Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

{"title":"Relation between change of effective lens position and toric IOL rotation after toric IOL implantation","authors":"Kyung-Sun Na , Dohyeon An , Hyun Seung Kim , Eun Chul Kim","doi":"10.1016/j.jcjo.2024.05.011","DOIUrl":"10.1016/j.jcjo.2024.05.011","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the relationship between change of effective lens position (ELP) and toric intraocular lens<span><span> (IOL) rotation in patients with increasing postoperative refractive astigmatism after successful toric </span>IOL implantation.</span></div></div><div><h3>Methods</h3><div><span>The subjects include 61 people (61 eyes) with increasing residual astigmatism >0.5 D 3 months after successful toric IOL implantation. Clinical measurements included preoperative, 1-week, and 1-, 2-, and 3-month postoperative visual acuity; refraction; </span>keratometer<span>; anterior and posterior corneal astigmatism; ELP by Scheimpflug camera imaging; and IOL axis by slit-lamp biomicroscopic photograph with pupil dilation.</span></div></div><div><h3>Results</h3><div>Residual astigmatism in postoperative month 3 (0.81 ± 0.50 D) is higher than that at postoperative week 1 (0.41 ± 0.38 D; <em>p</em> < 0.05). ELP decreased by 264.44 ± 163.25 μm, and the IOL rotated by 2.91 ± 1.44 degrees from week 1 to month 3 (<em>p</em> < 0.05). The ELP change had a positive correlation with IOL rotation (<em>R</em><sup>2</sup> = 0.383; <em>p</em> = 0.006), and the postoperative refractive astigmatic change had a positive correlation with ELP change (<em>R</em><sup>2</sup> = 0.272; <em>p</em> = 0.027) and IOL rotation (<em>R</em><sup>2</sup> = 0.272; <em>p</em> = 0.0001) from week 1 to month 3.</div></div><div><h3>Conclusion</h3><div>ELP change can influence toric IOL rotation and increase residual astigmatism after toric IOL implantation.</div></div><div><h3>Objectif</h3><div>Évaluer le lien entre une modification de la position effective de l'implant (PEI) et la rotation d'une lentille intraoculaire (LIO) torique chez des patients qui présentent un astigmatisme réfractif postopératoire progressif après l'implantation réussie d'une LIO torique.</div></div><div><h3>Méthodes</h3><div>L’étude regroupait 61 patients (61 yeux) qui présentaient un astigmatisme résiduel progressif de > 0,5 D 3 mois après l'implantation réussie d'une LIO torique. Les mesures cliniques comprenaient les suivantes: l'acuité visuelle préopératoire et postopératoire (après 1 semaine et après 1, 2 et 3 mois), la réfraction, la kératométrie, l'astigmatisme cornéen (antérieur et postérieur), la PEI mesurée par imagerie Scheimpflug et l'axe de la LIO mesuré par photographie au biomicroscope (lampe à fente) dans le cadre d'un examen dilaté.</div></div><div><h3>Résultats</h3><div>L'astigmatisme résiduel mesuré 3 mois après l'intervention (0,81 ± 0,50 D) était plus prononcé que celui qui avait été mesuré 1 semaine après l'intervention (0,41 ± 0,38 D; <em>p</em> < 0,05). La PEI a diminué de 264,44 ± 163,25 μm, et la LIO a subi une rotation de 2,91 ± 1,44 degrés entre la première semaine et le troisième mois après l'intervention (<em>p</em> < 0,05). On a observé une corrélation positive entre la variation de la PEI et la rotation de la LIO (<em>R</em><sup>2</sup> =","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages 8-14"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141396169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perspectives on ocular oncology care at hybrid telehealth satellite offices","authors":"Charlotte N. Shields, Chenab K. Khakh, G. Brandon Caudill, Carol L. Shields","doi":"10.1016/j.jcjo.2023.11.005","DOIUrl":"10.1016/j.jcjo.2023.11.005","url":null,"abstract":"<div><h3>Objective</h3><div><span>To assess patient satisfaction with the hybrid telehealth model in patients undergoing follow-up care in </span>ocular oncology.</div></div><div><h3>Design</h3><div>Retrospective survey study.</div></div><div><h3>Participants</h3><div>All patients who visited 1 of 2 satellite telehealth offices between July 2021 and October 2022 for their follow-up ocular oncology appointment.</div></div><div><h3>Methods</h3><div>A 13-question online survey was completed for outcome measures of patient demographics, patient satisfaction with the satellite offices, and overall patient experience with telehealth.</div></div><div><h3>Results</h3><div>The survey response rate was 32% (203 of 632)<em>.</em> The mean patient age was 65 years (median, 65 years), and 119 patients (58%) were female. A comparison (suburban satellite vs urban in-person office) revealed that the suburban satellite office had less difficulty in travel (3% vs 47%; <em>p</em> < 0.001) and less time commitment (<1 hour) for travel to the office (58% vs 23%; <em>p</em> < 0.001). On a scale (i.e., poor, fair, good, or excellent), the percentage of patients reported the following parameters as good or excellent: ease of finding satellite office (95%), check-in (94%), and time spent waiting for the doctor (72%). On a scale (i.e., extremely dissatisfied to extremely satisfied), the percentage of patients reported being extremely satisfied to the following parameters: the staff (81%) and the office overall (65%). Most patients (90%) would use this telehealth model for future visits (<em>p</em> < 0.0001), and 86% would recommend it to a friend (<em>p</em> < 0.0001).</div></div><div><h3>Conclusion</h3><div>In this study on a hybrid telehealth satellite office model for ocular oncology follow-up examinations, patient satisfaction was high, most patients would use this form of examination in the future.</div></div><div><h3>Objectif</h3><div>Mesurer la satisfaction des patients envers un modèle hybride de télémédecine pendant leur suivi en oncologie oculaire.</div></div><div><h3>Nature</h3><div>Étude rétrospective comportant un sondage.</div></div><div><h3>Participants</h3><div>Tous les patients qui se sont présenté à l'un des 2 bureaux satellites de télémédecine entre juillet 2021 et octobre 2022 dans le cadre de leur rendez-vous de suivi en oncologie oculaire.</div></div><div><h3>Méthodes</h3><div>Il s'agissait d'un sondage en ligne de 13 questions dont les paramètres de mesure portaient sur les caractéristiques démographiques des patients, leur satisfaction envers les bureaux satellites et leur expérience globale avec la télémédecine.</div></div><div><h3>Résultats</h3><div>Le taux de réponse au sondage était de 32 % (203 sur 632)<em>.</em> L’âge moyen des patients était de 65 ans (médiane : 65 ans), et 119 patients (58 %) étaient de sexe féminin. Une comparaison (bureau satellite en banlieue vs bureau en personne en milieu urbain) a permis de constater qu","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages e32-e37"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139028664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology of hypopyon in patients presenting acutely to the emergency eye department and characteristics of hypopyon uveitis","authors":"François Pépin , Soobin Namkung , Lilian Koh , Joanne L. Sims , Rachael L. Niederer","doi":"10.1016/j.jcjo.2024.05.003","DOIUrl":"10.1016/j.jcjo.2024.05.003","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the etiology of undifferentiated hypopyon presenting acutely and to better characterize hypopyon uveitis.</div></div><div><h3>Methods</h3><div>Patients with hypopyon were retrospectively identified from presentations to the emergency eye department between January 2015 and 2022 and also from a uveitis database of 3,925 patients seen between January 2008 and January 2022. A total of 426 episodes of hypopyon occurred in 375 eyes in 359 patients, and medical records were reviewed for each patient.</div></div><div><h3>Results</h3><div>In all, 222 hypopyon episodes were due to uveitis, and 204 were due to nonuveitic causes. The most common cause of hypopyon was HLA-B27-associated uveitis in 146 patients (34.3%). The next most common causes were infectious keratitis in 125 patients (29.3%) and endophthalmitis in 63 patients (14.8%). Compared with those presenting with nonuveitic hypopyon, patients with uveitis tended to present younger (<em>p</em> < 0.001), were more likely to be male (<em>p</em> < 0.0001), had better initial and final visual acuities (<em>p</em> < 0.001), and had lower intraocular pressures (<em>p</em> = 0.030).</div></div><div><h3>Conclusion</h3><div>About half of the cases of hypopyon were secondary to uveitis, most of them being associated with HLA-B27 conditions with a good prognosis, and the other half were secondary to infectious keratitis and endophthalmitis with a poor prognosis.</div></div><div><h3>Objectif</h3><div>Examiner l’étiologie de l'hypopyon indifférencié dans sa présentation en aigu et mieux caractériser l'hypopyon secondaire à l'uvéite.</div></div><div><h3>Méthodes</h3><div>Des patients qui présentaient un hypopyon ont été recensés rétrospectivement après avoir été examinés au service des urgences ophtalmologiques entre janvier 2015 et 2022, de même qu'au sein d'une base de données sur l'uvéite comportant 3925 patients examinés de janvier 2008 à janvier 2022. Au total, 426 épisodes d'hypopyon sont survenus dans 375 yeux (359 patients). On a passé en revue les dossiers médicaux de chacun de ces patients.</div></div><div><h3>Résultats</h3><div>Globalement, 222 épisodes d'hypopyon avaient été causés par une uvéite, et 204, par une pathologie autre que l'uvéite. La cause la plus fréquente d'un hypopyon était l'uvéite associée à l'antigène HLA-B27 (146 patients; 34,3 %). Viennent ensuite la kératite infectieuse (125 patients; 29,3 %) et l'endophtalmie (63 patients; 14,8 %). Comparativement aux patients présentant un hypopyon sans lien avec une uvéite, les patients atteints d'une uvéite avaient tendance à être plus jeunes (<em>p</em> < 0,001), étaient plus susceptibles d’être de sexe masculin (<em>p</em> < 0,0001), avaient une meilleure acuité visuelle initiale et finale (<em>p</em> < 0,001) et avaient une pression intraoculaire moins élevée (<em>p</em> = 0,030).</div></div><div><h3>Conclusion</h3><div>Environ la moitié des cas d'hypopyon étaient secondaires à une ","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages 50-56"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Bilateral sequential acute retinal necrosis following administration of an adjuvanted recombinant subunit vaccine for herpes zoster” Canadian Journal of Ophthalmology, volume 59 (2024), e187–e189","authors":"Ankur Ralhan , Adil Al-Mehiawi","doi":"10.1016/j.jcjo.2024.10.001","DOIUrl":"10.1016/j.jcjo.2024.10.001","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Page e184"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the efficacy and safety between femtosecond laser-assisted cataract surgery and conventional phacoemulsification cataract surgery: systematic review and meta-analysis","authors":"Xinzhi Song ,&nbsp;Ling Li ,&nbsp;Xuemei Zhang ,&nbsp;Jianjun Ma","doi":"10.1016/j.jcjo.2024.05.030","DOIUrl":"10.1016/j.jcjo.2024.05.030","url":null,"abstract":"<div><h3>Objectif</h3><div>Comparer l'efficacité et l'innocuité de 2 types de chirurgie de la cataracte : la chirurgie de la cataracte au laser femtoseconde (CCLF) et la phacoémulsification conventionnelle (PC).</div></div><div><h3>Méthodes</h3><div>On a procédé à une recherche systématique des bases de données PubMed, Embase, Cochrane Library, ClinicalTrials.gov, CNKI et Wanfang afin d'en extraire les études comparatives randomisées (ECR). Les principaux paramètres de mesure reposaient sur l'acuité visuelle, les détails relatifs à la capsulotomie, la position effective de l'implant (PEI) et les complications. Les résultats réfractifs de même que les caractéristiques peropératoires et cornéennes comptaient au nombre des paramètres secondaires.</div></div><div><h3>Résultats</h3><div>Au total, 41 ECR réunissant 9310 yeux ont été retenues. On a noté une différence statistiquement significative en faveur de la CCLF – comparativement à la PC – pour ce qui est de l'acuité visuelle non corrigée de loin à 12 mois (différence moyenne [DM] : –0,03; intervalle de confiance [IC] à 95 % : –0,05 à –0,01), de l'acuité visuelle corrigée de loin à 1 semaine (DM : –0,05; IC à 95 % : –0,07 à –0,02) et à 12 mois (DM : –0,02; IC à 95 % : –0,04 à –0,00), de l'aire de la capsulotomie à 1 mois (DM : 4,04 mm²; IC à 95 % : 3,45–4,64) et à 6 mois (DM : 5,02 mm²; IC à 95 % : 3,28–6,77) et de la distance du centre de l'implant par rapport au centre pupillaire à 1 semaine (DM : –0,06 mm; IC à 95 % : –0,08 à –0,05), à 1 mois (DM : –0,07 mm; IC à 95 % : –0,09 à –0,06) et à 6 mois (DM : –0,06 mm; IC à 95 % : –0,07 à –0,04). Au chapitre des complications chirurgicales, la CCLF a eu une incidence moindre de décentrement de la lentille intraoculaire, comparativement à la PC (rapport de cotes: 0,06; IC à 95 % : 0,01–0,24). Enfin, la CCLF n'a pas augmenté l'incidence d'autres complications per- ou postopératoires, à l'exception de l'hémorragie sous-conjonctivale.</div></div><div><h3>Conclusions</h3><div>La CCLF et la PC sont toutes deux sûres et efficaces. La CCLF produit de meilleurs résultats visuels tôt après la chirurgie et pendant le suivi à long terme, sans compter qu'elle a donné lieu à une capsulotomie plus précise et à une meilleure PEI que la PC. Cela dit, aucune différence n'a pu être notée au chapitre des résultats visuels après un suivi de durée intermédiaire.</div></div>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages e1-e10"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inferior vitreous pathology imaged with ultra-wide-field OCT following pneumatic retinopexy","authors":"Isabela Martins Melo ,&nbsp;David T. Wong ,&nbsp;Rajeev H. Muni","doi":"10.1016/j.jcjo.2024.07.010","DOIUrl":"10.1016/j.jcjo.2024.07.010","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Page e161"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior capsular opacification and YAG laser capsulotomy in uveitis patients following cataract surgery","authors":"Grace A. Levy-Clarke ,&nbsp;Craig W. Newcomb ,&nbsp;Gui-Shuang Ying ,&nbsp;Sylvia L. Groth ,&nbsp;Srishti Kothari ,&nbsp;Abhishek Payal ,&nbsp;Hosne Begum ,&nbsp;Teresa L. Liesegang ,&nbsp;C. Stephen Foster ,&nbsp;Douglas A. Jabs ,&nbsp;Robert Nussenblatt ((deceased)) ,&nbsp;James T. Rosenbaum ,&nbsp;H. Nida Sen ,&nbsp;Eric B. Suhler ,&nbsp;Jennifer E. Thorne ,&nbsp;Nirali P. Bhatt ,&nbsp;Kurt A. Dreger ,&nbsp;Jeanine M. Buchanich ,&nbsp;John H. Kempen ,&nbsp;Sapna Gangaputra","doi":"10.1016/j.jcjo.2024.05.004","DOIUrl":"10.1016/j.jcjo.2024.05.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;&lt;span&gt;&lt;span&gt;To evaluate the incidence of visually significant posterior capsule opacification (PCO with visual acuity ≤20/50) and the incidence of Nd:YAG laser &lt;/span&gt;capsulotomy in the year following &lt;/span&gt;cataract surgery for uveitic eyes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;Patients were identified from the Systemic Immunosuppressive Therapy&lt;span&gt; for Eye Diseases&lt;span&gt; (SITE) Cohort Study using a standardized chart review process.&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;&lt;span&gt;Among 1,855 uveitic eyes of 1,370 patients who had undergone cataract surgery, visually significant PCO&lt;span&gt; occurred in 297 eyes (16%), and YAG laser capsulotomy was done in 407 eyes (22%) within the first year following surgery. Higher odds of developing 20/50 visual acuity attributed to PCO were noted in children and young adults compared with adults older than 65 years of age (overall &lt;/span&gt;&lt;/span&gt;&lt;em&gt;p&lt;/em&gt; = 0.03). Poorer preoperative visual acuity (overall &lt;em&gt;p&lt;/em&gt;&lt;span&gt; = 0.0069) and postoperative inflammation (odds ratio [OR] = 1.83; 95% CI, 1.37–2.45; &lt;/span&gt;&lt;em&gt;p&lt;/em&gt; &lt; 0.0001) were associated with PCO incidence. In multivariable analysis, risk factors for YAG laser capsulotomy were younger age groups compared with those older than 65 years of age at the time of surgery (adjusted OR [aOR] = 1.90–2.24; 95% CI, 1.90–2.24; overall &lt;em&gt;p&lt;/em&gt; = 0.0007), female sex (aOR = 1.37; 95% CI, 1.03–1.82; &lt;em&gt;p&lt;/em&gt; = 0.03), postoperative active inflammation (aOR = 165; 95% CI, 1.27–2.16; overall &lt;em&gt;p&lt;/em&gt;&lt;span&gt;&lt;span&gt; &lt; 0.0001), extracapsular cataract extraction compared with &lt;/span&gt;phacoemulsification (aOR = 1.70; 95% CI, 1.17–2.47; overall &lt;/span&gt;&lt;em&gt;p&lt;/em&gt; &lt; 0.0001), and insertion of an intraocular lens (aOR = 4.60; 95% CI, –2.29–9.25; &lt;em&gt;p&lt;/em&gt; &lt; 0.0001). Black race was associated with lower YAG laser capsulotomy incidence than Whites (aOR = 0.36; 95% CI, 0.24–0.52; overall &lt;em&gt;p&lt;/em&gt; &lt; 0.0001).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Vision-reducing (≤20/50) PCO is common, occurring in about one sixth of uveitic eyes within 1 year of cataract surgery; a higher number (22%) of eyes underwent YAG laser capsulotomy within the first year. Age and postoperative inflammation following cataract surgery are the variables most associated with the incidence of visually significant PCO and YAG laser capsulotomy.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectif&lt;/h3&gt;&lt;div&gt;Évaluer l'incidence d'une opacification de la capsule postérieure (OCP) significative sur le plan visuel, soit une OCP s'accompagnant d'une acuité visuelle ≤ 20/50, de même que l'incidence de capsulotomie au laser Nd:YAG au cours de la première année suivant la chirurgie de la cataracte dans des yeux présentant une uvéite.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Méthodes&lt;/h3&gt;&lt;div&gt;Patients recensés au sein de la cohorte de l’étude SITE (&lt;span&gt;&lt;em&gt;Systemic &lt;/em&gt;&lt;em&gt;Immunosuppressive&lt;/em&gt;&lt;em&gt; Therapy for Eye Diseases&lt;/em&gt;&lt;/span&gt;) dans le cadre d'une revue de synthèse standardisée des dossiers méd","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages e124-e132"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratified choroidal vascular structure in treatment-naïve diabetic retinopathy","authors":"Hiroaki Endo ,&nbsp;Satoru Kase ,&nbsp;Mitsuo Takahashi ,&nbsp;Yuki Ito ,&nbsp;Shozo Sonoda ,&nbsp;Tomonori Sakoguchi ,&nbsp;Taiji Sakamoto ,&nbsp;Satoshi Katsuta ,&nbsp;Susumu Ishida ,&nbsp;Manabu Kase","doi":"10.1016/j.jcjo.2024.05.015","DOIUrl":"10.1016/j.jcjo.2024.05.015","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To analyze the anatomical choroidal vascular layers in topical treatment-naïve diabetic retinopathy (DR) eyes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;A retrospective, clinical case-control study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A total of 328 eyes from 228 patients with treatment-naive DR and 192 eyes matched for axial length from 174 healthy controls were enrolled in the study. Choroidal structure was quantitatively analyzed using enhanced depth imaging optical coherence tomography (EDI-OCT). Each choroidal vascular layer was divided into the choriocapillaris, Sattler's layer, and Haller's layer, and then the choroidal area (CA), luminal area (LA), stromal area (SA), and central choroidal thickness (CCT) were calculated using binarization techniques. The ratio of LA to CA was defined as the L/C ratio.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;In the choriocapillaris, CA was significantly lower in the mild/moderate non-proliferative DR (mNPDR) group than in the control group, and SA was significantly higher in all DR groups (each &lt;em&gt;P&lt;/em&gt; &lt; 0.01). The L/C ratio was significantly lower in all DR groups than controls (&lt;em&gt;P&lt;/em&gt; &lt; 0.01). In Sattler's layer, CA, LA, and SA were significantly higher in the severe NPDR (sNPDR) and PDR groups than in the control group (&lt;em&gt;P&lt;/em&gt; &lt; 0.01). In Haller's layer, the L/C ratio was significantly high among the PDR groups (&lt;em&gt;P&lt;/em&gt; &lt; 0.05).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;The choroidal parameters of DR patients by the binarization method were associated with the stage of DR, in which the choriocapillaris lumen decreased in all the DR stages. The expansion of CA seen in more advanced DR eyes mainly resulted from changes in the Sattler's and Haller's layers.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectif&lt;/h3&gt;&lt;div&gt;Analyser l'anatomie des couches vasculaires choroïdiennes dans des yeux atteints de rétinopathie diabétique (RD) qui n'ont jamais reçu de collyre.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Nature&lt;/h3&gt;&lt;div&gt;Étude clinique rétrospective avec cas témoins.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Méthodes&lt;/h3&gt;&lt;div&gt;Au total, 328 yeux de 228 patients dont la RD n'avait jamais été traitée et 192 yeux appariés pour la longueur axiale provenant de 174 sujets témoins en bonne santé ont été admis à notre étude. On a eu recours à la tomographie par cohérence optique à l'imagerie à profondeur améliorée (EDI-OCT, pour &lt;span&gt;&lt;em&gt;enhanced-depth imaging &lt;/em&gt;&lt;em&gt;optical coherence tomography&lt;/em&gt;&lt;/span&gt;) pour réaliser une analyse quantitative de la structure de la choroïde. Chaque couche vasculaire de la choroïde a été divisée en 3 (choriocapillaire, couche de Sattler et couche de Haller). Par la suite, 3 aires (aire choroïdienne [AC], aire luminale [AL] et aire stromale [AS]) et l’épaisseur choroïdienne centrale (ECC) ont été calculées grâce à des techniques de binarisation. Le rapport entre l'AL et l'AC se définissait comme le rapport L/C.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Résultats&lt;/h3&gt;&lt;div&gt;Dans la choriocapillaire, l'AC était significativemen","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages e73-e82"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal periosteum flap: an approach for improved vascular supply for buccal membrane graft","authors":"Gurkaran S. Sarohia ,&nbsp;Vivian T. Yin ,&nbsp;Sonia N. Yeung ,&nbsp;Alfonso Iovieno","doi":"10.1016/j.jcjo.2024.08.018","DOIUrl":"10.1016/j.jcjo.2024.08.018","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages e163-e165"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk in anti-VEGF treatment of neovascular age-related macular degeneration","authors":"David D. Chong ,&nbsp;Christopher M. Maatouk ,&nbsp;Jonathan Markle ,&nbsp;Jacqueline K. Shaia ,&nbsp;Rishi P. Singh ,&nbsp;Katherine E. Talcott","doi":"10.1016/j.jcjo.2024.05.013","DOIUrl":"10.1016/j.jcjo.2024.05.013","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;&lt;span&gt;Assess 5-year all-cause mortality (ACM), hemorrhagic stroke, &lt;/span&gt;ischemic stroke&lt;span&gt;, and myocardial infarction (MI) risks in nAMD patients receiving anti-VEGF injections compared with controls.&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;Population-based retrospective cohort study using a U.S. federated health research network, containing de-identified data of 96 million patients from 1/1/2003 to 3/6/2023.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Participants&lt;/h3&gt;&lt;div&gt;&lt;span&gt;nAMD Patients with anti-VEGF injections. Controls included nAMD patients without anti-VEGF injections, non-exudative &lt;/span&gt;AMD&lt;span&gt; patients, and patients without AMD.&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Patients were identified using nAMD &lt;em&gt;ICD-10&lt;/em&gt; and anti-VEGF &lt;em&gt;CPT&lt;/em&gt; codes and matched for age, sex, and comorbidities. Five-year relative risk of ACM (RR&lt;sub&gt;1&lt;/sub&gt;&lt;span&gt;), hemorrhagic stroke (RR&lt;/span&gt;&lt;sub&gt;2&lt;/sub&gt;&lt;span&gt;), ischemic stroke (RR&lt;/span&gt;&lt;sub&gt;3&lt;/sub&gt;), and MI (RR&lt;sub&gt;4&lt;/sub&gt;) in nAMD patients receiving anti-VEGF injections were calculated.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 27,609 nAMD patients (mean diagnosis age [SD], [78.2 (10.3)]) received anti-VEGF injections; 769 nAMD patients without injections (75.8 [12.2]), 27,599 non-exudative AMD patients (78.2 [10.3]), and 21,902 no-AMD patients (76.1 [10.5]) were identified. After matching, nAMD patients receiving injections did not show increased risk versus nAMD patients without injections (RR&lt;sub&gt;1&lt;/sub&gt;, 0.66; 95% CI [0.53, 0.82]), (RR&lt;sub&gt;2&lt;/sub&gt;, 1.00 [0.42, 2.38]), (RR&lt;sub&gt;3&lt;/sub&gt;, 1.70 [0.92,3.13]), (RR&lt;sub&gt;4&lt;/sub&gt;, 0.63 [0.33, 1.18]). No increased risk was found compared to non-exudative AMD patients (RR&lt;sub&gt;1&lt;/sub&gt;, 0.99 [0.95, 1.03]), (RR&lt;sub&gt;2&lt;/sub&gt;, 0.94 [0.83,1.07]), (RR&lt;sub&gt;3&lt;/sub&gt;, 1.04 [0.96, 1.12]), (RR&lt;sub&gt;4&lt;/sub&gt;, 0.99 [0.91, 1.08]). Increased risk for ACM was observed versus no-AMD patients (RR&lt;sub&gt;1&lt;/sub&gt;, 1.21 [1.15, 1.27]), but no other differences were found (RR&lt;sub&gt;2&lt;/sub&gt;, 0.81 [0.70, 0.93]), (RR&lt;sub&gt;3&lt;/sub&gt;, 1.00 [0.92, 1.09]), (RR&lt;sub&gt;4&lt;/sub&gt;, 0.986 [0.90, 1.09]).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Anti-VEGF injections were not associated with major cardiovascular events in nAMD patients over 5 years.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectif&lt;/h3&gt;&lt;div&gt;Évaluer le risque à 5 ans de mortalité toutes causes confondues (TCC), d'accident vasculaire cérébral (AVC) hémorragique, d'AVC ischémique et d'infarctus du myocarde (IM) chez des patients présentant une dégénérescence maculaire liée à l’âge néovasculaire (DMLAn) qui reçoivent des injections d'anti-VEGF (facteur de croissance endothélial vasculaire), comparativement aux sujets témoins.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Nature&lt;/h3&gt;&lt;div&gt;Étude de cohorte populationnelle rétrospective fondée sur un réseau fédéré américain de recherche en santé comprenant les données dépersonnalisées de 96 millions de patients datées du 1&lt;sup&gt;er&lt;/sup&gt; janvier 2003 au 6 mars 2023.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Participants&lt;/h3&gt;&lt;div&gt;Patients qui p","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":"60 1","pages":"Pages 35-41"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}