Case Reports in Endocrinology最新文献

{"title":"Intraindividual Comparison of the Anabolic Steroid Hormone Profile Between Hormonal Contraceptive Use and the Phases of a Natural Menstrual Cycle in a Recreational Athlete: A Single-Case Observational Study.","authors":"Jana Nolte, Sven C Voss, Annekathrin Martina Keiler, Kirsten Legerlotz, Petra Platen","doi":"10.1155/crie/9648747","DOIUrl":"10.1155/crie/9648747","url":null,"abstract":"<p><p>Endogenous androgens, including testosterone and the androgen precursor androstenedione, are known to influence muscular adaptation. However, variations in these hormones throughout the natural menstrual cycle (MC) and during oral hormonal contraception (HC) remain underexplored in the athletic population with cycle-based training approaches. This study investigates variations in steroid hormone profiles under HC and during a natural MC in one recreational athlete. An observational study was conducted on a 25-year-old female recreational athlete (167 cm, 60 kg, 6 h training/exercise activity per week). Testosterone and androstenedione concentrations were measured in her urine and plasma every two to 3 days during 3 weeks of HC use (hormonal vaginal ring) and the 1-week HC break and 11 months later during one natural MC. Hormone analysis was conducted using gas chromatography coupled with mass spectrometry for urine steroids and liquid chromatography coupled with mass spectrometry for plasma steroids. Throughout the MC, urinary total androgen and plasma androstenedione levels peaked around ovulation, followed by a decline in the luteal phase, suggesting phase-dependent variation in androgen precursor availability. Meanwhile, plasma testosterone remained unchanged throughout the cycle. HC use resulted in lower androgen concentrations with no notable fluctuations in plasma or urine. The suppression of naturally secreted androgens and their respective fluctuations throughout MC induced by HC may have implications for training adaptations and athletic performance. Furthermore, it is essential for female athletes and their coaches to consider the use of HC in order to optimize training strategies.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"9648747"},"PeriodicalIF":0.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Pneumatosis Following Fishbone Ingestion: A Rare Case Report.","authors":"Bruna Pimentel, Luís Baptista, Inês Medeiros, Beatriz Lança, Ana Coutinho Santos, Clara Cunha, João Sequeira Duarte","doi":"10.1155/crie/4133056","DOIUrl":"10.1155/crie/4133056","url":null,"abstract":"<p><strong>Background: </strong>Thyroid pneumatosis is an extremely rare condition, previously reported only once as a complication of an ultrasound-guided thyroid fine needle aspiration (FNA).</p><p><strong>Case report: </strong>A 70-year-old male sought emergency care after experiencing a foreign body sensation in his throat. He was diagnosed with a retropharyngeal abscess caused by upper digestive tract perforation from fishbone ingestion, which was surgically extracted. Postoperative day 3, a neck computed tomography (CT) revealed gas bubbles within the thyroid parenchyma, indicative of thyroid pneumatosis, likely leading to destructive thyroiditis (TSH 0.109 µUI/mL, free T4 of 27.1 pmol/L, and free T3 of 4.08 pmol/L). A multidisciplinary team opted for a conservative approach, and the patient showed a favorable recovery. Thyroid function normalized within 2 months (TSH 2.44 mUI/mL, free T4 13.6 pmol/L, and free T3 4.58 pmol/L).</p><p><strong>Conclusion: </strong>Thyroid pneumatosis should be recognized as a potential rare complication following esophageal perforation. This is the first documented case linking destructive thyroiditis to thyroid pneumatosis.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"4133056"},"PeriodicalIF":0.8,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GPIHBP1 Autoantibody-Related Hypertriglyceridemia in a 12-Year-Old Girl With Systemic Lupus Erythematosus.","authors":"Sin-Ting Tiffany Lai, Suk-Yan Suki Chan, Stephanie C Y Yu, Jenny Yeuk Ki Cheng, Kam-Chi Teresa Tsui, Chi-Hang Assunta Ho, Ho-Chung Yau","doi":"10.1155/crie/6673352","DOIUrl":"10.1155/crie/6673352","url":null,"abstract":"<p><p>Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) is critical for transporting lipoprotein lipase (LPL) to the capillary lumen, where LPL breaks down triglycerides in triglyceride-rich lipoproteins. We herein report a 12-year-old Chinese girl who presented with severe hypertriglyceridemia and a recent diagnosis of systemic lupus erythematosus (SLE). She was first noted to have severe hypertriglyceridemia at 8.5 years old, complicated by three episodes of acute pancreatitis within 2 years. Between these episodes, her plasma triglycerides remained elevated, but at lower levels. Next-generation sequencing for primary hypertriglyceridemia yielded no significant findings. Investigations for secondary causes, to include fasting glucose, HbA1c, and thyroid function testing, were unrevealing. Given the fluctuating triglyceride levels and negative genetic testing for primary hypertriglyceridemia in the background of SLE, autoimmune hypertriglyceridemia was suspected. The diagnosis of GPIHBP1 autoantibody syndrome was confirmed by an elevated GPIHBP1 autoantibody titer and a low LPL mass in her serum. Her SLE was well controlled with immunosuppressants and belimumab. Fenofibrate and omega-3 fatty acids, which were initially prescribed for her hypertriglyceridemia, were later discontinued. The GPIHBP1 autoantibody and LPL mass normalized 2 years after diagnosis. This case illustrates hypertriglyceridemia caused by a rare disease entity associated with autoantibodies against the GPIHBP1 protein. This entity is worth considering after excluding genetic and common secondary causes of hypertriglyceridemia, particularly in a patient with a history of autoimmune disease.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"6673352"},"PeriodicalIF":0.8,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Rapid and Significant Reduction in Size of Pituitary Adenoma in Children Treated with Fractionated Stereotactic Radiation Therapy: A Case Report\".","authors":"","doi":"10.1155/crie/9759156","DOIUrl":"10.1155/crie/9759156","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2011/187839.].</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"9759156"},"PeriodicalIF":0.9,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Strategies for the Surgical and Long-Term Management of Malignant Struma Ovarii.","authors":"Anna Hayden, Nathaniel Grabill, Mena Louis, Ezra Ellis, Nikita Machado","doi":"10.1155/crie/4120842","DOIUrl":"10.1155/crie/4120842","url":null,"abstract":"<p><p>Struma ovarii is a rare ovarian tumor characterized by the presence of thyroid tissue, which can occasionally undergo malignant transformation. Management varies due to its rarity and the potential for malignancy. A 25-year-old female with a history of polycystic ovary syndrome (PCOS) presented with a 7 cm left ovarian cyst. Laparoscopic cystectomy revealed struma ovarii with areas of papillary thyroid carcinoma. Preoperative evaluations, including thyroid ultrasound and PET scan, showed no evidence of primary thyroid cancer or metastatic disease. Given the malignant potential, a total thyroidectomy was recommended to facilitate monitoring of thyroglobulin levels for early detection of recurrence. The patient was also scheduled for left salpingectomy and oophorectomy to reduce reoccurrence and perform a complete oncologic resection which was completed approximately 1 month following thyroidectomy and found to be negative for carcinoma. Struma ovarii requires careful management due to its potential for malignancy. Proactive surgical intervention and regular monitoring are critical to managing recurrence and ensuring patient safety. Thyroglobulin levels serve as an effective biomarker for early detection of any residual disease, guiding follow-up care. This patient's initial level of thyroglobulin was 15.2 ng/mL. This was obtained post initial cystectomy but prior to thyroidectomy. Thyroglobulin monitoring and follow-up are essential for early detection and management of recurrence. This is particularly true for well-differentiated thyroid cancers, which this is not. However, it can still be an important indicator for the presence of thyroid tissue in other areas which could point to a recurrent malignancy. This case emphasizes the need for a tailored approach in managing struma ovarii, considering the variability in malignant transformation risk.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"4120842"},"PeriodicalIF":0.8,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occult Thyroid Carcinoma Localized to Three Cervical Lymph Nodes Without Primary Origin in the Thyroid Gland: A Case Report.","authors":"Daisuke Murayama, Yasunori Nishida, Shun Hishikawa, Ryosuke Hirano, Toko Hashizume, Koji Azuhata, Hisashi Shimojo, Nobuo Ito, Osamu Mishima","doi":"10.1155/crie/3603326","DOIUrl":"10.1155/crie/3603326","url":null,"abstract":"<p><p>Occult thyroid carcinoma (OTC) involves cervical lymph node metastases without primary papillary thyroid carcinoma (PTC). A 57-year-old man presented with a left neck mass. Ultrasonography (US) revealed a mass in the left cervical node (inferior internal jugular node, Level IV). Positron emission tomography/computed tomography (PET/CT) and fine needle aspiration biopsy indicated suspected PTC metastasis. The serum thyroglobulin (Tg) level was elevated. Total thyroidectomy and bilateral central neck and left cervical dissection revealed no thyroid carcinoma, while the left cervical node showed ground glass nuclei and proliferation. Our diagnosis was PTC with no primary origin, pT0N1bM0 Stage II. Due to a low risk of recurrence, we initiated thyroid-stimulating hormone (TSH) suppression therapy. Tg levels remained low 4 years postoperatively with no signs of recurrence. The optimal management of OTC cases remains unclear and blood tests (Tg levels), risk of recurrence, and patient characteristics must be considered.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"3603326"},"PeriodicalIF":0.8,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngectomy-Sparing Radio Frequency Ablation for Laryngeal Metastasis in Recurrent Papillary Thyroid Carcinoma: A Case Report.","authors":"Hossein Chegeni, Hojat Ebrahiminik, Haleh Chehrehgosha, Maryam Pourashraf, Hossein Parsa, Zeinab Azizi, Seyed Hossein Samadanifard, Vahan Moradians, Ebrahim Karimi","doi":"10.1155/crie/6647587","DOIUrl":"10.1155/crie/6647587","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrence rate of papillary thyroid carcinoma (PTC) due to laryngeal metastasis is rare, radio frequency ablation (RFA) shows efficacy in management of recurrent PTC. This case is important due to its rarity and limited evidence on using RFA for recurrent PTC with laryngeal metastasis, focusing on larynx preservation and voice maintenance.</p><p><strong>Case report: </strong>A 64-year-old woman with recurrent PTC experienced shortness of breath, hoarseness, and painful swallowing. Imaging revealed two masses affecting her vocal cords and severe airway narrowing. After declining a laryngectomy, she underwent RFA and temporary tracheostomy. Follow-up showed successful treatment, with no residual mass, and her voice improved.</p><p><strong>Conclusion: </strong>This case shows a successful performance of RFA in a patient with recurrent and invasive PTC with laryngeal involvement who refused laryngectomy. It seems that combining RFA with radioactive iodine and external beam radiation can be considered in patients with recurrent PTC with laryngeal metastasis to maintain voice.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"6647587"},"PeriodicalIF":0.8,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Ice Packing for Voice Changes During Thyroid Radiofrequency Ablation: A Retrospective Case Series.","authors":"Mei-Chen Yeh, Wei-Shin Yu, Hsiang-Lin Lee, Yu-Shen Lee, Kai-Lun Cheng","doi":"10.1155/crie/7160959","DOIUrl":"10.1155/crie/7160959","url":null,"abstract":"<p><p>Voice change is a recognized complication of radiofrequency ablation (RFA) for thyroid nodules, primarily resulting from thermal injury to the recurrent laryngeal nerve or adjacent structures. Although most cases resolve spontaneously over several weeks to months, timely intervention may help reduce patient discomfort and anxiety. This retrospective case series examined five patients who developed voice changes during or immediately after RFA for benign thyroid nodules and were managed with direct ice packing. Ipsilateral vocal cord (VC) hypomobility was confirmed via real-time laryngeal ultrasound, followed by immediate application of ice to the skin overlying the thyroid. VC movement and skin integrity were assessed every 10 min. All patients achieved complete symptom resolution within 20-50 min (median: 30 min) without complications. No cold-induced skin injury occurred, and no additional treatment was required. While spontaneous recovery cannot be excluded, the relatively rapid improvement observed in this series suggests that direct ice packing may represent a safe, practical, and noninvasive management option for RFA-related voice changes. Further studies are warranted to confirm its efficacy in larger and more diverse populations.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"7160959"},"PeriodicalIF":0.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfasalazine-Induced Urinary Normetanephrine Elevation Mimicking Recurrent Phaeochromocytoma-A Case Report.","authors":"Maria Hadjicosti, Anastasia Papapostolou, Michail Papoulas, Evdoxia Poulianiti, Nikoleta Christodoulidou, Michalis K Picolos","doi":"10.1155/crie/6661577","DOIUrl":"10.1155/crie/6661577","url":null,"abstract":"<p><p>Phaeochromocytomas and paragangliomas (PPGLs) are catecholamine-secreting neuroendocrine tumours (NETs) of the adrenal medulla and autonomic nervous system. Early recognition and management is critical given their potential morbidity and mortality. For this reason, stand-alone screening investigations rely on a low diagnostic threshold, achieving high sensitivity at the relative cost of specificity. Following diagnosis, the only curative option is surgical removal of the tumour. Similar investigations are employed for postoperative surveillance. Persistent urinary normetanephrine elevation after curative phaeochromocytoma resection is rare and may lead to unnecessary investigations and anxiety. Our case highlights a previously underreported cause-analytical interference from sulfasalazine-and underscores the importance of considering medication effects in postoperative biochemical surveillance. We hereby present a 73-year-old Caucasian woman with a history of rheumatoid arthritis treated with sulfasalazine, hypertension, type 2 diabetes and hypothyroidism who exhibited persistently and significantly elevated urine normetanephrine, up to 15 months following successful surgical resection of a phaeochromocytoma. This was secondary to long-term sulfasalazine use, causing gross interference with laboratory urine normetanephrine analysis without interfering with the serum normetanephrine value. Discontinuation of sulfasalazine normalised the urine normetanephrine results. This case identifies sulfasalazine as a clinically relevant source of urine normetanephrine assay interference, reinforcing the need for careful interpretation of biochemical diagnostic or surveillance results.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"6661577"},"PeriodicalIF":0.8,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Misuse of Insulin in an Adolescent With Type 1 Diabetes: A Case Report and Management Implications.","authors":"Sara C Pender, Mohamed Adil Shah Khoodoruth","doi":"10.1155/crie/3651243","DOIUrl":"10.1155/crie/3651243","url":null,"abstract":"<p><strong>Introduction: </strong>In Canada, nearly one in five children present with diabetic ketoacidosis (DKA) at the time of their first diabetes diagnosis, a serious and potentially life-threatening complication. Adolescence, marked by insulin resistance, fluctuating appetite, and increasing independence, presents unique challenges for diabetes management. Suicidality is more prevalent in adolescents with type 1 diabetes, with higher rates of ideation and attempts compared to peers without the condition. Insulin misuse, whether by omission or deliberate insulin overdose, is increasingly recognized as a maladaptive coping strategy linked to body image concerns, diabetes-related distress, and psychiatric comorbidity, further compounding vulnerability.</p><p><strong>Case report: </strong>A 15-year-old female with type 1 diabetes mellitus, diagnosed at age 11, was admitted to child and adolescent psychiatry following a suicide attempt by insulin overdose delivered via her Tandem X2 Control IQ insulin pump. She had a history of multiple suicide attempts, typically in the context of acute psychosocial stressors, and recently transitioned to foster care. Biochemistry revealed suboptimal glycemic control (HbA1c 8.5%) and mild metabolic acidosis. A multidisciplinary review led to targeted insulin adjustments and the introduction of a pump passcode lock, restricting unsupervised bolus dosing as a safeguarding measure against insulin overdose. Psychiatric management was optimized, and coordinated aftercare planning was arranged with child protection, endocrinology, and mental health services.</p><p><strong>Conclusion: </strong>This case illustrates insulin manipulation as a means of self-harm in adolescence. The current admission involved a deliberate insulin overdose with mild DKA in the context of a history of insulin omission and more severe DKA episodes. Few published reports describe such dual misuse, underscoring the need to explicitly assess both behaviors in routine care. In this instance, reintroduction of pump therapy with passcode-protected bolus delivery and tailored alarm configurations provided an additional safeguard, highlighting the potential for diabetes technology, when thoughtfully configured, to augment safety alongside psychiatric and psychosocial intervention.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"3651243"},"PeriodicalIF":0.8,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12910172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}