Central European Journal of Urology最新文献

{"title":"Impact of preoperative pelvic floor muscle strength and endurance on urinary continence after radical prostatectomy: a sub-analysis of a randomized clinical trial.","authors":"Daimantas Milonas, Laimonas Siupsinskas, Pavelas Zachovajevas, Brigita Zachovajeviene","doi":"10.5173/ceju.2025.0018","DOIUrl":"10.5173/ceju.2025.0018","url":null,"abstract":"<p><strong>Introduction: </strong>To assess the impact of preoperative pelvic floor muscle (PFM) strength on urinary incontinence (UI) after radical prostatectomy (RP).</p><p><strong>Material and methods: </strong>A total of 127 men who underwent surgical treatment for clinically localized prostate cancer in a tertiary university hospital were included in a sub-analysis. PFM strength (cmH₂O) and endurance (s) were measured using a perineometer on the day before and at 1, 3, and 6 months after surgery. UI volume was measured using an 8-hour pad test. The primary outcome was continence, defined as 0-5 grams of urine during the 8-hour pad test at 6 months post-RP. The association between baseline PFM strength and continence was analyzed using Spearman's correlation coefficient, receiver-operating characteristic analysis, and logistic regression analysis.</p><p><strong>Results: </strong>At 6 months post-RP, 45 of 127 (35.4%) men were continent. UI showed a strong negative (r = -0.7; p <0.001) association with preoperative PFM strength and a medium negative (r = -0.55; p <0.001) association with PFM endurance. PFM strength (odds ratio [OR] = 1.16, p <0.0001), PFM endurance (OR 1.6, p <0.0001), and preoperative prostate-specific antigen (OR = 0.87, p = 0.03) were the most significant predictors of continence in the univariate regression analysis. In the multivariate analysis, only PFM strength remained a significant predictor (OR = 1.13, p <0.001) of UI. The thresholds for PFM endurance and strength were 9.6 seconds and 98.9 cmH₂O, respectively.</p><p><strong>Conclusions: </strong>Preoperative PFM strength and endurance demonstrated significant associations with postoperative UI. Objectively measured preoperative PFM conditions could help identify patients at increased risk of UI after RP.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"339-346"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency and safety of microscopic cluster ligation of the internal spermatic veins: A prospective matched case-control study.","authors":"Wang Jingkai, Xu Peng, Wang Hailuo, Zhang Ruoran, Pang Kun","doi":"10.5173/ceju.2024.0163","DOIUrl":"10.5173/ceju.2024.0163","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate the surgical efficacy and safety of microscopic cluster ligation of the spermatic vein (MCLSV), and to compare the similarities and differences between MCLSV and microscopic traditional branch ligation of the spermatic vein (MTBLSV).</p><p><strong>Material and methods: </strong>A prospective matched case-control study of 91 patients with bilateral varicocele was conducted. Participants underwent microscopic bilateral spermatic vein ligation and were randomly assigned by computer to undergo MCLSV on one side and MTBLSV on the other. The operative outcomes of the two techniques were compared.</p><p><strong>Results: </strong>The operative time of MCLSV was significantly lower than that of MTBLSV (p <0.001). Postoperative day 1 VAS scores at the operative site in MCLSV were significantly lower than MTBLSV (p <0.05). There was no significant difference between the two groups in the number of spermatic vein ligations, the number of internal spermatic arteries and lymphatics, complications, occurrence of foreign body sensation of wire knots, improvement of scrotal pain and distant recurrence (p >0.05).</p><p><strong>Conclusions: </strong>Compared with MTBLSV, MCLSV can significantly shorten surgical time, improve surgical efficiency, and alleviate postoperative perineal pain and discomfort in patients while ensuring surgical safety and effectiveness.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"429-433"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuff downsizing in the treatment of non-mechanical persistent or recurrent stress urinary incontinence: narrative review.","authors":"Michał Skrzypczyk, Łukasz Białek, Yulian Mytsyk, Alexandre Dubois, Jakub Dobruch, Benoit Peyronnet","doi":"10.5173/ceju.2025.0028","DOIUrl":"10.5173/ceju.2025.0028","url":null,"abstract":"<p><strong>Introduction: </strong>Stress urinary incontinence (SUI) is a common complication following radical prostatectomy, affecting up to 60.0% of men. The artificial urinary sphincter (AUS) has been the gold standard for treating severe SUI since its introduction in 1973. Despite its efficacy, long-term complications such as device failure and recurrent incontinence are relatively common, often necessitating revision surgeries. This review focuses on cuff downsizing as a revision strategy for non-mechanical AUS failure.</p><p><strong>Material and methods: </strong>A literature review was conducted using PubMed/Medline, covering studies published between January 2000 and December 2023. Key words included: \"artificial urinary sphincter\", \"cuff downsizing\", \"urethral atrophy\", \"non-mechanical failure\" and \"male urinary incontinence revision\". Inclusion criteria were studies addressing cuff downsizing as a primary revision for non-mechanical failures. Only English-language studies were reviewed. We analyzed the timing of revisions, follow-up duration, and outcomes such as continence rates, complication rates, and device survival.</p><p><strong>Results: </strong>Six retrospective studies involving 206 patients were included in the present review. Cuff downsizing was performed as the sole intervention in 3 studies and in combination with other approaches in the remaining 3 studies. The median cuff size decreased from 4.5 cm preoperatively to 4.0 cm postoperatively, with 8.0-12.0% of patients receiving a cuff downsized by more than 1.0 cm. Across all studies, continence rates after revision surgery ranged from 52.0% to 90.0% based on patient-reported outcome measures (PROMs). Device survival rates varied from 64.0% to 95.0%, with infection and urethral erosion being the leading causes of device explantation.</p><p><strong>Conclusions: </strong>Cuff downsizing is a reasonable revision strategy for non-mechanical AUS failure, offering similar continence outcomes and complication rates compared to alternative techniques.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"413-418"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reclassification of prostate cancer on first confirmatory prostate biopsy in men under active surveillance: A systematic review and meta-analysis.","authors":"Benjamin M Mac Curtain, Killian Daly, Gavin Calpin, Eoin Collins, Avinash Deshwal, Olwyn Lynch, Wanyang Qian, Aaron O'Mahony, Hugo C Temperley, Reuben D Mac Curtain, Diarmaid Moran, John A O Kelly, Catherine Dowling","doi":"10.5173/ceju.2025.0011","DOIUrl":"10.5173/ceju.2025.0011","url":null,"abstract":"<p><strong>Introduction: </strong>Prostate cancer is typically diagnosed following prostate biopsy. In low-risk and selected favourable intermediate-risk disease, active surveillance is the treatment strategy of choice. In these men, a confirmatory biopsy performed. We report on the rates of risk upgrading at biopsy confirmatory that may represent a need to pursue further treatment in lieu of active surveillance.</p><p><strong>Material and methods: </strong>We performed a systematic review and meta-analysis of pooled reclassification rates of men on active surveillance at first confirmatory biopsy, in line with PRISMA recommendations. PubMed, EMBASE, and Cochrane central registry for clinical trials were searched until June 2024. Stata was used to pool reclassification rates at first confirmatory biopsy.</p><p><strong>Results: </strong>Seventeen studies from 9 countries comprising 6,039 patients were included. Transrectal biopsy was the most common biopsy method for confirmatory biopsy. Weighted pooled rates of upgrading on first confirmatory biopsy were 20% with a 95% confidence interval of 19-21%.</p><p><strong>Conclusions: </strong>Approximately 20% of men undergoing active surveillance were upgraded at confirmatory biopsy. This may alter the management of these patients, and it highlights the importance of a confirmatory biopsy.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 2","pages":"125-136"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-J versus double-J stents after ureterorenoscopy for renal stones: A randomized comparison of safety and tolerability.","authors":"Catarina Laranjo Tinoco, Luis Martins, Francisca Costa, Andreia Cardoso, Ana Sofia Araújo, Mariana Capinha, Luis Pinto, Aparício Coutinho, Carlos Oliveira, Vera Marques, Joao Pimentel Torres, Paulo Mota","doi":"10.5173/ceju.2024.0212","DOIUrl":"10.5173/ceju.2024.0212","url":null,"abstract":"<p><strong>Introduction: </strong>Ureteral stents are generally used after ureterorenoscopy (URS) procedures, even in uncomplicated ones. We aimed to compare the safety and tolerability of single-J (SJ) stents and double-J (DJ) stents in patients submitted to flexible URS for renal stones.</p><p><strong>Material and methods: </strong>This prospective, randomized, unblinded, single-center study was conducted between July 2022 and May 2024, involving patients undergoing flexible URS with holmium laser lithotripsy for renal stones. Patients were randomized to either SJ stents (removed within 24 hours) or DJ stents (removed 2-4 weeks post-surgery). Primary endpoints included emergency department admissions, postoperative complications, and reintervention rates. Secondary endpoints included stent tolerability and surgery efficacy. A symptom questionnaire was applied at postoperative weeks 1 (W1) and 4 (W4).</p><p><strong>Results: </strong>We included 125 patients (60 in group SJ and 65 in group DJ), with comparable baseline characteristics. Emergency department admissions were similar (18.3% vs 16.9%, p = 0.84), as were complications (18.3% vs 21.5%, p = 0.65) and reintervention rates (1.7% vs 3.1%, p = 1.0). SJ stents showed better tolerability, with lower scores for lower urinary tract symptoms (LUTS) and pain at both time points.</p><p><strong>Conclusions: </strong>SJ stents placed for less than 24 hours after complete flexible URS are comparable to DJ stents regarding safety and are better tolerated, particularly 4 weeks after the surgery. SJ stents should be prioritized, reducing costs and hospital visits for stent removal.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 2","pages":"192-198"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary incontinence as the first clinical symptom of urinary bladder leiomyosarcoma.","authors":"Łukasz Mazurczyk, Michał Czarnogórski, Aleksandra Czernicka, Paweł Lipowski, Adam Ostrowski, Kajetan Juszczak, Jan Adamowicz, Tomasz Drewa","doi":"10.5173/ceju.2024.0280","DOIUrl":"10.5173/ceju.2024.0280","url":null,"abstract":"<p><p>Urinary bladder leiomyosarcoma is an extremely rare malignancy of the urogenital system. We present the case of a 59-year-old Caucasian male with a gigantic bladder leiomyosarcoma. The patient was subdued to the surgical excision of the urinary bladder - laparoscopic radical cystectomy with extended pelvic lymphadenectomy, with urinary diversion by bilateral ureterocutaneostomy. The excision was complete both macroscopically and microscopically. No additional adjuvant therapy was administered. In the 6-month follow-up, the patient remained in radiological remission. Surgical excision with extended pelvic lymphadenectomy seems to be sufficient in the treatment of urinary bladder leiomyosarcoma.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 2","pages":"103-108"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography as a main diagnostic tool in prostate cancer staging.","authors":"Oleksii Pisotskyi, Piotr Petrasz, Piotr Zorga, Marcin Gałęski, Paweł Szponar, Krzysztof Koper, Katarzyna Brzeźniakiewicz-Janus, Tomasz Drewa, Krzysztof Kaczmarek, Michał Cezary Czarnogórski, Jan Adamowicz","doi":"10.5173/ceju.2025.0014","DOIUrl":"https://doi.org/10.5173/ceju.2025.0014","url":null,"abstract":"<p><strong>Introduction: </strong>Prostate cancer (PC) remains a significant global health burden, necessitating accurate staging for optimal treatment planning. Conventional imaging methods, including multiparametric magnetic resonance imaging (mpMRI), computed tomography (CT), and bone scintigraphy (BS), exhibit limitations in sensitivity and specificity. Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (⁶⁸Ga PSMA-PET/CT) has emerged as a promising alternative, with potential advantages in staging accuracy.</p><p><strong>Material and methods: </strong>A comprehensive review of current literature was conducted to assess the role of ⁶⁸Ga PSMA-PET/CT in primary PC staging. The diagnostic performance of PSMA-PET/CT was compared with conventional imaging techniques in detecting locoregional and distant metastases. Studies evaluating sensitivity, specificity, and clinical utility in treatment decision-making were analyzed.</p><p><strong>Results: </strong>⁶⁸Ga PSMA-PET/CT demonstrated superior sensitivity and specificity in detecting lymph node and distant metastases compared to conventional imaging. It enables earlier and more precise disease staging, potentially reducing the need for multiple imaging modalities. Emerging evidence suggests its role in guiding therapeutic strategies, particularly in high-risk and recurrent PC cases. Despite its advantages, limitations such as accessibility, cost, and occasional false-negative findings must be considered.</p><p><strong>Conclusions: </strong>⁶⁸Ga PSMA-PET/CT represents a transformative diagnostic tool for PC staging, offering enhanced accuracy compared to traditional imaging. Its integration into clinical practice could streamline diagnostic pathways, improve treatment selection, and potentially optimize patient outcomes. Further research and cost-effectiveness analyses are needed to establish its widespread implementation.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 1","pages":"52-60"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of gabapentin in the management of neurogenic overactive bladders: A systematic review.","authors":"Roshan Chanchlani, Ketan Mehra, Pramod K Sharma, Sudarsan Agarwal, Amit Gupta, Reyaz Ahmad, Rakesh Mishra, Amit Agarwal, Suresh Kumar Thanneeru","doi":"10.5173/ceju.2024.0125","DOIUrl":"https://doi.org/10.5173/ceju.2024.0125","url":null,"abstract":"<p><strong>Introduction: </strong>Neurogenic lower urinary tract dysfunction is typically managed through a step-up approach, beginning with anticholinergic medications, progressing to Botulinum toxin injections, and surgical interventions. Gabapentin offers a less invasive option, either as an adjunct to anticholinergics or as a standalone therapy. This systematic review examines gabapentin's efficacy and safety in treating neurogenic overactive bladders (NOAB) in both paediatric and adult populations.To determine gabapentin's effect on reducing bladder pressure, increasing bladder capacity, and alleviating incontinence symptoms in NOAB patients.</p><p><strong>Material and methods: </strong>A systematic search was conducted on PubMed, Scopus, ScienceDirect, and Cochrane to identify studies on gabapentin for NOAB. Articles were sorted according to PRISMA guidelines, and the risk of bias was assessed using the JBI clinical appraisal tool. Data from the selected articles were synthesized qualitatively.</p><p><strong>Results: </strong>Of the 116 identified articles, 6 were selected. Two focused on paediatric patients with neural tube defects, while four studies involved adults with conditions like spinal trauma, Parkinson's disease, and multiple sclerosis. Urodynamic parameters improved in four studies, whether gabapentin was used alone or as an adjunct. All 6 studies reported significant improvements and minimal side effects.</p><p><strong>Conclusions: </strong>While limitations in dosages and study durations hinder a definitive endorsement of gabapentin, the overall positive response across studies suggests its potential efficacy in managing NOAB. Further high-quality randomized controlled trials comparing gabapentin with other treatments and exploring factors related to non-responsiveness are warranted for conclusive insights.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 1","pages":"61-69"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Kaczmarek K, Jankowska M, Kalembkiewicz J, et al. Assessment of the incidence and risk factors of postoperative urosepsis in patients undergoing ureteroscopic lithotripsy. Cent European J Urol. 2024; 77: 122-128.","authors":"Akif Erbin, Bilal Kaya, Halil Lutfi Canat","doi":"10.5173/ceju.2024.0257","DOIUrl":"https://doi.org/10.5173/ceju.2024.0257","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 1","pages":"100-101"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal and ureteral temperatures changes during ureteroscopic pulsed thulium: YAG laser lithotripsy: an <i>in vitro</i> analysis.","authors":"Felipe Urrea, José M Villena, Matias Larrañaga, José Antonio Salvadó","doi":"10.5173/ceju.2024.0177","DOIUrl":"https://doi.org/10.5173/ceju.2024.0177","url":null,"abstract":"<p><strong>Introduction: </strong>Promising studies have shown a high stone-free rate achieved with the pulsed solid-state thulium YAG laser. However, studies on its safety concerning temperature effects during activation remain limited. The aim of this study was to characterize temperature variations during laser activation.</p><p><strong>Material and methods: </strong>This <i>in vitro</i> experimental study utilized a high-fidelity uretero-renal simulation model to assess temperature changes during intracorporeal laser lithotripsy. Temperatures reached after laser activation at 15, 20, and 30 seconds were recorded. The flow rates used were 10 ml/min and 20 ml/min. The maximum allowed temperature was set at 43°C, given its association with thermal tissue damage. A linear logistic regression model was used to analyze variations and project temperature behavior over time.</p><p><strong>Results: </strong>In the renal model, temperature increases were correlated with the applied energy. With a 10 ml/min flow rate, no laser configuration exceeded 43°C at 15 seconds; at 20 seconds, only the 30 W (2.5 J/20 Hz) configuration exceeded this temperature. By 30 seconds, all 30 W configurations exceeded 43°C, except for 0.4 J/75 Hz. With a 20 ml/min flow rate, no laser configuration exceeded 43°C. The 20 ml/min flow rate decreased renal temperature by 1.96°C (p = 0.01). In the ureteral model, the temperature increase was not proportional to the applied energy, but in no scenario the temperatures reach the 43°C.</p><p><strong>Conclusions: </strong>The temperature variations observed in this study with the use of the pulsed solid-state thulium YAG laser should be considered to avoid potential renal and ureteral thermal damage.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 1","pages":"70-76"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12073521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}