Cardiovascular Ultrasound最新文献

{"title":"Evaluation of right myocardial performance index of in vitro fertilization fetuses and spontaneous pregnancy fetuses: a cross-sectional study.","authors":"Shaoqi Chen,&nbsp;Zemin Zhuang,&nbsp;Qingzi Chen,&nbsp;Xiya Du,&nbsp;Weiping Li,&nbsp;Xuerui Tan","doi":"10.1186/s12947-021-00242-5","DOIUrl":"https://doi.org/10.1186/s12947-021-00242-5","url":null,"abstract":"<p><strong>Background: </strong>Whether the in vitro fertilization (IVF) has an effect on the cardiac function of the fetus is very important to evaluate the safety of the technique. The aim of this paper is to establish normal reference range for the fetal right myocardial performance index (RMPI), and compare the reference range between IVF fetuses and spontaneous pregnancy (SP) fetuses by automatic measurement of the RMPI.</p><p><strong>Methods: </strong>Three hundred seventy-one spontaneous singleton pregnancies (the control group) and 39 singleton pregnancies conceived by IVF (the experimental group) were enrolled into the current study. An automatic measurement system was used to acquire the RMPI. The cardiac function of the two groups was compared by t-test.</p><p><strong>Results: </strong>There was no significant difference in normal reference range of RMPI between IVF fetuses and SP fetuses (RMPI 0.42 ± 0.05 vs 0.43 ± 0.05). No strong correlation was also noted between RMPI with gestational age and heart rate.</p><p><strong>Conclusions: </strong>Normal reference ranges of RMPI of IVF fetuses and SP fetuses were established, and no significant difference between IVF fetuses and SP fetuses in RMPI was found. Thus, these findings may suggest that IVF has little impact on cardiac function of the fetus.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"13"},"PeriodicalIF":1.9,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-021-00242-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25310635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal evaluation of fetal atrioventricular valves by real-time 4D volume imaging with electronic matrix probe.","authors":"Huiyu Tang,&nbsp;Wei Sun,&nbsp;Xue Sun,&nbsp;Yu Wang,&nbsp;Yu Qi,&nbsp;Dong Wang,&nbsp;Ying Zhang","doi":"10.1186/s12947-021-00240-7","DOIUrl":"https://doi.org/10.1186/s12947-021-00240-7","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study is to evaluate the feasibility using real-time four-dimensional (RT 4D) volume imaging with electronic matrix probe to observe the morphology of atrioventricular valves in normal and abnormal fetuses, measure the area and circumference of atrioventricular valves in normal fetuses and analyze the correlation with gestational age.</p><p><strong>Methods: </strong>RT 4D volume imaging with electronic matrix probe was used to collect cardiac volume data of 162 normal fetuses with the gestational age from 22 to 32 weeks and 19 fetuses with atrioventricular valves abnormalities were also enrolled. All the volume data were analyzed and processed in real-time. The morphology of mitral and tricuspid valves was observed in surface mode. The area and circumference of valves were measured in a 4D render view at the end of diastole and analyzed the correlation with gestational age.</p><p><strong>Results: </strong>In 148 of 162 fetuses (91%), the 4D rendered image could be successfully obtained, which clearly showed the morphology of the atrioventricular valves. The area and circumference of mitral and tricuspid valves were positively correlated with gestational age (P < 0.01). Furthermore, 4D rendered images were successfully obtained in 17 of 19 fetuses (89%) with atrioventricular valves abnormalities.</p><p><strong>Conclusions: </strong>The reference range of the area and circumference of atrioventricular valves in normal fetuses at different gestational weeks could be determined by using the RT 4D volume imaging with electronic matrix probe, which can provide certain diagnostic information for the clinic. The RT 4D images could display the valves morphology vividly in both normal and abnormal fetuses, including some subtle lesions which are not identified by traditional two-dimensional (2D) echocardiography. It is feasible to use the RT 4D volume imaging with electronic matrix probe to perform the prenatal evaluation in the fetal atrioventricular valves.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"11"},"PeriodicalIF":1.9,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-021-00240-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38871225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Usefulness of speckle tracking echocardiography and biomarkers for detecting acute cellular rejection after heart transplantation.","authors":"Cecilia Beatriz Bittencourt Viana Cruz,&nbsp;Ludhmila A Hajjar,&nbsp;Fernando Bacal,&nbsp;Marco S Lofrano-Alves,&nbsp;Márcio S M Lima,&nbsp;Maria C Abduch,&nbsp;Marcelo Luiz Campos Vieira,&nbsp;Hsu P Chiang,&nbsp;Juliana B C Salviano,&nbsp;Isabela Bispo Santos da Silva Costa,&nbsp;Julia Tizue Fukushima,&nbsp;Joao C N Sbano,&nbsp;Wilson Mathias,&nbsp;Jeane M Tsutsui","doi":"10.1186/s12947-021-00241-6","DOIUrl":"https://doi.org/10.1186/s12947-021-00241-6","url":null,"abstract":"","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"12"},"PeriodicalIF":1.9,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-021-00241-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38870789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aborted sudden cardiac death due to ventricular fibrillation in a female patient with mitral valve prolapse.","authors":"Sofien Ayed,&nbsp;Rainer Hoffmann","doi":"10.1186/s12947-020-00236-9","DOIUrl":"https://doi.org/10.1186/s12947-020-00236-9","url":null,"abstract":"<p><strong>Background: </strong>Mitral valve prolapse is the most frequent valvular defect associated with a wide range of electro-hemodynamic abnormalities, leading to heart failure, arrhythmias and sudden cardiac death. Mitral valve prolapse, first described from Barlow in the 1960s, is defined as displacement of mitral leaflet tissue into the left atrium past the mitral annular plane during systole. The correlation between mitral valve prolapse and sudden cardiac death has been investigated and clarified by various studies in recent years. However, identifying patients at risk and applying measures to prevent those from sudden cardiac death is challenging.</p><p><strong>Case presentation: </strong>We report on a 61-year-old female patient who had undergone an aborted sudden cardiac death. An arrythmogenic mitral valve prolapse was diagnosed. In addition, electrocardiographically and morphologically risk markers for sudden cardiac death were found in this case. We performed an ICD implantation as secondary prophylaxis and intended to reconstruct the mitral valve.</p><p><strong>Conclusion: </strong>This article examines the association of mitral valve prolapse with sudden cardiac death, the underlying pathophysiological mechanisms and the strategies leading to identify the risk group.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"10"},"PeriodicalIF":1.9,"publicationDate":"2021-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-020-00236-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38801347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicentric quality-control study of exercise Doppler echocardiography of the right heart and the pulmonary circulation. The RIGHT Heart International NETwork (RIGHT-NET).","authors":"Francesco Ferrara,&nbsp;Luna Gargani,&nbsp;Carla Contaldi,&nbsp;Gergely Agoston,&nbsp;Paola Argiento,&nbsp;William F Armstrong,&nbsp;Francesco Bandera,&nbsp;Filippo Cademartiri,&nbsp;Rodolfo Citro,&nbsp;Antonio Cittadini,&nbsp;Rosangela Cocchia,&nbsp;Michele D'Alto,&nbsp;Antonello D'Andrea,&nbsp;Philipp Douschan,&nbsp;Stefano Ghio,&nbsp;Ekkehard Grünig,&nbsp;Marco Guazzi,&nbsp;Stefania Guida,&nbsp;Jaroslaw D Kasprzak,&nbsp;Theodore John Kolias,&nbsp;Giuseppe Limongelli,&nbsp;Alberto Maria Marra,&nbsp;Matteo Mazzola,&nbsp;Ciro Mauro,&nbsp;Antonella Moreo,&nbsp;Francesco Pieri,&nbsp;Lorenza Pratali,&nbsp;Nicola Riccardo Pugliese,&nbsp;Mauro Raciti,&nbsp;Brigida Ranieri,&nbsp;Lawrence Rudski,&nbsp;Rajan Saggar,&nbsp;Andrea Salzano,&nbsp;Walter Serra,&nbsp;Anna Agnese Stanziola,&nbsp;Mani Vannan,&nbsp;Damien Voilliot,&nbsp;Olga Vriz,&nbsp;Karina Wierzbowska-Drabik,&nbsp;Robert Naeije,&nbsp;Eduardo Bossone","doi":"10.1186/s12947-021-00238-1","DOIUrl":"https://doi.org/10.1186/s12947-021-00238-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study was a quality-control study of resting and exercise Doppler echocardiography (EDE) variables measured by 19 echocardiography laboratories with proven experience participating in the RIGHT Heart International NETwork.</p><p><strong>Methods: </strong>All participating investigators reported the requested variables from ten randomly selected exercise stress tests. Intraclass correlation coefficients (ICC) were calculated to evaluate the inter-observer agreement with the core laboratory. Inter-observer variability of resting and peak exercise tricuspid regurgitation velocity (TRV), right ventricular outflow tract acceleration time (RVOT Act), tricuspid annular plane systolic excursion (TAPSE), tissue Doppler tricuspid lateral annular systolic velocity (S'), right ventricular fractional area change (RV FAC), left ventricular outflow tract velocity time integral (LVOT VTI), mitral inflow pulsed wave Doppler velocity (E), diastolic mitral annular velocity by TDI (e') and left ventricular ejection fraction (LVEF) were measured.</p><p><strong>Results: </strong>The accuracy of 19 investigators for all variables ranged from 99.7 to 100%. ICC was > 0.90 for all observers. Inter-observer variability for resting and exercise variables was for TRV = 3.8 to 2.4%, E = 5.7 to 8.3%, e' = 6 to 6.5%, RVOT Act = 9.7 to 12, LVOT VTI = 7.4 to 9.6%, S' = 2.9 to 2.9% and TAPSE = 5.3 to 8%. Moderate inter-observer variability was found for resting and peak exercise RV FAC (15 to 16%). LVEF revealed lower resting and peak exercise variability of 7.6 and 9%.</p><p><strong>Conclusions: </strong>When performed in expert centers EDE is a reproducible tool for the assessment of the right heart and the pulmonary circulation.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"9"},"PeriodicalIF":1.9,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-021-00238-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38840635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the views and methods of ultrasonic screening and diagnosis for abnormal aortic arch in infants.","authors":"Xinjian He,&nbsp;Jiaoyang Chen,&nbsp;Gaoyang Li","doi":"10.1186/s12947-021-00237-2","DOIUrl":"https://doi.org/10.1186/s12947-021-00237-2","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to explore echocardiographic views and methods of aortic arch anomalies in infants, so as to improve the screening sensitivity and diagnostic accuracy.</p><p><strong>Methods: </strong>140 children with abnormal aortic arch diagnosed by ultrasound in Children's Hospital of Hebei Province from January 2014 to December 2019 were selected for retrospective analysis. All were confirmed by surgery or/and computerized tomography angiography. Series of views for aortic arch (the three-vessel and tracheal view, aortic arch short axis view, left aortic arch long axis view, aortic arch long axis continuous scan views) were performed in all cases on the basis of the routine views of echocardiography. The screening sensitivity and diagnostic coincidence rate of different echocardiographic views for aortic arch anomalies were analyzed.</p><p><strong>Results: </strong>Among the 140 infants, right aortic arch were 21 cases (6/21 were accompanied by mirror branch and 15/21 were with aberrant left subclavian artery). Left aortic arch with aberrant right subclavian artery were 2 cases, and double aortic arch with both arches open were 20 cases. Double aortic arch with left arch atresia were 2 cases, and atresia of the proximal aorta with aortic arch dysplasia was 1 case. Coarctation of the aorta were 67 cases, and interruption of aortic arch were 27 cases. All the patients were correctly diagnosed except that 2 infants with interruption of aortic arch were incorrectly diagnosed as coarctation of the aorta, and 1 infant with coarctation of the aorta was misdiagnosed as interruption of aortic arch by echocardiography. The screening sensitivities of four views and four-view combination for abnormal aortic arch were 99.3, 73.6, 87.1, 99.3, and 100%; the diagnostic coincidence rates were 85.7, 27.1,66.4, 95.0%, and 97.9% respectively. On the basis of traditional left aortic long axis view, other three views had their own advantages. The screening sensitivity and diagnostic coincidence rate of four-view combination were significantly improved.</p><p><strong>Conclusions: </strong>The three-vessel trachea view is simple and feasible, which is suitable for screening abnormal aortic arch. The combination of four views conduces to improving screening sensitivity and diagnostic accuracy of aortic arch abnormalities.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"8"},"PeriodicalIF":1.9,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-021-00237-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38819999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of speckle tracking echocardiography and biomarkers for detecting acute cellular rejection after heart transplantation.","authors":"Cecilia Beatriz Bittencourt Viana Cruz,&nbsp;Ludhmila A Hajjar,&nbsp;Fernando Bacal,&nbsp;Marco S Lofrano-Alves,&nbsp;Márcio S M Lima,&nbsp;Maria C Abduch,&nbsp;Marcelo L C Vieira,&nbsp;Hsu P Chiang,&nbsp;Juliana B C Salviano,&nbsp;Isabela Bispo Santos da Silva Costa,&nbsp;Julia Tizue Fukushima,&nbsp;Joao C N Sbano,&nbsp;Wilson Mathias,&nbsp;Jeane M Tsutsui","doi":"10.1186/s12947-020-00235-w","DOIUrl":"https://doi.org/10.1186/s12947-020-00235-w","url":null,"abstract":"<p><strong>Background: </strong>Acute cellular rejection (ACR) is a major complication after heart transplantation. Endomyocardial biopsy (EMB) remains the gold standard for its diagnosis, but it has concerning complications. We evaluated the usefulness of speckle tracking echocardiography (STE) and biomarkers for detecting ACR after heart transplantation.</p><p><strong>Methods: </strong>We prospectively studied 60 transplant patients with normal left and right ventricular systolic function who underwent EMB for surveillance 6 months after transplantation. Sixty age- and sex-matched healthy individuals constituted the control group. Conventional echocardiographic parameters, left ventricular global longitudinal, radial and circumferential strain (LV-GLS, LV-GRS and LV-GCS, respectively), left ventricular systolic twist (LV-twist) and right ventricular free wall longitudinal strain (RV-FWLS) were analyzed just before the procedure. We also measured biomarkers at the same moment.</p><p><strong>Results: </strong>Among the 60 studied patients, 17 (28%) had severe ACR (grade ≥ 2R), and 43 (72%) had no significant ACR (grade 0 - 1R). The absolute values of LV-GLS, LV-twist and RV-FWLS were lower in transplant patients with ACR degree ≥ 2 R than in those without ACR (12.5% ± 2.9% vs 14.8% ± 2.3%, p=0.002; 13.9° ± 4.8° vs 17.1° ± 3.2°, p=0.048; 16.6% ± 2.9% vs 21.4%± 3.2%, p < 0.001; respectively), while no differences were observed between the LV-GRS or LV-GCS. All of these parameters were lower in the transplant group without ACR than in the nontransplant control group, except for the LV-twist. Cardiac troponin I levels were significantly higher in patients with significant ACR than in patients without significant ACR [0.19 ng/mL (0.09-1.31) vs 0.05 ng/mL (0.01-0.18), p=0.007]. The combination of troponin with LV-GLS, RV-FWLS and LV-Twist had an area under curve for the detection of ACR of 0.80 (0.68-0.92), 0.89 (0.81-0.93) and 0.79 (0.66-0.92), respectively.</p><p><strong>Conclusion: </strong>Heart transplant patients have altered left ventricular dynamics compared with control individuals. The combination of troponin with strain parameters had higher accuracy for the detection of ACR than the isolated variables and this association might select patients with a higher risk for ACR who will benefit from an EMB procedure in the first year after heart transplantation.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"6"},"PeriodicalIF":1.9,"publicationDate":"2021-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-020-00235-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39148815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of left atrial and left atrial appendage mechanics in the risk stratification of stroke in patients with atrial fibrillation.","authors":"Yankai Mao,&nbsp;Chan Yu,&nbsp;Yuan Yang,&nbsp;Mingming Ma,&nbsp;Yunhe Wang,&nbsp;Ruhong Jiang,&nbsp;Ran Chen,&nbsp;Bowen Zhao,&nbsp;Chenyang Jiang","doi":"10.1186/s12947-020-00232-z","DOIUrl":"https://doi.org/10.1186/s12947-020-00232-z","url":null,"abstract":"<p><strong>Background: </strong>Left atrial (LA) and left atrial appendage (LAA) dysfunction has been demonstrated to contribute to atrial fibrillation (AF)-related stroke. However, usefulness of LA and LAA mechanics has not been fully compared. We sought to investigate the association of LA and LAA mechanics with stroke and to compare their diagnostic values in the risk stratification of stroke in patients with nonvalvular AF.</p><p><strong>Methods: </strong>A total of 208 consecutive patients with AF (63.58 ± 10.37 years, 63.9% male,57.7% persistent AF) who underwent echocardiography before catheter ablation were prospectively enrolled. Speckle-tracking was used to measure LA and LAA global longitudinal strain (GLS). LA and LAA mechanical dispersions (MD) were defined as the standard deviation (SD) of time to peak positive strain corrected by the R-R interval.</p><p><strong>Results: </strong>Patients with prior stroke/ transient ischemic attack (TIA) (n = 31) had significantly higher LA and LAA MD than those without (n = 177) (11.56 ± 4.38% vs. 8.43 ± 3.44%, 15.15 ± 5.46% vs. 10.94 ± 4.40%, both P < 0.01). In multivariable analysis, LA and LAA MD were independently associated with stroke/TIA (odds ratio, 1.18-1.29, 1.19-1.22, respectively, both P < 0.01), providing incremental values over clinical and standard echocardiographic parameters. In a subgroup analysis, LA MD was more useful than LAA MD in patients with normal LA volumes, while LAA MD was superior to LA MD in patients with LA enlargement.</p><p><strong>Conclusions: </strong>Higher LA and LAA mechanical dispersion are independently associated with stroke/TIA in AF patients and had incremental values over clinical and conventional echocardiographic parameters. What's more, priorities of dispersion assessment are different depending on patients' LA size.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"7"},"PeriodicalIF":1.9,"publicationDate":"2021-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-020-00232-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38800345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic effect of increased left ventricular wall thickness in severe aortic stenosis.","authors":"Kyungil Park,&nbsp;Tae-Ho Park,&nbsp;Yoon-Seong Jo,&nbsp;Young-Rak Cho,&nbsp;Jong-Sung Park,&nbsp;Moo-Hyun Kim,&nbsp;Young-Dae Kim","doi":"10.1186/s12947-020-00234-x","DOIUrl":"https://doi.org/10.1186/s12947-020-00234-x","url":null,"abstract":"<p><strong>Background: </strong>It is unclear whether increased left ventricular (LV) thickness is associated with worse clinical outcomes in severe aortic stenosis (AS). The aim of this study was to determine the effect of increased LV wall thickness (LVWT) on major clinical outcomes in patients with severe AS.</p><p><strong>Methods and results: </strong>This study included 290 severe AS patients (mean age 69.4 ± 11.0 years; 136 females) between January 2008 and December 2018. For outcome assessment, the endpoint was defined as death from all causes, cardiovascular death, and the aortic valve replacement (AVR) surgery rate. During follow-up (48.7 ± 39.0 months), 157 patients had AVR, 43 patients died, and 28 patients died from cardiovascular causes. Patients with increased LVWT underwent AVR surgery much more than those without LVWT (60.0% vs. 39.0%, p < 0.001). Furthermore, in patients with increased LVWT, the all-cause and cardiovascular death rates were significantly lower in the AVR group than in the non-AVR group (8.8% vs. 27.3%, p < 0.001, 4.8%, vs. 21.0%, p < 0.001). Multivariate analysis revealed that increased LVWT, age, dyspnea, and AVR surgery were significantly correlated with cardiovascular death.</p><p><strong>Conclusions: </strong>In patients with severe AS, increased LVWT was associated with a higher AVR surgery rate and an increased rate of cardiovascular death independent of other well-known prognostic variates. Thus, these findings suggest that increased LVWT might be used as a potential prognostic factor in severe AS patients.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"5"},"PeriodicalIF":1.9,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-020-00234-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38788295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of sarcomere gene mutations to left atrial function in patients with hypertrophic cardiomyopathy.","authors":"Hyemoon Chung,&nbsp;Yoonjung Kim,&nbsp;Chul Hwan Park,&nbsp;In-Soo Kim,&nbsp;Jong-Youn Kim,&nbsp;Pil-Ki Min,&nbsp;Young Won Yoon,&nbsp;Tae Hoon Kim,&nbsp;Byoung Kwon Lee,&nbsp;Bum-Kee Hong,&nbsp;Se-Joong Rim,&nbsp;Hyuck Moon Kwon,&nbsp;Kyung-A Lee,&nbsp;Eui-Young Choi","doi":"10.1186/s12947-020-00233-y","DOIUrl":"https://doi.org/10.1186/s12947-020-00233-y","url":null,"abstract":"<p><strong>Background: </strong>Left atrial (LA) enlargement and dysfunction are related to clinical course in patients with hypertrophic cardiomyopathy (HCM). We aimed to investigate genetic contribution to LA structural and functional remodeling.</p><p><strong>Methods: </strong>Two hundred twelve patients were consecutively enrolled, and echocardiography and extensive genetic analysis were performed. Cardiac magnetic resonance (CMR) was performed in 135 patients. Echocardiography was also performed in controls (n = 30).</p><p><strong>Results: </strong>Patients with HCM had lower late-diastolic mitral annular velocity (a') and higher LA volume index (LAVI) than controls. Patients with pathogenic or likely pathogenic sarcomere gene mutations (PSM, n = 67, 32%) had higher LAVI and lower CMR-derived LA total emptying fraction (37.0 ± 18.5 vs. 44.2 ± 12.4%, p = 0.025). In patients without AF (n = 187), the PSM had lower a' (6.9 ± 2.0 vs. 7.8 ± 1.9 cm/s, p = 0.004) than others. The PSM had higher prevalence and amount of late gadolinium enhancement (LGE) in the left ventricle (LV). In multivariate analysis, PSM was significantly related to lower a' independent of E/e', LV mass index, and LAVI. However, the relation significantly attenuated after adjustment for the extent of LGE in the LV, suggesting common myopathy in the LV and LA. In addition, PSM was significantly related to lower LA total emptying fraction independent of age, E/e', s', LV ejection fraction, LV myocardial global longitudinal strain and %LGE mass.</p><p><strong>Conclusions: </strong>PSM was related to LA dysfunction independent of LV filling pressure and LAVI, suggesting its contribution to atrial myopathy in HCM.</p>","PeriodicalId":9613,"journal":{"name":"Cardiovascular Ultrasound","volume":"19 1","pages":"4"},"PeriodicalIF":1.9,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12947-020-00233-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39124510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}