Case Reports in Nephrology and Dialysis最新文献_第7页

Undetected Iatrogenic Drug-Induced Complications in a Hemodialyzed Anuric Patient: A Case Report and Review of the Literature. 无尿血液透析患者未被发现的医源性药物引起的并发症:1例报告及文献复习。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-27 eCollection Date: 2022-09-01 DOI: 10.1159/000527197

Edouard Cubilier, Mohamed Tayeb Salaouatchi, Maxime Taghavi, Saleh Kaysi, Joëlle Nortier, Maria do Carmo Filomena Mesquita

{"title":"Undetected Iatrogenic Drug-Induced Complications in a Hemodialyzed Anuric Patient: A Case Report and Review of the Literature.","authors":"Edouard Cubilier, Mohamed Tayeb Salaouatchi, Maxime Taghavi, Saleh Kaysi, Joëlle Nortier, Maria do Carmo Filomena Mesquita","doi":"10.1159/000527197","DOIUrl":"https://doi.org/10.1159/000527197","url":null,"abstract":"Anuric hemodialyzed end-stage renal disease patients are prone to multiple complications and comorbidities and are therefore often treated with various medications. Adverse drug reactions and risk factors leading to them can be difficult to discern in such polymedicated patients. Most problems regarding low phosphate levels are frequently underdiagnosed in clinical practice and sometimes overlooked in these regularly hyperphosphatemic patients. Hemodialysis vascular accesses are frequently subject to infections and therefore require adapted antibiotic treatments. We report a case of an occult severe multifactorial hypophosphatemia in an anuric hemodialyzed patient with multiple comorbidities who required two hospitalizations for encephalopathy, seizures, and cardiac failure. Retrospective analysis of the medical record revealed several underlying causes of hypophosphatemia, as well as undetected risk factors for adverse drug reactions related to cephalosporins. A global approach to these concerns in routine clinical practice would raise awareness of often disregarded issues related to hypophosphatemia and drug prescription in these patients.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":" ","pages":"212-218"},"PeriodicalIF":0.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/a4/cnd-0012-0212.PMC9710459.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35252875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Friend or a Foe? Bariatric Surgery in Chronic Kidney Disease: A Case Report. 朋友还是敌人?慢性肾脏疾病的减肥手术一例报告

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-24 eCollection Date: 2022-09-01 DOI: 10.1159/000525736

Sahil Bagai, Bhavna Bansal, Vipra Malik, Pallavi Prasad, Dinesh Khullar

引用次数: 0

An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report. 运动后横纹肌溶解和急性肾损伤的不寻常表现:1例报告。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-20 eCollection Date: 2022-09-01 DOI: 10.1159/000527194

Luiz Henrique Lélis Miranda, Débora Nóbrega de Lima, Marclébio Manuel Coêlho Dourado

{"title":"An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report.","authors":"Luiz Henrique Lélis Miranda, Débora Nóbrega de Lima, Marclébio Manuel Coêlho Dourado","doi":"10.1159/000527194","DOIUrl":"https://doi.org/10.1159/000527194","url":null,"abstract":"Exercise-induced rhabdomyolysis refers to the breakdown of striated muscle, which releases intracellular elements into the bloodstream due to heavy physical activity. In rare instances, this condition may be the first clinical manifestation of sickle cell trait (SCT). We report on a 31-year-old woman with post-infectious fatigue who, after suffering mild COVID-19 symptoms 3 weeks prior, presented with intense muscle pain in the ankles, dyspnea, and choluria hours after strenuous physical exercise during a practical test. She sought emergent care the next day, where serum creatinine was measured at 2.4 mg/dL (baseline 1.0 mg/dL) and creatine phosphokinase at 118,000 U/L. She was previously healthy, without regular use of any medication, and habitually sedentary except in training, with no personal or family history of blood or muscle diseases. She was admitted without hemodialysis and discharged after 2 weeks. At 3 months, she had normalization of creatine phosphokinase and creatinine. As an outpatient, other tests were requested. Hemoglobin (Hb) electrophoresis revealed HbA1 of 57.8%, HbA2 of 3.1%, HbF of 0.3%, and HbS of 38.8%, which were compatible with SCT. Evaluation for SCT should be considered in cases of exercise-induced rhabdomyolysis, especially in young, healthy patients.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":" ","pages":"193-200"},"PeriodicalIF":0.7,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/6c/cnd-0012-0193.PMC9710430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35252869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antineutrophil Cytoplasmic Autoantibody-Negative Pauci-Immune Crescentic Glomerulonephritis in a Patient with Systemic Lupus Erythematosus. 系统性红斑狼疮患者的抗中性粒细胞胞浆自身抗体阴性的包囊免疫新月形肾小球肾炎1例。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-20 eCollection Date: 2022-09-01 DOI: 10.1159/000527248

Chee Eng Chan, Tze Jian Ng, Mohd Kamil Ahmad, Fariz Safhan Mohamad Nor

{"title":"Antineutrophil Cytoplasmic Autoantibody-Negative Pauci-Immune Crescentic Glomerulonephritis in a Patient with Systemic Lupus Erythematosus.","authors":"Chee Eng Chan, Tze Jian Ng, Mohd Kamil Ahmad, Fariz Safhan Mohamad Nor","doi":"10.1159/000527248","DOIUrl":"https://doi.org/10.1159/000527248","url":null,"abstract":"Renal involvement in systemic lupus erythematosus is usually exhibited as lupus nephritis, which is a form of immune complex-mediated glomerulonephritis and one of the most severe organ manifestations of systemic lupus erythematosus. The pathogenesis involved glomerular immune complex deposition, which leads to glomerular inflammation and typically shows a \"full-house\" pattern on immunofluorescence microscopy. Other forms of glomerulonephritis are rarely observed in patients with systemic lupus erythematosus. Pauci-immune crescentic glomerulonephritis is the pattern of injury most commonly observed in patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. The characteristic histological feature of pauci-immune crescentic glomerulonephritis is focal necrotizing and crescentic glomerulonephritis with little or no glomerular staining for immunoglobulin by immunofluorescence microscopy. We report a rare case of antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":" ","pages":"201-206"},"PeriodicalIF":0.7,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/fe/cnd-0012-0201.PMC9710425.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35252872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Uromodulin Is a Possible Auxiliary Diagnostic Tool for Acute Tubular Injury and Acute Interstitial Nephritis: A Case Series. 血清尿调素可能是急性肾小管损伤和急性间质性肾炎的辅助诊断工具:一个病例系列。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000523855

Ryosuke Usui, Tetsuya Ogawa, Chihiro Iwasaki, Kosaku Nitta, Minako Koike

引用次数: 2

Tip Lesion Variant of Focal and Segmental Glomerulosclerosis in a COVID-19 Patient. 1例COVID-19患者局灶性和节段性肾小球硬化尖端病变变异

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000528029

Rita Serra Afonso, Roberto Calças Marques, Henrique Borges, Eduarda Carias, Ana Teresa Domingos, Ana Cabrita, Sandra Sampaio, Ana Paula Silva

{"title":"Tip Lesion Variant of Focal and Segmental Glomerulosclerosis in a COVID-19 Patient.","authors":"Rita Serra Afonso, Roberto Calças Marques, Henrique Borges, Eduarda Carias, Ana Teresa Domingos, Ana Cabrita, Sandra Sampaio, Ana Paula Silva","doi":"10.1159/000528029","DOIUrl":"https://doi.org/10.1159/000528029","url":null,"abstract":"Acute kidney injury is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathologic findings are continually being reported, showing a probably multifactorial etiology. The authors present a case of a patient diagnosed with a tip lesion variant of focal segmental glomerulosclerosis (FSGS) in the setting of COVID-19. A 43-year-old African American female with no known renal disease presented to the emergency department with a 6-day history of fatigue, headache, hypoageusia, myalgia, cough, nausea, and vomiting. Laboratory tests confirmed SARS-CoV-2 infection. During hospitalization, there was a progressive decline in kidney function and evidence of nephrotic-range proteinuria without nephrotic syndrome. Biopsy specimen showed a tip lesion variant of FSGS. Genetic test revealed a homozygous variant of uncertain clinical significance (c.397G>A [p.V133M]) in the epithelial membrane protein 2 (EMP2) gene. To our knowledge, this is the first case report of a tip lesion in a COVID-19 patient with no renal history. More studies are warranted to define susceptible groups and identify the detailed mechanisms of COVID-19-related kidney disease that would allow for specific management of this complication.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"248-254"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/f7/cnd-0012-0248.PMC9841791.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Catastrophic Fibromuscular Dysplasia Presenting with Concomitant Bilateral Renal Infarction, Vertebral Artery Dissection, and Mesenteric Ischaemia. 灾难性纤维肌肉发育不良伴有双侧肾梗死、椎动脉夹层和肠系膜缺血。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000527438

Nicholas Martin Gourd, Hannah Elizabeth Jenkins, Richard Miles, Adrienne Lee, Justin Mason, Andrew Connor

引用次数: 0

Butyricimonas virosa Peritonitis in Peritoneal Dialysis Patient: A Case Report and Review. 腹膜透析患者病毒性丁酸单胞菌腹膜炎1例报告及复习。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000525177

Siew Yan Lau, Boon Cheak Bee, Hin-Seng Wong, Ahneez Abdul Hameed

{"title":"Butyricimonas virosa Peritonitis in Peritoneal Dialysis Patient: A Case Report and Review.","authors":"Siew Yan Lau, Boon Cheak Bee, Hin-Seng Wong, Ahneez Abdul Hameed","doi":"10.1159/000525177","DOIUrl":"https://doi.org/10.1159/000525177","url":null,"abstract":"Butyricimonas virosa is a Gram-negative bacillus, which was first discovered in rat faeces in 2009. To date, only seven human infections have been reported in literature. To our knowledge, this is the first reported case of peritoneal dialysis (PD)-related peritonitis due to B. virosa. A 65-year-old Chinese man presented to the hospital with complaints of dizziness and vomiting. On admission, the drained peritoneal dialysate was cloudy. He was empirically treated as a case of PD-related peritonitis with intraperitoneal (IP) cefazolin, ceftazidime, and gentamicin. B. virosa was isolated from peritoneal fluid sample and the antibiotics were changed to IP imipenem and amikacin. Three weeks after completion of the antibiotics, the patient presented again with cloudy peritoneal dialysate and blood stained diarrhoea. IP imipenem and amikacin were recommenced. Multiple peritoneal dialysate samples were sent to the microbiology laboratory, but this time no microorganism was isolated. Colonoscopy examination revealed the presence of extensive rectosigmoidal ulcerations. IP imipenem was replaced with IP piperacillin-tazobactam when the patient developed imipenem-associated neurotoxicity at Day 9 of treatment. The patient recovered fully after completing 3 weeks of IP piperacillin-tazobactam and 2 weeks of IP amikacin. This is the first reported case of PD-related peritonitis due to B. virosa. Susceptibility data for B. virosa are scarce, but a 3-week course of IP piperacillin-tazobactam, imipenem, or meropenem could be potentially useful in treating PD-related peritonitis caused by this organism.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"157-162"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/46/30/cnd-0012-0157.PMC9743142.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10755442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Primary Sclerosing Cholangitis and Amyloid A Amyloidosis: Association or Coincidence? 原发性硬化性胆管炎与淀粉样蛋白A:关联还是巧合?

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000524665

Rosanna Lacetera, Letizia Roggero, Paolo Vercelloni, Martina Uzzo, Marco Carbone, Pietro Invernizzi, Vincenzo L'Imperio, Federico Pieruzzi, Renato Alberto Sinico

{"title":"Primary Sclerosing Cholangitis and Amyloid A Amyloidosis: Association or Coincidence?","authors":"Rosanna Lacetera, Letizia Roggero, Paolo Vercelloni, Martina Uzzo, Marco Carbone, Pietro Invernizzi, Vincenzo L'Imperio, Federico Pieruzzi, Renato Alberto Sinico","doi":"10.1159/000524665","DOIUrl":"https://doi.org/10.1159/000524665","url":null,"abstract":"AA amyloidosis may complicate several chronic inflammatory conditions. From a clinical point of view, causality between inflammatory pathology and AA amyloidosis can be assumed because of the data described in the literature; some of the best known include rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and chronic infections. Singles cases of inflammatory diseases have been found at AA amyloidosis. Causality becomes more plausible if at least two different cases with AA amyloidosis are both found to have the same rare inflammatory disease. We describe the case of a patient with primary sclerosing cholangitis (PSC) with development of AA amyloidosis conditioning a nephrotic syndrome, likely secondary to failure to control the chronic inflammatory process. Only two cases in the literature describe the association of this rare disease and the appearance of AA amyloidosis. The treatment of AA amyloidosis consists in treating the underlying inflammatory disorder; to date, few effective treatments are available for PSC. Therefore, and in view of the limited data in the literature, we believe it is important to describe its association.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"178-184"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/69/cnd-0012-0178.PMC9743140.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10755443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients. 更多的药物监测和更少的脑部CT扫描:加巴喷丁过量在两个腹膜透析患者。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000525922

Kijanosh Lehmann, Sara Diab, Torsten M Meyer, Jan T Kielstein, Gabriele Eden

{"title":"More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients.","authors":"Kijanosh Lehmann, Sara Diab, Torsten M Meyer, Jan T Kielstein, Gabriele Eden","doi":"10.1159/000525922","DOIUrl":"https://doi.org/10.1159/000525922","url":null,"abstract":"In parallel with the decline of renal excretory function, drug dosing of many drugs becomes more challenging. Finding the right dose is even more difficult if kidney replacement therapy is instituted. This is further aggravated by the fact that even for substances with a narrow therapeutic range, drug monitoring is only rarely offered, let alone advocated. This holds also true for gabapentin, an anticonvulsant drug that is increasingly prescribed for indications such as cancer-related pain, restless legs syndrome, migraine, or uremic pruritus. The drug is excreted unchanged in urine, so plasma clearance of gabapentin is directly proportional to creatinine clearance. Hence, renal impairment reduces gabapentin excretion and increases plasma gabapentin concentrations in a linear fashion. Therefore, the elimination half-life of gabapentin is between 5 and 9 h, in patients with normal renal function but increases to 132 h in patients on dialysis. Epidemiological data from the USRDS underline this problem. About 19% of the 140,899 adult USA patients enrolled in Medicare coverage received gabapentin in 2011. Its use was associated with an increased risk of altered mental status, fall, and fracture. We report 2 patients in which overdose of gabapentin occurred. In 1 patient, severe neurological symptoms prompted an extensive diagnostic work up, while the underlying cause of the clinical presentation was a supra-therapeutic drug level of gabapentin. Consequently, symptoms subsided with the discontinuation of the drug. Indication and drug dose of gabapentin in dialysis patients should be tightly controlled, and drug monitoring used to avoid unintended overdose.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"145-149"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/32/cnd-0012-0145.PMC9743139.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1