Case Reports in Ophthalmological Medicine最新文献

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Treatment of Recurrent Primary Cutaneous Mucinous Carcinoma of the Eyelid with Modified Wide Local Excision. 改良大面积局部切除治疗复发性眼睑原发性皮肤黏液癌。
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-12-18 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6668640
Stephanie M Tillit, Siva S R Iyer, Eric J Grieser, John T LiVecchi
{"title":"Treatment of Recurrent Primary Cutaneous Mucinous Carcinoma of the Eyelid with Modified Wide Local Excision.","authors":"Stephanie M Tillit,&nbsp;Siva S R Iyer,&nbsp;Eric J Grieser,&nbsp;John T LiVecchi","doi":"10.1155/2020/6668640","DOIUrl":"https://doi.org/10.1155/2020/6668640","url":null,"abstract":"<p><p>Primary cutaneous mucinous carcinoma (PCMC) is a rare, low-grade malignant neoplasm of the sweat gland, whose history has been controversial regarding eccrine versus apocrine origin. This case report describes a 53-year-old male who presented to the University of Florida, Gainesville, ophthalmology clinic and was referred to the oculoplastics service with a painless, subcentimeter mass on the lateral right upper eyelid including the canthus, consistent with recurrent primary cutaneous mucinous carcinoma of the eyelid. Four years prior, the patient had undergone excisional biopsy of the lesion in a clinic, which revealed residual tumor, but the patient deferred further surgery at the time. The patient underwent surgical excision of the mass with reconstruction without operative complications and with negative surgical margins. PCMC is difficult to diagnose clinically due to its rarity and requires a histopathological examination for confirmation of the diagnosis. This report presents the first case in the literature of primary cutaneous mucinous carcinoma in a patient with human immunodeficiency virus (HIV). With this case report, we aim to raise awareness of primary cutaneous mucinous carcinoma as a potential part of the differential diagnosis for malignant eyelid lesions, including those present in patients with HIV.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"6668640"},"PeriodicalIF":0.9,"publicationDate":"2020-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38766597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Solitary Choroidal Mass with Spontaneous Resolution. 一个孤立的脉络膜团与自发分解。
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-12-10 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8882617
Fariba Ghassemi, Nazanin Ebrahimiadib, Hamid Riazi-Esfahani, Hassan Khojasteh, Zahra Mahdizad, Elias Khalili Pour
{"title":"A Solitary Choroidal Mass with Spontaneous Resolution.","authors":"Fariba Ghassemi,&nbsp;Nazanin Ebrahimiadib,&nbsp;Hamid Riazi-Esfahani,&nbsp;Hassan Khojasteh,&nbsp;Zahra Mahdizad,&nbsp;Elias Khalili Pour","doi":"10.1155/2020/8882617","DOIUrl":"https://doi.org/10.1155/2020/8882617","url":null,"abstract":"<p><strong>Background: </strong>To report an atypical case of a transient choroidal mass lesion with spontaneous resolution. <i>Case Presentation</i>. A solitary choroidal mass with an overlying neurosensory retinal detachment was seen in an otherwise healthy 31-year-old female. General physical examinations and serum chemistry were unremarkable. The patient had spontaneous resolution two weeks after initial examination without treatment.</p><p><strong>Conclusions: </strong>Inflammatory choroidal masses may be self-limited, but complete diagnostic measures must always be performed in these patients to distinguish between important causes such as tuberculosis, sarcoidosis, and tumors.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"8882617"},"PeriodicalIF":0.9,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39102770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Outcomes in Macular Telangiectasia Type 2-Related Macular Holes: A Report on Four Patients. 4例黄斑毛细血管扩张2型相关黄斑孔的手术疗效分析
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-12-07 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8884638
Kinza T Ahmad, Joseph Chacko, Ahmed B Sallam, David B Warner, Sami H Uwaydat
{"title":"Surgical Outcomes in Macular Telangiectasia Type 2-Related Macular Holes: A Report on Four Patients.","authors":"Kinza T Ahmad,&nbsp;Joseph Chacko,&nbsp;Ahmed B Sallam,&nbsp;David B Warner,&nbsp;Sami H Uwaydat","doi":"10.1155/2020/8884638","DOIUrl":"https://doi.org/10.1155/2020/8884638","url":null,"abstract":"<p><strong>Introduction: </strong>The few published studies that exist on the surgical outcomes of full-thickness macular hole (FTMH) repair in Macular Telangiectasia (MacTel) Type 2 report poor rates of hole closure of around 30%. This study is the largest case series of patients with FTMH in MacTel Type 2 and describes an 80% hole closure rate.</p><p><strong>Purpose: </strong>/.</p><p><strong>Aim: </strong>To describe the outcomes of four patients who underwent surgery for FTMH associated with MacTel Type 2.</p><p><strong>Methods: </strong>A retrospective review of clinical, surgical, and imaging data of five eyes in four patients with MacTel Type 2 FTMH who underwent pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling and 30% SF<sub>6</sub> or 15% C<sub>3</sub>F<sub>8</sub> gas tamponade within 3-9 months of initial vision decline.</p><p><strong>Results: </strong>Visual acuity (VA) at the time of surgery ranged from 20/50 to 20/200. Successful hole closure was achieved in four out of five eyes, and final VA ranged from 20/20 to 20/40 at follow-up visits greater than 20 months postoperatively. The single eye that did not achieve hole closure had a final VA of 20/60.</p><p><strong>Conclusion: </strong>Our case series describes higher hole closure rates and better final VA than previously published reports for macular hole surgery in patients with MacTel Type 2 FTMH.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"8884638"},"PeriodicalIF":0.9,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38855977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Impurities in Drug Vials Intended for Intravitreal Medication. 玻璃体内给药药瓶中的杂质。
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-12-02 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8824585
Lisa Pohl, Lisa Strudel, Spyridon Dimopoulos, Focke Ziemssen
{"title":"Impurities in Drug Vials Intended for Intravitreal Medication.","authors":"Lisa Pohl,&nbsp;Lisa Strudel,&nbsp;Spyridon Dimopoulos,&nbsp;Focke Ziemssen","doi":"10.1155/2020/8824585","DOIUrl":"https://doi.org/10.1155/2020/8824585","url":null,"abstract":"<p><p>Sterility is an important prerequisite for minimizing the risk of severe vision loss due to endophthalmitis after intravitreal injections. We describe three cases series of incidents where an unclear contamination of the drug solution or syringe caused the injection process to stop and continue with a new preparation. During a period of 12 months with 30,502 intravitreal injections at a tertiary center, wherein 7,076 were of the drug Aflibercept drawn up from a glass vial, three cases of the critical incident reporting system relating to intravitreal injections were identified: (1) After a typical contact with the filter cannula, the glass of an Aflibercept vial was no longer intact. (2) In the course of another injection, there was a clear deposition of debris on the outer edge of the syringe when removing the attached filter cannula. (3) After inserting the syringe into the rubber top of the vial, a whitish particle of unclear origin was identified within the drug solution. Later, this contamination/particle was identified as part of the greyish rubber that was punched out with the cannula, according to the analyses of the material sent in and the manufacturer's investigations. Thus, even in busy clinics, visual inspection of the injection solution and materials used for impurities, preferably before and after pulling them out of a vial, must be an essential part of the injection process. Even when using ready-to-use prefilled syringes (PFS), vigilance must be kept high, knowing the risk of potential contamination.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"8824585"},"PeriodicalIF":0.9,"publicationDate":"2020-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39034647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chromophore-Assisted Retinal Break Detection to Manage Challenging Situations in Retinal Detachment Redo Surgery. 发色团辅助视网膜破裂检测在视网膜脱离重做手术中管理具有挑战性的情况。
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-11-30 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1389434
Antonio Berarducci, Martina Colasante, Antonio Laborante
{"title":"Chromophore-Assisted Retinal Break Detection to Manage Challenging Situations in Retinal Detachment Redo Surgery.","authors":"Antonio Berarducci,&nbsp;Martina Colasante,&nbsp;Antonio Laborante","doi":"10.1155/2020/1389434","DOIUrl":"https://doi.org/10.1155/2020/1389434","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this case series is to demonstrate that subretinal blue dye injection, with and without 180-degree endolaser retinopexy, can be considered a useful tool in finding occult rhegmatogenous retinal breaks in eyes with recurrent retinal detachment. <i>Case Presentation</i>. Three patients with recurrent retinal detachment were treated between January and March 2018. In all cases, the intraoperative internal search did not demonstrate any obvious break or hole. MembraneBlue-Dual (Trypan Blue 0.15% + Brilliant Blue G 0.025% + 4% PEG) was then injected into the subretinal space using a 41-gauge cannula. The eye was rotated such that the dye was pushed through a tiny break which was causing the retinal detachment. 180-degree laser retinopexy was performed on a single eye. After silicon oil removal and absorption of the gas tamponade, retinas remained attached at three-months follow-up.</p><p><strong>Conclusions: </strong>Chromophore-assisted occult retinal break detection can be considered a useful but not risk-free surgical technique in managing some unexpected and challenging intraoperative situations.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"1389434"},"PeriodicalIF":0.9,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38387152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Vitreous and Intraretinal Hemorrhage with Multifocal Subretinal Fluid in Juvenile X-Linked Retinoschisis. 儿童x连锁视网膜裂急性玻璃体和视网膜内出血伴多灶性视网膜下积液。
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-11-24 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6638553
Sidra Ibad, Carl S Wilkins, Alexander Pinhas, Vincent Sun, Matthew S Wieder, Avnish Deobhakta
{"title":"Acute Vitreous and Intraretinal Hemorrhage with Multifocal Subretinal Fluid in Juvenile X-Linked Retinoschisis.","authors":"Sidra Ibad,&nbsp;Carl S Wilkins,&nbsp;Alexander Pinhas,&nbsp;Vincent Sun,&nbsp;Matthew S Wieder,&nbsp;Avnish Deobhakta","doi":"10.1155/2020/6638553","DOIUrl":"https://doi.org/10.1155/2020/6638553","url":null,"abstract":"<p><strong>Purpose: </strong>To report a rare case of spontaneous vitreous and intraretinal hemorrhage in a patient with juvenile X-linked retinoschisis which was managed conservatively.</p><p><strong>Methods: </strong>Single patient case report.</p><p><strong>Introduction: </strong>Juvenile X-linked retinoschisis (JXLR) most often occurs as a result of a genetic defect in the retinoschisin (RS1) gene, causing a separation between the ganglion cell layer and the nerve fiber layer. Spontaneous vitreous hemorrhage has been reported as an uncommon secondary consequence of JXLR. We present a case of spontaneous vitreous and diffuse macular intraretinal hemorrhages in a patient with JXLR which resolved with medical management alone.</p><p><strong>Results: </strong>A 23-year-old man with a history of juvenile X-linked retinoschisis presented to the ophthalmic emergency room complaining of acute onset of floaters in his right eye. On examination, the patient was found to have a new vitreous hemorrhage with diffuse intraretinal hemorrhages in his right eye, without new retinal tears or detachment. SD-OCT demonstrated multifocal pockets of subretinal fluid. The genetic testing panel revealed a hemizygous mutation in the RS-1 gene. He was managed conservatively on oral acetazolamide, with the resolution of the subretinal fluid and with both visual and symptomatic improvement.</p><p><strong>Conclusions: </strong>Spontaneous vitreous hemorrhage may rarely occur in patients with JXLR, even in the absence of acute retinal tear or detachment. This case demonstrates an atypical presentation of vitreous hemorrhage with diffuse intraretinal hemorrhage and new multifocal areas of subretinal fluid which improved without surgical intervention. Good outcomes may be achieved in these patients with conservative management alone, even in atypical presentations.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"6638553"},"PeriodicalIF":0.9,"publicationDate":"2020-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6638553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38694613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Binocular Diplopia: A Possible Adverse Effect of Fluoroquinolone Therapy. 双眼复视:氟喹诺酮类药物治疗可能的不良反应。
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-11-24 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8843182
Mariama Touray, Victoria Ando, Erwin Samutelela, Jean-Philippe Zuber
{"title":"Binocular Diplopia: A Possible Adverse Effect of Fluoroquinolone Therapy.","authors":"Mariama Touray,&nbsp;Victoria Ando,&nbsp;Erwin Samutelela,&nbsp;Jean-Philippe Zuber","doi":"10.1155/2020/8843182","DOIUrl":"https://doi.org/10.1155/2020/8843182","url":null,"abstract":"<p><p>The adverse effects of fluoroquinolones are yet to be fully elucidated. We present an interesting case of a 41-year-old male with binocular diplopia most likely induced by the use of a fluoroquinolone antibiotic.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"8843182"},"PeriodicalIF":0.9,"publicationDate":"2020-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38694614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Large Choroidal Melanocytoma Simulating Choroidal Melanoma: A Difficult Differential Diagnosis and an Inevitable Enucleation. 大脉络膜黑色素细胞瘤模拟脉络膜黑色素瘤:一个困难的鉴别诊断和不可避免的去核。
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-11-21 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8890857
Taoufik Abdellaoui, Soukaina Belfaiza, Yassine Malek, Mohamed-Amine Essaoudi, Fouad Elasri, Karim Reda, Abdelbarre Oubaaz
{"title":"Large Choroidal Melanocytoma Simulating Choroidal Melanoma: A Difficult Differential Diagnosis and an Inevitable Enucleation.","authors":"Taoufik Abdellaoui,&nbsp;Soukaina Belfaiza,&nbsp;Yassine Malek,&nbsp;Mohamed-Amine Essaoudi,&nbsp;Fouad Elasri,&nbsp;Karim Reda,&nbsp;Abdelbarre Oubaaz","doi":"10.1155/2020/8890857","DOIUrl":"https://doi.org/10.1155/2020/8890857","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a case of choroidal melanocytoma mimicking a melanoma.</p><p><strong>Methods: </strong>Retrospective case report. <i>Patient</i>. A 48-year-old Moroccan woman presented with progressive, painless decreased vision in her left eye for 2 months.</p><p><strong>Results: </strong>Her visual acuity was light perception in the left eye and 20/20 in the right one. Fundus examination and fluorescein angiography of the left eye showed a total retinal detachment with a large superior brownish mass. The clinical examination, B-scan ultrasonography, and magnetic resonance imaging all suggested a malignant melanoma. Consequently, the eye was enucleated. The histopathology later revealed a benign melanocytoma of the choroid. <i>Discussion</i>. Melanocytoma is a rare benign pigmented tumor. It is classically described as a tumor of the optic nerve head, but there are some exceptional case reports of uveal tract locations (iris, ciliary body, and choroid). In such cases, it can be difficult to clinically differentiate a melanocytoma from a malignant melanoma.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"8890857"},"PeriodicalIF":0.9,"publicationDate":"2020-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8890857","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38351395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Successful Technique for Closure of Macular Hole Retinal Detachment Using Autologous Retinal Transplant 自体视网膜移植治疗黄斑裂孔视网膜脱离的成功方法
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-11-19 DOI: 10.1155/2020/8830985
J. A. Ramirez-Estudillo, Geovanni Rios-Nequis, Martin Jiménez-Rodríguez, Hugo Valdez-Flores, Ximena Ramirez-Galicia
{"title":"Successful Technique for Closure of Macular Hole Retinal Detachment Using Autologous Retinal Transplant","authors":"J. A. Ramirez-Estudillo, Geovanni Rios-Nequis, Martin Jiménez-Rodríguez, Hugo Valdez-Flores, Ximena Ramirez-Galicia","doi":"10.1155/2020/8830985","DOIUrl":"https://doi.org/10.1155/2020/8830985","url":null,"abstract":"Macular hole retinal detachment (MHRD) for the most part develops in highly myopic eyes. Several surgical methods have been introduced to treat MHRD. We describe our experience with the autologous retinal transplant in patient with MHRD. A 49-year-old female presented with a 2-week history of a sudden decrease in the central vision in the right eye (RE). A 3-port, 25-gauge pars plana vitrectomy was performed with the ILM dye staining and peeling. Endodiathermy was applied around a 1.5-disc diameter neurosensory donor site in the supertemporal retina. The graft was cut with standard 25-gauge curved scissors. Perfluoro-n-octane (PFO) was instilled. The free graft was gently handled until its packing into the macular hole. Two months following the initial PPV, the macular hole was closed, and vision improved from 0.05 to 0.25 logMAR.","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"20 1","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79045672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium-Glucose Cotransporter 2 Inhibitors Improve Chronic Diabetic Macular Edema. 钠-葡萄糖共转运蛋白2抑制剂改善慢性糖尿病黄斑水肿。
IF 0.9
Case Reports in Ophthalmological Medicine Pub Date : 2020-11-12 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8867079
Yoko Takatsuna, Ryoichi Ishibashi, Tomoaki Tatsumi, Masaya Koshizaka, Takayuki Baba, Shuichi Yamamoto, Koutaro Yokote
{"title":"Sodium-Glucose Cotransporter 2 Inhibitors Improve Chronic Diabetic Macular Edema.","authors":"Yoko Takatsuna,&nbsp;Ryoichi Ishibashi,&nbsp;Tomoaki Tatsumi,&nbsp;Masaya Koshizaka,&nbsp;Takayuki Baba,&nbsp;Shuichi Yamamoto,&nbsp;Koutaro Yokote","doi":"10.1155/2020/8867079","DOIUrl":"https://doi.org/10.1155/2020/8867079","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic macular edema (DME) is a vision-threatening condition that develops in diabetic patients. The first-line therapy for DME is intravitreal injections of antivascular endothelial growth factor (anti-VEGF) agents; however, the high frequency of repeat injections, invasiveness of the procedure, and high cost are drawbacks for this treatment. The purpose of this report is to present our findings in 3 patients with chronic DME whose edema was resolved soon after oral doses of sodium-glucose cotransporter-2 (SGLT2) inhibitors were used. <i>Case Presentation</i>. Case 1 was a 66-year-old woman diagnosed with moderate nonproliferative diabetic retinopathy (DR) with DME that had developed a decade earlier. The DME persisted for 4 years in the left eye. The addition of oral empagliflozin, a SGLT2 inhibitor, led to a marked improvement of the DME after one month, and this improvement continued over two years. Case 2 was a 68-year-old woman who was diagnosed with preproliferative DR with bilateral DME. The addition of oral dapagliflozin led to the improvement of the DME after two months, and this improvement continued over one year. Case 3 was a 61-year-old woman who was diagnosed with moderate nonproliferative DR with DME. Oral luseogliflozin was given which led to better glycemic control, and her left central retinal thickness (CRT) was markedly reduced after only two weeks. This reduction was maintained in her left eye for six months without any additional ophthalmic procedures.</p><p><strong>Conclusions: </strong>Although this study involved only three cases, our findings indicate that SGLT2 inhibitors might have possible efficacy for chronic DME.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2020 ","pages":"8867079"},"PeriodicalIF":0.9,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8867079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38676343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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