Immunoregulatory cryogel-based contact lenses for bacterial keratitis prevention and treatment

IF 7.9 2区综合性期刊 Q1 CHEMISTRY, MULTIDISCIPLINARY

Cell Reports Physical Science Pub Date : 2024-09-06 DOI:10.1016/j.xcrp.2024.102179

Yuzhuo Fan, Fanfan Chen, Wanzhong Yuan, Yuchun Sun, Jiarui Li, Yan Li, Mingwei Zhao, Xu Zhang, Kai Wang

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Abstract

Contact lens (CL)-associated bacterial keratitis (BK), a prevalent and underestimated disorder caused by unhygienic CL wear, poses a risk to permanent loss of visual acuity. Clinically, low drug-delivery efficiency, frequent administration, hormone complications, and antibiotic resistance remain the major unsolved challenges. Here, we introduce a chlorogenic acid (CGA)-conjugated CL material based on gelatin methacrylate via cryogelation(cGelMA/CGA-CL) to strengthen the prevention and treatment of BK. The cGelMA/CGA-CL features a highly moist, macroporous, adjustable structure for sustained release of CGA and is favorably biocompatible to cells, providing antimicrobial protection against opportunistic pathogens and inhibiting excessive ocular inflammatory responses through the JAK2-STAT1/STAT2 signaling pathway. Furthermore, the cGelMA/CGA-CL effectively alleviates the symptoms of BK with immunoregulation of macrophage recruitment and anti-inflammatory factor release in a mouse model of BK. The cGelMA/CGA-CL offers a promising candidate for the prevention and treatment of BK, which may significantly reduce the risk of infection for CL wearers.

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用于预防和治疗细菌性角膜炎的基于免疫调节冷凝胶的隐形眼镜

隐形眼镜（CL）相关细菌性角膜炎（BK）是一种因配戴隐形眼镜不卫生而导致的普遍存在且被低估的疾病，有可能导致视力永久丧失。在临床上，给药效率低、给药频繁、激素并发症和抗生素耐药性仍是尚未解决的主要难题。在此，我们通过冷凝胶技术推出了一种基于甲基丙烯酸明胶的绿原酸（CGA）共轭 CL 材料（cGelMA/CGA-CL），以加强对 BK 的预防和治疗。cGelMA/CGA-CL 具有高湿润性、大孔可调结构，可持续释放 CGA，与细胞具有良好的生物相容性，可提供抗菌保护，抵御机会性病原体，并通过 JAK2-STAT1/STAT2 信号通路抑制过度的眼部炎症反应。此外，在小鼠 BK 模型中，cGelMA/CGA-CL 通过免疫调节巨噬细胞的招募和抗炎因子的释放，有效缓解了 BK 的症状。cGelMA/CGA-CL 为预防和治疗 BK 提供了一个很有前景的候选方案，可大大降低 CL 佩戴者的感染风险。

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来源期刊

Cell Reports Physical Science Energy-Energy (all)

CiteScore

11.40

自引率

2.20%

发文量

388

审稿时长

62 days

期刊介绍： Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.