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Hepatocellular carcinoma, multiple primary neoplasia, and their association with diabetes type 2. 肝细胞癌、多发性原发瘤变及其与2型糖尿病的关系
Casopis lekaru ceskych Pub Date : 2023-01-01
Lucie Žabová, Petr Hříbek, Johana Klasová, Kateřina Příhodová, Petr Urbánek
{"title":"Hepatocellular carcinoma, multiple primary neoplasia, and their association with diabetes type 2.","authors":"Lucie Žabová,&nbsp;Petr Hříbek,&nbsp;Johana Klasová,&nbsp;Kateřina Příhodová,&nbsp;Petr Urbánek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a frequent fatal complication of chronic liver diseases in the stage of liver cirrhosis. HCC develops at a higher rate in patients with type 2 diabetes mellitus (DM2). DM2 is associated with an increased risk of developing malignant tumors. The term multiple primary neoplasia (MPN) is used to describe the occurrence of multiple primary tumors of different organs in the same individual. To the best of the authors knowledge, the topic of the association between HCC and MPN and DM2 has not been addressed in the Czech literature. Here we present the outcomes of retrospective statistical analysis of a cohort of patients with HCC who were dispensed at the Internal Medicine Clinic of the 1st Faculty of Medicine of the Charles University in the period 2011-2021 and the impact of DM2 and MPN on overall survival (OS). MPNs are relatively common in patients with HCC. The occurrence of MPNs in our cohort was associated with DM2 in half of the cases. Median OS in HCC patients was not significantly affected by the coincidence of DM2 and/or MPNs.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 2-3","pages":"112-118"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9856933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical drainage, the origins and where we are today. 外科引流，起源和我们今天的处境。
Casopis lekaru ceskych Pub Date : 2023-01-01
Ján Hrubovčák, Ubomír Tulinský, Ivana Slívová, Petr Jelínek, František Jalůvka, Petr Ostruszka, Ubor Bialy
{"title":"Surgical drainage, the origins and where we are today.","authors":"Ján Hrubovčák,&nbsp;Ubomír Tulinský,&nbsp;Ivana Slívová,&nbsp;Petr Jelínek,&nbsp;František Jalůvka,&nbsp;Petr Ostruszka,&nbsp;Ubor Bialy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The use of drains in surgery has a rich history. Since ancient times, drainage has experienced a long progress, and its development has continued all the way to the present era. Both the indications for drainage and the material of surgical drains have changed over the last 2500 years. Indeed, drainage as we know today, was not always a practice so common or generally so well accepted, as it is today. The current concept of surgical drainage has witnessed not only periods of success, but also dead ends and mistakes of both science and medicine.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 2-3","pages":"119-121"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vlastimil Dostálek, MD - the founder of the ENT department in Nový Jičín - and his followers. Vlastimil Dostálek，医学博士，NovýJičín耳鼻喉科的创始人，以及他的追随者。
Casopis lekaru ceskych Pub Date : 2023-01-01
Ivan Kalivoda, Pavel Večeřa
{"title":"Vlastimil Dostálek, MD - the founder of the ENT department in Nový Jičín - and his followers.","authors":"Ivan Kalivoda,&nbsp;Pavel Večeřa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vlastimil Dostálek was born on January 18th, 1910, in the village of Včelary. Within his university studies in Brno, he was interested in otorhinolaryngology and subsequent the graduating from the medical faculty of Masaryk University, dr. Dostálek began to devote himself entirely to this field. He worked in various ENT departments led by important protagonists of his time. After the end of the Second World War, he was entrusted with building the ENT department in Nový Jičín, which he succeeded and led this department for over three decades until 1976 when he was dismantled for political reasons. Vlastimil Dostálek contributed to the development of the field in the entire district and educated many expert doctors, making him one of the prominent personalities of the Nový Jičín region. He died in 1988 at the age of 78.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 4","pages":"167-171"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is abdominal pain after an injury just an injury? Case report of rare aspiration pneumonia with lung gangrene and peritoneal response in a 5-year-old child. 受伤后的腹痛只是一种伤害吗？一例5岁儿童罕见吸入性肺炎并发肺坏疽和腹膜反应的病例报告。
Casopis lekaru ceskych Pub Date : 2023-01-01
Ján Hrubovčák, Ubomír Tulinský, Peter Ihnát, Petr Jelínek, Ivana Slívová, Marcel Mitták, Jan Roman, Jan Stránský
{"title":"Is abdominal pain after an injury just an injury? Case report of rare aspiration pneumonia with lung gangrene and peritoneal response in a 5-year-old child.","authors":"Ján Hrubovčák,&nbsp;Ubomír Tulinský,&nbsp;Peter Ihnát,&nbsp;Petr Jelínek,&nbsp;Ivana Slívová,&nbsp;Marcel Mitták,&nbsp;Jan Roman,&nbsp;Jan Stránský","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although pneumonia presents a relatively common diagnosis, it does not always present with classic clinical symptoms, nor does it follow a regular course without complications. The presented case describes a rare case of aspiration necrotizing pneumonia, which despite intensive therapy, progressed to lung gangrene and required a lung lobectomy. Another peculiarity is that the correct diagnosis was established only after the onset of abdominal pain, surprisingly by a trauma surgeon. This case emphasizes the necessity of a thorough general examination and draws attention to a rare, but conservatively intractable necrotizing pneumonia complicated by lung gangrene.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 4","pages":"160-163"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41098051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of interleukin 6 in the pathogenesis and therapy of Castleman disease - an immunologist's perspective. 白细胞介素6在Castleman病发病机制和治疗中的作用——免疫学家的观点。
Casopis lekaru ceskych Pub Date : 2023-01-01
Tomáš Milota, Zuzana Střížová, Marta Sobotková, Jiřina Bartůňková
{"title":"The role of interleukin 6 in the pathogenesis and therapy of Castleman disease - an immunologist's perspective.","authors":"Tomáš Milota,&nbsp;Zuzana Střížová,&nbsp;Marta Sobotková,&nbsp;Jiřina Bartůňková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Castleman disease (CD) is a heterogeneous group of diseases characterized by lymphadenopathy and systemic inflammatory manifestations. CD can be divided into uni- (UCD) and multicentric form (MCD) according to the disease extent. MCD is usually accompanied by the features of a systemic inflammatory response including fever, weight loss, hepatosplenomegaly, ascites, and edema. In these patients, we can also observe elevation of inflammatory parameters and anemia within the laboratory assessment. Based on etiological nature, the CD can be further divided into human herpesvirus-8-associated (HHV8-associated) and idiopathic form. Interleukin 6 (IL-6) plays a central role in the disease pathogenesis. Inhibition of IL-6 has been shown to be an effective treatment modality. Currently, siltuximab, a chimeric monoclonal antibody targeting IL-6, is the only approved treatment for MCD. Its short-term and long-term efficacy and safety have been demonstrated in a few clinical studies.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 2-3","pages":"106-111"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9865007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prescription rules of hormone replacement therapy and its alternative. 激素替代疗法的处方规则及其替代品。
Casopis lekaru ceskych Pub Date : 2023-01-01
Tomáš Fait
{"title":"Prescription rules of hormone replacement therapy and its alternative.","authors":"Tomáš Fait","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hormone replacement therapy is still the most effective treatment for acute climacteric syndrome and prevention of osteoporosis. When starting treatment within 10 years of menopause, i.e., before the onset of irreversible changes in the vessel wall and nervous tissues, it is a window of opportunity to prevent atherosclerosis and dementia. At a later start, on the contrary, it worsens these processes. To increase the safety of the treatment, especially in affecting the breast tissue, we choose the lowest effective dose of estrogen and give preference to gestagens structurally close to progesterone. For women who, for objective or subjective reasons, prefer non-hormonal treatment, they can choose from an extensive range of complementary and alternative medicines. Unfortunately, it does not always reliable documentation of efficacy and safety from well-performed studies. However, the data for fermented soybean extract DT56a, pollen extract PI82/GC Fem, and some traditional Chinese medicine procedures offer an interesting opportunity. Physical activity cannot be forgotten in a comprehensive approach.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"161 7-8","pages":"309-313"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9393221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assisted reproduction - principles, procedures, and their effectiveness. 辅助生殖——原则、程序及其有效性。
Casopis lekaru ceskych Pub Date : 2023-01-01
Karel Řežábek, Martina Moosová, Simona Jirsová
{"title":"Assisted reproduction - principles, procedures, and their effectiveness.","authors":"Karel Řežábek,&nbsp;Martina Moosová,&nbsp;Simona Jirsová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Assisted reproduction is an integral part of infertility treatment. The basic method is in vitro fertilisation (IVF), and intracytoplasmic sperm injection into the oocyte, cryopreservation of sperm, oocytes and embryos is also commonly used. The proportion of embryos tested with preimplantation genetic testing (PGT) for chromosomal aneuploidy or defects in specific genes is increasing. The use of donated oocytes is also significant, particularly because of the depletion of ovarian reserve in women over 40 years of age. The effectiveness of treatment is always very fundamentally dependent on the age of the woman. Assisted reproductive treatment is very well available in the Czech Republic, as is fertility preservation by sperm/oocyte freezing.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 5","pages":"179-193"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71478478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seasonal and weekly fluctuations in alcohol use in the Czech Republic. 捷克共和国酒精使用的季节性和每周波动。
Casopis lekaru ceskych Pub Date : 2023-01-01
Miroslav Barták, Jaroslav Vacek, Benjamin Petruželka, Marie Nejedlá, Vladimír Rogalewicz
{"title":"Seasonal and weekly fluctuations in alcohol use in the Czech Republic.","authors":"Miroslav Barták,&nbsp;Jaroslav Vacek,&nbsp;Benjamin Petruželka,&nbsp;Marie Nejedlá,&nbsp;Vladimír Rogalewicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sezónní a týdenní výkyvy v užívání alkoholu patří mezi doposud neanalyzované aspekty epidemiologického výzkumu užívání alkoholu českou dospělou populací. Cílem studie je nabídnout deskriptivní a analytický pohled na sezónní a týdenní vzorce užívání alkoholu u české dospělé populace. Výzkum byl realizován na reprezentativním vzorku 809 osob v rámci on-line šetření v prostředí Českého národního panelu. Sledovanými proměnnými jsou užívání alkoholu, sezónní užívání a užívání alkoholu v rámci dní v týdnu. Výsledky ukazují, že nejčastější je konzumace v pátek, případně v sobotu, s výjimkou lidí v důchodovém věku, kteří alkohol užívání rovnoměrněji v rámci celého týdne. Z hlediska měsíců v roce je nejvyšší spotřeba uváděna v létě (červen, červenec, srpen) a v prosinci. Respondenti s vyšším skóre dotazníku AUDIT užívají alkohol více v letních měsících než v prosinci. Výsledky výzkumu mohou přispět k lepšímu časovému zacílení preventivních i klinických aktivit.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 2-3","pages":"48-51"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung cancer prevention and prevention programs. 癌症预防和预防方案。
Casopis lekaru ceskych Pub Date : 2023-01-01
Lubomír Tulinský
{"title":"Lung cancer prevention and prevention programs.","authors":"Lubomír Tulinský","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lung cancer is the malignancy with the highest mortality rate worldwide. Its high mortality is mainly due to diagnostic delays leading to detection of the disease at an advanced stage. Therefore, prevention plays a key role in improving the overall survival of patients. The purpose of this article is to summarize the current status of lung cancer prevention in the Czech Republic and to provide a comprehensive view of current prevention programs.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"162 4","pages":"131-135"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41100777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in spa and balneology in postcovid era, outcomes, and perspectives. 后covid时代spa和balneology的趋势、结果和前景。
Casopis lekaru ceskych Pub Date : 2023-01-01
Judita Kinkorová
{"title":"Trends in spa and balneology in postcovid era, outcomes, and perspectives.","authors":"Judita Kinkorová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The COVID-19 pandemic has dramatically affected spa and balneology not only in the Czech Republic. Generally, almost two years without spa patients and clients led to a dramatic outflow of labor. The article main purpose is to analyze pandemic impact on the structure of spa patients and clients, to identify main current spa problems to be overcome, and to summarize possible future trends in modern spa and balneology for current and future spa clients. Spa will remain an important medical solution for treatment of some diagnoses using healing mineral-medical waters and natural sources, but they must innovate their services and treating programs to answer current questions and clients 'demands. It will be a complex patient care combining body and mental treatment and care with the use of so-called therapeutic landscape, a unique landscape surrounding spa towns and places, as well as wellness aspects. Modern spa must be an integral part of health care systems in Europe.</p>","PeriodicalId":9645,"journal":{"name":"Casopis lekaru ceskych","volume":"161 7-8","pages":"329-331"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9098666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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