Canadian journal of ophthalmology. Journal canadien d'ophtalmologie最新文献

{"title":"Contrasting approaches to estimate the epidemiology of uveitis in Canadian health administrative data.","authors":"Tina Felfeli, Luis Palma, Laura Rosella, Sherif El-Defrawy, Thomas Albini, Efrem D Mandelcorn, Jessica Widdifield","doi":"10.1016/j.jcjo.2025.08.015","DOIUrl":"10.1016/j.jcjo.2025.08.015","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the age- and sex-standardized incidence and prevalence of uveitis in Ontario, Canada, from 2000 to 2021. By employing various case definitions, this research seeks to discern trends in uveitis occurrence and provide a comprehensive understanding of its epidemiology.</p><p><strong>Methods: </strong>A retrospective cohort study utilizing health administrative data was conducted. Multiple case definitions were employed to capture the diverse epidemiological trends of uveitis. Annual age/sex standardized incidence and prevalence rates with 95% confidence intervals (CI) were determined using annual population denominators.</p><p><strong>Results: </strong>The age- and sex-standardized incidence rates exhibited variations over the study period showing a general decline from 2000 to 2021, more notably in recent years. The case definition with one diagnosis code estimated an incidence per 100,000 people of 184.4 (95% CI: 181.5-187.2) in 2000 and 109.2 (95% CI: 107.4-110.9) in 2021. The standardized prevalence exhibited a consistent upward trend, with the case definition requiring \"at least one diagnosis code ever\" recording 1 998.3 (1 989.1-2 007.5) in 2000 and 2 761.2 (2 752.7-2 769.7) in 2021 per 100,000 people. Lower incidence and prevalence rates were observed when employing case definitions requiring more stringent criteria with additional uveitis-related health encounters.</p><p><strong>Conclusions: </strong>The estimated trends showed declining standardized incidence, but a persistent increase in prevalence rates over time. These insights contribute valuable knowledge for health care professionals, policymakers, and researchers on the rising prevalence of uveitis and implications for planning for appropriate health care provisions to meet growing demands for uveitis care.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in evisceration and enucleation surgeries at a tertiary care hospital: A 10-year retrospective study.","authors":"Catherine Liu, Kyoung A Viola Lee, Kristie Labib, Randall Aziz, Rebecca Lipscomb, Charles Slonim, Jorge Agi","doi":"10.1016/j.jcjo.2025.09.003","DOIUrl":"https://doi.org/10.1016/j.jcjo.2025.09.003","url":null,"abstract":"<p><strong>Objective: </strong>This study examines 10-year trends in enucleation and evisceration surgeries at a tertiary care hospital, focusing on changing indications, procedural volume, and demographic associations.</p><p><strong>Methods: </strong>A retrospective chart review was conducted at Tampa General Hospital from 2015 to 2024, including 261 enucleations and eviscerations. Patient demographics, clinical indications, surgical details, and histopathological findings were analyzed. Exenteration cases (n = 30) were assessed separately.</p><p><strong>Results: </strong>A total of 261 eye removal surgeries were performed between 2015 and 2024. During the 10-year period, 129 (49.4%) enucleations and 132 (50.6%) eviscerations were performed. The cohort consisted of 139 (53.3%) males and 122 (46.7%) females. Infection (37.9%) and trauma (26.4%) were the leading indications. Enucleation was strongly associated with malignancy, particularly melanoma (p < 0.001), while evisceration was preferred for infections (p < 0.001). The total number of surgeries increased over the study period (p < 0.05).</p><p><strong>Conclusions: </strong>There was a similar incidence of enucleations and eviscerations, although both increased throughout the study period. There was no association between gender and diagnosis for these surgeries.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-utility analysis of cultured human corneal endothelial cells for corneal edema secondary to endothelial dysfunction: a Monte Carlo simulation model.","authors":"Tina Felfeli, Aswen Sriranganathan, Charlotte Wedge, Christine Humphreys, David M Naimark, Clara C Chan","doi":"10.1016/j.jcjo.2025.07.005","DOIUrl":"10.1016/j.jcjo.2025.07.005","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the cost-effectiveness of injectable human corneal endothelial cell therapy, known as cultured human corneal endothelial cells (hCEC), compared to the current standard of Descemet stripping (automated) endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) for endothelial dysfunction using an economic simulation model.</p><p><strong>Methods: </strong>In this Monte Carlo simulation cost-utility analysis, injectable hCEC therapy versus DSAEK/DMEK costs and effects were projected over a lifetime horizon for a simulated cohort of adult patients (≥18 years old), requiring endothelial keratoplasty in theoretical surgical centres in Ontario, Canada. Procedural wait times, effectiveness (quality-adjusted life year), and cost (2025 Canadian dollars) values were obtained from the literature and discounted at 3% per year. A cost-effectiveness threshold of incremental cost-effectiveness ratio ≤ $50,000 per quality-adjusted life year (QALY) gained was applied as a criterion for determining the economic viability of the interventions.</p><p><strong>Results: </strong>The patient population consisted of 35,222 adults (estimated prevalence of endothelial dysfunction in Ontario). The preoperative wait time (days) was 102.99 (5.17) and 173.99 (5.54) for hCEC and DSAEK/DMEK, respectively. The life-time costs for hCEC and DSAEK/DMEK were $18,139.03 (SD 1,040.93) and $11,039.38 (SD 531.78), respectively. The expected lifetime QALYs were higher for those receiving hCEC (11.76; SD 2.74) relative to DSAEK/DMEK (9.16; SD 3.22). The incremental cost-effectiveness ratio for hCEC therapy against DSAEK/DMEK was $2,715.59 per QALY. The threshold analyses indicated that hCEC would be the dominant cost-effective option with a cost equal to or less than $10,000.</p><p><strong>Conclusions: </strong>Injectable hCEC therapy is a cost-effective option when compared to DSAEK/DMEK for endothelial dysfunction in this simulation model. The implementation of injectable hCEC therapy has the potential to improve clinical outcomes and increase accessibility for patients with endothelial dysfunction globally.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose cotransporter 2 inhibitors and risk of diabetic retinopathy: systematic review and meta-analysis.","authors":"Le Liang, Liping Yu, Yani He, Li Liu, Haohuan Yuan, Yating Hu, Jin Sun","doi":"10.1016/j.jcjo.2025.08.009","DOIUrl":"10.1016/j.jcjo.2025.08.009","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the relationship between sodium-glucose cotransporter 2 inhibitors (SGLT2i) and diabetic retinopathy (DR) in diabetes mellitus.</p><p><strong>Methods: </strong>We conducted a systematic search in PubMed, Embase, Cochrane Library, and ClinicalTrials.gov from their inception to November 9, 2024, for randomized controlled trials (RCTs) and real-world studies of SGLT2i in the treatment of diabetes mellitus. Outcome measures included DR incidence, DR progression, and sight-threatening diabetic retinopathy (STDR). The relative risk (RR) with its 95% confidence interval (CI) was used for the meta-analysis.</p><p><strong>Results: </strong>A total of 16 RCTs and 19 real-world studies were included, involving 2,319,193 patients. The meta-analysis of RCTs indicated that, compared with the control group, SGLT2i was not significantly associated with DR incidence [RR = 0.92, 95% CI 0.60-1.44, I² = 0%]. The meta-analysis of real-world studies demonstrated that SGLT2i significantly reduced DR incidence [RR = 0.81, 95% CI 0.73-0.90, I² = 93%], DR progression [RR = 0.86, 95% CI 0.76-0.97, I² = 70%], and STDR [RR = 0.69, 95% CI 0.61-0.79, I² = 84%] compared with the control group. Subgroup analyses revealed that the type of control group might be a source of heterogeneity for DR incidence (p_interaction < 0.00001) and STDR (p_interaction = 0.01). Sensitivity analysis and assessment of publication bias indicated that the results were robust.</p><p><strong>Conclusions: </strong>SGLT2i may have a role in reducing the risk of DR, but more multicenter, prospective, and high-quality RCTs are needed to validate our findings in the future.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An atypical case of thyroid-related orbitopathy presenting as bilateral infiltrative mass lesions.","authors":"Nishanth S Iyengar, Edward Xie, Casey Bunge, Tahmeena Ahmed, Nariman S Boyle","doi":"10.1016/j.jcjo.2025.08.013","DOIUrl":"10.1016/j.jcjo.2025.08.013","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-week response of retinal hemangioblastomas to oral belzutifan.","authors":"Taweevat Attaseth, Yu-Bai Chou, Carol L Shields","doi":"10.1016/j.jcjo.2025.08.014","DOIUrl":"10.1016/j.jcjo.2025.08.014","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrophilic intraocular lens with crystalline deposits.","authors":"Turner D Wibbelsman, Heather Skeens, Ralph C Eagle","doi":"10.1016/j.jcjo.2025.08.010","DOIUrl":"10.1016/j.jcjo.2025.08.010","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented paravenous chorioretinal atrophy.","authors":"Sara Fard, Melis Kabaalioglu Guner, Wei Wang","doi":"10.1016/j.jcjo.2025.07.004","DOIUrl":"10.1016/j.jcjo.2025.07.004","url":null,"abstract":"","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal endothelial and ocular biometric parameters in children with history of retinopathy of prematurity and treated with laser or intravitreal injections.","authors":"Chia-Yi Lee, Shun-Fa Yang, Hung-Chi Chen, Jing-Yang Huang, Yi-Jen Hsueh, Ming-Hui Sun, Ming-Chou Chiang, Yu-Shu Huang, Shih-Ming Chu, Jen-Fu Hsu, Chun-Hsiu Liu, Chao-Kai Chang, Kuan-Jen Chen, Yih-Shiou Hwang, Chi-Chun Lai, Chung-Ying Huang, Wei-Chi Wu","doi":"10.1016/j.jcjo.2025.07.006","DOIUrl":"10.1016/j.jcjo.2025.07.006","url":null,"abstract":"<p><strong>Objective: </strong>To investigate corneal endothelial and ocular biometric parameters in children with retinopathy of prematurity (ROP) treated with intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) or laser photocoagulation.</p><p><strong>Design: </strong>A retrospective cohort study.</p><p><strong>Participants: </strong>Seventy-four children with a history of ROP who visited a tertiary hospital between 2016 and 2021; 13 children were treated with laser and 61 with IVI.</p><p><strong>Methods: </strong>Patients were divided into ROP-laser and ROP-IVI groups. Evaluated parameters included endothelial cell density (ECD), coefficient of variation (CV), hexagonal cell ratio (HEX), central corneal thickness (CCT), refractive status, axial length, anterior chamber depth (ACD), and corneal diameter (CD). The main outcomes were the corneal endothelial and ocular biometric differences between the two groups. A generalized estimating equation was used for comparison.</p><p><strong>Results: </strong>The ROP-laser group exhibited significantly higher spherical power (p = 0.0019), cylindrical power (p = 0.0060), spherical equivalent (p = 0.0003), and steeper corneal curvature (p < 0.0001) compared to the ROP-IVI group. Conversely, the ROP IVI group had deeper ACD (p = 0.0078), and larger CD (p = 0.0006). ECD was significantly higher in the ROP-laser group (P = 0.0011), whereas CV, HEX, and CCT were similar. Over time, the ROP-IVI group exhibited a greater decrease in ECD (p = 0.0016) and a significant increase in HEX (p = 0.0421). Trends in CV and CCT are similar.</p><p><strong>Conclusions: </strong>Children treated with laser for ROP had more myopia, steeper corneas, smaller CD, and higher ECD compared to IVI. However, HEX improved more in the ITVI group. The significance of these differences requires further investigation.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual outcomes, incidence and risk factors for RPE atrophy in myopic patients with dome-shaped macula and serous retinal detachment.","authors":"Sebastiano Del Fabbro, Alessandro Arrigo, Lorenza Bruno, Federico Procopio, Mara Iantomasi, Giovanni Scalabrin, Maria Vittoria Cicinelli, Francesco Bandello, Maurizio Battaglia Parodi","doi":"10.1016/j.jcjo.2025.07.007","DOIUrl":"10.1016/j.jcjo.2025.07.007","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the visual outcomes, incidence, and risk factors for retinal pigment epithelium (RPE) atrophy in highly myopic patients with dome-shaped macula (DSM) and serous retinal detachment (SRD).</p><p><strong>Methods: </strong>Baseline and follow-up data were analyzed for visual acuity (VA), myopic classification, spherical equivalent (SE), and SRD presence. Incomplete RPE atrophy is characterized by discontinuous hypertransmission (<250 μm) with an irregular or interrupted RPE band. Persistent SRD was defined as fluid present in all follow-up visits. The primary outcome was VA change over time and its predictors. RPE atrophy incidence was estimated using Kaplan-Meier analysis, and risk factors were assessed using univariate Cox regression.</p><p><strong>Results: </strong>Thirty eyes from 23 patients were included, mean age (SD) 53.4 ± 11.7 years, with a mean follow-up of 6.8 (2.7) years. Mean SE (SD) was -9.33 (3.6) diopters. Persistent SRD was observed in 18 (60%) eyes. The baseline VA was 0.34 ± 0.26 logMAR. Eyes with patchy atrophy and incomplete RPE atrophy exhibited worse VA (p < 0.01). VA declined minimally over time (+0.02 logMAR/year; p < 0.001).</p><p><strong>Discussion: </strong>Persistent SRD (p = 0.04) and incomplete RPE atrophy (p < 0.01) were associated with faster visual loss. The incidence rate of incomplete RPE atrophy was low (9/100 eye-years, 95% CI: 2.8-15.4). Younger age (HR = 0.95; p = 0.043) was associated with RPE atrophy progression. Across the follow-up period 5 eyes (17%) developed macular neovascularization (MNV).</p><p><strong>Conclusions: </strong>DSM with SRD is characterized by minimal visual decline and a low risk of incomplete RPE atrophy but can be complicated by MNV. SRD is persistent in most eyes but does not accelerate RPE atrophy.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}