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Bacteria in metastatic sites: Unveiling hidden players in cancer progression 转移部位的细菌：揭开癌症发展过程中隐藏的角色
IF 50.3 1区 医学
Cancer Cell Pub Date : 2024-06-13 DOI: 10.1016/j.ccell.2024.05.022
Philippe Stevens, Elena Benidovskaya, Veronica Llorens-Rico, Jeroen Raes, Marc Van Den Eynde
{"title":"Bacteria in metastatic sites: Unveiling hidden players in cancer progression","authors":"Philippe Stevens, Elena Benidovskaya, Veronica Llorens-Rico, Jeroen Raes, Marc Van Den Eynde","doi":"10.1016/j.ccell.2024.05.022","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.05.022","url":null,"abstract":"<p>Bacteria exhibit key features of cancer metastasis, such as motility, invasion, and modulation of the tumor microenvironment. They migrate through lymphatic and blood systems, invade metastatic tissues, and alter local microenvironments to support metastatic growth. Bacteria also shape the tumor microenvironment, affecting immune responses and inflammation, which influence tumor progression and therapy response. While they hold therapeutic potential, challenges like contamination and complex characterization persist, necessitating advanced sequencing and research for clinical application.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":50.3,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence 人工智能
IF 50.3 1区 医学
Cancer Cell Pub Date : 2024-06-10 DOI: 10.1016/j.ccell.2024.05.021
Moritz Gerstung, David Liu, Marzyeh Ghassemi, James Zou, Diego Chowell, Jonas Teuwen, Faisal Mahmood, Jakob Nikolas Kather
{"title":"Artificial intelligence","authors":"Moritz Gerstung, David Liu, Marzyeh Ghassemi, James Zou, Diego Chowell, Jonas Teuwen, Faisal Mahmood, Jakob Nikolas Kather","doi":"10.1016/j.ccell.2024.05.021","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.05.021","url":null,"abstract":"<p>Experts discuss the challenges and opportunities of using artificial intelligence (AI) to study the evolution of cancer cells and their microenvironment, improve diagnosis, predict treatment response, and ensure responsible implementation in the clinic.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":50.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking up the CD8+ T cell: Treg pas de deux 分解 CD8+ T 细胞：Treg双人舞
IF 50.3 1区 医学
Cancer Cell Pub Date : 2024-06-10 DOI: 10.1016/j.ccell.2024.05.016
Chenyu Zhang, Alissa Bockman, Michel DuPage
{"title":"Breaking up the CD8+ T cell: Treg pas de deux","authors":"Chenyu Zhang, Alissa Bockman, Michel DuPage","doi":"10.1016/j.ccell.2024.05.016","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.05.016","url":null,"abstract":"<p>Checkpoint blockade immunotherapies, such as anti-programmed death-1 (PD-1), unleash anti-tumor CD8<sup>+</sup> T cell responses but may also induce immunosuppressive regulatory T cells (Tregs). In this issue of <em>Cancer Cell</em>, Geels et al. uncover that anti-PD-1 leads to Treg expansion via interleukin-2 (IL-2)-producing CD8<sup>+</sup> T cells. Combining anti-PD-1 with anti-ICOSL interrupts this crosstalk, thereby enhancing tumor control.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":50.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression. 前列腺上皮内瘤依赖 p27Kip1 检查点诱导衰老并抑制细胞增殖和癌症进展
IF 48.8 1区 医学
Cancer Cell Pub Date : 2024-06-10 Epub Date: 2024-05-30 DOI: 10.1016/j.ccell.2024.05.008
Pradip K Majumder, Chiara Grisanzio, Fionnuala O'Connell, Marc Barry, Joseph M Brito, Qing Xu, Isil Guney, Raanan Berger, Paula Herman, Rachel Bikoff, Giuseppe Fedele, Won-Ki Baek, Shunyou Wang, Katharine Ellwood-Yen, Hong Wu, Charles L Sawyers, Sabina Signoretti, William C Hahn, Massimo Loda, William R Sellers
{"title":"A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression.","authors":"Pradip K Majumder, Chiara Grisanzio, Fionnuala O'Connell, Marc Barry, Joseph M Brito, Qing Xu, Isil Guney, Raanan Berger, Paula Herman, Rachel Bikoff, Giuseppe Fedele, Won-Ki Baek, Shunyou Wang, Katharine Ellwood-Yen, Hong Wu, Charles L Sawyers, Sabina Signoretti, William C Hahn, Massimo Loda, William R Sellers","doi":"10.1016/j.ccell.2024.05.008","DOIUrl":"10.1016/j.ccell.2024.05.008","url":null,"abstract":"","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":48.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The temporal progression of lung immune remodeling during breast cancer metastasis. 乳腺癌转移过程中肺部免疫重塑的时间进程
IF 48.8 1区 医学
Cancer Cell Pub Date : 2024-06-10 Epub Date: 2024-05-30 DOI: 10.1016/j.ccell.2024.05.004
Christopher S McGinnis, Zhuang Miao, Daphne Superville, Winnie Yao, Andrei Goga, Nathan E Reticker-Flynn, Juliane Winkler, Ansuman T Satpathy
{"title":"The temporal progression of lung immune remodeling during breast cancer metastasis.","authors":"Christopher S McGinnis, Zhuang Miao, Daphne Superville, Winnie Yao, Andrei Goga, Nathan E Reticker-Flynn, Juliane Winkler, Ansuman T Satpathy","doi":"10.1016/j.ccell.2024.05.004","DOIUrl":"10.1016/j.ccell.2024.05.004","url":null,"abstract":"<p><p>Tumor metastasis requires systemic remodeling of distant organ microenvironments that impacts immune cell phenotypes, population structure, and intercellular communication. However, our understanding of immune phenotypic dynamics in the metastatic niche remains incomplete. Here, we longitudinally assayed lung immune transcriptional profiles in the polyomavirus middle T antigen (PyMT) and 4T1 metastatic breast cancer models from primary tumorigenesis, through pre-metastatic niche formation, to the final stages of metastatic outgrowth at single-cell resolution. Computational analyses of these data revealed a TLR-NFκB inflammatory program enacted by both peripherally derived and tissue-resident myeloid cells that correlated with pre-metastatic niche formation and mirrored CD14<sup>+</sup> \"activated\" myeloid cells in the primary tumor. Moreover, we observed that primary tumor and metastatic niche natural killer (NK) cells are differentially regulated in mice and human patient samples, with the metastatic niche featuring elevated cytotoxic NK cell proportions. Finally, we identified cell-type-specific dynamic regulation of IGF1 and CCL6 signaling during metastatic progression that represents anti-metastatic immunotherapy candidate pathways.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":48.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finding the sweet spot: Targeting RAS in tumors while sparing normal tissue 寻找甜蜜点：靶向肿瘤中的 RAS，同时保护正常组织
IF 50.3 1区 医学
Cancer Cell Pub Date : 2024-06-10 DOI: 10.1016/j.ccell.2024.05.020
Naiara Perurena, Karen Cichowski
{"title":"Finding the sweet spot: Targeting RAS in tumors while sparing normal tissue","authors":"Naiara Perurena, Karen Cichowski","doi":"10.1016/j.ccell.2024.05.020","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.05.020","url":null,"abstract":"<p>The development of mutant-selective KRAS inhibitors represents a major therapeutic advance; however, patients can develop resistance through feedback mechanisms and genetic alterations in the RAS pathway. Three publications in <em>Nature</em> and <em>Cancer Discovery</em> describe a promising RAS(ON) multi-selective inhibitor that simultaneously targets oncogenic RAS and multiple potential resistance mechanisms while sparing normal tissue.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":50.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping myeloid cell function: Spatial diversity in tumor and neuronal microenvironment 绘制髓系细胞功能图：肿瘤和神经元微环境的空间多样性
IF 50.3 1区 医学
Cancer Cell Pub Date : 2024-06-10 DOI: 10.1016/j.ccell.2024.05.018
Giulia Villa, Daniel Delev, Dieter Henrik Heiland
{"title":"Mapping myeloid cell function: Spatial diversity in tumor and neuronal microenvironment","authors":"Giulia Villa, Daniel Delev, Dieter Henrik Heiland","doi":"10.1016/j.ccell.2024.05.018","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.05.018","url":null,"abstract":"<p>In this issue of <em>Cancer Cell</em>, Zhong et al. explore the dual role of TREM2 in glioblastoma-associated myeloid cells, demonstrating its function in promoting inflammation at the tumor-neural interface and suppression within the tumor core, influenced by the local microenvironment. These findings open up promising prospects for advancements in neuro-oncological immunotherapy.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":50.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation T 淋巴细胞淋巴瘤细胞表达高水平的 BCL2、S1P1 和 ICAM1，导致肿瘤细胞内侵受阻
IF 50.3 1区 医学
Cancer Cell Pub Date : 2024-06-10 DOI: 10.1016/j.ccell.2024.05.019
Hui Feng, David L. Stachura, Richard M. White, Alejandro Gutierrez, Lu Zhang, Takaomi Sanda, Cicely A. Jette, Joseph R. Testa, Donna S. Neuberg, David M. Langenau, Jeffery L. Kutok, Leonard I. Zon, David Traver, Mark D. Fleming, John P. Kanki, A. Thomas Look
{"title":"T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation","authors":"Hui Feng, David L. Stachura, Richard M. White, Alejandro Gutierrez, Lu Zhang, Takaomi Sanda, Cicely A. Jette, Joseph R. Testa, Donna S. Neuberg, David M. Langenau, Jeffery L. Kutok, Leonard I. Zon, David Traver, Mark D. Fleming, John P. Kanki, A. Thomas Look","doi":"10.1016/j.ccell.2024.05.019","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.05.019","url":null,"abstract":"No Abstract","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":50.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton 牵手成功的免疫疗法：CD8+ T 细胞和 M1 样巨噬细胞互换指挥棒
IF 50.3 1区 医学
Cancer Cell Pub Date : 2024-06-10 DOI: 10.1016/j.ccell.2024.05.012
Abir Hussein, Slava Stamova, Maria Xydia, Philipp Beckhove
{"title":"Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton","authors":"Abir Hussein, Slava Stamova, Maria Xydia, Philipp Beckhove","doi":"10.1016/j.ccell.2024.05.012","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.05.012","url":null,"abstract":"<p>Cancer immunotherapy is a pillar of clinical oncology but only achieves long-term remissions in a minority of cases. In this issue, van Elsas et al. show that effective immunotherapy requires a series of processes orchestrated by CD8<sup>+</sup> T cells that result in the recruitment and local activation of M1-like macrophages.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":50.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy 阻断肿瘤内CD8+ T细胞：Treg串扰可提高PD-1免疫疗法的疗效
IF 50.3 1区 医学
Cancer Cell Pub Date : 2024-06-10 DOI: 10.1016/j.ccell.2024.05.013
Shannon N. Geels, Alexander Moshensky, Rachel S. Sousa, Claire Murat, Matias A. Bustos, Benjamin L. Walker, Rima Singh, Stacey N. Harbour, Giselle Gutierrez, Michael Hwang, Thorsten R. Mempel, Casey T. Weaver, Qing Nie, Dave S.B. Hoon, Anand K. Ganesan, Shivashankar Othy, Francesco Marangoni
{"title":"Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy","authors":"Shannon N. Geels, Alexander Moshensky, Rachel S. Sousa, Claire Murat, Matias A. Bustos, Benjamin L. Walker, Rima Singh, Stacey N. Harbour, Giselle Gutierrez, Michael Hwang, Thorsten R. Mempel, Casey T. Weaver, Qing Nie, Dave S.B. Hoon, Anand K. Ganesan, Shivashankar Othy, Francesco Marangoni","doi":"10.1016/j.ccell.2024.05.013","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.05.013","url":null,"abstract":"<p>PD-1 blockade unleashes potent antitumor activity in CD8<sup>+</sup> T cells but can also promote immunosuppressive T regulatory (Treg) cells, which may worsen the response to immunotherapy. Tumor-Treg inhibition is a promising strategy to improve the efficacy of checkpoint blockade immunotherapy; however, our understanding of the mechanisms supporting tumor-Tregs during PD-1 immunotherapy is incomplete. Here, we show that PD-1 blockade increases tumor-Tregs in mouse models of melanoma and metastatic melanoma patients. Mechanistically, Treg accumulation is not caused by Treg-intrinsic inhibition of PD-1 signaling but depends on an indirect effect of activated CD8<sup>+</sup> T cells. CD8<sup>+</sup> T cells produce IL-2 and colocalize with Tregs in mouse and human melanomas. IL-2 upregulates the anti-apoptotic protein ICOS on tumor-Tregs, promoting their accumulation. Inhibition of ICOS signaling before PD-1 immunotherapy improves control over immunogenic melanoma. Thus, interrupting the intratumor CD8<sup>+</sup> T cell:Treg crosstalk represents a strategy to enhance the therapeutic efficacy of PD-1 immunotherapy.</p>","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":null,"pages":null},"PeriodicalIF":50.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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