Cell Reports Physical Science最新文献_第3页

Bio-inspired biped microwalker with magneto-acoustic actuation for cell manipulation. 仿生两足微行走器，磁声驱动，用于细胞操作。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-01-21 DOI: 10.1016/j.xcrp.2025.103033

Subrahmanyam Cherukumilli, David P Rivas, Fatma Ceren Kirmizitas, Max Sokolich, Sambeeta Das

引用次数: 0

Embedded bioprinting with multiscale on-demand sub-voxel assembly for integrated coordination 嵌入式生物打印与多尺度按需子体素组装集成协调

2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-01-01 DOI: 10.1016/j.xcrp.2025.103067

Shuyuan Yu, Huilong Du, Ziqi Gao, Qi Li, Yanru Wang, Huayong Yang, Hongzhao Zhou

{"title":"Embedded bioprinting with multiscale on-demand sub-voxel assembly for integrated coordination","authors":"Shuyuan Yu, Huilong Du, Ziqi Gao, Qi Li, Yanru Wang, Huayong Yang, Hongzhao Zhou","doi":"10.1016/j.xcrp.2025.103067","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.103067","url":null,"abstract":"<h2>Summary</h2> Extrusion-based bioprinting struggles to replicate the cross-scale heterogeneity of native tissues, where micron-scale features must integrate seamlessly within centimeter-scale architectures. We present multiscale on-demand sub-voxel assembly for integrated coordination (MOSAIC), an embedded bioprinting framework that enables dynamic programming of internal filament patterns, referred to as sub-voxels, synchronized with global geometry during continuous printing. MOSAIC combines a physics-informed model of multi-material filament formation and hierarchical path planning to achieve controlled heterogeneity from approximately 0.03 cm micro-patterns to 2 cm structures in a single uninterrupted process. We demonstrate this capability through anatomically inspired constructs: a dual-layer artery model integrating soft-to-stiff gradients for physiological compliance and an intestinal model combining micro-scale villi and millimeter-scale folds with spatially organized cells. This approach expands the design space of embedded bioprinting, overcoming static material constraints and enabling efficient fabrication of multiscale architectures that are critical for advanced tissue models.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"7 1","pages":"103067-103067"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147888863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-recycling of waste lithium-ion batteries and polyvinyl chloride plastics 废旧锂离子电池和聚氯乙烯塑料的共同回收

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-12-31 DOI: 10.1016/j.xcrp.2025.103048

Teng Wang, Erkang Feng, Zhenyu Ren, Mingyue Xu, Ziyu Huang, Hao Bi, Chengcheng Liu, Chun Huang, Y. S. Chan, Bing Deng

引用次数: 0

Flowthrough thermal regulation enables ultrafast real-time PCR 流式热调节实现超快速实时PCR

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-12-31 DOI: 10.1016/j.xcrp.2025.103052

Weidong Chen, Zelin Yang, Yuheng Luo, Jianxun Huang, Lijie Wu, Wenxiong Liu, Yifei Wang, Jiajia Wu, Yining Li, Fang Sun, Pengming Song, Baoce Sun, Qiang Xu

引用次数: 0

Multiple GSH-depleting dimeric cyanine for photothermal-ferroptosis induction with NIR-II fluorescence visualization and renal clearance 多种gsh消耗二聚氰胺用于NIR-II荧光可视化和肾脏清除率的光热-铁下垂诱导

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-12-29 DOI: 10.1016/j.xcrp.2025.103027

Yuantao Pan, Shan Lei, Qiang Liu, Kaiwei Chen, Yu Zhang, Meng Li, Yurong Liu, Mengwei Bai, Huishan Guo, Peng Huang, Jing Lin

引用次数: 0

Understanding varenicline function via key receptor and ligand interactions. 通过关键受体和配体相互作用了解伐尼克兰的功能。

IF 7.3 2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-12-17 DOI: 10.1016/j.xcrp.2025.102992

Sheenagh G Aiken, Daniele Fiorito, Matthew Harper, Grzegorz Pikus, Juno Underhill, Jacob Murray, Joshua Rawlinson, AnnMarie C O'Donoghue, Cecilia Gotti, Sarah C R Lummis, Teresa Minguez Viñas, Franco Viscarra, Isabel Bermudez, Timothy Gallagher, A Sofia F Oliveira

{"title":"Understanding varenicline function via key receptor and ligand interactions.","authors":"Sheenagh G Aiken, Daniele Fiorito, Matthew Harper, Grzegorz Pikus, Juno Underhill, Jacob Murray, Joshua Rawlinson, AnnMarie C O'Donoghue, Cecilia Gotti, Sarah C R Lummis, Teresa Minguez Viñas, Franco Viscarra, Isabel Bermudez, Timothy Gallagher, A Sofia F Oliveira","doi":"10.1016/j.xcrp.2025.102992","DOIUrl":"10.1016/j.xcrp.2025.102992","url":null,"abstract":"<p><p>Approved by the US Food and Drug Administration in 2006, varenicline was the first nicotinic-based therapy for smoking cessation, targeting the α4β2 nicotinic acetylcholine receptor (nAChR). While inspired by cytisine, varenicline has distinct effects at both target and off-target receptors; however, despite being widely used clinically, the precise molecular interactions underpinning varenicline's mode of action remain unclear. Using a multidisciplinary approach, the interactions that set varenicline apart from related compounds such as nicotine and cytisine have been identified. In particular, the binding-site residues α4T139, α4T183, and especially β2S133 were shown to be key modulators for varenicline's function. Substituting β2S133 with valine significantly reduced efficacy, pinpointing it as a crucial determinant. Additionally, a set of novel varenicline variants showed that the positioning of the quinoxaline moiety in varenicline is essential for receptor activation. These insights reveal a unique interaction network at α4β2 that underlies varenicline's function, offering a deeper understanding of the ligand's working mechanism.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 12","pages":"102992"},"PeriodicalIF":7.3,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12711630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversal of the Leloir pathway to promote galactose and tagatose synthesis from glucose. 逆转Leloir通路促进葡萄糖合成半乳糖和塔格糖。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-12-17 DOI: 10.1016/j.xcrp.2025.102993

Aaron M Love, Christopher G Toomey, Abhishek Kumar, Sukesh Narayan Kashyap, Dhinesh Kumar Santhamoorthy, Likith Muthuraj, Hannah L Lynch, Parayil Kumaran Ajikumar, Kumar R Pravin, Nikhil U Nair, Christine N S Santos

{"title":"Reversal of the Leloir pathway to promote galactose and tagatose synthesis from glucose.","authors":"Aaron M Love, Christopher G Toomey, Abhishek Kumar, Sukesh Narayan Kashyap, Dhinesh Kumar Santhamoorthy, Likith Muthuraj, Hannah L Lynch, Parayil Kumaran Ajikumar, Kumar R Pravin, Nikhil U Nair, Christine N S Santos","doi":"10.1016/j.xcrp.2025.102993","DOIUrl":"10.1016/j.xcrp.2025.102993","url":null,"abstract":"<p><p>D-Tagatose is a low-calorie rare sugar with health benefits as a low-glycemic sweetener. Current production methods are limited, often relying on galactose isomerization, and remain inefficient and costly. Here, we report a whole-cell process in <i>Escherichia coli</i> that converts glucose directly to tagatose by reversing the Leloir pathway. Central to this approach is a galactose-1-phosphate-specific phosphatase that drives equilibrium toward galactose. Computational analyses reveal hydrogen-bond networks that underlie stringent substrate selectivity. By co-expressing this phosphatase with an L-arabinose isomerase in a metabolically engineered strain, we demonstrate direct glucose-to-tagatose conversion. Cultures produced ~10.5 g/L galactose from 30 g/L glucose (35% yield) and >1 g/L tagatose. While this is a proof-of-principle demonstration and further optimization is required to improve tagatose production, this strategy eliminates dependence on lactose-derived galactose and provides a framework for scalable, glucose-based biosynthesis of tagatose and other galactose-derived molecules, supporting sustainable rare-sugar production.</p>","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 12","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-hybridized lignin-derived carbon nanotube as a supercapacitor electrode material 铜杂化木质素衍生碳纳米管作为超级电容器电极材料

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-12-01 DOI: 10.1016/j.xcrp.2025.103025

Wenjie Zong, Wangjie Xu, Qi Chen, Qiqi Zhou, Zhengyu Zhou, Yulin Zhan, Qingguo Feng, Chunfeng Hu, Jin Huang, Ruihuan Gu, Man Jiang

引用次数: 0

Ion-pair-engineered nanoassemblies for synergistic integration of type I and II immunogenic cell death and chemo-photo-immunotherapy 离子对工程纳米组件用于I型和II型免疫原性细胞死亡和化学光免疫治疗的协同整合

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-12-01 DOI: 10.1016/j.xcrp.2025.102983

Jingxuan Zhang, Yaqiao Li, Hongkai Fang, Yuebin Dai, Dan Li, Lingxiao Li, Shiyi Zuo, Tian Liu, Yixin Sun, Xin Li, Zhonggui He, Jin Sun, Bingjun Sun

引用次数: 0

0.34 emissivity surface using a hot mirror and directional heat conduction for photothermal energy storage 0.34发射率表面采用热镜和定向热传导光热储能

2区综合性期刊

Cell Reports Physical Science Pub Date : 2025-12-01 DOI: 10.1016/j.xcrp.2025.103017

Nan Zhang, Xiaohan Li, Zhaoli Zhang, Zhixing Luo, Yang Liu, Xiaoling Cao, Yanping Yuan

{"title":"0.34 emissivity surface using a hot mirror and directional heat conduction for photothermal energy storage","authors":"Nan Zhang, Xiaohan Li, Zhaoli Zhang, Zhixing Luo, Yang Liu, Xiaoling Cao, Yanping Yuan","doi":"10.1016/j.xcrp.2025.103017","DOIUrl":"https://doi.org/10.1016/j.xcrp.2025.103017","url":null,"abstract":"<h2>Summary</h2> Photothermal conversion phase-change materials (PCPCMs) effectively harvest and store solar thermal energy but suffer from high radiative losses due to their intrinsic infrared emissivity. Here, we report a bidirectional thermal regulation approach integrating spectrally selective low-infrared-emissivity surfaces with directional thermal transport channels to address this issue. This design achieves a mid-infrared emissivity of 0.34 on the surface and a 65% enhancement in internal heat transfer while maintaining enthalpy with negligible reduction. A photothermal physical model with a cutoff wavelength accurately quantifies the convective and radiative losses induced by the hot mirror. The results reveal that the heat dissipation pathway shifts from radiation dominated to convection dominated, leading to a 76% reduction in radiative loss and a 27% improvement in photothermal conversion efficiency. This work decouples optical absorption from thermal emission, providing an efficient and generalizable route for high-performance solar thermal energy harvesting and storage systems.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"6 12","pages":"103017-103017"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0