Case Reports in Nephrology and Dialysis最新文献_第7页

Primary Sclerosing Cholangitis and Amyloid A Amyloidosis: Association or Coincidence? 原发性硬化性胆管炎与淀粉样蛋白A:关联还是巧合?

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000524665

Rosanna Lacetera, Letizia Roggero, Paolo Vercelloni, Martina Uzzo, Marco Carbone, Pietro Invernizzi, Vincenzo L'Imperio, Federico Pieruzzi, Renato Alberto Sinico

{"title":"Primary Sclerosing Cholangitis and Amyloid A Amyloidosis: Association or Coincidence?","authors":"Rosanna Lacetera, Letizia Roggero, Paolo Vercelloni, Martina Uzzo, Marco Carbone, Pietro Invernizzi, Vincenzo L'Imperio, Federico Pieruzzi, Renato Alberto Sinico","doi":"10.1159/000524665","DOIUrl":"https://doi.org/10.1159/000524665","url":null,"abstract":"AA amyloidosis may complicate several chronic inflammatory conditions. From a clinical point of view, causality between inflammatory pathology and AA amyloidosis can be assumed because of the data described in the literature; some of the best known include rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, and chronic infections. Singles cases of inflammatory diseases have been found at AA amyloidosis. Causality becomes more plausible if at least two different cases with AA amyloidosis are both found to have the same rare inflammatory disease. We describe the case of a patient with primary sclerosing cholangitis (PSC) with development of AA amyloidosis conditioning a nephrotic syndrome, likely secondary to failure to control the chronic inflammatory process. Only two cases in the literature describe the association of this rare disease and the appearance of AA amyloidosis. The treatment of AA amyloidosis consists in treating the underlying inflammatory disorder; to date, few effective treatments are available for PSC. Therefore, and in view of the limited data in the literature, we believe it is important to describe its association.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/69/cnd-0012-0178.PMC9743140.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10755443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients. 更多的药物监测和更少的脑部CT扫描:加巴喷丁过量在两个腹膜透析患者。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000525922

Kijanosh Lehmann, Sara Diab, Torsten M Meyer, Jan T Kielstein, Gabriele Eden

{"title":"More Drug Monitoring and Less CT Scans of the Brain: Gabapentin Overdose in Two Peritoneal Dialysis Patients.","authors":"Kijanosh Lehmann, Sara Diab, Torsten M Meyer, Jan T Kielstein, Gabriele Eden","doi":"10.1159/000525922","DOIUrl":"https://doi.org/10.1159/000525922","url":null,"abstract":"In parallel with the decline of renal excretory function, drug dosing of many drugs becomes more challenging. Finding the right dose is even more difficult if kidney replacement therapy is instituted. This is further aggravated by the fact that even for substances with a narrow therapeutic range, drug monitoring is only rarely offered, let alone advocated. This holds also true for gabapentin, an anticonvulsant drug that is increasingly prescribed for indications such as cancer-related pain, restless legs syndrome, migraine, or uremic pruritus. The drug is excreted unchanged in urine, so plasma clearance of gabapentin is directly proportional to creatinine clearance. Hence, renal impairment reduces gabapentin excretion and increases plasma gabapentin concentrations in a linear fashion. Therefore, the elimination half-life of gabapentin is between 5 and 9 h, in patients with normal renal function but increases to 132 h in patients on dialysis. Epidemiological data from the USRDS underline this problem. About 19% of the 140,899 adult USA patients enrolled in Medicare coverage received gabapentin in 2011. Its use was associated with an increased risk of altered mental status, fall, and fracture. We report 2 patients in which overdose of gabapentin occurred. In 1 patient, severe neurological symptoms prompted an extensive diagnostic work up, while the underlying cause of the clinical presentation was a supra-therapeutic drug level of gabapentin. Consequently, symptoms subsided with the discontinuation of the drug. Indication and drug dose of gabapentin in dialysis patients should be tightly controlled, and drug monitoring used to avoid unintended overdose.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/32/cnd-0012-0145.PMC9743139.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Actinotignum schaalii Can Be an Uropathogen of "Culture-Negative" Febrile Urinary Tract Infections in Children with Urinary Tract Abnormalities. 沙利放线菌可能是尿路异常儿童“培养阴性”发热性尿路感染的尿源病原体。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000526398

Mami Washio, Nobutaka Harada, Daisuke Nishima, Megumi Takemoto

{"title":"Actinotignum schaalii Can Be an Uropathogen of \"Culture-Negative\" Febrile Urinary Tract Infections in Children with Urinary Tract Abnormalities.","authors":"Mami Washio, Nobutaka Harada, Daisuke Nishima, Megumi Takemoto","doi":"10.1159/000526398","DOIUrl":"https://doi.org/10.1159/000526398","url":null,"abstract":"Accurate diagnosis and treatment of febrile urinary tract infections (UTI) during childhood are important for the prevention of renal parenchymal damage and functional loss, and detection of underlying diseases related to chronic kidney disease (CKD). Actinotignum schaalii (A. schaalii)-related febrile UTI in children is rare, and its incidence and risk factors remain unclear. A 3-year-old boy with a history of UTI presented with fever and vomiting. Although the culture of his urine specimen in air was negative, A. schaalii was observed in a 5% carbon dioxide (CO2) culture condition, as well as an anaerobic one. A diagnosis of febrile UTI was made, and he recovered with antibiotic therapy. He was found to have CKD associated with vesicoureteral reflux (VUR) after further investigations. A. schaalii is one of the causative agents of febrile UTI in children with urinary tract abnormalities. Although the culture in the air could show negative results, urine culture in 5% CO2 and anaerobic conditions is useful for diagnosis. Our case is the youngest and the first known case of A. schaalii-related febrile UTI associated with VUR in children.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dc/59/cnd-0012-0150.PMC9743144.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10813546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemadsorption: A New Therapeutic Option for Selected Cases of Bromazepam Intoxication. 血液吸附:溴西泮中毒的一种新的治疗选择。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000526323

Michaël Mekeirele, Silke Verheyen, Ruth Van Lancker, Stephanie Wuyts, Tim Balthazar

引用次数: 1

Rituximab, Mycophenolic Acid, and Calcineurin Inhibitors Achieve Long-Term Remission in Pediatric Focal Segmental Glomerulosclerosis with Steroid-Resistant and Frequently Relapsing Nephrotic Syndrome: A Report of Two Cases. 利妥昔单抗、霉酚酸和钙调磷酸酶抑制剂治疗小儿局灶节段性肾小球硬化伴类固醇抵抗和频繁复发肾病综合征的长期缓解:两例报告

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Case Reports in Nephrology and Dialysis Pub Date : 2022-09-01 DOI: 10.1159/000525776

Cahyani Gita Ambarsari, Meilania Saraswati, Genta Syaifrin Laudza

{"title":"Rituximab, Mycophenolic Acid, and Calcineurin Inhibitors Achieve Long-Term Remission in Pediatric Focal Segmental Glomerulosclerosis with Steroid-Resistant and Frequently Relapsing Nephrotic Syndrome: A Report of Two Cases.","authors":"Cahyani Gita Ambarsari, Meilania Saraswati, Genta Syaifrin Laudza","doi":"10.1159/000525776","DOIUrl":"https://doi.org/10.1159/000525776","url":null,"abstract":"Studies investigating the effect of rituximab in children with nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS) have reported conflicting results, with some concluding that patients may require additional immunosuppressive therapy to achieve and/or maintain long-term remission. We report successful treatment of pediatric FSGS with rituximab infusions, followed by maintenance immunosuppression with mycophenolic acid (MPA) and a calcineurin inhibitor (CNI) in 1 patient with refractory steroid-resistant NS (SRNS), and one with frequently relapsing NS (FRNS). Case 1 is a patient with refractory SRNS due to FSGS. MPA and tacrolimus induced complete remission within 6 months following rituximab treatment. Remission was maintained for over 2 years, and the patient's kidney function and body height also returned to normal ranges within this time. Case 2 is a patient with FRNS due to FSGS, who was treated with rituximab followed by MPA and cyclosporine, which successfully prevented relapses for 18 months, that is, at the end point of the observation. Our case report demonstrates that rituximab and a combination of CNIs and MPA can be effective in achieving complete remission in pediatric refractory SRNS and sustaining remission in pediatric FSGS with FRNS and SRNS for several years. This treatment regimen has the advantage of eliminating the need for long-term high-dose steroid treatments, allowing 1 patient to achieve normal growth and recover from other adverse steroid effects.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/cb/cnd-0012-0167.PMC9743143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10813548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Severe Bullous Pemphigoid Onset after Jugular Catheter Placement in a Patient on Hemodialysis. 1例血液透析患者颈静脉置管后发生严重大疱性类天疱疮。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-08-29 eCollection Date: 2022-05-01 DOI: 10.1159/000524903

Lucas Jacobs, Francesco Feoli, Pascal Bruderer, Semra Top, Ivan Grozdev, Edouard Cubilier, Frederic Collart

引用次数: 1

Vena Cava Superior Syndrome Six Years after Central Venous Catheter Removal in a Patient on Hemodialysis. 1例血液透析患者中心静脉导管拔除6年后的上腔静脉综合征。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-08-29 eCollection Date: 2022-05-01 DOI: 10.1159/000525795

Michelle Janssen, Susan Logtenberg

引用次数: 0

Rifabutin-Induced SIADH and Leucopenia in a Renal Transplant Recipient with Genitourinary Tract Tuberculosis: A Case Report and Review of the Literature. 利法布汀致肾移植受者伴泌尿生殖道结核的SIADH和白细胞减少1例报告及文献复习。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-08-19 eCollection Date: 2022-05-01 DOI: 10.1159/000525921

Maha Mohamed, Muhammad Waseem Athar, Yaasir Mamoojee, Alison Brown, Frances Dowen, Jim Macfarlane

{"title":"Rifabutin-Induced SIADH and Leucopenia in a Renal Transplant Recipient with Genitourinary Tract Tuberculosis: A Case Report and Review of the Literature.","authors":"Maha Mohamed, Muhammad Waseem Athar, Yaasir Mamoojee, Alison Brown, Frances Dowen, Jim Macfarlane","doi":"10.1159/000525921","DOIUrl":"https://doi.org/10.1159/000525921","url":null,"abstract":"Tuberculosis (TB) infection of the genitourinary tract (GU TB) is rare in renal transplant recipients, with only a few published case series. GU TB is difficult to diagnose with or without immunosuppression but must always be suspected in any patient with unexplained sterile pyuria. As GU TB is associated with graft rejection, prompt diagnosis and treatment are vital. Treatment is challenging, as rifampicin, the most effective drug used to treat tuberculosis, is a significant inducer of cytochrome P-450 3A metabolism, with the potential to cause significant reductions in the serum levels of calcineurin inhibitors. For this reason, rifabutin, a weaker cytochrome P-450 3A inducer, with similar efficacy against TB, is sometimes used as an alternative to rifampicin in transplant recipients. We present a renal transplant patient diagnosed with GU TB, treated with a regime containing rifabutin, who subsequently developed profound hyponatremia and leucopenia. Serum and urine biochemistry was consistent with a diagnosis of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Both SIADH and leucopenia resolved with rifabutin cessation. This is the first report of biochemically proven, idiosyncratic SIADH and leucopenia associated with the use of rifabutin in the treatment of GU TB in a renal transplant recipient.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/26/cnd-0012-0117.PMC9459626.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33485336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four Cases of Serum Copper Excess in Patients with Renal Anemia Receiving a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor: A Possible Safety Concern. 4例接受缺氧诱导因子-丙氨酸羟化酶抑制剂治疗的肾性贫血患者血清铜过量:可能的安全问题

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Case Reports in Nephrology and Dialysis Pub Date : 2022-08-19 eCollection Date: 2022-05-01 DOI: 10.1159/000525735

Hironori Nakamura, Shigekazu Kurihara, Mariko Anayama, Yasushi Makino, Masaki Nagasawa

{"title":"Four Cases of Serum Copper Excess in Patients with Renal Anemia Receiving a Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor: A Possible Safety Concern.","authors":"Hironori Nakamura, Shigekazu Kurihara, Mariko Anayama, Yasushi Makino, Masaki Nagasawa","doi":"10.1159/000525735","DOIUrl":"https://doi.org/10.1159/000525735","url":null,"abstract":"Copper is an indispensable trace metal element and is mainly absorbed in the stomach and small intestine and excreted into the bile. Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) have emerged as a novel approach for renal anemia management. Many intestinal genes, including divalent metal transporter 1, duodenal cytochrome B, and copper transporter ATPase7A, related to iron absorption are transactivated by HlF-α, during iron deficiency. We first report 4 cases of patients with renal anemia who showed excess in serum copper level during roxadustat or daprodustat treatment, which were decreased to the normal level after discontinuing HIF-PHIs and changing the drug to darbepoetin alfa, suggesting that HIF-PHI is associated with serum copper excess. HIF-PHI modulates iron metabolism, such as iron absorption, sequestration, and mobilization, and may increase serum copper levels by increasing copper absorption and/or redistribution of copper in tissues. Therefore, it is urgent to examine the correlation between HIF-PHI use and serum copper levels because copper excess might be involved in several acute or chronic adverse events.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/57/cnd-0012-0124.PMC9459559.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33485334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Acute Kidney Injury following Exposure to Formaldehyde-Free Hair-Straightening Products. 接触无甲醛直发产品后急性肾损伤。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-07-11 eCollection Date: 2022-05-01 DOI: 10.1159/000525567

Nabil Abu-Amer, Natalie Silberstein, Margarita Kunin, Sharon Mini, Pazit Beckerman

{"title":"Acute Kidney Injury following Exposure to Formaldehyde-Free Hair-Straightening Products.","authors":"Nabil Abu-Amer, Natalie Silberstein, Margarita Kunin, Sharon Mini, Pazit Beckerman","doi":"10.1159/000525567","DOIUrl":"https://doi.org/10.1159/000525567","url":null,"abstract":"Formaldehyde-free hair-straightening products are hair-smoothening solutions widely used by professional beauty salons. Formaldehyde-free hair straighteners do not technically contain formaldehyde; however, they contain other chemicals such as glyoxyloyl carbocysteine which releases formaldehyde upon contact with heat. Moreover, its by-product glyoxylate may convert to oxalate; both compounds have potential nephrotoxic effect. Here, we report a case of a 41-year-old woman who presented to the emergency room with weakness, nausea, vomiting, and stage 3 acute kidney injury (AKI) according to Kidney Disease: Improving Global Outcomes (KDIGO) acute kidney injury staging shortly after exposure to formaldehyde-free hair-straightening product; other causes of AKI were excluded such as preceding acute illness, drug history, or other nephrotoxic agent exposure. On physical examination, the patient was pale, and her vital signs were normal. The urine microscopy and serologic workup were not indicative. Kidney core biopsy revealed interstitial edema, acute interstitial nephritis, and oxalate crystal nephropathy. Kidney function completely recovered after a short course of steroid therapy. In this case, AKI was a complication caused by exposure to hair-straightening products branded as formaldehyde free but actually containing other chemical products which release formaldehyde and other toxic chemicals when heated during the straightening procedure and may cause systemic toxicity, particularly kidney injury. Different cosmetic products are widely in use, but not all are under tight regulation, and therefore, it is important to raise the awareness among both medical teams and consumers of possible adverse health effects of different cosmetic products.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b5/ab/cnd-0012-0112.PMC9386411.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0