置转换过程中的染色质可及性图谱

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2025-01-01 Epub Date: 2024-09-08 DOI: 10.1111/cpr.13733

Shuai Zhu, Jiashuo Li, Xiuwan Wang, Yifei Jin, Hengjie Wang, Huiqing An, Hongzheng Sun, Longsen Han, Bin Shen, Qiang Wang

{"title":"The chromatin accessibility landscape of mouse oocytes during configuration transition.","authors":"Shuai Zhu, Jiashuo Li, Xiuwan Wang, Yifei Jin, Hengjie Wang, Huiqing An, Hongzheng Sun, Longsen Han, Bin Shen, Qiang Wang","doi":"10.1111/cpr.13733","DOIUrl":"10.1111/cpr.13733","url":null,"abstract":"The transition of chromatin configuration in mammalian oocytes from a non-surrounded nucleolus (NSN) to a surrounded nucleolus (SN) is critical for acquiring the developmental competence. However, the genomic and epigenomic features underlying this process remain poorly understood. In the present study, we first establish the chromatin accessibility landscape of mouse oocytes from NSN to SN stage. Through the integrative analysis of multi-omics, we find that the establishment of DNA methylation in oocytes is independent of the dynamics of chromatin accessibility. In contrast, histone H3K4me3 status is closely associated with the dynamics of accessible regions during configuration transition. Furthermore, by focusing on the actively transcribed genes in NSN and SN oocytes, we discover that chromatin accessibility coupled with histone methylation (H3K4me3 and H3K27me3) participates in the transcriptional control during phase transition. In sum, our data provide a comprehensive resource for probing configuration transition in oocytes, and offer insights into the mechanisms determining chromatin dynamics and oocyte quality.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13733"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional heterogeneity of meniscal fibrochondrocytes and microtissue models is dependent on modality of fibrochondrocyte isolation. 半月板纤维软骨细胞和微组织模型的功能异质性取决于纤维软骨细胞的分离方式。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2025-01-01 Epub Date: 2024-10-08 DOI: 10.1111/cpr.13735

Zhiyao Ma, Shikha Chawla, Xiaoyi Lan, Eva Zhou, Aillette Mulet-Sierra, Melanie Kunze, Mark Sommerfeldt, Adetola B Adesida

{"title":"Functional heterogeneity of meniscal fibrochondrocytes and microtissue models is dependent on modality of fibrochondrocyte isolation.","authors":"Zhiyao Ma, Shikha Chawla, Xiaoyi Lan, Eva Zhou, Aillette Mulet-Sierra, Melanie Kunze, Mark Sommerfeldt, Adetola B Adesida","doi":"10.1111/cpr.13735","DOIUrl":"10.1111/cpr.13735","url":null,"abstract":"Collagenase digestion (d) and cellular outgrowth (og) are the current modalities of meniscus fibrochondrocytes (MFC) isolation for bioengineering and mechanobiology-related studies. However, the impact of these modalities on study outcomes is unknown. Here, we show that og- and d-isolated MFC have distinct proliferative capacities, transcriptomic profiles via RNA sequencing (RNAseq), extracellular matrix (ECM)-forming, and migratory capacities. Our data indicate that microtissue pellet models developed from og-isolated MFC display a contractile phenotype with higher expressions of alpha-smooth muscle actin (ACTA2) and transgelin (TAGLN) and are mechanically stiffer than their counterparts from d-MFC. Moreover, we introduce a novel method of MFC isolation designated digestion-after-outgrowth (dog). The transcriptomic profile of dog-MFC is distinct from d- and og-MFC, including a higher expression of mechanosensing caveolae-associated caveolin-1 (CAV1). Additionally, dog-MFC were superior chondrogenically and generated larger-size microtissue pellet models containing a higher frequency of smaller collagen fibre diameters. Thus, we demonstrate that the modalities of MFC isolation influence the downstream outcomes of bioengineering and mechanobiology-related studies.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13735"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncolytic herpes simplex virus propagates tertiary lymphoid structure formation via CXCL10/CXCR3 to boost antitumor immunity. 肿瘤溶解性单纯疱疹病毒通过 CXCL10/CXCR3 促进三级淋巴结构的形成，从而增强抗肿瘤免疫力。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2025-01-01 Epub Date: 2024-09-01 DOI: 10.1111/cpr.13740

Meng-Jie Zhang, Wen-Ping Lin, Qing Wang, Shuo Wang, An Song, Yuan-Yuan Wang, Hao Li, Zhi-Jun Sun

{"title":"Oncolytic herpes simplex virus propagates tertiary lymphoid structure formation via CXCL10/CXCR3 to boost antitumor immunity.","authors":"Meng-Jie Zhang, Wen-Ping Lin, Qing Wang, Shuo Wang, An Song, Yuan-Yuan Wang, Hao Li, Zhi-Jun Sun","doi":"10.1111/cpr.13740","DOIUrl":"10.1111/cpr.13740","url":null,"abstract":"Inducing tertiary lymphoid structure (TLS) formation can fuel antitumor immunity. It is necessary to create mouse models containing TLS to explore strategies of TLS formation. Oncolytic herpes simplex virus-1 (oHSV) exhibited intense effects in preclinical and clinical trials. However, the role of oHSV in TLS formation remains to be elucidated. Here, we observed the presence of TLS in 4MOSC1 and MC38 subcutaneous tumour models. Interestingly, oHSV evoked TLS formation, and increased infiltration of B cells and stem-like TCF1+CD8+ T cells proliferation. Mechanistically, oHSV increased the expression of TLS-related chemokines, along with upregulated CXCL10/CXCR3 to facilitate TLS formation. Notably, CXCL10 and CXCR3 were favourable prognostic factors for cancer patients, and closely related with immune cells infiltration. Inhibiting CXCL10/CXCR3 reduced TCF1+CD8+ T cells and granzyme B expression, and impaired oHSV-mediated TLS formation. Furthermore, oHSV-mediated TLS formation revealed superior response and survival rate when combined with αPD-1 treatment. Collectively, these findings indicate that oHSV recruits stem-like TCF1+CD8+ T cells through CXCL10/CXCR3 pathway to propagate TLS formation, and warrants future antitumor immunity development.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13740"},"PeriodicalIF":5.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle-Derived Bioactive Factors: MyoEVs and Myokines. 肌肉来源的生物活性因子：myoev和Myokines。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-12-30 DOI: 10.1111/cpr.13801

Xupeng Liu, Ziyue Yao, Liping Zhang, Ng Shyh-Chang

引用次数: 0

Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non-Viral CAR-NK Cell Engineering. 革命性的癌症免疫治疗：非病毒CAR-NK细胞工程的进展和前景。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-12-27 DOI: 10.1111/cpr.13791

Zhaokai Zhou, Yifeng Chen, Yuhao Ba, Hui Xu, Anning Zuo, Shutong Liu, Yuyuan Zhang, Siyuan Weng, Yuqing Ren, Peng Luo, Quan Cheng, Lulu Zuo, Shanshan Zhu, Xing Zhou, Chuhan Zhang, Yukang Chen, Xinwei Han, Teng Pan, Zaoqu Liu

{"title":"Revolutionising Cancer Immunotherapy: Advancements and Prospects in Non-Viral CAR-NK Cell Engineering.","authors":"Zhaokai Zhou, Yifeng Chen, Yuhao Ba, Hui Xu, Anning Zuo, Shutong Liu, Yuyuan Zhang, Siyuan Weng, Yuqing Ren, Peng Luo, Quan Cheng, Lulu Zuo, Shanshan Zhu, Xing Zhou, Chuhan Zhang, Yukang Chen, Xinwei Han, Teng Pan, Zaoqu Liu","doi":"10.1111/cpr.13791","DOIUrl":"https://doi.org/10.1111/cpr.13791","url":null,"abstract":"The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)-transduced NK cells. These cells, pivotal in innate immunity, offer a rapid and potent response against cancer cells and pathogens without the need for prior sensitization or recognition of peptide antigens. Although NK cell genetic modification is evolving, the viral transduction method continues to be inefficient and fraught with risks, often resulting in cytotoxic outcomes and the possibility of insertional mutagenesis. Consequently, there has been a surge in the development of non-viral transfection technologies to overcome these challenges in NK cell engineering. Non-viral approaches for CAR-NK cell generation are becoming increasingly essential. Cutting-edge techniques such as trogocytosis, electroporation, lipid nanoparticle (LNP) delivery, clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9) gene editing and transposons not only enhance the efficiency and safety of CAR-NK cell engineering but also open new avenues for novel therapeutic possibilities. Additionally, the infusion of technologies already successful in CAR T-cell therapy into the CAR-NK paradigm holds immense potential for further advancements. In this review, we present an overview of the potential of NK cells in cancer immunotherapies, as well as non-viral transfection technologies for engineering NK cells.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13791"},"PeriodicalIF":5.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Cell Transcriptomics Uncovers Core Signature for Regulating Mitochondrial Homeostasis During Testicular Ageing. 单细胞转录组学揭示了睾丸衰老过程中调节线粒体稳态的核心特征。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-12-27 DOI: 10.1111/cpr.13797

Weijie Xu, Qiuru Huang, Yujuan Qi, Qingqing Hu, Cong Shen, Xia Chen, Jiaxin Li, Qiushi Xia, Ziyue Pan, Yi Zhang, Guoqing Han, Jingqi Huang, Yiheng Liu, Ziyu Cao, Ying Zheng, Bo Zheng, Zhifeng Gu, Jun Yu, Chi Sun

{"title":"Single-Cell Transcriptomics Uncovers Core Signature for Regulating Mitochondrial Homeostasis During Testicular Ageing.","authors":"Weijie Xu, Qiuru Huang, Yujuan Qi, Qingqing Hu, Cong Shen, Xia Chen, Jiaxin Li, Qiushi Xia, Ziyue Pan, Yi Zhang, Guoqing Han, Jingqi Huang, Yiheng Liu, Ziyu Cao, Ying Zheng, Bo Zheng, Zhifeng Gu, Jun Yu, Chi Sun","doi":"10.1111/cpr.13797","DOIUrl":"https://doi.org/10.1111/cpr.13797","url":null,"abstract":"Testicular ageing is accompanied by a series of morphological changes, while the features of mitochondrial dysfunction remain largely unknown. Herein, we observed a range of age-related modifications in testicular morphology and spermatogenic cells, and conducted single-cell RNA sequencing on young and old testes in Drosophila. Pseudotime trajectory revealed significant changes in germline subpopulations during ageing. Our examination unveiled that genes showing bias in spermatids exhibited higher dN/dS than those in GSCs_Spermatogonia. Genes biased towards young GSCs_Spermatogonia displayed higher dN/dS than those in old GSCs_Spermatogonia. Interestingly, genes biased towards young spermatids demonstrated lower dN/dS in contrast to those in old spermatids, revealing the complexity of evolutionary adaptations during ageing. Furthermore, mitochondria associated events, including oxidative phosphorylation, TCA cycle and pyruvate metabolism, were significantly enriched in germline subpopulations. Specifically, mitochondrial function was significantly impaired during the process of testicular ageing, concurrently emphasising the role of several key nuclear genome-encoded mitochondrial regulatory genes, such as Hsp60B, fzo, Tim17b1 and mRpL12. Our data offer insights into testicular homeostasis regulated by mitochondrial function during the ageing process.","PeriodicalId":9760,"journal":{"name":"Cell Proliferation","volume":" ","pages":"e13797"},"PeriodicalIF":5.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitonuclear Communication in Stem Cell Function. 干细胞功能中的有丝核通讯。

IF 5.9 1区生物学

Cell Proliferation Pub Date : 2024-12-26 DOI: 10.1111/cpr.13796

Baozhou Peng, Yaning Wang, Hongbo Zhang

引用次数: 0