Case Reports in Endocrinology最新文献_第5页

Coronary Artery and Peripheral Vascular Disease in a Patient with Poorly Differentiated Thyroid Cancer Treated with the Tyrosine Kinase Inhibitor Lenvatinib. 应用酪氨酸激酶抑制剂乐伐替尼治疗一例低分化甲状腺癌症患者的冠状动脉和外周血管疾病。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8841696

Vineeth Sukrithan, Lisa Kim, Jennifer A Sipos, Ashima Goyal, Ye Zhou, Daniel Addison, Manisha Shah, Bhavana Konda, Ajay Vallakati

{"title":"Coronary Artery and Peripheral Vascular Disease in a Patient with Poorly Differentiated Thyroid Cancer Treated with the Tyrosine Kinase Inhibitor Lenvatinib.","authors":"Vineeth Sukrithan, Lisa Kim, Jennifer A Sipos, Ashima Goyal, Ye Zhou, Daniel Addison, Manisha Shah, Bhavana Konda, Ajay Vallakati","doi":"10.1155/2023/8841696","DOIUrl":"10.1155/2023/8841696","url":null,"abstract":"A subset of patients with differentiated thyroid carcinoma develop radioiodine refractory (RAIR) incurable disease, which typically has a poor prognosis. The multitargeted tyrosine kinase inhibitor lenvatinib has demonstrated significant improvements in progression-free survival in RAIR thyroid cancers compared to placebos. However, in the phase III SELECT trial of the drug in thyroid cancer, 5.4% of patients on lenvatinib experienced arterial thromboembolic events, with 2.7% experiencing severe grade ≥3 toxicities associated with arterial vascular events. This case study reports a patient with metastatic poorly differentiated follicular thyroid cancer who developed significant obstructive coronary artery disease following initiation of lenvatinib treatment, despite no predisposing cardiovascular risk factors apart from a remote smoking history. The possibility of developing coronary or peripheral artery disease should be considered in patients who are on targeted therapies, such as lenvatinib, even in the absence of traditional cardiovascular risk factors. In addition, baseline cardiac risk assessment and early treatment should be pursued to minimize interruptions to potentially lifesaving cancer therapy.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2023 ","pages":"8841696"},"PeriodicalIF":1.1,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes Insipidus due to Metastases of Undiagnosed Lung Cancer: A Case Report from Syria. 未确诊肺癌转移引起的血脂异常：叙利亚病例报告。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-09-12 eCollection Date: 2023-01-01 DOI: 10.1155/2023/1482675

Ibrahim Alali, Alaa Al-Sarraj, Younes Kabalan

引用次数: 0

Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion. 继发于 20p11 缺失的高胰岛素血症和生长激素缺乏症

IF 0.9

Case Reports in Endocrinology Pub Date : 2023-06-26 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8658540

Erica Wee, John Herriges, Kavitha Dileepan, Sarah L Tsai, Joseph T Alaimo, Emily Paprocki

引用次数: 0

A Case of Pituitary Apoplexy and Cavernous Sinus Syndrome during Hemodialysis. 一例血液透析期间脑垂体骤停和海绵窦综合征病例。

IF 0.9

Case Reports in Endocrinology Pub Date : 2023-04-25 eCollection Date: 2023-01-01 DOI: 10.1155/2023/3183088

Yusra Jamal, Yudi Camacho, Simon Hanft, Patrick Chiarolanzio, Michael D Goldberg, Jamie A Mullally

{"title":"A Case of Pituitary Apoplexy and Cavernous Sinus Syndrome during Hemodialysis.","authors":"Yusra Jamal, Yudi Camacho, Simon Hanft, Patrick Chiarolanzio, Michael D Goldberg, Jamie A Mullally","doi":"10.1155/2023/3183088","DOIUrl":"10.1155/2023/3183088","url":null,"abstract":"Background: Pituitary apoplexy (PA) is a clinical syndrome of pituitary hemorrhage or infarction and can result in hypopituitarism as well as compression of adjacent brain structures. Visual loss occurs frequently, as a result of tumor expansion and compression of the optic chiasm and optic nerves. Additionally, with pituitary tumor invasion into the fixed space of the cavernous sinus, compression of multiple cranial nerves can result in cavernous sinus syndrome (CSS). We describe a case of an undiagnosed pituitary tumor manifesting as abrupt PA with CSS during hemodialysis (HD). Clinical Case. A 77-year-old male with end-stage renal disease (ESRD) presented with acute onset of severe headache, decreased vision, ophthalmoplegia of the left eye, and hypotension during HD. MRI of the brain revealed a 2.5 cm pituitary adenoma with acute hemorrhage, compression of the left prechiasmatic optic nerve, and invasion into the left cavernous sinus (CS). The hormonal profile was consistent with multiple pituitary hormone deficiencies. The patient was treated with glucocorticoids and underwent transsphenoidal resection of the tumor. He had an uneventful postoperative hospital course, and his left visual acuity stabilized, although there was no immediate improvement in his other ocular symptoms.Conclusion: Our case highlights a rare constellation of a pituitary adenoma with CS invasion complicated by PA and CSS during HD. The pathophysiology of PA is not well understood, and there are very limited data regarding PA in patients with end-stage renal disease (ESRD) on HD. Prompt recognition of PA in a patient presenting with CSS, particularly in the HD setting, is essential to ensure appropriate care is provided for this medical emergency.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2023 ","pages":"3183088"},"PeriodicalIF":0.9,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uveal Melanoma Metastasis to the Thyroid. 葡萄膜黑色素瘤向甲状腺转移。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/2118672

Rokshana R Thanadar, Uzma M Siddiqui, Shi Bai, Runhua Hou

{"title":"Uveal Melanoma Metastasis to the Thyroid.","authors":"Rokshana R Thanadar, Uzma M Siddiqui, Shi Bai, Runhua Hou","doi":"10.1155/2023/2118672","DOIUrl":"https://doi.org/10.1155/2023/2118672","url":null,"abstract":"Background: Around 1.2 to 3.1% of thyroid malignancies are due to metastasis. Among them, cutaneous malignant melanomas constitute 4% of malignancy metastasized to the thyroid. Uveal melanoma is uncommon, and its metastasis to the thyroid has only rarely been reported. Hereby, we describe an unusual case of uveal melanoma metastasized to the thyroid and discuss the concept of correct diagnosis. Case Report. During a routine ophthalmological examination, an 86-year-old Caucasian female was found to have retinal detachment secondary to choroidal melanoma. She was treated with gamma knife which resulted in reduction of tumor size. Three months later, she was noted to have a goiter on physical examination. Follow-up thyroid ultrasonography demonstrated numerous vascularized nodules in both lobes. The fine needle aspiration (FNA) of the left dominant nodule was indeterminate the first time and nondiagnostic the second time. FNA of the right dominant nodule was nondiagnostic twice but showed malignant cells the third time. Subsequent immunohistochemistry staining of the FNA sample from the right thyroid nodule confirmed a profile consistent with malignant melanoma.Conclusion: It should be kept in mind that a thyroid nodule detected in a patient with a diagnosis of uveal melanoma can be metastasis and that uveal melanoma diagnosis should be taken into account for the examination of the thyroid tumors of these patients. It is important to employ immunohistochemical staining FNA examination of the patient with such tumors for markers associated with a patient's known malignancy to facilitate diagnosis.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2023 ","pages":"2118672"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Pheochromocytoma Diagnosis Confounded by Amphetamine Use. 巨大嗜铬细胞瘤的诊断与使用安非他明混淆。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/8799089

Shreya Amin, Matthew Gilbert, Kaitlyn Barrett

{"title":"Giant Pheochromocytoma Diagnosis Confounded by Amphetamine Use.","authors":"Shreya Amin, Matthew Gilbert, Kaitlyn Barrett","doi":"10.1155/2023/8799089","DOIUrl":"https://doi.org/10.1155/2023/8799089","url":null,"abstract":"Objective: Diagnosis of giant pheochromocytoma is difficult; patients often lack the classic triad and presence of gross biochemical positivity. At times, presence of sympathetic stimulant drugs can further complicate the clinical picture. Here, we present a case of giant \"functional\" pheochromocytoma with a history of amphetamine use. Case Description. 37-year-old female presented with a 1-day history of abdominal pain. CT abdomen identified a 12.5 cm heterogeneously enhancing left adrenal mass. Plasma/urine catecholamine and metanephrine levels were markedly elevated with evidence of elevated serum/urine cortisol. However, the patient's subsequent urine toxicology was found to be positive for amphetamines, which she later admitted to using, 1 week prior to admission. Repeat biochemical workup after 1 week drug washout period showed improvement in both catecholamine and cortisol levels. Given the high degree of suspicion for PCC, an open laparoscopic adrenalectomy was performed with histology confirming SDHB gene mutation positive giant pheochromocytoma. Discussion. Diagnosis of PCC in a patient with a history of amphetamine abuse remains an enigma, to which addition of it being a giant PCC that are rare and typically silent further confounds the clinical picture as seen in this case.Conclusion: PCC could be termed a \"chameleon\" tumor given its varied clinical presentations and lack of standardized biochemical and radiological data (giant, pheochromocytoma, and amphetamine).","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2023 ","pages":"8799089"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10659632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Pancreatitis as an Unusual Culprit of Diabetic Ketoacidosis in a Nondiabetic: A Case-Based Review. 急性胰腺炎是非糖尿病患者糖尿病酮症酸中毒的一个不寻常的罪魁祸首:一个基于病例的回顾。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/9122669

Steven Imburgio, Apurva Vedire, Harshavardhan Sanekommu, Anmol Johal, Sobaan Taj, Christopher Lesniak, Arman Mushtaq

引用次数: 0

Thyrotoxicosis after COVID-19 Infection with a Delay in Graves' Disease Antibody Positivity. COVID-19感染后甲状腺毒症伴Graves病抗体阳性延迟。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/8402725

Dennis C Boyle, Jamie A Mullally

{"title":"Thyrotoxicosis after COVID-19 Infection with a Delay in Graves' Disease Antibody Positivity.","authors":"Dennis C Boyle, Jamie A Mullally","doi":"10.1155/2023/8402725","DOIUrl":"https://doi.org/10.1155/2023/8402725","url":null,"abstract":"Background and Objective. Mounting evidence implicates COVID-19 as a cause of thyroid dysfunction, including thyrotoxicosis due to both thyroiditis and Graves' disease (GD). In this report, we present a case of thyrotoxicosis following COVID-19 infection that was ultimately found to represent GD with significantly delayed diagnostic serum antibody positivity. Case Report. A 65-year-old woman with a history of uncomplicated COVID-19 infection one month prior, presented to the Emergency Department with exertional dyspnea and palpitations, and was found to be in atrial fibrillation with rapid ventricular response (AF with RVR). Labs showed subclinical hyperthyroidism and the patient was started on a beta-blocker and methimazole. One month later, thyroid-stimulating immunoglobulin (TSI) resulted negative and thyroid function tests had normalized. The clinical picture suggested thyroiditis, and methimazole was stopped. One month later, the patient again presented in AF with RVR, with labs showing overt biochemical thyrotoxicosis. Antibodies were re-tested, and the thyrotropin receptor antibody (TRAb) and TSI resulted positive, confirming GD. Discussion. Most notable in this case is the feature of delayed GD antibody positivity: the diagnostic immunoassay for GD resulted negative one and two months after infection, but was ultimately positive three months after infection. To the authors' knowledge, this represents the longest delayed antibody positivity reported to date, amongst cases of new-onset GD following COVID. Conclusion. The clinical course of GD following COVID-19 infection is highly variable. This case underscores the need for vigilance in monitoring for delayed GD antibody positivity due to the important therapeutic implications of distinguishing thyroiditis from GD.","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2023 ","pages":"8402725"},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical Glucocorticoid Use and the Risk of Posttransplant Diabetes. 局部使用糖皮质激素与移植后糖尿病的风险。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/3648178

Simon Bøtker, Henrik Birn, Lara Aygen Øzbay

引用次数: 2

A Case of Iatrogenic Cushing's Syndrome following Use of an Over-the-Counter Arthritis Supplement. 使用非处方关节炎补充剂后发生医源性库欣综合征1例。

IF 1.1

Case Reports in Endocrinology Pub Date : 2023-01-01 DOI: 10.1155/2023/4769258

Colin Dunn, Joshua Amaya, Patrick Green

引用次数: 3