{"title":"Advocating for change—Integration of efforts across the drug discovery and development continuum","authors":"Timothy P. Heffernan, Giulio F. Draetta","doi":"10.1016/j.ccell.2025.03.009","DOIUrl":null,"url":null,"abstract":"In recent decades, we’ve witnessed tremendous advances in oncology with an increase in drug approvals across various modalities and indications, enabled by breakthroughs in personalized medicine, fundamental discoveries in cancer biology, advances in biotechnology, and the growing power of data science. Cancer, however, remains the leading cause of death worldwide, highlighting the need for a transformative approach to clinical care. We propose a shift in industry-academia partnerships that realigns cultural and financial priorities, leveraging advances in pharmaceutical R&D alongside academic innovation throughout the research continuum.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"11 1","pages":""},"PeriodicalIF":48.8000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Cell","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ccell.2025.03.009","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In recent decades, we’ve witnessed tremendous advances in oncology with an increase in drug approvals across various modalities and indications, enabled by breakthroughs in personalized medicine, fundamental discoveries in cancer biology, advances in biotechnology, and the growing power of data science. Cancer, however, remains the leading cause of death worldwide, highlighting the need for a transformative approach to clinical care. We propose a shift in industry-academia partnerships that realigns cultural and financial priorities, leveraging advances in pharmaceutical R&D alongside academic innovation throughout the research continuum.
期刊介绍:
Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows:
Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers.
Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice.
Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers.
Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies.
Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.