Cancer Cell最新文献_第8页

Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity 淋巴定位的Treg-mregDC串扰限制了抗原贩运并抑制了抗肿瘤免疫力

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-18 DOI: 10.1016/j.ccell.2024.06.014

引用次数: 0

Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies 在 POU2F-POU2AF 转录因子驱动的恶性肿瘤中瞄准 mSWI/SNF 复合物

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-18 DOI: 10.1016/j.ccell.2024.06.006

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Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer 淋巴周围调节性 T 细胞-树突状细胞相互作用是癌症免疫抑制的新轴心

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-18 DOI: 10.1016/j.ccell.2024.06.016

引用次数: 0

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution 用循环肿瘤细胞外囊泡监测转移性前列腺癌基因组学和转录组学演变

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-08 DOI: 10.1016/j.ccell.2024.06.003

Irene Casanova-Salas, Daniel Aguilar, Sarai Cordoba-Terreros, Laura Agundez, Julian Brandariz, Nicolas Herranz, Alba Mas, Macarena Gonzalez, Rafael Morales-Barrera, Alexandre Sierra, Mario Soriano-Navarro, Pablo Cresta, Gisela Mir, Sara Simonetti, Gonçalo Rodrigues, Sara Arce-Gallego, Luisa Delgado-Serrano, Irene Agustí, Elena Castellano-Sanz, Richard Mast, Joaquin Mateo

{"title":"Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution","authors":"Irene Casanova-Salas, Daniel Aguilar, Sarai Cordoba-Terreros, Laura Agundez, Julian Brandariz, Nicolas Herranz, Alba Mas, Macarena Gonzalez, Rafael Morales-Barrera, Alexandre Sierra, Mario Soriano-Navarro, Pablo Cresta, Gisela Mir, Sara Simonetti, Gonçalo Rodrigues, Sara Arce-Gallego, Luisa Delgado-Serrano, Irene Agustí, Elena Castellano-Sanz, Richard Mast, Joaquin Mateo","doi":"10.1016/j.ccell.2024.06.003","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.06.003","url":null,"abstract":"Extracellular vesicles (EVs) secreted by tumors are abundant in plasma, but their potential for interrogating the molecular features of tumors through multi-omic profiling remains widely unexplored. Genomic and transcriptomic profiling of circulating EV-DNA and EV-RNA isolated from in vitro and in vivo models of metastatic prostate cancer (mPC) reveal a high contribution of tumor material to EV-loaded DNA/RNA, validating the findings in two cohorts of longitudinal plasma samples collected from patients during androgen receptor signaling inhibitor (ARSI) or taxane-based therapy. EV-DNA genomic features recapitulate matched-patient biopsies and circulating tumor DNA (ctDNA) and associate with clinical progression. We develop a novel approach to enable transcriptomic profiling of EV-RNA (RExCuE). We report how the transcriptome of circulating EVs is enriched for tumor-associated transcripts, captures certain patient and tumor features, and reflects on-therapy tumor adaptation changes. Altogether, we show that EV profiling enables longitudinal transcriptomic and genomic profiling of mPC in liquid biopsy.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"12 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer 时空单细胞分析解码结直肠癌免疫疗法不同反应的细胞动力学基础

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-08 DOI: 10.1016/j.ccell.2024.06.009

Yuqing Chen, Dongfang Wang, Yingjie Li, Lu Qi, Wen Si, Yufei Bo, Xueyan Chen, Zhaochen Ye, Hongtao Fan, Baolin Liu, Chang Liu, Li Zhang, Xiaoyan Zhang, Zhongwu Li, Linna Zhu, Aiwen Wu, Zemin Zhang

{"title":"Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer","authors":"Yuqing Chen, Dongfang Wang, Yingjie Li, Lu Qi, Wen Si, Yufei Bo, Xueyan Chen, Zhaochen Ye, Hongtao Fan, Baolin Liu, Chang Liu, Li Zhang, Xiaoyan Zhang, Zhongwu Li, Linna Zhu, Aiwen Wu, Zemin Zhang","doi":"10.1016/j.ccell.2024.06.009","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.06.009","url":null,"abstract":"Expanding the efficacy of immune checkpoint blockade (ICB) in colorectal cancer (CRC) presses for a comprehensive understanding of treatment responsiveness. Here, we analyze multiple sequential single-cell samples from 22 patients undergoing PD-1 blockade to map the evolution of local and systemic immunity of CRC patients. In tumors, we identify coordinated cellular programs exhibiting distinct response associations. Specifically, exhausted T (Tex) or tumor-reactive-like CD8+ T (Ttr-like) cells are closely related to treatment efficacy, and Tex cells show correlated proportion changes with multiple other tumor-enriched cell types following PD-1 blockade. In addition, we reveal the less-exhausted phenotype of blood-associated Ttr-like cells in tumors and find that their higher abundance suggests better treatment outcomes. Finally, a higher major histocompatibility complex (MHC) II-related signature in circulating CD8+ T cells at baseline is linked to superior responses. Our study provides insights into the spatiotemporal cellular dynamics following neoadjuvant PD-1 blockade in CRC.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"45 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune cell triads reprogram exhausted CD8+ T cells for effective tumor elimination 免疫细胞三元组对衰竭的 CD8+ T 细胞进行重编程，从而有效消除肿瘤

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-08 DOI: 10.1016/j.ccell.2024.06.010

Veronica Lise, Ines Malenica, Rahul Roychoudhuri, Enrico Lugli

引用次数: 0

Casting a wider net: The clinical potential of EV transcriptomics in multi-analyte liquid biopsy 撒下更大的网：EV转录组学在多分析物液体活检中的临床潜力

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-08 DOI: 10.1016/j.ccell.2024.06.007

Yari Ciani, Caterina Nardella, Francesca Demichelis

引用次数: 0

Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors Th9 细胞代表了一种独特的 CD4+ T 细胞亚群，具有消灭晚期肿瘤的能力

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-08 DOI: 10.1016/j.ccell.2024.06.008

Yong Lu, Qiang Wang, Gang Xue, Enguang Bi, Xingzhe Ma, Aibo Wang, Jianfei Qian, Chen Dong, Qing Yi

引用次数: 0

HRS-4642: The next piece of the puzzle to keep KRAS in check HRS-4642：控制 KRAS 的下一块拼图

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-08 DOI: 10.1016/j.ccell.2024.06.005

引用次数: 0

Multi-scale signaling and tumor evolution in high-grade gliomas 高级别胶质瘤的多尺度信号传导与肿瘤演化

IF 50.3 1区医学

Cancer Cell Pub Date : 2024-07-08 DOI: 10.1016/j.ccell.2024.06.004

Jingxian Liu, Song Cao, Kathleen J. Imbach, Marina A. Gritsenko, Tung-Shing M. Lih, Jennifer E. Kyle, Tomer M. Yaron-Barir, Zev A. Binder, Yize Li, Ilya Strunilin, Yi-Ting Wang, Chia-Feng Tsai, Weiping Ma, Lijun Chen, Natalie M. Clark, Andrew Shinkle, Nataly Naser Al Deen, Wagma Caravan, Andrew Houston, Faria Anjum Simin, Li Ding

{"title":"Multi-scale signaling and tumor evolution in high-grade gliomas","authors":"Jingxian Liu, Song Cao, Kathleen J. Imbach, Marina A. Gritsenko, Tung-Shing M. Lih, Jennifer E. Kyle, Tomer M. Yaron-Barir, Zev A. Binder, Yize Li, Ilya Strunilin, Yi-Ting Wang, Chia-Feng Tsai, Weiping Ma, Lijun Chen, Natalie M. Clark, Andrew Shinkle, Nataly Naser Al Deen, Wagma Caravan, Andrew Houston, Faria Anjum Simin, Li Ding","doi":"10.1016/j.ccell.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.ccell.2024.06.004","url":null,"abstract":"Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of high-grade glioma, composed of IDH-wildtype GBM and IDH-mutant grade 4 astrocytoma, by integrating proteomic, metabolomic, lipidomic, and post-translational modifications (PTMs) with genomic and transcriptomic measurements to uncover multi-scale regulatory interactions governing tumor development and evolution. Applying 14 proteogenomic and metabolomic platforms to 228 tumors (212 GBM and 16 grade 4 IDH-mutant astrocytoma), including 28 at recurrence, plus 18 normal brain samples and 14 brain metastases as comparators, reveals heterogeneous upstream alterations converging on common downstream events at the proteomic and metabolomic levels and changes in protein-protein interactions and glycosylation site occupancy at recurrence. Recurrent genetic alterations and phosphorylation events on PTPN11 map to important regulatory domains in three dimensions, suggesting a central role for PTPN11 signaling across high-grade gliomas.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"15 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141561729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0