食管癌全球负担概况、趋势和贡献者。

IF 5.6 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Yi Teng, Changfa Xia, Maomao Cao, Fan Yang, Xinxin Yan, Siyi He, Mengdi Cao, Shaoli Zhang, Qianru Li, Nuopei Tan, Jiachen Wang, Wanqing Chen
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引用次数: 0

摘要

研究目的本研究旨在全面概述食管癌(EC)的全球负担,并确定影响全球负担变化的时间趋势和因素:方法:从2022年全球食管癌数据库(GLOBALCAN)中获取全球食管癌的最新发病率和死亡率数据。1990-2019年EC的死亡率和残疾调整生命年(DALYs)率来自《2019年全球疾病负担》(2019 Global Burden of Diseases)。利用连接点回归模型分析了11个风险因素或风险群组导致的心血管疾病死亡率和残疾调整生命年的趋势。采用分解法评估了与年龄相关的心血管疾病负担趋势:结果:据估计,2022年全球共确诊511 054例新的心肌梗死病例,死亡人数为445 391人。约75%的病例和死亡病例发生在亚洲。2019年,全球近50%的心血管疾病死亡和残疾调整寿命年数归因于男性吸烟,20%归因于女性体重指数过高。1990-2019年期间,几乎所有风险因素导致的心血管疾病死亡人数和残疾调整寿命年数都呈下降趋势,而高体重指数导致的男性心血管疾病死亡人数和残疾调整寿命年数则呈上升趋势。在人口增长和老龄化的推动下,与年龄相关的心血管疾病负担呈上升趋势,导致30.740万人因心血管疾病死亡,720万人因心血管疾病导致残疾调整寿命年数减少:结论:在全球范围内,心血管疾病造成的负担依然巨大。有效的烟草和肥胖控制措施对于解决欧共体的风险归因负担至关重要。人口增长和老龄化给预防和控制心血管疾病的工作带来了挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Esophageal cancer global burden profiles, trends, and contributors.

Objective: This study aimed to provide a comprehensive overview of the global burden of esophageal cancer (EC) and determine the temporal trends and factors influencing changes in the global burden.

Methods: The latest incidence and mortality data for EC worldwide were obtained from GLOBALCAN 2022. The mortality and disability-adjusted life years (DALYs) rates for EC from 1990-2019 were sourced from the 2019 Global Burden of Diseases. Trends in EC mortality and DALYs attributable to 11 risk factors or clusters of risk were analyzed using the joinpoint regression model. The trends in age-related EC burden were assessed using a decomposition approach.

Results: An estimated 511,054 new cases of EC were diagnosed in 2022 with 445,391 deaths worldwide. Approximately 75% of cases and deaths occurred in Asia. Nearly 50% of global EC deaths and DALYs were attributed to tobacco use in men in 2019, while 20% were attributed to high body mass index (BMI) in women. From 1990-2019, EC deaths and DALYs attributable to almost all risk factors had declining trends, while EC deaths and DALYs attributed to high BMI in men had upward trends. The age-related EC burden exhibited an upward trend driven by population growth and aging, which contributed to 307.4 thousand deaths and 7.2 million DALYs due to EC.

Conclusions: The EC burden remains substantial worldwide. Effective tobacco and obesity control measures are critical for addressing the risk-attributable burden of EC. Population growth and aging pose challenges for EC prevention and control efforts.

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来源期刊
Cancer Biology & Medicine
Cancer Biology & Medicine Medicine-Oncology
CiteScore
9.80
自引率
3.60%
发文量
1143
审稿时长
12 weeks
期刊介绍: Cancer Biology & Medicine (ISSN 2095-3941) is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China.
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