Case Reports in Nephrology and Dialysis最新文献_第7页

Serum Uromodulin Is a Possible Auxiliary Diagnostic Tool for Acute Tubular Injury and Acute Interstitial Nephritis: A Case Series. 血清尿调素可能是急性肾小管损伤和急性间质性肾炎的辅助诊断工具:一个病例系列。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000523855

Ryosuke Usui, Tetsuya Ogawa, Chihiro Iwasaki, Kosaku Nitta, Minako Koike

引用次数: 2

Tip Lesion Variant of Focal and Segmental Glomerulosclerosis in a COVID-19 Patient. 1例COVID-19患者局灶性和节段性肾小球硬化尖端病变变异

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000528029

Rita Serra Afonso, Roberto Calças Marques, Henrique Borges, Eduarda Carias, Ana Teresa Domingos, Ana Cabrita, Sandra Sampaio, Ana Paula Silva

{"title":"Tip Lesion Variant of Focal and Segmental Glomerulosclerosis in a COVID-19 Patient.","authors":"Rita Serra Afonso, Roberto Calças Marques, Henrique Borges, Eduarda Carias, Ana Teresa Domingos, Ana Cabrita, Sandra Sampaio, Ana Paula Silva","doi":"10.1159/000528029","DOIUrl":"https://doi.org/10.1159/000528029","url":null,"abstract":"Acute kidney injury is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathologic findings are continually being reported, showing a probably multifactorial etiology. The authors present a case of a patient diagnosed with a tip lesion variant of focal segmental glomerulosclerosis (FSGS) in the setting of COVID-19. A 43-year-old African American female with no known renal disease presented to the emergency department with a 6-day history of fatigue, headache, hypoageusia, myalgia, cough, nausea, and vomiting. Laboratory tests confirmed SARS-CoV-2 infection. During hospitalization, there was a progressive decline in kidney function and evidence of nephrotic-range proteinuria without nephrotic syndrome. Biopsy specimen showed a tip lesion variant of FSGS. Genetic test revealed a homozygous variant of uncertain clinical significance (c.397G>A [p.V133M]) in the epithelial membrane protein 2 (EMP2) gene. To our knowledge, this is the first case report of a tip lesion in a COVID-19 patient with no renal history. More studies are warranted to define susceptible groups and identify the detailed mechanisms of COVID-19-related kidney disease that would allow for specific management of this complication.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"248-254"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/f7/cnd-0012-0248.PMC9841791.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Catastrophic Fibromuscular Dysplasia Presenting with Concomitant Bilateral Renal Infarction, Vertebral Artery Dissection, and Mesenteric Ischaemia. 灾难性纤维肌肉发育不良伴有双侧肾梗死、椎动脉夹层和肠系膜缺血。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000527438

Nicholas Martin Gourd, Hannah Elizabeth Jenkins, Richard Miles, Adrienne Lee, Justin Mason, Andrew Connor

引用次数: 0

Butyricimonas virosa Peritonitis in Peritoneal Dialysis Patient: A Case Report and Review. 腹膜透析患者病毒性丁酸单胞菌腹膜炎1例报告及复习。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000525177

Siew Yan Lau, Boon Cheak Bee, Hin-Seng Wong, Ahneez Abdul Hameed

{"title":"Butyricimonas virosa Peritonitis in Peritoneal Dialysis Patient: A Case Report and Review.","authors":"Siew Yan Lau, Boon Cheak Bee, Hin-Seng Wong, Ahneez Abdul Hameed","doi":"10.1159/000525177","DOIUrl":"https://doi.org/10.1159/000525177","url":null,"abstract":"Butyricimonas virosa is a Gram-negative bacillus, which was first discovered in rat faeces in 2009. To date, only seven human infections have been reported in literature. To our knowledge, this is the first reported case of peritoneal dialysis (PD)-related peritonitis due to B. virosa. A 65-year-old Chinese man presented to the hospital with complaints of dizziness and vomiting. On admission, the drained peritoneal dialysate was cloudy. He was empirically treated as a case of PD-related peritonitis with intraperitoneal (IP) cefazolin, ceftazidime, and gentamicin. B. virosa was isolated from peritoneal fluid sample and the antibiotics were changed to IP imipenem and amikacin. Three weeks after completion of the antibiotics, the patient presented again with cloudy peritoneal dialysate and blood stained diarrhoea. IP imipenem and amikacin were recommenced. Multiple peritoneal dialysate samples were sent to the microbiology laboratory, but this time no microorganism was isolated. Colonoscopy examination revealed the presence of extensive rectosigmoidal ulcerations. IP imipenem was replaced with IP piperacillin-tazobactam when the patient developed imipenem-associated neurotoxicity at Day 9 of treatment. The patient recovered fully after completing 3 weeks of IP piperacillin-tazobactam and 2 weeks of IP amikacin. This is the first reported case of PD-related peritonitis due to B. virosa. Susceptibility data for B. virosa are scarce, but a 3-week course of IP piperacillin-tazobactam, imipenem, or meropenem could be potentially useful in treating PD-related peritonitis caused by this organism.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"157-162"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/46/30/cnd-0012-0157.PMC9743142.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10755442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Primary Sclerosing Cholangitis and Amyloid A Amyloidosis: Association or Coincidence? 原发性硬化性胆管炎与淀粉样蛋白A:关联还是巧合?

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000524665

Rosanna Lacetera, Letizia Roggero, Paolo Vercelloni, Martina Uzzo, Marco Carbone, Pietro Invernizzi, Vincenzo L'Imperio, Federico Pieruzzi, Renato Alberto Sinico

{"title":"Primary Sclerosing Cholangitis and Amyloid A Amyloidosis: Association or Coincidence?","authors":"Rosanna Lacetera, Letizia Roggero, Paolo Vercelloni, Martina Uzzo, Marco Carbone, Pietro Invernizzi, Vincenzo L'Imperio, Federico Pieruzzi, Renato Alberto Sinico","doi":"10.1159/000524665","DOIUrl":"https://doi.org/10.1159/000524665","url":null,"abstract":"AA amyloidosis may complicate several chronic inflammatory conditions. From a clinical point of view, causality between inflammatory pathology and AA amyloidosis can be assumed because of the data described in the literature; some of the best known include rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and chronic infections. Singles cases of inflammatory diseases have been found at AA amyloidosis. Causality becomes more plausible if at least two different cases with AA amyloidosis are both found to have the same rare inflammatory disease. We describe the case of a patient with primary sclerosing cholangitis (PSC) with development of AA amyloidosis conditioning a nephrotic syndrome, likely secondary to failure to control the chronic inflammatory process. Only two cases in the literature describe the association of this rare disease and the appearance of AA amyloidosis. The treatment of AA amyloidosis consists in treating the underlying inflammatory disorder; to date, few effective treatments are available for PSC. Therefore, and in view of the limited data in the literature, we believe it is important to describe its association.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"178-184"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/69/cnd-0012-0178.PMC9743140.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10755443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients. 更多的药物监测和更少的脑部CT扫描:加巴喷丁过量在两个腹膜透析患者。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000525922

Kijanosh Lehmann, Sara Diab, Torsten M Meyer, Jan T Kielstein, Gabriele Eden

{"title":"More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients.","authors":"Kijanosh Lehmann, Sara Diab, Torsten M Meyer, Jan T Kielstein, Gabriele Eden","doi":"10.1159/000525922","DOIUrl":"https://doi.org/10.1159/000525922","url":null,"abstract":"In parallel with the decline of renal excretory function, drug dosing of many drugs becomes more challenging. Finding the right dose is even more difficult if kidney replacement therapy is instituted. This is further aggravated by the fact that even for substances with a narrow therapeutic range, drug monitoring is only rarely offered, let alone advocated. This holds also true for gabapentin, an anticonvulsant drug that is increasingly prescribed for indications such as cancer-related pain, restless legs syndrome, migraine, or uremic pruritus. The drug is excreted unchanged in urine, so plasma clearance of gabapentin is directly proportional to creatinine clearance. Hence, renal impairment reduces gabapentin excretion and increases plasma gabapentin concentrations in a linear fashion. Therefore, the elimination half-life of gabapentin is between 5 and 9 h, in patients with normal renal function but increases to 132 h in patients on dialysis. Epidemiological data from the USRDS underline this problem. About 19% of the 140,899 adult USA patients enrolled in Medicare coverage received gabapentin in 2011. Its use was associated with an increased risk of altered mental status, fall, and fracture. We report 2 patients in which overdose of gabapentin occurred. In 1 patient, severe neurological symptoms prompted an extensive diagnostic work up, while the underlying cause of the clinical presentation was a supra-therapeutic drug level of gabapentin. Consequently, symptoms subsided with the discontinuation of the drug. Indication and drug dose of gabapentin in dialysis patients should be tightly controlled, and drug monitoring used to avoid unintended overdose.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"145-149"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/32/cnd-0012-0145.PMC9743139.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Actinotignum schaalii Can Be an Uropathogen of "Culture-Negative" Febrile Urinary Tract Infections in Children with Urinary Tract Abnormalities. 沙利放线菌可能是尿路异常儿童“培养阴性”发热性尿路感染的尿源病原体。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000526398

Mami Washio, Nobutaka Harada, Daisuke Nishima, Megumi Takemoto

{"title":"Actinotignum schaalii Can Be an Uropathogen of \"Culture-Negative\" Febrile Urinary Tract Infections in Children with Urinary Tract Abnormalities.","authors":"Mami Washio, Nobutaka Harada, Daisuke Nishima, Megumi Takemoto","doi":"10.1159/000526398","DOIUrl":"https://doi.org/10.1159/000526398","url":null,"abstract":"Accurate diagnosis and treatment of febrile urinary tract infections (UTI) during childhood are important for the prevention of renal parenchymal damage and functional loss, and detection of underlying diseases related to chronic kidney disease (CKD). Actinotignum schaalii (A. schaalii)-related febrile UTI in children is rare, and its incidence and risk factors remain unclear. A 3-year-old boy with a history of UTI presented with fever and vomiting. Although the culture of his urine specimen in air was negative, A. schaalii was observed in a 5% carbon dioxide (CO2) culture condition, as well as an anaerobic one. A diagnosis of febrile UTI was made, and he recovered with antibiotic therapy. He was found to have CKD associated with vesicoureteral reflux (VUR) after further investigations. A. schaalii is one of the causative agents of febrile UTI in children with urinary tract abnormalities. Although the culture in the air could show negative results, urine culture in 5% CO2 and anaerobic conditions is useful for diagnosis. Our case is the youngest and the first known case of A. schaalii-related febrile UTI associated with VUR in children.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"150-156"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/59/cnd-0012-0150.PMC9743144.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10813546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication. 血液吸附:溴西泮中毒的一种新的治疗选择。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000526323

Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts, Tim Balthazar

引用次数: 1

Rituximab, Mycophenolic Acid, and Calcineurin Inhibitors Achieve Long-Term Remission in Pediatric Focal Segmental Glomerulosclerosis with Steroid-Resistant and Frequently Relapsing Nephrotic Syndrome: A Report of Two Cases. 利妥昔单抗、霉酚酸和钙调磷酸酶抑制剂治疗小儿局灶节段性肾小球硬化伴类固醇抵抗和频繁复发肾病综合征的长期缓解:两例报告

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000525776

Cahyani Gita Ambarsari, Meilania Saraswati, Genta Syaifrin Laudza

{"title":"Rituximab, Mycophenolic Acid, and Calcineurin Inhibitors Achieve Long-Term Remission in Pediatric Focal Segmental Glomerulosclerosis with Steroid-Resistant and Frequently Relapsing Nephrotic Syndrome: A Report of Two Cases.","authors":"Cahyani Gita Ambarsari, Meilania Saraswati, Genta Syaifrin Laudza","doi":"10.1159/000525776","DOIUrl":"https://doi.org/10.1159/000525776","url":null,"abstract":"Studies investigating the effect of rituximab in children with nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS) have reported conflicting results, with some concluding that patients may require additional immunosuppressive therapy to achieve and/or maintain long-term remission. We report successful treatment of pediatric FSGS with rituximab infusions, followed by maintenance immunosuppression with mycophenolic acid (MPA) and a calcineurin inhibitor (CNI) in 1 patient with refractory steroid-resistant NS (SRNS), and one with frequently relapsing NS (FRNS). Case 1 is a patient with refractory SRNS due to FSGS. MPA and tacrolimus induced complete remission within 6 months following rituximab treatment. Remission was maintained for over 2 years, and the patient's kidney function and body height also returned to normal ranges within this time. Case 2 is a patient with FRNS due to FSGS, who was treated with rituximab followed by MPA and cyclosporine, which successfully prevented relapses for 18 months, that is, at the end point of the observation. Our case report demonstrates that rituximab and a combination of CNIs and MPA can be effective in achieving complete remission in pediatric refractory SRNS and sustaining remission in pediatric FSGS with FRNS and SRNS for several years. This treatment regimen has the advantage of eliminating the need for long-term high-dose steroid treatments, allowing 1 patient to achieve normal growth and recover from other adverse steroid effects.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 3","pages":"167-177"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/cb/cnd-0012-0167.PMC9743143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10813548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Severe Bullous Pemphigoid Onset after Jugular Catheter Placement in a Patient on Hemodialysis. 1例血液透析患者颈静脉置管后发生严重大疱性类天疱疮。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-08-29 eCollection Date: 2022-05-01 DOI: 10.1159/000524903

Lucas Jacobs, Francesco Feoli, Pascal Bruderer, Semra Top, Ivan Grozdev, Edouard Cubilier, Frederic Collart

引用次数: 1