Case Reports in Ophthalmological Medicine最新文献

{"title":"Rhino-Orbital-Cerebral Mucormycosis With Bilateral Endogenous <i>Aspergillus</i> Endophthalmitis Following Steroid Therapy for COVID-19 Infection.","authors":"Nasser Shoeibi, Mohammad Etezad Razavi, Farid Shekarchian, Hamid Reza Heidarzadeh, Seyedeh Maryam Hosseini","doi":"10.1155/crop/6610355","DOIUrl":"10.1155/crop/6610355","url":null,"abstract":"<p><strong>Purpose: </strong>We report a diabetic patient with rhino-orbital-cerebral mucormycosis (ROCM) and bilateral endogenous Aspergillus endophthalmitis post-coronavirus disease 2019 (COVID-19) infection.</p><p><strong>Case report: </strong>A 45-year-old man who had diabetes experienced vision loss and sought medical assistance. Prior to developing orbital symptoms, he had undergone intensive corticosteroid therapy for COVID-19. His uncorrected visual acuity was 20/20 in the right eye, but he had no light perception in his left eye. While hospitalized for ROCM, he developed endogenous endophthalmitis in his left eye, which was caused by Aspergillus fumigatus. Additionally, Aspergillus retinitis was diagnosed in his right eye due to the development of white retinal lesions and preretinal hemorrhage. To treat ROCM, he received systemic and retrobulbar injections of amphotericin B, which led to regression. Posaconazole was prescribed for the treatment of Aspergillus endophthalmitis. The retinitis lesions in his right eye responded well to oral posaconazole without any long-term complications.</p><p><strong>Conclusion: </strong>Patients with COVID-19-associated immunodeficiency may be more vulnerable to opportunistic pathogens, such as mucormycosis and Aspergillus, particularly if they have comorbidities like diabetes mellitus. It is also possible for one person to be coinfected with multiple opportunistic pathogens.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"6610355"},"PeriodicalIF":0.8,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHARGE Syndrome Associated With Persistent Hyperplastic Primary Vitreous: A Case Report.","authors":"Li Liu, Liyun Guo, Zailin Xiao, Liwei Zhang, Xuan Ma, Wen Tang, Mei Liu, Shuai Xiong","doi":"10.1155/crop/2159237","DOIUrl":"10.1155/crop/2159237","url":null,"abstract":"<p><strong>Background: </strong>CHARGE syndrome is a rare genetic disorder caused primarily by CHD7 mutations, affecting multiple organs, including the eyes, heart, and ears. Ocular abnormalities are common, but bilateral persistent fetal vasculature (PFV) has not been previously reported in CHARGE syndrome. PFV results from the failure of the fetal hyaloid vasculature to regress, typically affecting one eye.</p><p><strong>Case presentation: </strong>We report a 10-month-old female with bilateral PFV associated with CHARGE syndrome, confirmed by a de novo CHD7 mutation. Systemic evaluation revealed sensorineural hearing loss and congenital cardiac defects. The patient subsequently underwent cataract extraction and intraocular lens implantation in the left eye. Postoperatively, a partial improvement in esotropia was observed.</p><p><strong>Conclusions: </strong>This case represents the first documented instance of bilateral PFV in CHARGE syndrome. It expands the known ocular manifestations of the syndrome and underscores the importance of early genetic diagnosis and multidisciplinary care to optimize patient outcomes.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"2159237"},"PeriodicalIF":0.8,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13243766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Capsular Bag Distension Syndrome: Case Report of an Early Case Following Athalamia due to Vigorous Eye Rubbing.","authors":"Lilian Demolin, Elie Motulsky, Ayoub El Belhadji, Oscar Kallay","doi":"10.1155/crop/8798298","DOIUrl":"10.1155/crop/8798298","url":null,"abstract":"<p><strong>Introduction: </strong>Capsular bag distension syndrome (CBDS) is a rare complication of phacoemulsification, characterized by fluid retention in the capsular bag leading to reduced visual acuity, a myopic shift, and a risk of pupillary block.</p><p><strong>Case presentation: </strong>We report the case of a 65-year-old male who developed CBDS after rubbing his eye vigorously postoperatively. On Postoperative Day 1, his best corrected visual acuity (BCVA) was 0.1 with a myopic shift. We made the diagnosis of CBDS with the Scheimpflug camera and AS-OCT. Conservative management was initially attempted, but due to persistent symptoms, surgical aspiration of the trapped fluid was performed on Day 4. This intervention resulted in BCVA improvement to 0.8 and resolution of the myopic shift.</p><p><strong>Discussion: </strong>Differential diagnoses considered included incorrect IOL power, IOL misplacement, transient corneal edema, and incisional astigmatism. We hypothesize that mechanical athalamia due to eye rubbing was an acute trigger leading to forward IOL displacement, adhering it to the anterior capsule and trapping fluid. A stepwise management approach, including observation followed by surgical intervention, proved effective.</p><p><strong>Conclusion: </strong>CBDS may be precipitated by transient mechanical athalamia following vigorous eye rubbing, which can promote acute intraocular lens-capsular apposition and fluid entrapment. This case highlights the importance of postoperative patient education. Early recognition and management are essential to prevent severe complications such as endophthalmitis and pupillary block.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"8798298"},"PeriodicalIF":0.8,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13239047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Lens Subluxation and Pseudohypopyon.","authors":"Faiza Sarwar, Ahmed Alshaikhsalama, Amer Alsoudi, Ronald Gross","doi":"10.1155/crop/1289814","DOIUrl":"10.1155/crop/1289814","url":null,"abstract":"<p><p>Asteroid hyalosis is a benign condition caused by refractile particles in the posterior segment, typically discovered incidentally during eye examination. Rarely, these particles may migrate to the anterior chamber due to lens subluxation, trauma, or pressure changes and mimic a pseudohypopyon or iris metastasis. This case report describes a 67-year-old man with acute, painful vision loss in the left eye and elevated intraocular pressure. Slit lamp examination revealed anterior lens subluxation with a pseudohypopyon. This case highlights the diagnostic challenge of asteroid hyalosis presenting as a pseudohypopyon. Thus, a pseudohypopyon in patients with lens subluxation, traumatic lens changes, or pressure gradients should prompt consideration of asteroid hyalosis migration, as delayed diagnosis could impair vision. Early recognition of the potential for migration of asteroid hyalosis, especially in an acute presentation, is crucial for effective management.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"1289814"},"PeriodicalIF":0.8,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Angle-Closure Glaucoma Secondary to Vitreous Prolapse Following Ocular Trauma.","authors":"Cullen Moran, So Yeon Uhm, Fitz Gerald I Diala, Vaama Patel, Sylvia Groth","doi":"10.1155/crop/9483412","DOIUrl":"10.1155/crop/9483412","url":null,"abstract":"<p><p>Secondary acute angle-closure glaucoma (AACG) caused by vitreous prolapse in a phakic patient is exceedingly rare. We report a case of AACG secondary to vitreous prolapse, occurring 2 weeks after orbital trauma in a 34-year-old male healthcare worker. The patient presented with acute left eye pain, nausea, and vision loss after performing cardiopulmonary resuscitation (CPR) at his workplace. Two weeks earlier, he sustained a nonoperative orbital floor fracture and commotio retinae from a motor vehicle accident. Examination revealed decreased vision and an intraocular pressure (IOP) of 59 mmHg. Vitreous prolapse into the anterior chamber was detected. Urgent anterior vitrectomy was performed, leading to normalization of IOP and visual acuity improvement to 20/50 at 2 months postoperatively. Valsalva maneuvers and repetitive head movements during CPR likely precipitated vitreous herniation through trauma-induced zonular loss. This case underscores the need to consider vitreous prolapse in the differential for acute angle closure, especially in patients with recent ocular trauma.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"9483412"},"PeriodicalIF":0.8,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Epithelial Ingrowth Following Laser In Situ Keratomileusis due to Screwdriver Trauma.","authors":"Yuhan Kuo, Takashi Ono, Yukako Taketani, Mikiko Kimakura, Tetsuya Toyono, Makoto Aihara, Takashi Miyai","doi":"10.1155/crop/5271498","DOIUrl":"10.1155/crop/5271498","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to report a unique case of rapid epithelial ingrowth following laser in situ keratomileusis (LASIK) flap trauma due to a flat blade screwdriver.</p><p><strong>Observations: </strong>A 36-year-old woman who had undergone LASIK 9 years ago experienced ocular trauma with a flat-blade screwdriver during construction work. She was referred to our hospital with complaints of blurred vision and pain in the right eye and was prescribed antibiotic eye drops. Treatment improved the corneal epithelial defect within 3 weeks of the injury; however, epithelial ingrowth rapidly progressed beneath the LASIK flap 3 months after the trauma. The epithelial ingrowth reached the pupil area 10 months postinjury; nevertheless, the patient's corrected visual acuity remained stable (1.2), and she continues to be followed up.</p><p><strong>Conclusion: </strong>Post-LASIK trauma may lead to epithelial cell ingrowth at the interface of the corneal flap. Thus, careful long-term follow-up is essential, particularly following post-LASIK corneal injury.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"5271498"},"PeriodicalIF":0.8,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Idiopathic Foveal Haemorrhage in a Young Female Adult.","authors":"Michal Ruta, Marta Misiuk-Hojlo","doi":"10.1155/crop/5222043","DOIUrl":"10.1155/crop/5222043","url":null,"abstract":"<p><strong>Background: </strong>Unilateral idiopathic foveal haemorrhage is a rare condition, most often reported in otherwise healthy adults younger than 40 years, and is generally associated with a favourable prognosis.</p><p><strong>Case presentation: </strong>We report the case of a 35-year-old woman who presented to the emergency department with isolated intraretinal foveal haemorrhage. Multimodal imaging, including optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), fundus photography and follow-up fluorescein angiography, was performed to assess the lesion localisation and exclude an underlying retinal vascular abnormality. Systemic evaluation did not identify any underlying cause.</p><p><strong>Conclusions: </strong>Foveal haemorrhage in a young, otherwise healthy patient is a diagnostic challenge and should be evaluated gradually, with a thorough medical history and multimodal imaging, to accurately diagnose and treat the patient. The treatment of idiopathic foveal haemorrhages has no standardised protocol and should be tailored to each case individually. Further research is needed to define evidence-based management strategies for this patient group.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"5222043"},"PeriodicalIF":0.8,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral Rectus Myectomy Combined With Medial Rectus Plication for Complete Oculomotor Nerve Palsy: A Case Report With Detailed Postoperative Course.","authors":"Yuna Irie, Kie Iida, Kazusa Kuwano, Masanobu Iida, Takaaki Hayashi, Tadashi Nakano","doi":"10.1155/crop/1985508","DOIUrl":"10.1155/crop/1985508","url":null,"abstract":"<p><strong>Background: </strong>Lateral rectus myectomy has been reported as an effective and simple surgical option for large-angle paralytic exotropia. We report a case of complete oculomotor nerve palsy treated with lateral rectus myectomy combined with medial rectus plication, focusing on serial changes in ocular alignment and abduction limitation.</p><p><strong>Case report: </strong>A woman in her 20s developed left oculomotor nerve palsy following surgery for an intracranial tumor. At presentation, visual acuity was 20/16 and 20/100, with temporal hemianopia and a central scotoma in the right and left eyes, respectively. She exhibited severe left exotropia exceeding 100 prism diopters (<i>Δ</i>), consistent with complete oculomotor nerve palsy, with a marked limitation of adduction graded as -7. Lateral rectus myectomy and 10 mm medial rectus plication were performed on the left eye. The lateral rectus muscle was resected 10 mm posterior to its insertion, and the distal stump was cauterized and allowed to retract into the posterior Tenon's capsule, intentionally creating a lost muscle. On Postoperative Day 1, ocular alignment improved to 18 <i>Δ</i> of esotropia with severe limitation of abduction graded as -4. From 2 months postoperatively, abduction limitation gradually decreased to -2 at 4 months, concomitant with the gradual recurrence of exotropia, after which both findings remained stable. Orbital MRI performed 5 months postoperatively demonstrated posterior reattachment of the lateral rectus muscle via fibrous tissue. At final follow-up, ocular alignment stabilized at 30 <i>Δ</i> of exotropia.</p><p><strong>Conclusions: </strong>Combined lateral rectus myectomy and medial rectus plication achieved a substantial corrective effect for large-angle paralytic exotropia due to oculomotor nerve palsy. While this technique represents a safe and effective treatment option, postoperative recurrence may occur due to reattachment of the resected lateral rectus muscle to the globe or orbital pulley, highlighting the need for long-term follow-up.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"1985508"},"PeriodicalIF":0.8,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Anterior Lamellar Keratoplasty on a Descemet's Membrane Endothelial Keratoplasty Graft: A Case Report.","authors":"Yuto Yukari, Takahiko Hayashi, Satoru Yamagami","doi":"10.1155/crop/5652228","DOIUrl":"10.1155/crop/5652228","url":null,"abstract":"<p><strong>Introduction: </strong>Deep anterior lamellar keratoplasty (DALK) has been reported in eyes following Descemet's stripping automated endothelial keratoplasty (DSAEK); however, its application after Descemet's membrane endothelial keratoplasty (DMEK) has not been reported.</p><p><strong>Case presentation: </strong>The patient was an 87-year-old woman who underwent repeat DMEK for late DMEK graft failure that had healed with corneal haze due to long-term endothelial dysfunction. DALK was then performed to remove opacity and improve corneal irregular astigmatism. The corneal epithelium and stroma were removed via manual dissection to the pre-Descemet's layer. <i>Candida parapsilosis</i> was detected in a culture test of the obtained host corneal specimen. Because a fungal infection was detected, 0.1% voriconazole eye drops were administered in addition to antibiotic eye drops. Corneal clarity improved, but optical coherence tomography revealed cystoid macular edema (CME). Subtenon triamcinolone acetonide (STTA) injection was performed. The CME resolved 1 week after STTA injection, and the best corrected visual acuity was 0.5 (decimal) 1 month after STTA injection.</p><p><strong>Discussion: </strong>This case demonstrates that DALK can be safely performed after DMEK to treat stromal opacity and irregular astigmatism, with favorable visual and anatomical outcomes. Therapeutic DALK and prophylactic antifungal eye drops effectively treated the fungal infection and recurrence was not observed. This case highlights the clinical feasibility of staged keratoplasty and suggests that DALK may be considered a viable option for managing stromal opacity even after endothelial keratoplasty. These findings may contribute to expanding the surgical indications of DALK in complex corneal cases following endothelial keratoplasty.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"5652228"},"PeriodicalIF":0.8,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Mixed Mechanism Glaucoma Secondary to NewColorIris Implant Using an Ab Externo Xen Gel Stent.","authors":"Roshun Sangani, Param Shukla, Miriam M Habiel","doi":"10.1155/crop/9742946","DOIUrl":"10.1155/crop/9742946","url":null,"abstract":"<p><strong>Background and aims: </strong>We present a case of mixed mechanism glaucoma following NewColorIris implant that was successfully treated using an off-label use of Xen Gel Stent.</p><p><strong>Methods: </strong>A retrospective review of the patient's medical records was conducted following the acquisition of informed consent.</p><p><strong>Results: </strong>A 42-year-old female with a history of bilateral cosmetic iris implants presented to the emergency room due to corneal decompensation and a secondary mixed mechanism glaucoma caused by implant iris chafing in her left eye. The patient underwent prosthetic iris implant removal and had persistently elevated intraocular pressures (IOPs) postoperatively. She underwent a subsequent off-label Xen Gel Stent implantation which has successfully controlled her eye pressures without the need for supplementary antiglaucoma medications for 13 months. This off-label use of the Xen Gel Stent helped the patient maintain excellent IOP and satisfied the patient's cosmetic preferences.</p><p><strong>Conclusion: </strong>Xen Gel Stent may be a safe and effective option to treat secondary glaucoma due to cosmetic iris implants.</p>","PeriodicalId":9603,"journal":{"name":"Case Reports in Ophthalmological Medicine","volume":"2026 ","pages":"9742946"},"PeriodicalIF":0.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}