靶向脑巨噬细胞：NF-κB作为黑素瘤脑转移的治疗途径

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-03-10 DOI:10.1016/j.ccell.2025.02.020

Martina Molgora, Marco Colonna

引用次数: 0

摘要

黑色素瘤脑转移（MBM）与预后不良有关。在这一期的Cancer Cell中，Rodriguez-Baena等人发现核因子κB (NF-κB) （Rela）是MBM中促肿瘤小胶质细胞的驱动因素。Rela缺失重编程小胶质细胞，增强促炎和抗转移T细胞反应，而Rela在人巨噬细胞中的激活与免疫治疗耐药性相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis

Melanoma brain metastasis (MBM) is associated with poor prognosis. In this issue of Cancer Cell, Rodriguez-Baena et al. identify nuclear factor κB (NF-κB) (Rela) as a driver of pro-tumoral microglia in MBM. While Rela deletion reprograms microglia, enhancing proinflammatory and anti-metastasis T cell responses, RELA activation in human macrophages correlates with immunotherapy resistance.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.