Case Reports in Endocrinology最新文献

{"title":"Optimal Strategies for the Surgical and Long-Term Management of Malignant Struma Ovarii.","authors":"Anna Hayden, Nathaniel Grabill, Mena Louis, Ezra Ellis, Nikita Machado","doi":"10.1155/crie/4120842","DOIUrl":"https://doi.org/10.1155/crie/4120842","url":null,"abstract":"<p><p>Struma ovarii is a rare ovarian tumor characterized by the presence of thyroid tissue, which can occasionally undergo malignant transformation. Management varies due to its rarity and the potential for malignancy. A 25-year-old female with a history of polycystic ovary syndrome (PCOS) presented with a 7 cm left ovarian cyst. Laparoscopic cystectomy revealed struma ovarii with areas of papillary thyroid carcinoma. Preoperative evaluations, including thyroid ultrasound and PET scan, showed no evidence of primary thyroid cancer or metastatic disease. Given the malignant potential, a total thyroidectomy was recommended to facilitate monitoring of thyroglobulin levels for early detection of recurrence. The patient was also scheduled for left salpingectomy and oophorectomy to reduce reoccurrence and perform a complete oncologic resection which was completed approximately 1 month following thyroidectomy and found to be negative for carcinoma. Struma ovarii requires careful management due to its potential for malignancy. Proactive surgical intervention and regular monitoring are critical to managing recurrence and ensuring patient safety. Thyroglobulin levels serve as an effective biomarker for early detection of any residual disease, guiding follow-up care. This patient's initial level of thyroglobulin was 15.2 ng/mL. This was obtained post initial cystectomy but prior to thyroidectomy. Thyroglobulin monitoring and follow-up are essential for early detection and management of recurrence. This is particularly true for well-differentiated thyroid cancers, which this is not. However, it can still be an important indicator for the presence of thyroid tissue in other areas which could point to a recurrent malignancy. This case emphasizes the need for a tailored approach in managing struma ovarii, considering the variability in malignant transformation risk.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"4120842"},"PeriodicalIF":0.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occult Thyroid Carcinoma Localized to Three Cervical Lymph Nodes Without Primary Origin in the Thyroid Gland: A Case Report.","authors":"Daisuke Murayama, Yasunori Nishida, Shun Hishikawa, Ryosuke Hirano, Toko Hashizume, Koji Azuhata, Hisashi Shimojo, Nobuo Ito, Osamu Mishima","doi":"10.1155/crie/3603326","DOIUrl":"https://doi.org/10.1155/crie/3603326","url":null,"abstract":"<p><p>Occult thyroid carcinoma (OTC) involves cervical lymph node metastases without primary papillary thyroid carcinoma (PTC). A 57-year-old man presented with a left neck mass. Ultrasonography (US) revealed a mass in the left cervical node (inferior internal jugular node, Level IV). Positron emission tomography/computed tomography (PET/CT) and fine needle aspiration biopsy indicated suspected PTC metastasis. The serum thyroglobulin (Tg) level was elevated. Total thyroidectomy and bilateral central neck and left cervical dissection revealed no thyroid carcinoma, while the left cervical node showed ground glass nuclei and proliferation. Our diagnosis was PTC with no primary origin, pT0N1bM0 Stage II. Due to a low risk of recurrence, we initiated thyroid-stimulating hormone (TSH) suppression therapy. Tg levels remained low 4 years postoperatively with no signs of recurrence. The optimal management of OTC cases remains unclear and blood tests (Tg levels), risk of recurrence, and patient characteristics must be considered.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"3603326"},"PeriodicalIF":0.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngectomy-Sparing Radio Frequency Ablation for Laryngeal Metastasis in Recurrent Papillary Thyroid Carcinoma: A Case Report.","authors":"Hossein Chegeni, Hojat Ebrahiminik, Haleh Chehrehgosha, Maryam Pourashraf, Hossein Parsa, Zeinab Azizi, Seyed Hossein Samadanifard, Vahan Moradians, Ebrahim Karimi","doi":"10.1155/crie/6647587","DOIUrl":"https://doi.org/10.1155/crie/6647587","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrence rate of papillary thyroid carcinoma (PTC) due to laryngeal metastasis is rare, radio frequency ablation (RFA) shows efficacy in management of recurrent PTC. This case is important due to its rarity and limited evidence on using RFA for recurrent PTC with laryngeal metastasis, focusing on larynx preservation and voice maintenance.</p><p><strong>Case report: </strong>A 64-year-old woman with recurrent PTC experienced shortness of breath, hoarseness, and painful swallowing. Imaging revealed two masses affecting her vocal cords and severe airway narrowing. After declining a laryngectomy, she underwent RFA and temporary tracheostomy. Follow-up showed successful treatment, with no residual mass, and her voice improved.</p><p><strong>Conclusion: </strong>This case shows a successful performance of RFA in a patient with recurrent and invasive PTC with laryngeal involvement who refused laryngectomy. It seems that combining RFA with radioactive iodine and external beam radiation can be considered in patients with recurrent PTC with laryngeal metastasis to maintain voice.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"6647587"},"PeriodicalIF":0.9,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Ice Packing for Voice Changes During Thyroid Radiofrequency Ablation: A Retrospective Case Series.","authors":"Mei-Chen Yeh, Wei-Shin Yu, Hsiang-Lin Lee, Yu-Shen Lee, Kai-Lun Cheng","doi":"10.1155/crie/7160959","DOIUrl":"https://doi.org/10.1155/crie/7160959","url":null,"abstract":"<p><p>Voice change is a recognized complication of radiofrequency ablation (RFA) for thyroid nodules, primarily resulting from thermal injury to the recurrent laryngeal nerve or adjacent structures. Although most cases resolve spontaneously over several weeks to months, timely intervention may help reduce patient discomfort and anxiety. This retrospective case series examined five patients who developed voice changes during or immediately after RFA for benign thyroid nodules and were managed with direct ice packing. Ipsilateral vocal cord (VC) hypomobility was confirmed via real-time laryngeal ultrasound, followed by immediate application of ice to the skin overlying the thyroid. VC movement and skin integrity were assessed every 10 min. All patients achieved complete symptom resolution within 20-50 min (median: 30 min) without complications. No cold-induced skin injury occurred, and no additional treatment was required. While spontaneous recovery cannot be excluded, the relatively rapid improvement observed in this series suggests that direct ice packing may represent a safe, practical, and noninvasive management option for RFA-related voice changes. Further studies are warranted to confirm its efficacy in larger and more diverse populations.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"7160959"},"PeriodicalIF":0.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfasalazine-Induced Urinary Normetanephrine Elevation Mimicking Recurrent Phaeochromocytoma-A Case Report.","authors":"Maria Hadjicosti, Anastasia Papapostolou, Michail Papoulas, Evdoxia Poulianiti, Nikoleta Christodoulidou, Michalis K Picolos","doi":"10.1155/crie/6661577","DOIUrl":"https://doi.org/10.1155/crie/6661577","url":null,"abstract":"<p><p>Phaeochromocytomas and paragangliomas (PPGLs) are catecholamine-secreting neuroendocrine tumours (NETs) of the adrenal medulla and autonomic nervous system. Early recognition and management is critical given their potential morbidity and mortality. For this reason, stand-alone screening investigations rely on a low diagnostic threshold, achieving high sensitivity at the relative cost of specificity. Following diagnosis, the only curative option is surgical removal of the tumour. Similar investigations are employed for postoperative surveillance. Persistent urinary normetanephrine elevation after curative phaeochromocytoma resection is rare and may lead to unnecessary investigations and anxiety. Our case highlights a previously underreported cause-analytical interference from sulfasalazine-and underscores the importance of considering medication effects in postoperative biochemical surveillance. We hereby present a 73-year-old Caucasian woman with a history of rheumatoid arthritis treated with sulfasalazine, hypertension, type 2 diabetes and hypothyroidism who exhibited persistently and significantly elevated urine normetanephrine, up to 15 months following successful surgical resection of a phaeochromocytoma. This was secondary to long-term sulfasalazine use, causing gross interference with laboratory urine normetanephrine analysis without interfering with the serum normetanephrine value. Discontinuation of sulfasalazine normalised the urine normetanephrine results. This case identifies sulfasalazine as a clinically relevant source of urine normetanephrine assay interference, reinforcing the need for careful interpretation of biochemical diagnostic or surveillance results.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"6661577"},"PeriodicalIF":0.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Misuse of Insulin in an Adolescent With Type 1 Diabetes: A Case Report and Management Implications.","authors":"Sara C Pender, Mohamed Adil Shah Khoodoruth","doi":"10.1155/crie/3651243","DOIUrl":"https://doi.org/10.1155/crie/3651243","url":null,"abstract":"<p><strong>Introduction: </strong>In Canada, nearly one in five children present with diabetic ketoacidosis (DKA) at the time of their first diabetes diagnosis, a serious and potentially life-threatening complication. Adolescence, marked by insulin resistance, fluctuating appetite, and increasing independence, presents unique challenges for diabetes management. Suicidality is more prevalent in adolescents with type 1 diabetes, with higher rates of ideation and attempts compared to peers without the condition. Insulin misuse, whether by omission or deliberate insulin overdose, is increasingly recognized as a maladaptive coping strategy linked to body image concerns, diabetes-related distress, and psychiatric comorbidity, further compounding vulnerability.</p><p><strong>Case report: </strong>A 15-year-old female with type 1 diabetes mellitus, diagnosed at age 11, was admitted to child and adolescent psychiatry following a suicide attempt by insulin overdose delivered via her Tandem X2 Control IQ insulin pump. She had a history of multiple suicide attempts, typically in the context of acute psychosocial stressors, and recently transitioned to foster care. Biochemistry revealed suboptimal glycemic control (HbA1c 8.5%) and mild metabolic acidosis. A multidisciplinary review led to targeted insulin adjustments and the introduction of a pump passcode lock, restricting unsupervised bolus dosing as a safeguarding measure against insulin overdose. Psychiatric management was optimized, and coordinated aftercare planning was arranged with child protection, endocrinology, and mental health services.</p><p><strong>Conclusion: </strong>This case illustrates insulin manipulation as a means of self-harm in adolescence. The current admission involved a deliberate insulin overdose with mild DKA in the context of a history of insulin omission and more severe DKA episodes. Few published reports describe such dual misuse, underscoring the need to explicitly assess both behaviors in routine care. In this instance, reintroduction of pump therapy with passcode-protected bolus delivery and tailored alarm configurations provided an additional safeguard, highlighting the potential for diabetes technology, when thoughtfully configured, to augment safety alongside psychiatric and psychosocial intervention.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"3651243"},"PeriodicalIF":0.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12910172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonmetastatic Pulmonary Carcinoid Presenting With Carcinoid Syndrome Despite Negative 5-HIAA: A Case Report.","authors":"Aditya Chauhan, Muhammed Kizilgul, Emilian Racila, Kidmealem Zekarias","doi":"10.1155/crie/2260680","DOIUrl":"https://doi.org/10.1155/crie/2260680","url":null,"abstract":"<p><strong>Background: </strong>Carcinoid syndrome from pulmonary carcinoids without hepatic metastases is rare and diagnostically challenging when biochemical markers are normal.</p><p><strong>Case presentation: </strong>A woman in her mid-60 s presented with an incidental right adrenal mass during evaluation for dyspnea and elevated D-dimer. She reported a 20-year history of paroxysmal tachycardia and 5 years of episodic flushing, profuse sweating, exertional dyspnea, and fine tremors triggered by minimal physical activity. Imaging revealed a 3.6 cm lipid-rich adrenal adenoma and an 8 × 10 mm left upper lobe pulmonary nodule. Comprehensive biochemical evaluation was normal: 24 h urinary 5-hydroxyindoleacetic acid 6 mg/d (normal 0-15), chromogranin A 50 ng/mL (normal 0-187), plasma metanephrine 0.12 nmol/L (normal 0.00-0.49), and normetanephrine 0.68 nmol/L (normal 0.00-0.89), excluding pheochromocytoma. Fine needle aspiration of the left pulmonary nodule confirmed a typical carcinoid tumor. Left upper lobe trisegmentectomy revealed low-grade neuroendocrine neoplasm (pT1b pN0) with minimal mitotic activity (<1 per 10 HPF) and no necrosis. Postoperative 68Ga-DOTATATE PET/CT demonstrated a radiotracer-avid suspicious right lower lobe nodule (SUVmax 2.8) without hepatic metastases. Surgery markedly improved carcinoid syndrome symptoms, with residual episodes responding to long-acting octreotide 20-30 mg every 4 weeks.</p><p><strong>Discussion: </strong>This case illustrates that pulmonary carcinoid tumors can present with carcinoid syndrome despite normal biochemical markers and the absence of hepatic metastases. The temporal improvement following resection and response to octreotide established the diagnosis when biochemical testing was uninformative.</p><p><strong>Conclusion: </strong>Clinicians should maintain high suspicion for pulmonary carcinoids in patients with unexplained paroxysmal symptoms, even with negative biochemical testing and absent metastatic disease.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"2260680"},"PeriodicalIF":0.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Insights on Hypertriglyceridaemia-Induced Acute Pancreatitis in Pregnancy: A Case Series and Literature Review.","authors":"Christopher Son Nguyen, Nicholas Adams, Emily Gianatti, I-Lynn Lee, Dev Kevat","doi":"10.1155/crie/5330997","DOIUrl":"10.1155/crie/5330997","url":null,"abstract":"<p><strong>Context: </strong>Hypertriglyceridaemia-induced pancreatitis in pregnancy (HTG-IPP) is a rare but serious condition. There is a paucity of evidence-based guidelines and recommendations for screening and management of HTG-IPP. Individual genomics can predispose certain populations to a higher risk of developing HTG-IPP.</p><p><strong>Objective: </strong>To report on a case series of the management of four individual pregnancies complicated by HTG-IPP, subsequently found to be associated with pathogenic genetic variants involved in triglyceride (TG) metabolism.</p><p><strong>Methods: </strong>The medical records of four individual pregnancies from two metropolitan hospitals in Australia were reviewed regarding the management of their HTG-IPP and genetic testing for hypertriglyceridaemia (HTG). A literature review of previous cases of HTG-IPP with an identified pathogenic variant was performed.</p><p><strong>Results: </strong>The identified genetic variants resulting in a diagnosis of HTG and HTG-IPP were within glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1), lipoprotein lipase (LPL) and apolipoprotein A5 (APOA-5). All patients had co-morbid gestational diabetes mellitus (GDM) and were of South Asian or Asian ethnicity. All four patients were effectively managed with fasting, intravenous insulin, omega-3 fatty acids (O3FAs) and very low-fat diet (VLFD) with supplementation with medium-chain TG (MCT) oil.</p><p><strong>Conclusion: </strong>Further genomics research is needed to increase our understanding for its use in predicting risk of severe gestational HTG. With additional case identification, particular variants of pathogenic interest can be identified and screened for antenatally in patients with a moderate fasting HTG of more than 200 mg/dL (11.1 mmol/L) in the absence of other causative factors. Pre-conception optimisation of TGs and regular monitoring in pregnancy can reduce the incidence and disease burden associated with HTG-IPP and HTG.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"5330997"},"PeriodicalIF":0.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Known Cushing's Disease in a Nonsurgical Candidate Secondary to a History of Hemorrhagic Stroke Case Report.","authors":"Kyle Distler, Jean Ramos Cardona, Suzanne Martinez","doi":"10.1155/crie/2844939","DOIUrl":"10.1155/crie/2844939","url":null,"abstract":"<p><strong>Background: </strong>Cushing's disease can present with hyperglycemia, hypertension, electrolyte abnormalities, headaches, confusion, gastrointestinal (GI) bleeds, and more. Macroadenomas of the pituitary causing cortisol excess can complicate these cases of patients with a recent hemorrhagic stroke with the medical complexities found within both disease processes of hemorrhagic stroke and Cushing's disease.</p><p><strong>Case: </strong>This is a 61-year-old female patient who returned from a rehabilitation facility after confusion, abdominal pain, vaginal bleeding, and weakness. History included hypertension, hypothyroidism, type 2 diabetes mellitus, suspected Cushing's disease, hemorrhagic stroke, and a lumbar compression fracture. Blood pressure was 195/87 with a potassium of 2.0. X-ray showed a nonobstructive bowel gas pattern, and computed tomography (CT) of the abdomen and pelvis was concerning for stercolitis, multiple pancreatic cysts, and atelectasis. Insulin, intravenous (IV) fluids, and electrolyte replacement were initiated. She developed a deep venous thrombosis (DVT) in the right lower extremity and was placed on enoxaparin. Worsening of GI bleeding occurred, and an inferior vena cava filter was placed. Osilodrostat was started. Colonoscopy showed ulcerations in the sigmoid colon. Pathology showed no findings concerning dysplasia or malignancy. Osilodrostat was increased to 2 mg twice a day. She was discharged home, with follow-ups for resection of her macroadenoma, biopsy of uterine endometrium, and genetic testing.</p><p><strong>Discussion/conclusions: </strong>The clinical manifestations found in this case are largely due to hypercortisolism, and while she is going to still have additional testing including biopsy of the fibroid, colorectal surgical evaluation for hemorrhoids, and genetic testing with confirmatory lab work per endocrinology outpatient, her illness was medically uncontrolled. As osilodrostat takes a couple weeks to a couple months for full control with frequent cortisol checks, adjustments including insulin, blood pressure control, electrolyte corrections, and more should be considered.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"2844939"},"PeriodicalIF":0.9,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Thyroid Carcinoma Combined With Thyroid Hemiagenesis.","authors":"Shaohua Chen, Fengwei Wang, Shenli Huang, Shuting Qin, Junyang Mo, Minmin Zhang, Yan Chen","doi":"10.1155/crie/6636902","DOIUrl":"10.1155/crie/6636902","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Thyroid hemiagenesis (THA) is a rare congenital anomaly characterized by the underdevelopment or complete absence of one thyroid lobe. The coexistence of thyroid carcinoma in patients with this condition is exceedingly uncommon, with only a limited number of cases reported worldwide. Awareness of this presentation is essential due to its diagnostic and therapeutic implications.</p><p><strong>Case presentation: </strong>We report a 36-year-old female who presented with a right thyroid nodule and was subsequently diagnosed with papillary thyroid carcinoma in the context of left THA. Ultrasonography and contrast-enhanced computed tomography (CT) confirmed the absence of the left thyroid lobe and isthmus. Fine-needle aspiration biopsy (FNAB) was not performed due to the small size of the nodule and patient preference. The patient underwent right thyroidectomy with prophylactic right central neck dissection. Intraoperative frozen section confirmed papillary carcinoma, guiding the surgical extent. Postoperative pathology revealed a 0.4 cm papillary carcinoma without lymph node metastasis.</p><p><strong>Clinical discussion: </strong>THA is typically asymptomatic and often discovered incidentally. However, anatomical variations may complicate the diagnosis and surgical management of thyroid carcinoma. Preservation of parathyroid glands, recurrent laryngeal nerves, and awareness of possible ectopic thyroid tissue, are critical during surgery.</p><p><strong>Conclusion: </strong>Papillary thyroid carcinoma occurring in THA is rare but clinically significant. This case highlights the importance of careful preoperative assessment and the value of intraoperative frozen section analysis in determining the need for central neck dissection. Early detection, individualized surgical planning, and multidisciplinary follow-up can optimize outcomes in such atypical presentations.</p>","PeriodicalId":9621,"journal":{"name":"Case Reports in Endocrinology","volume":"2026 ","pages":"6636902"},"PeriodicalIF":0.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}