Cancer Biology & Medicine最新文献_第10页

Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer. 大规模功能缺失扰动揭示了乳腺癌的综合表观遗传调控网络。

IF 5.5 2区医学

Cancer Biology & Medicine Pub Date : 2023-12-07 DOI: 10.20892/j.issn.2095-3941.2023.0276

Yumei Wang, Haiyan Wang, Wei Shao, Yuhui Chen, Yu Gui, Chao Hu, Xiaohong Yi, Lijun Huang, Shasha Li, Dong Wang

{"title":"Large-scale loss-of-function perturbations reveal a comprehensive epigenetic regulatory network in breast cancer.","authors":"Yumei Wang, Haiyan Wang, Wei Shao, Yuhui Chen, Yu Gui, Chao Hu, Xiaohong Yi, Lijun Huang, Shasha Li, Dong Wang","doi":"10.20892/j.issn.2095-3941.2023.0276","DOIUrl":"10.20892/j.issn.2095-3941.2023.0276","url":null,"abstract":"Objective: Epigenetic abnormalities have a critical role in breast cancer by regulating gene expression; however, the intricate interrelationships and key roles of approximately 400 epigenetic regulators in breast cancer remain elusive. It is important to decipher the comprehensive epigenetic regulatory network in breast cancer cells to identify master epigenetic regulators and potential therapeutic targets.Methods: We employed high-throughput sequencing-based high-throughput screening (HTS2) to effectively detect changes in the expression of 2,986 genes following the knockdown of 400 epigenetic regulators. Then, bioinformatics analysis tools were used for the resulting gene expression signatures to investigate the epigenetic regulations in breast cancer.Results: Utilizing these gene expression signatures, we classified the epigenetic regulators into five distinct clusters, each characterized by specific functions. We discovered functional similarities between BAZ2B and SETMAR, as well as CLOCK and CBX3. Moreover, we observed that CLOCK functions in a manner opposite to that of HDAC8 in downstream gene regulation. Notably, we constructed an epigenetic regulatory network based on the gene expression signatures, which revealed 8 distinct modules and identified 10 master epigenetic regulators in breast cancer.Conclusions: Our work deciphered the extensive regulation among hundreds of epigenetic regulators. The identification of 10 master epigenetic regulators offers promising therapeutic targets for breast cancer treatment.","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide drugs: a new direction in cancer immunotherapy. 多肽药物：癌症免疫疗法的新方向。

IF 5.6 2区医学

Cancer Biology & Medicine Pub Date : 2023-12-07 DOI: 10.20892/j.issn.2095-3941.2023.0297

Xinghua Sui, Xiaoshuang Niu, Xiuman Zhou, Yanfeng Gao

引用次数: 0

Improving the value of molecular testing: current status and opportunities in colorectal cancer precision medicine. 提高分子检测的价值:结直肠癌精准医学的现状与机遇。

IF 5.5 2区医学

Cancer Biology & Medicine Pub Date : 2023-11-30 DOI: 10.20892/j.issn.2095-3941.2023.0293

Haiyun Li, Linwei Guo, Chenchen Wang, Xin Hu, Ye Xu

引用次数: 0

Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy. 深入了解b细胞相关的三级淋巴结构和肿瘤免疫治疗。

IF 5.5 2区医学

Cancer Biology & Medicine Pub Date : 2023-11-30 DOI: 10.20892/j.issn.2095-3941.2023.0308

Jilong Yang, Jin Xu, Haotian Liu, Wanyi Xiao, Gengpu Zhang

引用次数: 0

The outpost against cancer: universal cancer only markers. 对抗癌症的前哨:通用的癌症标记。

IF 5.5 2区医学

Cancer Biology & Medicine Pub Date : 2023-11-28 DOI: 10.20892/j.issn.2095-3941.2023.0313

Chengchen Qian, Xiaolong Zou, Wei Li, Yinshan Li, Wenqiang Yu

{"title":"The outpost against cancer: universal cancer only markers.","authors":"Chengchen Qian, Xiaolong Zou, Wei Li, Yinshan Li, Wenqiang Yu","doi":"10.20892/j.issn.2095-3941.2023.0313","DOIUrl":"10.20892/j.issn.2095-3941.2023.0313","url":null,"abstract":"Cancer is the leading cause of death worldwide. Early detection of cancer can lower the mortality of all types of cancer; however, effective early-detection biomarkers are lacking for most types of cancers. DNA methylation has always been a major target of interest because DNA methylation usually occurs before other detectable genetic changes. While investigating the common features of cancer using a novel guide positioning sequencing for DNA methylation, a series of universal cancer only markers (UCOMs) have emerged as strong candidates for effective and accurate early detection of cancer. While the clinical value of current cancer biomarkers is diminished by low sensitivity and/or low specificity, the unique characteristics of UCOMs ensure clinically meaningful results. Validation of the clinical potential of UCOMs in lung, cervical, endometrial, and urothelial cancers further supports the application of UCOMs in multiple cancer types and various clinical scenarios. In fact, the applications of UCOMs are currently under active investigation with further evaluation in the early detection of cancer, auxiliary diagnosis, treatment efficacy, and recurrence monitoring. The molecular mechanisms by which UCOMs detect cancers are the next important topics to be investigated. The application of UCOMs in real-world scenarios also requires implementation and refinement.","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging trends in clinical cancer genomic research. 临床癌症基因组研究的新趋势。

IF 5.5 2区医学

Cancer Biology & Medicine Pub Date : 2023-11-28 DOI: 10.20892/j.issn.2095-3941.2023.0383

Yingyan Yu

引用次数: 0

Single-arm trials for domestic oncology drug approvals in China. 中国国内肿瘤药物审批单臂试验。

IF 5.5 2区医学

Cancer Biology & Medicine Pub Date : 2023-11-27 DOI: 10.20892/j.issn.2095-3941.2023.0360

Hong Zhang, Sen Liu, Chenghao Ge, Xiaozhen Liu, Yang Liu, Chen Yin, Yi Li, Jing An, Zhongtian Yan, Xiaoyuan Chen

引用次数: 0

Progress in oncolytic viruses modified with nanomaterials for intravenous application. 静脉应用纳米材料修饰溶瘤病毒的研究进展。

IF 5.5 2区医学

Cancer Biology & Medicine Pub Date : 2023-11-24 DOI: 10.20892/j.issn.2095-3941.2023.0275

Liting Chen, Zhijun Ma, Chen Xu, Youbang Xie, Defang Ouyang, Shuhui Song, Xiao Zhao, Funan Liu

引用次数: 0

Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer. 靶向机械微环境和肝癌干细胞:一种有前景的肝癌治疗策略。

IF 5.5 2区医学

Cancer Biology & Medicine Pub Date : 2023-11-24 DOI: 10.20892/j.issn.2095-3941.2023.0229

Xiaorong Fu, Yi Zhang, Qing Luo, Yang Ju, Guanbin Song

{"title":"Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer.","authors":"Xiaorong Fu, Yi Zhang, Qing Luo, Yang Ju, Guanbin Song","doi":"10.20892/j.issn.2095-3941.2023.0229","DOIUrl":"10.20892/j.issn.2095-3941.2023.0229","url":null,"abstract":"Over the past 2 decades, cancer stem cells (CSCs) have been identified as the root cause of cancer occurrence, progression, chemoradioresistance, recurrence, and metastasis. Targeting CSCs is a novel therapeutic strategy for cancer management and treatment. Liver cancer (LC) is a malignant disease that can endanger human health. Studies are increasingly suggesting that changes in the liver mechanical microenvironment are a primary driver triggering the occurrence and development of liver cancer. In this review, we summarize current understanding of the roles of the liver mechano-microenvironment and liver cancer stem cells (LCSCs) in liver cancer progression. We also discuss the relationship between the mechanical heterogeneity of liver cancer tissues and LCSC recruitment and metastasis. Finally, we highlight potential mechanosensitive molecules in LCSCs and mechanotherapy in liver cancer. Understanding the roles and regulatory mechanisms of the mechano-microenvironment and LCSCs may provide fundamental insights into liver cancer progression and aid in further development of novel therapeutic strategies.","PeriodicalId":9611,"journal":{"name":"Cancer Biology & Medicine","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10690881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138447222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate IgM antibodies to mannose in patients with gastric cancer. 胃癌患者抗甘露糖的先天性IgM抗体。

IF 5.6 2区医学

Cancer Biology & Medicine Pub Date : 2023-11-17 DOI: 10.20892/j.issn.2095-3941.2023.0156

Maxim Petrovich Nikulin, Nadezhda Vladimirovna Shilova, Alexander Dmitrievich Lipatnikov, Ivan Sokratovich Stilidi, Alexandra Vladimirovna Semyanikhina, Nikolai Vladimirovich Bovin, Nikolai Nikolaevich Tupitsyn

引用次数: 0