Cancer Biology & Medicine最新文献

{"title":"Vitamin D potentiates STING agonist-induced antitumor immunity in NSCLC.","authors":"Ke Li, Guichao Liu, Wenhui Yuan, Xinhai Zhu, Peng Li","doi":"10.20892/j.issn.2095-3941.2026.0211","DOIUrl":"https://doi.org/10.20892/j.issn.2095-3941.2026.0211","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal B7H3 drives immunosuppression and serves as a biomarker for PD-1 blockage response in head and neck squamous cell carcinoma.","authors":"Wen Wang, Chulong Xie, Juncong Luo, Leru Kuang, Yihong Wu, Nini Li, Xiaoli Liu, Xiaoyu Feng, Zizi Li, Zhanyu Li, Hongyu Zhang, Jiaoping Mi, Qi Zeng","doi":"10.20892/j.issn.2095-3941.2025.0835","DOIUrl":"https://doi.org/10.20892/j.issn.2095-3941.2025.0835","url":null,"abstract":"<p><strong>Objective: </strong>Patients with head and neck squamous cell carcinoma (HNSCC) display a remarkably low response rate to immune checkpoint inhibitor (ICI) therapy. Currently, there is an urgent unmet need for reliable non-invasive biomarkers capable of predicting clinical therapeutic outcomes. This study sought to elucidate the role of exosomal B7H3 in the HNSCC immune microenvironment and evaluate the potential utility of B7H3 as a predictive biomarker for ICI therapy.</p><p><strong>Methods: </strong>Exosomal B7H3 was characterized <i>via</i> transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). The biological functions and regulatory mechanisms underlying exosomal B7H3 were explored using Western blot, ELISA, flow cytometry, and immunofluorescence staining. <i>In vivo</i> animal studies and immunohistochemical (IHC) analyses of clinical tissue specimens were further performed to verify the <i>in vitro</i> findings.</p><p><strong>Results: </strong>In the present study secretion of exosomal B7H3 was significantly elevated in HNSCC. Functional assays confirmed that HNSCC-derived exosomal B7H3 mediates robust immunosuppression both <i>in vitro</i> and <i>in vivo</i>. Notably, HNSCC cells exhibited a mutually exclusive pattern of B7H3 and PD-L1 expression. Specifically, high B7H3 expression was closely associated with resistance to anti-PD-1 therapy. A significant negative correlation was detected between circulating exosomal B7H3 and exosomal PD-L1 levels. Furthermore, HNSCC patients with high circulating exosomal B7H3 levels exhibited poorer responses to anti-PD-1 treatment compared to HNSCC patients with low exosomal B7H3 expression.</p><p><strong>Conclusions: </strong>The findings herein demonstrated that exosomal B7H3 exerts potent immunosuppressive effects and displays a mutually exclusive expression pattern with PD-L1, thereby contributing to anti-PD-1 immunotherapy resistance in HNSCC. These results provide a solid theoretical basis for using exosomal B7H3 as a non-invasive predictive biomarker and highlight a promising novel therapeutic target for HNSCC patients.</p>","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NSAIDs for PI3K-altered head and neck cancer: a biomarker-driven therapeutic opportunity.","authors":"Jovanka Gencel-Augusto, Daniel E Johnson, Jennifer R Grandis","doi":"10.20892/j.issn.2095-3941.2026.0202","DOIUrl":"10.20892/j.issn.2095-3941.2026.0202","url":null,"abstract":"<p><p>Non-steroidal anti-inflammatory drugs (NSAIDs), primarily aspirin, have long been studied for their anti-cancer properties. Epidemiologic studies have reported diminished rates of several cancers in regular NSAID users. NSAIDs inhibit cyclooxygenase (COX) enzymes, thus decreasing the production of pro-inflammatory prostaglandins, which are known to stimulate tumor growth. Efforts to characterize the molecular features of human cancer, such as The Cancer Genome Atlas (TCGA), have revealed the presence of genetic alterations that activate the Phosphoinositide 3-kinase (PI3K) signaling pathway in a large subset of cancers, including head and neck squamous cell carcinoma (HNSCC). Mutation or amplification of the <i>PIK3CA</i> oncogene, or decreased expression of the tumor suppressor protein phosphatase and tensin homolog (PTEN), is found in one-third of HNSCCs. Cumulative evidence from retrospective clinical analyses and preclinical laboratory studies has demonstrated the anti-tumor effects of NSAIDs, including aspirin, in PI3K-altered HNSCC. In a recent trial, daily aspirin significantly decreased disease recurrence in PI3K-altered colorectal cancer, thus providing a compelling justification for a prospective trial of aspirin in HNSCC. Given the prevalence of PI3K alterations in HNSCC, aspirin has potential to benefit nearly 1 million patients with HNSCC annually worldwide.</p>","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells.","authors":"Wei Tang, Yu Wu, Xin Qi, Rilei Yu, Zhimin Lu, Ao Chen, Xinglong Fan, Jing Li","doi":"10.20892/j.issn.2095-3941.2026.0435","DOIUrl":"https://doi.org/10.20892/j.issn.2095-3941.2026.0435","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less is more: patients with cervical cancer benefit from de-escalated chemotherapy plus immuno-targeted therapies.","authors":"Bohao Zheng, Dian Fan, Shengtao Zhou","doi":"10.20892/j.issn.2095-3941.2026.0139","DOIUrl":"10.20892/j.issn.2095-3941.2026.0139","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148307102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling molecular incomplete response (mIR) <i>via</i> ultra-deep NGS: a novel concept contrasting pathologic complete response (pCR) in occult lymph node micrometastases of non-small cell lung cancer.","authors":"Meng Lu, Ran Zhang, Haidi Xu, Bingsheng Sun, Peng Chen, Xuan Gao, Meiming Zhong, Jian You","doi":"10.20892/j.issn.2095-3941.2026.0171","DOIUrl":"10.20892/j.issn.2095-3941.2026.0171","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13498876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal ablation <i>versus</i> loop electrosurgical excision procedure and cold knife conization for cervical intraepithelial neoplasia: efficacy and HPV clearance in a 5-year cohort of Chinese women.","authors":"Meiwen Yuan, Xuelian Zhao, Shangying Hu, Shuang Zhao, Qinjing Pan, Xun Zhang, Xianzhi Duan, Fanghui Zhao","doi":"10.20892/j.issn.2095-3941.2025.0415","DOIUrl":"https://doi.org/10.20892/j.issn.2095-3941.2025.0415","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the 5-year efficacy of thermal ablation (TA) for cervical intraepithelial neoplasia (CIN) and high-risk HPV (hrHPV) clearance in Chinese women.</p><p><strong>Methods: </strong>A total of 17,202 women aged 20-65 years were recruited to screening cohorts in 2017-2018 from 3 rural counties in Shanxi and Inner Mongolia and an urban area in Shenzhen with follow-up evaluations until 2022. The hrHPV-positive women with ablation-eligible lesions on colposcopy underwent biopsy and TA (<i>n</i> = 228) in one visit. A loop electrosurgical excision procedure (LEEP) or cold knife conization (CKC) was recommended for ineligible women with high-grade CIN on histology (<i>n</i> = 106 and 41, respectively), while untreated hrHPV-positive women served as controls. Treated women had annual hrHPV testing and cytology. Untreated women had annual hrHPV testing. Positive cases were referred for colposcopy, with biopsy performed when indicated. Cure rates and hrHPV clearance rates were analyzed using Kaplan-Meier and competing risk models with sub-distribution hazard ratios (SHRs) assessing treatment effects.</p><p><strong>Results: </strong>The 5-year cure rate for CIN1 regressing to normal was 79.0% after TA treatment and the 5-year cure rate for CIN2 regressing to CIN1/normal was 87.9%, comparable to LEEP (90.3%) and CKC (94.4%) for CIN2 (<i>P</i> = 0.54). The TA cure (66.0%) was significantly lower for CIN3 than LEEP and CKC (97.0% and 94.1%; <i>P</i> = 0.006). TA achieved 98.0% 5-year hrHPV clearance in CIN1/normal cases, which was higher than untreated women (87.7%; SHR = 0.81, 95% CI = 0.73-0.90), particularly for HPV16 (SHR = 0.67), HPV31 (SHR = 0.56), and HPV33 (SHR = 0.65). The 5-year hrHPV clearance after TA was comparable to LEEP and CKC for CIN2/3.</p><p><strong>Conclusions: </strong>TA provides durable efficacy for CIN1 and CIN2 and promotes hrHPV clearance, reducing progression risk. It could complement excisional treatments for CIN2 and enhance treatment accessibility in low-resource settings.</p>","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome: an emerging player and therapeutic target in cancer.","authors":"Jun Yu","doi":"10.20892/j.issn.2095-3941.2026.0349","DOIUrl":"10.20892/j.issn.2095-3941.2026.0349","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":"23 5","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the precision use of Chinese PARP inhibitors in ovarian cancer: clinical progress, resistance mechanisms, and future perspectives.","authors":"Jing Yu, Maochen Li, Yuhan Zhu, Shengnan Wang, Yuzhao Jiang, Wei Cui, Lingying Wu","doi":"10.20892/j.issn.2095-3941.2026.0102","DOIUrl":"10.20892/j.issn.2095-3941.2026.0102","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13326598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics and probiotics differentially shape immunotherapy outcomes in non-small cell lung cancer.","authors":"Shuling Ma, Zijun Zhai, Rui Ding, Shijie Shang, Xinyi Liang, Shan Yin, Haofeng Lin, Guomeng Sha, Ran Zhang, Jinming Yu, Qian Song, Dawei Chen","doi":"10.20892/j.issn.2095-3941.2025.0844","DOIUrl":"10.20892/j.issn.2095-3941.2025.0844","url":null,"abstract":"","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}