Research progress and challenges in the treatment of oncogene-addicted non-small cell lung cancer.

IF 8.4 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Hanyi Li, Xuanguang Li, Tong Li, Fan Ren, Haochuan Yu, Dianxun Fu, Zuoqing Song, Song Xu
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引用次数: 0

Abstract

Over the past 2 decades, remarkable advancements in the screening, diagnosis, and treatment of non-small cell lung cancer (NSCLC) have led to improved patient outcomes. For the treatment of NSCLC with actionable gene mutations, tyrosine kinase inhibitors developed against EGFR, ALK, RET, BRAF, ROS1, NTRK, MET, and KRAS, exhibit substantial antitumor activity and have been incorporated into standard treatment regimens. Additionally, numerous novel therapies, including immunotherapy and antibody-drug conjugate therapy, have been found to benefit patients with NSCLC. This review summarizes current advancements in targeted therapy for NSCLC, according to a systematic search of the PubMed database and synthesis of cutting-edge findings presented at the 2024 American Society of Clinical Oncology Annual Meeting and 2024 World Conference on Lung Cancer.

癌基因成瘾非小细胞肺癌治疗的研究进展与挑战。
在过去的20年里,非小细胞肺癌(NSCLC)的筛查、诊断和治疗取得了显著进展,改善了患者的预后。对于具有可操作基因突变的NSCLC,针对EGFR、ALK、RET、BRAF、ROS1、NTRK、MET和KRAS的酪氨酸激酶抑制剂具有显著的抗肿瘤活性,并已被纳入标准治疗方案。此外,许多新疗法,包括免疫疗法和抗体-药物结合疗法,已被发现对NSCLC患者有益。根据对PubMed数据库的系统检索和对2024年美国临床肿瘤学会年会和2024年世界肺癌大会上发表的前沿研究结果的综合,本综述总结了目前NSCLC靶向治疗的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Biology & Medicine
Cancer Biology & Medicine Medicine-Oncology
CiteScore
9.80
自引率
3.60%
发文量
1143
审稿时长
12 weeks
期刊介绍: Cancer Biology & Medicine (ISSN 2095-3941) is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China.
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