Shuji Nakatsuka, Yo Iwata, Hirotaka Ito, Yuta Nakano, Kumiko Mokuno, Tomoya Handa
{"title":"Successful Dichoptic Therapy for Amblyopia in a Child Unable to Tolerate Occlusion Therapy due to Autism Spectrum Disorder.","authors":"Shuji Nakatsuka, Yo Iwata, Hirotaka Ito, Yuta Nakano, Kumiko Mokuno, Tomoya Handa","doi":"10.1155/crop/9634126","DOIUrl":"10.1155/crop/9634126","url":null,"abstract":"<p><p>Children with autism spectrum disorder (ASD) often face challenges with occlusion therapy using eye patches owing to the sensory sensitivity, rigid behaviors, and communication difficulties associated with ASD. In this study, we report the case of a child with ASD who had significant difficulty with eye patch therapy for anisometropic amblyopia and was treated with visual acuity training using Occlu-pad, a dichoptic therapy device. This treatment led to marked improvement in visual acuity and high compliance. After 3 months of home-based therapy for 30 min per day, the best corrected visual acuity in the right eye improved from logarithm of minimum angle of resolution of 0.5 to 0.0, with an average compliance rate of 92%. This case highlights the importance of flexible treatment approaches tailored to individual patient characteristics in managing amblyopia in children with ASD and also demonstrates the potential utility of dichoptic therapy using Occlu-pad.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"9634126"},"PeriodicalIF":0.8,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A True Double Optic Disc.","authors":"Mesut Tekerek, Nur Demir","doi":"10.1155/crop/6157555","DOIUrl":"10.1155/crop/6157555","url":null,"abstract":"<p><p>A true double optic disc with two separate vasculatures is an extremely rare condition. The division of the optic nerve into two distinct fascicles is presumed to occur during early stages of embryonic development. Two separate optic discs or one optic disc with two retinal vasculatures are variants of a true double optic disc. This case report highlights a rare form of a true double optic disc with two retinal vasculatures in the same optic disc cup with multimodal imaging.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"6157555"},"PeriodicalIF":0.8,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute Retinal Detachment Following Ozurdex Implant in a Nonvitrectomized Eye.","authors":"Abdullah Alkhamees, Khaled Alsabah","doi":"10.1155/crop/6671556","DOIUrl":"10.1155/crop/6671556","url":null,"abstract":"<p><p>Intravitreal injection (IVI) of antivascular endothelial growth factors and dexamethasone implants are among the most performed procedures in ophthalmology, as they are used to treat various retinal diseases. Although considered safe, some rare but sight-threatening complications can occur, like endophthalmitis and retinal detachment. Here, we report a case of a 53-year-old male with a history of lymphoma (treated with chemotherapy in 2016 and currently on Cellcept and low-dose oral prednisolone), diabetes mellitus (DM), hypertension (HTN), and hyperlipidemia, who presented shortly after intravitreal Ozurdex injection in the left eye with retinal detachment (RD). Ozurdex is a valuable option for treatment of chronic diabetic macular edema (DME). This case highlights the need for a high index of suspicion for retinal detachment in pseudophakic patients with compromised retina, even after seemingly routine Ozurdex injection.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"6671556"},"PeriodicalIF":0.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiara Vivarelli, Marco Pellegrini, Francesco Parmeggiani, Ginevra Giovanna Adamo, Carla Enrica Gallenga, Paola Ferri, Marco Mura
{"title":"Bilateral Simultaneous Acute Angle-Closure Glaucoma Following Over-the-Counter Cold Medication.","authors":"Chiara Vivarelli, Marco Pellegrini, Francesco Parmeggiani, Ginevra Giovanna Adamo, Carla Enrica Gallenga, Paola Ferri, Marco Mura","doi":"10.1155/crop/8847063","DOIUrl":"10.1155/crop/8847063","url":null,"abstract":"<p><strong>Purpose: </strong>We report a case of bilateral acute angle-closure glaucoma occurring concurrently after the intake of dextromethorphan, a commonly used over-the-counter medication for flu symptom relief.</p><p><strong>Case presentation: </strong>A 65-year-old woman presented with bilateral acute angle-closure glaucoma following 5 days of treatment with an OTC medication. Her intraocular pressures (IOPs) were 57 mmHg in the right eye and 50 mmHg in the left. Slit lamp biomicroscopy revealed shallow anterior chambers bilaterally, and gonioscopy confirmed angle closure. Management involved immediate discontinuation of the offending medication, initiation of antiglaucoma treatment, and bilateral Nd: YAG laser iridotomy, which successfully normalized IOP and resolved the angle-closure attack.</p><p><strong>Conclusion: </strong>This case highlights that commonly used OTC cold and flu remedies can trigger acute angle-closure glaucoma, particularly in predisposed individuals. Early diagnosis and prompt intervention are crucial to prevent vision loss.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"8847063"},"PeriodicalIF":0.8,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intrapapillary Hemorrhage With Adjacent Peripapillary Subretinal Hemorrhage and Reduced Blood Flow in the Optic Papillary Region Observed on Laser Speckle Flowgraphy.","authors":"Mizuki Ikeda, Toshiyuki Oshitari, Tomohiko Usui","doi":"10.1155/crop/2726088","DOIUrl":"10.1155/crop/2726088","url":null,"abstract":"<p><p>Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage (IHAPSH), commonly observed in myopic eyes with tilted optic discs, typically resolves without treatment. Although IHAPSH cases have been rarely reported, no prior studies have assessed laser speckle flowgraphy (LSFG) in this context. We report a case of IHAPSH evaluated using LSFG. A 54-year-old woman presented with floater symptoms in her right eye upon awakening. She had no history of trauma or medication use. Her best corrected visual acuity (BCVA) was 1.2 in both eyes. Fundus examination and optical coherence tomography revealed a tilted disc with adjacent peripapillary subretinal hemorrhage surrounding the disc hemorrhage. After 1 month, the hemorrhages partially resolved without treatment, and complete resolution was observed after 3 months, with BCVA remaining at 1.2 in the affected eye. The mean blur rate obtained from LSFG showed mild improvement following a temporary decline in the affected eye but remained lower than that in the unaffected left eye. This case underscores the potential utility of LSFG in evaluating IHAPSH and suggests that reduced local blood flow around the disc following the initial disruption may prevent recurrence, even under conditions of elevated blood pressure.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"2726088"},"PeriodicalIF":0.8,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafaela Saalfeld, Ana H Hirata Choi, Leonardo P Zeni, Manuel A P Vilela
{"title":"Peripapillary Hyperreflective Ovoid Mass-Like Structure as an Optic Disc Pseudo-Edema Case Report and Review.","authors":"Rafaela Saalfeld, Ana H Hirata Choi, Leonardo P Zeni, Manuel A P Vilela","doi":"10.1155/crop/9417297","DOIUrl":"10.1155/crop/9417297","url":null,"abstract":"<p><strong>Background: </strong>The peripapillary hyperreflective ovoid mass-like structure (PHOMS) has been defined by the Optic Disc Drusen Studies (ODDS) Consortium as a distinct finding separate from the optic disc drusen (ODD). Given that PHOMS is neither a precursor nor subtype of ODD, its role as an independent risk factor for optic nerve diseases and its secondary consequences on nerve fibre function remain unclear.</p><p><strong>Case presentation: </strong>We present the case of a 12-year-old child diagnosed with PHOMS. Multimodal ophthalmic imaging, including optical coherence tomography (OCT), revealed a peripapillary hyperreflective ovoid mass without calcification and elevated disc margins, but no signs of increased intracranial pressure or subretinal fluid, thereby distinguishing PHOMS from papilledema. Visual acuity was preserved, and no neurological abnormalities were detected.</p><p><strong>Conclusions: </strong>This case illustrates important clinical and imaging distinctions between PHOMS and papilledema, emphasising the need for dedicated examination of PHOMS across disease groups. Longitudinal studies involving larger cohorts are warranted to determine whether PHOMS can serve as a biomarker for the magnitude and severity of optic nerve damage.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"9417297"},"PeriodicalIF":0.8,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12887224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reconstructive Technique in the Treatment of Merkel Cell Carcinoma of the Upper Eyelid: A Case Report.","authors":"Ryo Yamochi, Toshiaki Numajiri","doi":"10.1155/crop/8152342","DOIUrl":"10.1155/crop/8152342","url":null,"abstract":"<p><strong>Background and aims: </strong>Merkel cell carcinoma is a rare highly malignant disease that requires a wide resection and careful reconstruction of the resulting defect. We removed a Merkel cell carcinoma that had developed on the upper eyelid of an 86-year-old man and reconstructed the eyelid using a switch flap.</p><p><strong>Methods: </strong>The large size of the defect made it difficult to close the lower eyelid switch harvest site. Because of the patient's high risk of bleeding, closure of the switch flap donor site using a malar flap and cartilage graft was not performed. Instead, lateral canthotomy and lateral cantholysis were performed, and the ear-side end of the switch flap donor site was advanced 5 mm toward the nasal side, which allowed closure of the lower eyelid flap donor site.</p><p><strong>Results: </strong>The switch flap was detached 16 days after the initial surgery. In the 6 months since the surgery, there have been no problems with the function of the eyelids or the cosmetic appearance, or recurrence of the tumor. The results of this case suggest that this method is a good option for large full-thickness upper eyelid defects of 13-20 mm. Lateral canthotomy with lateral cantholysis is a well-known procedure, but there have been no reports of its combination with a switch flap.</p><p><strong>Conclusion: </strong>We believe that this method is positioned between the direct closure and malar flap, and that this method allows for a quick and minimally invasive reconstruction. The treatment of Merkel cell carcinoma requires extensive excision, and it is easy to meet the aforementioned criteria when it occurs in the upper eyelid. Because this carcinoma occurs frequently in older people, who can have a high bleeding risk, this minimally invasive method is useful for treating Merkel cell carcinoma of the upper eyelid.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"8152342"},"PeriodicalIF":0.8,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12848788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microsporidium Keratitis After Hurricane Francine: A Case Report.","authors":"Zachary A Dwyer, Stephen V Lau","doi":"10.1155/crop/5069667","DOIUrl":"10.1155/crop/5069667","url":null,"abstract":"<p><p>Microsporidial ocular infections are being increasingly reported, especially in temperate climates. In this case report, we describe five patients who presented to a private ophthalmology practice in Southeastern Louisiana in 2024, all within 3 months of Hurricane Francine landing. The patients' ages ranged from 5 to 23 and included two female and three male patients. All patients except one had exposure to contaminated water, and microsporidia were detected via PCR in all patients. Microsporidial keratoconjunctivitis was diagnosed based on typical clinical features. The patients were all effectively treated with a course of moxifloxacin and subsequent fluorometholone. This paper reports the typical clinical course of microsporidial keratoconjunctivitis and offers an effective management approach to this condition.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"5069667"},"PeriodicalIF":0.8,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick C Fisel, Martin Spitzer, Aydin Özen, Christos Skevas
{"title":"Early and Pronounced PVR Reaction After Revitrectomy With Allogeneic Platelet Concentrate in Persistent Macular Hole.","authors":"Patrick C Fisel, Martin Spitzer, Aydin Özen, Christos Skevas","doi":"10.1155/crop/5152170","DOIUrl":"10.1155/crop/5152170","url":null,"abstract":"<p><p>We report two cases of pronounced development of proliferative vitreoretinopathy (PVR) within a few days after 23G revitrectomy with allogeneic platelet concentrate (PC) in persistent macular hole in 2023-2024. None of the cases had relevant risk factors for PVR development such as intraoperative retinal tears. Because the revitrectomy with PC was performed as a no-touch technique after a previous uncomplicated vitrectomy, it is suspected that PC was the etiological factor. Many findings from previous studies indicate that the same growth factors that are secreted by the platelets and that are thought to have a positive effect on the closure of the macular foramina were also responsible for the development of PVR. Vitrectomy with PC-usually performed with autologous PC-is considered a safe standard procedure for the treatment of large and persistent macular holes. Why such a pronounced and early PVR reaction occurred in these two cases is unclear. One possible reason could be the use of allogeneic PC in our cases. To the best of our knowledge, there are no reported cases of this kind.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"5152170"},"PeriodicalIF":0.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Refractory Childhood Glaucoma Associated With Sturge-Weber Syndrome Treated With Baerveldt Glaucoma Implant.","authors":"Wakako Imamura, Akira Matsuda, Akira Hirota, Kohei Kuroda, Yorihisa Kitagawa, Tadashiro Saeki, Tomoka Kambe, Shutaro Yamamoto, Satoru Yamagami","doi":"10.1155/crop/8624998","DOIUrl":"10.1155/crop/8624998","url":null,"abstract":"<p><p>We reported the clinical course of refractory childhood glaucoma associated with Sturge-Weber syndrome (SWS) treated with Baerveldt glaucoma implant (BGI). The patient was a 14-year-old male diagnosed with SWS after birth. He had previously undergone four trabeculotomies for glaucoma and vitrectomy for submacular hemorrhage from a diffuse choroidal hemangioma in his left eye. Before the BGI surgery, his intraocular pressure was 30 mmHg under full medications. The patient experienced extensive serous retinal and choroidal detachments on Postoperative Day 9. The cause may have been the increased leakage of serous fluid from the choroidal hemangioma and the high venous pressure in the episclera due to SWS. Retinal and choroidal detachments subsided within 8 days with conservative therapy. It is important to avoid postoperative hypotony for the treatment of secondary childhood glaucoma due to SWS.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"8624998"},"PeriodicalIF":0.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}