Cell Reports Physical Science最新文献

{"title":"Nucleation dynamics in amyloid-beta dimerization revealed by single-molecule fingerprinting.","authors":"A K M Kafi, Mathias Bogetoft Danielsen, Shixi Song, Deepak Karna, Sajan Shakya, Jiahao Ji, Yitong Hao, Pelayo Alvarez Penanes, Frank Kjeldsen, Hanbin Mao, Chenguang Lou","doi":"10.1016/j.xcrp.2025.102930","DOIUrl":"10.1016/j.xcrp.2025.102930","url":null,"abstract":"<p><p>The aggregation of amyloid-beta <math><mo>(</mo> <mtext>A</mtext> <mi>β</mi> <mo>)</mo></math> peptides ( <math><mtext>A</mtext> <msub><mrow><mi>β</mi></mrow> <mrow><mn>1</mn> <mo>-</mo> <mn>40</mn></mrow> </msub> </math> or <math><mtext>A</mtext> <msub><mrow><mi>β</mi></mrow> <mrow><mn>1</mn> <mo>-</mo> <mn>42</mn></mrow> </msub> </math> ) is closely related to the pathology of Alzheimer's disease (AD). Soluble oligomers that appear during <math><mtext>A</mtext> <mi>β</mi></math> aggregation are primary neurotoxic species; however, their misfolding kinetics have yet to be determined. Here, we report a bottom-up construction of parallel and antiparallel <math><mtext>A</mtext> <msub><mrow><mi>β</mi></mrow> <mrow><mn>1</mn> <mo>-</mo> <mn>40</mn></mrow> </msub> </math> dimers, the first oligomers formed during <math><mtext>A</mtext> <mi>β</mi></math> aggregation. We apply single-molecule mechanical unfolding in optical tweezers to investigate the dynamic structural evolution of these dimers at the single-amino-acid resolution. We observe three intermediates during the association and dissociation of individual <math><mtext>A</mtext> <msub><mrow><mi>β</mi></mrow> <mrow><mn>1</mn> <mo>-</mo> <mn>40</mn></mrow> </msub> </math> dimers, with the diphenylalanine <math> <mfenced><mrow><mtext>A</mtext> <msub><mrow><mi>β</mi></mrow> <mrow><mn>19</mn> <mo>-</mo> <mn>20</mn></mrow> </msub> </mrow> </mfenced> </math> dimer having the highest formation probability. Our single-molecule fingerprinting method reveals that a known <math><mtext>A</mtext> <mi>β</mi></math> aggregation inhibitor, rosmarinic acid, can reduce <math><mtext>A</mtext> <msub><mrow><mi>β</mi></mrow> <mrow><mn>1</mn> <mo>-</mo> <mn>40</mn></mrow> </msub> </math> dimerization by binding to the <math><mtext>A</mtext> <msub><mrow><mi>β</mi></mrow> <mrow><mn>19</mn> <mo>-</mo> <mn>20</mn></mrow> </msub> </math> site. We anticipate that the molecular tool innovated in our study is extensible to investigating other amyloid aggregations responsible for a myriad of neurodegenerative diseases.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 11","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Non-local Schrödinger diffusion model reveals mechanisms of critical brain dynamics.","authors":"Gustavo Deco, Yonatan Sanz Perl, Morten L Kringelbach","doi":"10.1016/j.xcrp.2025.102936","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102936","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.xcrp.2025.102663.].</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 11","pages":"102936"},"PeriodicalIF":7.3,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12630072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upscaling of gaseous alkanes into large-volume commodity chemicals via photocatalytic acylation.","authors":"Akshay M Nair, Sergio Barbeira-Arán, Jose M Malga, Martín Fañanás-Mastral","doi":"10.1016/j.xcrp.2025.102912","DOIUrl":"10.1016/j.xcrp.2025.102912","url":null,"abstract":"<p><p>From a circular economy point of view, the valorization of gaseous alkanes into large-volume commodity chemicals is of the utmost importance. Such protocols would help reduce the current reliance on a petroleum-based economy and contribute to the challenge of reducing greenhouse gas emissions. In this regard, we hereby report a methodology based on dual photoredox/nickel catalysis that enables the direct coupling of gaseous alkanes with a range of acid chlorides. The protocol is operationally simple, proceeds under mild reaction conditions, and features high chemo- and regioselectivity and good functional group tolerance. Of note, this method serves as an efficient tool for the upscaling of feedstock gaseous alkanes into industrially relevant ketones, such as propiophenone, acetophenone, or isobutyrophenone derivatives.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 11","pages":"102912"},"PeriodicalIF":7.3,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12630074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationalizing notable hole scavenger effects in g-C3N4-catalyzed H2O2 photosynthesis","authors":"Fan Wu, Yukun Ma, Lijing Fan, Shaohua Chen, Jieyi Shen, Yanxin Chen, Pengxin Liu","doi":"10.1016/j.xcrp.2025.102957","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102957","url":null,"abstract":"<h2>Summary</h2> Hydrogen peroxide (H₂O₂) is a versatile and environmentally friendly oxidant whose industrial production has potentially more sustainable routes. Photocatalyzed H₂O₂ generation represents a mild and efficient alternative, utilizing solar energy to reduce oxygen. However, how the photooxidation half reactions of hole scavengers affect the overall catalytic performances is largely overlooked. Here, we report that photooxidation half reactions are the real rate-limiting steps and that the choice of hole scavengers vitally affects the overall production rate of H₂O₂. The H₂O₂ formation kinetic constants for 12 hole scavengers are compared with their electrooxidation potentials, calculated orbital energies, and energy gaps. No general correlation is found. Several possibilities are proposed, including the influences of different surface adsorption and surface reaction pathways. Our finding suggests that in practice, it is difficult to choose the right half reaction based on intuition or experiences with other systems. A case-by-case study is needed.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 11","pages":"102957-102957"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.cell.com/cell-reports-physical-science/pdf/S2666-3864(25)00556-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedle with d-band-modulated Pd@Pt nanozyme modulates glucose metabolism via inflammatory microenvironment","authors":"Yanan Wang, Teng Wang, Boran Li, Yitong Lin, Qí Zhāng, Fei Chang, Yutong Han, Wenxuan Li, Hao Zhang, Xiaoyun He, Huilian Che, Kun‐Lun Huang, Nan Cheng","doi":"10.1016/j.xcrp.2025.102959","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102959","url":null,"abstract":"<h2>Summary</h2> Pd@Pt nanozymes are recognized for their extensive specific surface area and enzyme-like catalytic capabilities. However, the role of Pd@Pt nanoparticles in managing metabolic disorders such as diabetes and its related disorders remains poorly understood. This study endeavors to explore the regulatory function of Pd@Pt nanoparticles in metabolic balance, elucidating the associated mechanisms. We demonstrate that Pd@Pt inhibits the production of reactive oxygen species and modulates oxidative stress through its superoxide-dismutase-like enzyme activity in palmitic-acid-induced insulin resistance cell model. Furthermore, Pd@Pt was found to enhance glucose uptake, reduce hyperglycemia, and improve glucose tolerance and insulin sensitivity, attributable to its anti-inflammatory effects. Additionally, the effectiveness of the multifunctional Pd@Pt-based microneedle in expediting the healing of diabetic wounds was confirmed by suppressing key inflammatory signaling pathways. Collectively, our findings highlight the potential of Pd@Pt nanoparticles as powerful anti-inflammatory agents, offering promising therapeutic options for type 2 diabetes and its associated complications.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 11","pages":"102959-102959"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methanol steam reforming with samarium-stabilized copper sites for efficient hydrogen production","authors":"Zehan Sun, Jiancong Fang, Bowen Sun, Yifan Li, Zhihui Wang, Yi Cui, Bingbing Chen, Chuan Shi","doi":"10.1016/j.xcrp.2025.102933","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102933","url":null,"abstract":"<h2>Summary</h2> The rational design of Cu-based catalysts with tailored interfacial structures and electronic states remains challenging yet essential for advancing hydrogen production via methanol steam reforming (MSR). Here, we developed a samarium-mediated strategy to construct a 30Sm-CuAl catalyst. The introduction of Sm promotes Cu dispersion and induces strong metal-support interactions, resulting in the formation of Sm₂O₃-encapsulated Cu nanoparticles enriched with Cu⁺-O-Sm interfaces. The optimized 30Sm-CuAl demonstrates exceptional MSR performance, achieving a hydrogen production rate of 1,126 mmol g_cat⁻¹ h⁻¹ at 250°C. Mechanistic studies revealed that the reaction follows the formate pathway in <i>x</i>Sm-CuAl, with formate accumulation identified as the primary reason for the deactivation of 30Sm-CuAl. Dynamic regeneration of 30Sm-CuAl through redox treatment restores its activity, thereby enabling cyclic operation. These findings provide insights into rare-earth oxide regulation of Cu-based catalysts and lay the foundation for targeted resolution of formate intermediate accumulation to enhance MSR stability.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 11","pages":"102933-102933"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.cell.com/cell-reports-physical-science/pdf/S2666-3864(25)00532-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147902393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrally formed Janus adhesive conductive hydrogel with excellent interfacial stability and fatigue resistance for robust flexible sensing","authors":"Ning Ren, Gaoyi Zheng, Mei Cui, Lei Zhang, Yusen Ai, Cancan Shan, Qi Wei, Renliang Huang, Rongxin Su","doi":"10.1016/j.xcrp.2025.102916","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102916","url":null,"abstract":"<h2>Summary</h2> Engineering Janus conductive hydrogel sensors with asymmetrically adhesive characteristics remains challenging due to complicated fabrication procedures, unstable interfacial connections, and fatigue-induced deterioration. Herein, a one-step integrated strategy is proposed that combines Pickering emulsion-enabled phase separation with charge shielding to construct Janus adhesive conductive hydrogel sensors, featuring a tri-layer architecture with contrasting stiffness: a soft adhesive top layer for skin-adaptive attachment, a stiff anti-adhesive bottom layer providing mechanical and electrical support, and a gradient middle layer bridging the two distinct layers. This tri-layer structure significantly achieves asymmetric adhesion diversity (15.7-fold) while maintaining symmetric wettability on opposite surfaces. It also enhances interfacial mechanics, demonstrating an interfacial strength of 24.31 kPa over 300 cycles, thereby outperforming conventional strategies (8.62 kPa; 60 cycles). Consequently, the assembled hydrogel sensor effectively prevents unintentional adhesion to external objects and supports robust, long-term dynamic motion detection and pressure perception, offering promising potential for flexible sensing applications.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 11","pages":"102916-102916"},"PeriodicalIF":0.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.cell.com/cell-reports-physical-science/pdf/S2666-3864(25)00515-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging machine learning and neuroscience with a silicon nanosheet neuromorphic device","authors":"Chenhao Wang, Xinyi Xu, Anzhe Chen, Feng Tian, Zhenyi Ni, X. Yuan, Bodepudi Srikrishna Chanakya, Yang Xu, Wei Sun, Deren Yang","doi":"10.1016/j.xcrp.2025.102915","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102915","url":null,"abstract":"In brief 2D properties of the silicon nanosheets (SiNSs) enable the neuromorphic behaviors of the devices, which are rigorously analyzed by mathematical deduction and modeling.The prototype chip demonstrated on-chip pattern recognition capabilities.The quasi-ReLU activation function of the SiNS device network maps onto artificial neural networks used in machine learning.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 11","pages":"102915-102915"},"PeriodicalIF":0.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.cell.com/cell-reports-physical-science/pdf/S2666-3864(25)00514-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actin rings as mechanical barriers in endothelial resistance to tumor invasion","authors":"Chaohui Jiang, Guangsong Xie, Qianchun Wang, Baohua Ji","doi":"10.1016/j.xcrp.2025.102898","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102898","url":null,"abstract":"Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 10","pages":"102898-102898"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147897145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large vision model supported tracking of high-density particles based on optical flow learning","authors":"Yongyu Zhang, Junlun Zhu, Yi Du, Hao Xie, Yan He","doi":"10.1016/j.xcrp.2025.102904","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.102904","url":null,"abstract":"<h2>Summary</h2> Single-particle tracking (SPT) has enabled the quantification of dynamic biological processes, revealing heterogeneity masked by ensemble averaging. However, precise tracking of biomolecules in complex flows poses considerable challenges, typically requiring sparse labeling and high signal quality. Here, we present a method for high-density particle tracking using a video flow-informed neural network (VFINN) that estimates dense optical flow without requiring ground-truth data. VFINN fine-tunes a large visual neural network with a flow-informed loss function, achieving sub-pixel average endpoint error. When integrated with dense optical flow, VFINN outperforms existing tracking algorithms in simulated and biological systems with fluorescence blinking and high particle density. By combining optical flow with trajectory analysis, the VFINN reveals a new fluid-driven mechanism of long-range transport during liquid-liquid phase separation (LLPS), including bridging and shielding effects on charged residues. This high-resolution flow field ultimately supports the estimation of mesoscopic-scale molecular diffusion in various complex fluid structures.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 10","pages":"102904-102904"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147911735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}