Angelo Mottaran, Pietro Piazza, Riccardo Scarlatti, Massimiliano Presutti, Marco Salvador, Matteo Droghetti, Lorenzo Bianchi, Riccardo Schiavina, Eugenio Brunocilla
{"title":"Robot-assisted pyeloplasty with direct pyelo-ureteral anastomosis for retrocaval ureter.","authors":"Angelo Mottaran, Pietro Piazza, Riccardo Scarlatti, Massimiliano Presutti, Marco Salvador, Matteo Droghetti, Lorenzo Bianchi, Riccardo Schiavina, Eugenio Brunocilla","doi":"10.5173/ceju.2024.0258","DOIUrl":"10.5173/ceju.2024.0258","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 2","pages":"250-251"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stone fragmentation with subsequent evacuation using a novel single-use flexible cystoscope/nephroscope with integrated direct in-scope suction: An <i>ex vivo</i> experimental study.","authors":"Arman Tsaturyan, Arkadya Musayelyan, Stefano Mancon, Aram Adamyan, Vahan Babayan, Begona Ballesta Martinez, Laurian Dragos, Eugenio Ventimiglia, Angelis Peteinaris, Vasileios Tatanis, Evangelos Liatsikos, Panagiotis Kallidonis, Steffi Kar Kei Yuen, Vineet Gauhar, Olivier Traxer, Bhaskar Somani, Amelia Pietropaolo","doi":"10.5173/ceju.2024.0274","DOIUrl":"10.5173/ceju.2024.0274","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to evaluate the feasibility of stone fragmentation and aspiration of dust and small stone particles via a direct-in-scope suction (DISS) system using a novel single-use flexible cystoscope (PC200, Pusen Medical Technology, Guangdon, China) in a straight position and with extreme bending.</p><p><strong>Material and methods: </strong>An <i>ex vivo</i> experimental study was performed on freshly harvested porcine lower urinary systems (bladder and urethra) with natural urinary stones (calcium oxalate dihydrate 70%, urate 30%). In the first set of trials (3 trials) the stones were placed in the bladder and lithotripsy was performed with a scope in a straight position. For the second set of trials, porcine gallbladder was additionally used, circumferentially sutured to the anterior wall of the porcine bladder, and the stone was positioned in the gallbladder (imaginary diverticulum). In the latter trials, lithotripsy was achieved with the scope at an almost 180° bend.</p><p><strong>Results: </strong>Laser lithotripsy was successfully completed in all trials. Stone fragmentation and aspiration were faster in the first set of trials with the cystoscope in a straight position. In the second set, to access the anterior-wall \"diverticulum\", continuous suction and irrigation were employed. After lithotripsy, the stone fragments were effectively flushed from the simulated diverticulum into the main bladder cavity.</p><p><strong>Conclusions: </strong>Bladder stone lithotripsy using a flexible cystoscope with DISS is feasible. The DISS system offers several advantages, including improved visibility through simultaneous fluid and dust aspiration, as well as enhanced maneuverability of the scope due to suction-assisted positioning.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"367-372"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frank Robisom Costa de Sousa, Francisco Jazon de Araújo Neto, Thomas Silva de Queiroz, Camille Rodrigues Aggensteiner, Vinícius Silva Alves, Pedro Aquiles Souza das Chagas, Francisco Eliel Batista Madeiro, Lorena do Carmo de Souza Martins, João Pompeu Frota Magalhães, Bárbara Vieira Lima Aguiar Melão
{"title":"Safety and efficacy of tranexamic acid in radical cystectomy: a systematic review and meta-analysis.","authors":"Frank Robisom Costa de Sousa, Francisco Jazon de Araújo Neto, Thomas Silva de Queiroz, Camille Rodrigues Aggensteiner, Vinícius Silva Alves, Pedro Aquiles Souza das Chagas, Francisco Eliel Batista Madeiro, Lorena do Carmo de Souza Martins, João Pompeu Frota Magalhães, Bárbara Vieira Lima Aguiar Melão","doi":"10.5173/ceju.2025.0079","DOIUrl":"10.5173/ceju.2025.0079","url":null,"abstract":"<p><strong>Introduction: </strong>Perioperative blood transfusion (BT) is often required in radical cystectomy (RC) due to significant blood loss. Tranexamic acid (TXA), an antifibrinolytic agent, reduces bleeding, but concerns about thromboembolic risks persist. This systematic review and meta-analysis evaluate TXA's efficacy and safety in RC.</p><p><strong>Material and methods: </strong>A systematic search was conducted in PubMed, Embase, and Cochrane Central databases. Randomized controlled trials (RCTs) and retrospective studies comparing TXA versus controls in RC were included. Primary outcomes were perioperative, intraoperative, and postoperative BT rates. Secondary outcomes included estimated blood loss (EBL) and thromboembolic events (PROSPERO; CRD420251013502).</p><p><strong>Results: </strong>Four studies totaling 1,656 patients were included. TXA significantly reduced perioperative transfusion rates (OR = 0.40; 95% CI: 0.30-0.51; p < 0.00001). However, intraoperative (OR = 0.87; 95% CI: 0.50-1.52; p = 0.63) and postoperative transfusion rates (OR = 0.51; 95% CI: 0.21-1.23; p = 0.13) were not significantly different. No significant difference was found in EBL (MD = -9.31; 95% CI: from -82.50 to 63.87; p = 0.80). Safety analysis showed no increased risk of deep vein thrombosis (OR = 1.14; 95% CI: 0.54-2.41; p = 0.72) or pulmonary embolism (OR = 1.49; 95% CI: 0.69-3.24; p = 0.31).</p><p><strong>Conclusions: </strong>TXA reduces perioperative transfusion needs in RC without significantly affecting intraoperative or postoperative transfusion rates, EBL, or thromboembolic risk. Further RCTs are needed to optimize TXA use in RC.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"305-317"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samer Morsy, Mostafa Abdelraouf, Alaa Meshref, Ahmed Abdallah Ashmawy, Mahmoud Abdelhakim, Ahmed Assem, Ayman Kassem
{"title":"Feasibility, safety and efficacy of using low-power thulium: YAG laser enucleation of prostate compared to HoLEP in developing country.","authors":"Samer Morsy, Mostafa Abdelraouf, Alaa Meshref, Ahmed Abdallah Ashmawy, Mahmoud Abdelhakim, Ahmed Assem, Ayman Kassem","doi":"10.5173/ceju.2025.0007","DOIUrl":"10.5173/ceju.2025.0007","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to assess and compare the feasibility and perioperative outcomes using low-power thulium laser enucleation of the prostate (ThuLEP) compared to standard holmium laser enucleation of the prostate (HoLEP) in the management of BPO-related symptoms due to prostates volume exceeding 80 ml.</p><p><strong>Material and methods: </strong>One hundred and fifty patients with large prostates indicated for prostate enucleation were prospectively randomized into two groups: HoLEP group (74 patients), and the low-power ThuLEP group (76 patients). Preoperative assessment included digital rectal examination, serum prostate-specific antigen, transrectal ultrasonography, uroflowmetry, postvoid residual urine (PVR) measurement, and International Prostate Symptom Score (IPSS) and QoL scoring systems.</p><p><strong>Results: </strong>The mean age for the HoLEP group was 68 ±5.0 years and 69 ±4.8 years for the low-power ThuLEP group. The mean prostate volume was 87 ±11.5 cc for HoLEP and 90 ±12.0 cc for ThuLEP, with no statistically significant differences between both groups (p = 0.1079). There was a statistically significant difference between both groups with regard the mean total operative time, which was 72 ±10.5 minutes for HoLEP and 92 ±11.5 minutes for ThuLEP, and the mean enucleation time, which was 50 ±8.5 minutes for HoLEP and 70 ±7.0 minutes for ThuLEP (p <0.001). No significant differences between the groups regarding catheterization time, hospital stay, or haemoglobin drop. Subjective and objective voiding parameters as IPSS and Qol scores, Q<sub>max</sub>, and PVR improved significantly after treatment with both techniques with no statistically significant difference between both groups. The complication rate was low.</p><p><strong>Conclusions: </strong>Although HoLEP offers shorter operative time, low-power ThuLEP is a feasible choice for surgical management of benign prostatic obstruction as it offers similar clinical outcomes.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"331-338"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet Yilmaz, Mustafa Karaaslan, Mehmet Emin Şirin, Halil Çağrı Aybal, Muhammed Emin Polat, Zeynep Akdagcik, Mustafa Yigit Ozdemir, Tuncay Toprak, Arkadiusz Miernik
{"title":"Feasibility and safety of robot-assisted radical prostatectomy following laser enucleation of the prostate.","authors":"Mehmet Yilmaz, Mustafa Karaaslan, Mehmet Emin Şirin, Halil Çağrı Aybal, Muhammed Emin Polat, Zeynep Akdagcik, Mustafa Yigit Ozdemir, Tuncay Toprak, Arkadiusz Miernik","doi":"10.5173/ceju.2025.0123","DOIUrl":"10.5173/ceju.2025.0123","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to systematically review the available evidence on the feasibility and safety of robot-assisted radical prostatectomy (RARP) in patients with prostate cancer following laser enucleation of the prostate (LEP).</p><p><strong>Material and methods: </strong>A systematic search was conducted using PubMed (MEDLINE) and Web of Science online databases until 31 July 2025 with the search terms (\"HoLEP\" OR \"endoscopic enucleation\" OR \"laser enucleation of the prostate\" OR \"ThuLEP\" OR \"ThuFLEP\" OR \"EEP\" OR \"LEP\") AND (\"robot assisted radical prostatectomy\" OR \"robotic assisted radical prostatectomy\" OR \"RARP\") by incorporating the PICO formula (population, intervention, comparison, outcome).</p><p><strong>Results: </strong>Three studies were identified. Continence rates and recovery times differed between patients with prior LEP and those who were LEP-naïve. In one study, postoperative incontinence rates were significantly different between the prior HoLEP and HoLEP-naïve groups (74.0% vs 22.0%, p <0.001), whereas in the other two studies there was no significant difference between groups. Erectile function was documented in 2 studies, which exhibited no statistically significant differences between the prior-LEP group and LEP-naïve group. Complication rates across the studies remained relatively low (7.0-9.0%). Biochemical recurrence and positive surgical margins between the previous LEP and LEP naïve groups were comparable.</p><p><strong>Conclusions: </strong>In patients undergoing RARP after LEP, complications are low and the oncological outcomes are promising, similar to patients who are LEP-naïve. It is essential for surgeons to counsel patients on the potential for prolonged recovery, particularly in regard to continence and sexual function.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 4","pages":"532-539"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehdi Kardoust Parizi, Nirmish Singla, Siamak Daneshmand, Axel Heidenreich, Aditya Bagrodia, Vitaly Margulis, Akihiro Matsukawa, Ichiro Tsuboi, Shahrokh F Shariat
{"title":"Late relapse of testicular germ cell tumor: An individual patient data meta-analysis of disease characteristics, treatments, and oncological outcomes.","authors":"Mehdi Kardoust Parizi, Nirmish Singla, Siamak Daneshmand, Axel Heidenreich, Aditya Bagrodia, Vitaly Margulis, Akihiro Matsukawa, Ichiro Tsuboi, Shahrokh F Shariat","doi":"10.5173/ceju.2025.0069","DOIUrl":"10.5173/ceju.2025.0069","url":null,"abstract":"<p><strong>Introduction: </strong>Late relapse (LR) of testicular germ cell tumor (TGCT) is a relatively rare event with limited data to help refine evidence-based decision-making. This individual patient data meta-analysis aims to analyze disease characteristics, treatment modalities, and factors affecting oncological outcomes of TGCT patients suffering from LR.</p><p><strong>Material and methods: </strong>A systematic search and individual patient data gathering was performed. The primary end points were disease-free survival (DFS) and cancer-specific survival (CSS).</p><p><strong>Results: </strong>A total of 12 studies, comprising 240 patients, were selected for review. In multivariable analysis, surveillance as primary management of TGCT was associated with a higher risk of retroperitoneal LR (OR = 10.08, 95% CI: 2.34-43.31). On univariable analyses, longer time to LR, LR multiplicity, and chemotherapy (as the sole treatment of LR) were significantly associated with worse DFS and CSS, while pure teratoma at LR, teratoma element at LR, surgery (as the sole treatment of LR), and surgery-based combination treatment of LR were significantly associated with better DFS and CSS. Salvage chemotherapy for LR was associated with worse DFS and CSS compared to first-line chemotherapy in multivariable cox regression analysis (HR = 13.03, 95% CI: 1.13-150.25). Two decision-tree models are proposed to help shared decision making regarding chemotherapy-based vs surgery-only and surgery-based versus combination treatments; the accuracies of these models were 0.94 and 0.88.</p><p><strong>Conclusions: </strong>Available data suggest a benefits to surgery alone or surgery-based combination therapy compared to chemotherapy alone for LR of TGCT. We propose decision-tree models to help clinical decision-making in TGCT patients with LR.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"289-304"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jakub Szymanski, Pawel Rajwa, Wojciech Krajewski, Piotr Bryniarski, Przemyslaw Dudek, Piotr Chlosta, Mikolaj Przydacz
{"title":"Treatment patterns for urolithiasis and renal colic-like pain symptoms in Poland: The POLSTONE Study.","authors":"Jakub Szymanski, Pawel Rajwa, Wojciech Krajewski, Piotr Bryniarski, Przemyslaw Dudek, Piotr Chlosta, Mikolaj Przydacz","doi":"10.5173/ceju.2025.0112","DOIUrl":"10.5173/ceju.2025.0112","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to determine population-level treatment patterns for urolithiasis and renal colic-like pain symptoms in Poland.</p><p><strong>Material and methods: </strong>We used data from POLSTONE, a survey representative of the entire Polish population stratified by age, sex, and place of residence. We identified and evaluated non-surgical and surgical treatment patterns for urolithiasis and renal colic-like pain symptoms.</p><p><strong>Results: </strong>In this nationally representative survey of 10,029 Polish adults, the lifetime prevalence of urolithiasis was 12.85% (n = 1,289) and 43.05% (n = 4,317) reported renal colic-like pain symptoms. Ultrasound was the most used diagnostic method for urolithiasis (73.78%; n = 951), followed by computed tomography (22.11%; n = 285). Conservative treatment predominated in the management of urolithiasis, with 58.73% (n = 757) of patients receiving prescription drugs and 29.87% (n = 385) using over-the-counter medications. Among surgical interventions, transurethral procedures were most frequent (13.42%; n = 173), followed by shockwave lithotripsy (11.48%; n = 148), laparoscopic or open surgery (6.75%; n = 87), and percutaneous nephrolithotripsy (6.05%; n = 78). Physicians gave preventive advice to 88.98% (n = 1,147) of respondents who had urolithiasis, most often recommending increased fluid intake (58.65%; n = 756). For renal colic-like pain, medications were the mainstay of treatment, with nearly 90% of patients reporting satisfaction. Some treatment patterns varied by age, sex, and/or residence, highlighting the influence of sociodemographic factors on care.</p><p><strong>Conclusions: </strong>This study offers the first in-depth, population-level evaluation of how urolithiasis and renal colic-like pain symptoms are treated in Poland. The results can guide healthcare policy, support cost-effectiveness studies, and inform targeted strategies for management of urolithiasis and renal colic-like pain symptoms.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"385-393"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan Łaszkiewicz, Łukasz Nowak, Wojciech Tomczak, Joanna Chorbińska, Maciej Kaczorowski, Agnieszka Hałoń, Tomasz Szydełko, Wojciech Krajewski
{"title":"<i>In vivo</i> endoscopic cryobiopsy of urothelial tumors in the upper urinary tract and bladder: A feasibility pilot study in humans.","authors":"Jan Łaszkiewicz, Łukasz Nowak, Wojciech Tomczak, Joanna Chorbińska, Maciej Kaczorowski, Agnieszka Hałoń, Tomasz Szydełko, Wojciech Krajewski","doi":"10.5173/ceju.2025.0132","DOIUrl":"10.5173/ceju.2025.0132","url":null,"abstract":"<p><strong>Introduction: </strong>Biopsy of the upper tract urothelial carcinoma (UTUC) often provides low-quality or non-diagnostic material. Cryobiopsy may improve the quality of UTUC samples. Our aim was to assess the feasibility of <i>in vivo</i> endoscopic cryobiopsy of UTUC and bladder cancer (BC).</p><p><strong>Material and methods: </strong>Cryobiopsies were performed using the ERBECRYO® device and ø 1.1 mm flexible cryoprobes. Adult patients with UTUC/BC undergoing diagnostic/therapeutic endoscopic procedures were included. The cryoprobes were introduced in the proximity of the tumors and activated. The tissue samples were avulsed from the tumor, extracted and placed in a fixative.</p><p><strong>Results: </strong>Six males were included. Out of these, 4 had UTUC, while 2 had BC. The median age was 68 years. Transurethral procedures were performed in 4 patients, percutaneous in 1 and combined in 1. Cryobiopsies were conducted using cystoscopes (n = 2), rigid ureterorenoscopes (n = 2), nephroscopes (n = 1) and without endoscope, through the ureteral access sheath (n = 1). Mean obtained sample size was 6.2 × 4.7 × 3.0 mm. All the specimens allowed for a histopathologic evaluation; no crushing artifacts were reported, lamina propria was present in 4 specimens, and muscularis propria was present in 1. Bleeding from the sample bed was subjectively significantly less intense than after conventional biopsies, and the procedure was found to be less challenging than standard methods.</p><p><strong>Conclusions: </strong>Cryobiopsy represents a promising advancement in the endoscopic diagnosis of UTUC. Our pilot study demonstrates its feasibility in human <i>in vivo</i> settings. Further comparative research is warranted to establish its role in routine practice.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 3","pages":"263-270"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of a predictive risk score for 1-year intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma.","authors":"Rıdvan Kayar, Kemal Kayar, İlker Artuk, Samet Demir, Emre Erdoğan, Emre Tokuc, Metin Öztürk","doi":"10.5173/ceju.2025.0191","DOIUrl":"10.5173/ceju.2025.0191","url":null,"abstract":"<p><strong>Introduction: </strong>The study aims to develop and internally validate a novel risk stratification model specifically designed to predict 1-year intravesical recurrence (IVR) following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), integrating readily available clinicopathologic parameters.</p><p><strong>Material and methods: </strong>We retrospectively analyzed 87 patients who underwent RNU for UTUC between 2012 and 2024. Patients were stratified according to IVR status at 12 months postoperatively. Univariate and LASSO logistic regression analyses were conducted to identify independent predictors. A simplified risk score was derived from regression coefficients. Model performance was assessed using area under the ROC curve (AUC), calibration plots, and bootstrap validation. Clinical utility was evaluated with decision curve analysis (DCA).</p><p><strong>Results: </strong>One-year IVR occurred in 34 patients (39.1%). Seven independent predictors were identified: tumor multifocality, ureteral tumor location, history of non-muscle-invasive bladder cancer, chronic kidney disease, preoperative ureteroscopy, intravesical bladder cuff excision, and positive surgical margins. The final model showed excellent discriminative performance (AUC = 0.854) and good calibration. Patients were stratified into low (0-2 points), intermediate (3-5), and high-risk (6-9) groups, with IVR rates of 11.1%, 53.7%, and 80.0%, respectively (p for trend <0.001). DCA demonstrated a favorable net benefit across a wide range of thresholds.</p><p><strong>Conclusions: </strong>We present a novel, internally validated scoring system that integrates routine clinicopathologic parameters to predict early IVR following RNU for UTUC. This tool may support urologists in implementing risk-adapted cystoscopic surveillance protocols and identifying candidates for early intravesical therapy. External validation is warranted prior to clinical implementation.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 4","pages":"453-461"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piotr Kania, Markijan Kubis, Jakub Biedrzycki, Paweł Marczuk
{"title":"Modified posterior reconstruction and vesicourethral anastomosis in robot-assisted radical prostatectomy and its impact on anastomosis stricture rate and clips migration.","authors":"Piotr Kania, Markijan Kubis, Jakub Biedrzycki, Paweł Marczuk","doi":"10.5173/ceju.2024.0239","DOIUrl":"10.5173/ceju.2024.0239","url":null,"abstract":"","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":"78 2","pages":"252-253"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}