Cell Reports Physical Science最新文献_第3页

Reconfigurable neuromorphic computing by a microdroplet 通过微滴实现可重构神经形态计算

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-09 DOI: 10.1016/j.xcrp.2024.102202

Yu Ma, Yueke Niu, Ruochen Pei, Wei Wang, Bingyan Wei, Yanbo Xie

{"title":"Reconfigurable neuromorphic computing by a microdroplet","authors":"Yu Ma, Yueke Niu, Ruochen Pei, Wei Wang, Bingyan Wei, Yanbo Xie","doi":"10.1016/j.xcrp.2024.102202","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102202","url":null,"abstract":"The emerging fluidic memristor, capable of emulating ion transport and signaling in brains, has shown promising features in neuromorphic computing but is still in its nascent stage of development. We introduce a droplet memristor in which applied voltage drives a non-conductive liquid crystal droplet to penetrate into a microwell, blocking the ionic conduction path and increasing the resistance. Our system exhibits switchable excitatory and inhibitory features, modulated by altering the polarity of the ionic surfactants at the liquid-liquid interface. We find that memory effects are proportional to the voltage amplitude and inversely proportional to the scanning frequency, consistent with predictions by Newton’s dynamic theory. We emulate adaptive learning akin to biological synapses and demonstrate that low-temperature-induced phase changes in droplets reduce the handwriting recognition accuracy in droplet artificial neuron networks, promising in-sensing computing capabilities. The droplet memristor can benefit from the diverse liquid properties to extend the functionalities and applications in future neuromorphic computing.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"3 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inter-protein energy transfer dynamics in the PSII antenna PSII 天线中的蛋白质间能量传递动力学

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-07 DOI: 10.1016/j.xcrp.2024.102198

Eduard Elias, Chen Hu, Roberta Croce

{"title":"Inter-protein energy transfer dynamics in the PSII antenna","authors":"Eduard Elias, Chen Hu, Roberta Croce","doi":"10.1016/j.xcrp.2024.102198","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102198","url":null,"abstract":"Efficient long-distance energy transport is a cornerstone of photosynthetic light harvesting, enabling excitation energy to traverse multiple antenna proteins to reach the reaction center (RC), where it drives photochemistry. While extensive studies on energy transfer dynamics within individual light-harvesting complexes (LHCs) have been conducted, the inter-protein transfers crucial for understanding the overall efficiency of these systems have remained experimentally elusive. This arises mainly because the spectral signatures of the subunits are often remarkably similar, complicating the identification of energy transfer pathways among them. This study bridges this gap by utilizing ultrafast transient absorption spectroscopy, under conditions with and without singlet-singlet annihilation, on the photosystem II (PSII) LHCII-CP24-CP29 subcomplex and on its constituents. Our findings reveal rapid equilibration within monomeric complexes, contrasted by six-times slower equilibration in the LHCII trimer and eight-times slower equilibration in the LHCII-CP24-CP29 subcomplex, highlighting the inter-complex energy transfer as the rate-limiting step in excitation delivery to the RC.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"2 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep-learning-assisted insights into molecular transport in heterogeneous electrolyte films on electrodes 深度学习辅助洞察电极上异质电解质薄膜中的分子传输

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-06 DOI: 10.1016/j.xcrp.2024.102196

Linhao Fan, Ruiwang Zuo, Yumeng Zhou, Aoxin Ran, Xing Li, Qing Du, Kui Jiao

{"title":"Deep-learning-assisted insights into molecular transport in heterogeneous electrolyte films on electrodes","authors":"Linhao Fan, Ruiwang Zuo, Yumeng Zhou, Aoxin Ran, Xing Li, Qing Du, Kui Jiao","doi":"10.1016/j.xcrp.2024.102196","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102196","url":null,"abstract":"Mass transfer in electrolyte films on electrodes is crucial to the performance of electrochemical energy devices, which is difficult or impossible to observe experimentally. Here, we develop a framework utilizing deep learning to analyze vast molecular dynamics (MD) data to reveal the molecular-level transport properties in electrolyte films. This framework contains physical feature analysis and selection based on MD simulations, surrogate model training, structure-transport relationship analysis, and structure discovery. This framework is then applied to explore oxygen transport in fuel cells, which allows the transport properties and their relationships to the structural characteristics of electrolyte films to be revealed, and thus, the critical features limiting oxygen transport are identified. Accordingly, increasing the catalyst surface hydrophilicity and suppressing the electrolyte film density fluctuation are favorable for oxygen transport. Moreover, this framework is transferable to revealing similar molecular-level transport phenomena in electrolyte films that widely exist in other electrochemical energy devices.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"2 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical boundary conditions for motor protein dictate geometric pattern and dynamics of actin gel contraction 运动蛋白的机械边界条件决定了肌动蛋白凝胶收缩的几何形态和动态变化

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-06 DOI: 10.1016/j.xcrp.2024.102195

Donyoung Kang, Hyungsuk Lee

引用次数: 0

Immunoregulatory cryogel-based contact lenses for bacterial keratitis prevention and treatment 用于预防和治疗细菌性角膜炎的基于免疫调节冷凝胶的隐形眼镜

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-06 DOI: 10.1016/j.xcrp.2024.102179

Yuzhuo Fan, Fanfan Chen, Wanzhong Yuan, Yuchun Sun, Jiarui Li, Yan Li, Mingwei Zhao, Xu Zhang, Kai Wang

{"title":"Immunoregulatory cryogel-based contact lenses for bacterial keratitis prevention and treatment","authors":"Yuzhuo Fan, Fanfan Chen, Wanzhong Yuan, Yuchun Sun, Jiarui Li, Yan Li, Mingwei Zhao, Xu Zhang, Kai Wang","doi":"10.1016/j.xcrp.2024.102179","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102179","url":null,"abstract":"Contact lens (CL)-associated bacterial keratitis (BK), a prevalent and underestimated disorder caused by unhygienic CL wear, poses a risk to permanent loss of visual acuity. Clinically, low drug-delivery efficiency, frequent administration, hormone complications, and antibiotic resistance remain the major unsolved challenges. Here, we introduce a chlorogenic acid (CGA)-conjugated CL material based on gelatin methacrylate via cryogelation(cGelMA/CGA-CL) to strengthen the prevention and treatment of BK. The cGelMA/CGA-CL features a highly moist, macroporous, adjustable structure for sustained release of CGA and is favorably biocompatible to cells, providing antimicrobial protection against opportunistic pathogens and inhibiting excessive ocular inflammatory responses through the JAK2-STAT1/STAT2 signaling pathway. Furthermore, the cGelMA/CGA-CL effectively alleviates the symptoms of BK with immunoregulation of macrophage recruitment and anti-inflammatory factor release in a mouse model of BK. The cGelMA/CGA-CL offers a promising candidate for the prevention and treatment of BK, which may significantly reduce the risk of infection for CL wearers.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"21 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-generation generalist energy artificial intelligence for navigating smart energy 新一代通用能源人工智能，为智慧能源导航

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-06 DOI: 10.1016/j.xcrp.2024.102192

Xu Zhu, Siliang Chen, Xinbin Liang, Xinqiao Jin, Zhimin Du

{"title":"Next-generation generalist energy artificial intelligence for navigating smart energy","authors":"Xu Zhu, Siliang Chen, Xinbin Liang, Xinqiao Jin, Zhimin Du","doi":"10.1016/j.xcrp.2024.102192","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102192","url":null,"abstract":"The rapid advancement of highly flexible and reliable artificial intelligence (AI) holds the promise of unlocking transformative capabilities in response to imminent energy and environmental challenges. Toward future energy, we propose this perspective and introduce a groundbreaking paradigm for a versatile energy AI, termed artificial general intelligence for energy (AGIE). AGIE is designed to address a spectrum of energy-related issues with flexibility, drawing upon information such as energy parameters, equipment images, and expert voice feedback. The applications of AGIE are diverse, ranging from energy diagnostics and operational optimization to offering advice on energy policies. By incorporating human-in-the-loop interactions and leveraging domain knowledge, AGIE has the capacity to assimilate the habits of energy users. Through continuous reinforcement learning, it aspires to establish a new paradigm of explainable reasoning, paving the way for the development of credible energy robots with attributes similar to human understanding. We anticipate that AGIE-enabled applications will lead to new approaches in energy usage and the consideration of serious technical and societal challenges ranging from data integration to privacy and security concerns, environmental impacts, and constraints in hardware and software. Addressing these issues is crucial for realizing the full potential of generalist energy intelligence, leading to enhanced energy efficiency and contributing to the resolution of global energy problems.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"45 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon dioxide photoreduction using a photocatalyst with prolonged charge-separated states and excess electron reservoirs 利用具有长时间电荷分离态和过剩电子库的光催化剂进行二氧化碳光还原

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-05 DOI: 10.1016/j.xcrp.2024.102194

Lang Pei, Zhenggang Luo, Jiasong Zhong, Xusheng Wang, Peng Zhou, Shicheng Yan, Zhigang Zou

{"title":"Carbon dioxide photoreduction using a photocatalyst with prolonged charge-separated states and excess electron reservoirs","authors":"Lang Pei, Zhenggang Luo, Jiasong Zhong, Xusheng Wang, Peng Zhou, Shicheng Yan, Zhigang Zou","doi":"10.1016/j.xcrp.2024.102194","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102194","url":null,"abstract":"A persistent challenge in operating S-scheme photocatalysts involves maintaining complete neutralization of low-energy electrons and holes between reducing and oxidizing photocatalysts. To address this, we propose a charge replenishment-assisted S-scheme mechanism that combines a compatible host catalyst with a luminescence phosphor semiconductor capable of long-term storage of photogenerated electrons. Stored electrons can replenish the host photocatalyst, depleting the low-oxidizing holes, thus prolonging the charge-separated state. The concept is demonstrated in a core-shell-structured SrGa2O4:Cu2+/g-C3N4 (SGO/CN) photocatalyst, where stored electrons with a lifetime of up to several hours can continuously consume holes in the CN. The well-defined core-shell structure, abundant interfacial Sr-N bonds, and staggered band alignment between SGO and CN are crucial for this S-scheme interfacial charge transfer, which contributes to the enhanced CO2-to-CO transformation activity and selectivity. This S-scheme heterojunction, incorporating a charge-storing material as an excess electron reservoir, offers a promising template for designing efficient photocatalytic systems.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"18 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetically powered cancer cell microrobots for surgery-free generation of targeted tumor mouse models 磁动力癌细胞微型机器人，用于免手术生成靶向肿瘤小鼠模型

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-04 DOI: 10.1016/j.xcrp.2024.102182

Zehao Wu, Heng Sun, Zichen Xu, Kai Feng, Josh Haipeng Lei, Chu-Xia Deng, Qingsong Xu

引用次数: 0

Tuning pH-dependent cytotoxicity in cancer cells by peripheral fluorine substitution on pseudopeptidic cages 通过伪肽笼上的外围氟替代物调节癌细胞的 pH 依赖性细胞毒性

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-03 DOI: 10.1016/j.xcrp.2024.102152

Lucía Tapia, Yolanda Pérez, Israel Carreira-Barral, Jordi Bujons, Michael Bolte, Carmen Bedia, Jordi Solà, Roberto Quesada, Ignacio Alfonso

{"title":"Tuning pH-dependent cytotoxicity in cancer cells by peripheral fluorine substitution on pseudopeptidic cages","authors":"Lucía Tapia, Yolanda Pérez, Israel Carreira-Barral, Jordi Bujons, Michael Bolte, Carmen Bedia, Jordi Solà, Roberto Quesada, Ignacio Alfonso","doi":"10.1016/j.xcrp.2024.102152","DOIUrl":"https://doi.org/10.1016/j.xcrp.2024.102152","url":null,"abstract":"The acidic microenvironment of solid tumors is a potential source of selectivity in the anti-cancer activity of ionophores, which requires delicate control of their biophysical properties. In this context, we have systematically studied fluorine substitutions in the aromatic side chains of HCl-binding pseudopeptidic cages. Interconnected factors like chloride binding, protonation, lipophilicity, and conformation and diffusiveness of the cages can impact their ability to transport HCl through the aqueous-lipid interphase, as demonstrated by robust experimental (X-ray, nuclear magnetic resonance [NMR], fluorescence) and theoretical results. The fine-tuning of these properties allows the modulation of their pH-dependent cytotoxicity against cancer cells, from essentially non-cytotoxic at pH 7.5 (like the extracellular surroundings of healthy tissues) to highly toxic in slightly acidic microenvironments (like those around solid tumors). Thus, a distal fluorine substitution produces a big impact on the physicochemical and biological properties of the cages, improving their selectivity as potential therapeutic ionophores.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"61 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142226021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pure radiant cooling device for “air conditioning” without conditioning air 无需调节空气即可实现 "空调 "的纯辐射冷却装置

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2024-09-03 DOI: 10.1016/j.xcrp.2024.102191

Xinyao Zheng, Yuekuan Zhou, Jinbo Li, Siyi Li

引用次数: 0