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IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-03-10 DOI:10.1016/j.ccell.2025.02.012

Mathieu Desaunay, Poulikos I. Poulikakos

引用次数: 0

摘要

皮肤黑色素瘤经常由BRAF（V600X）突变驱动，常常对丝裂原活化蛋白激酶（MAPK）靶向疗法和免疫检查点抑制剂产生抗药性。在本期《癌细胞》（Cancer Cell）杂志上，Lubrano 等人将 RhoA-FAK-AKT 信号转导确定为一种耐药机制，并证明将 RAF-MEK 胶与 FAK 抑制剂结合可增强肿瘤消退和免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition

Cutaneous melanoma, frequently driven by BRAF (V600X) mutations, often develops resistance to mitogen-activated protein kinase (MAPK)-targeted therapies and immune checkpoint inhibitors. In this issue of Cancer Cell, Lubrano et al. identify RhoA-FAK-AKT signaling as a resistance mechanism and demonstrate that combining RAF-MEK glue with a FAK inhibitor enhances tumor regression and immune response.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.