Case Reports in Nephrology and Dialysis最新文献_第10页

Genetically Confirmed Edwardsiella tarda Peritonitis was Associated with Improper Caregiver's Hand Hygiene during Peritoneal Dialysis Bag Exchange 经遗传学证实的迟发爱德华菌腹膜炎与腹膜透析袋交换期间护理人员的手卫生不当有关

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Case Reports in Nephrology and Dialysis Pub Date : 2022-03-04 DOI: 10.1159/000521351

R. Chieochanthanakij, Wasin Manuprasert, N. Udomsantisuk, L. Pearson, T. Kanjanabuch

引用次数: 0

Small Bowel Obstruction with a Transition Point in a Patient on Peritoneal Dialysis 腹膜透析患者小肠梗阻伴转移点

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Case Reports in Nephrology and Dialysis Pub Date : 2022-03-01 DOI: 10.1159/000521350

Babak S. Jazayeri-Moghadass, Ryan Sutherland, Lakir D. Patel, Valeriu Cebotaru

引用次数: 1

Transient Hyperkalemia Following Treatment of Chronic Hypokalemia: A Case Report and Review of Distal Tubule Physiology 慢性低钾血症治疗后的一过性高钾血症:一例报告及远端小管生理学回顾

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Case Reports in Nephrology and Dialysis Pub Date : 2022-01-31 DOI: 10.1159/000521477

Matthew C. Breeggemann, S. Gluck

{"title":"Transient Hyperkalemia Following Treatment of Chronic Hypokalemia: A Case Report and Review of Distal Tubule Physiology","authors":"Matthew C. Breeggemann, S. Gluck","doi":"10.1159/000521477","DOIUrl":"https://doi.org/10.1159/000521477","url":null,"abstract":"Hypokalemia is a relatively common electrolyte disorder usually resulting from gastrointestinal wasting. Transient hyperkalemia in those treated for hypokalemia has been previously described to occur in 16% of hospitalized patients. The majority of those patients had acute, hospital-acquired hypokalemia. Here, we report a case of a young man with alcohol use disorder and chronic hypokalemia who was hospitalized for muscle weakness, abdominal pain, and intractable emesis. His potassium was 2.5 mEq/L on the day of admission. Four days later, with a creatinine at baseline (0.9 mg/dL), potassium abruptly increased to 6.7 mEq/L. He did not have evidence of hyperaldosteronism. In cases of chronic hypokalemia, we propose that the adaptive mechanisms of the distal tubule with total body potassium deficits require time to revert back to a nonactive state and that transient hyperkalemia may be observed during these “refractory” periods during which potassium supplementation is continued. The time required for disassembly of with no lysine kinases following resolution of hypokalemia is unknown. Hyperkalemia is an important consideration when treating patients with chronic hypokalemia.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"12 1","pages":"1 - 4"},"PeriodicalIF":0.7,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43783407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Efficacy of Plasmapheresis in Nivolumab-Associated ANCA Glomerulonephritis: A Case Report and Pathophysiology Discussion. 血浆置换治疗尼伏单抗相关性ANCA肾小球肾炎1例及病理生理学探讨。

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Case Reports in Nephrology and Dialysis Pub Date : 2021-12-30 eCollection Date: 2021-09-01 DOI: 10.1159/000518304

Reda Laamech, Florian Terrec, Camille Emprou, Anne Claire Toffart, Thomas Pierret, Hamza Naciri-Bennani, Lionel Rostaing, Johan Noble

{"title":"Efficacy of Plasmapheresis in Nivolumab-Associated ANCA Glomerulonephritis: A Case Report and Pathophysiology Discussion.","authors":"Reda Laamech, Florian Terrec, Camille Emprou, Anne Claire Toffart, Thomas Pierret, Hamza Naciri-Bennani, Lionel Rostaing, Johan Noble","doi":"10.1159/000518304","DOIUrl":"https://doi.org/10.1159/000518304","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have revolutionized solid organ and hematologic cancer treatments by improving overall prognoses. However, they can lead to overactivation of the immune system and several immune-related adverse events and sometimes affecting the renal system. Although acute interstitial nephritis is well described, we know little about ICI-associated glomerular injury. Herein, we report an exceptional case of renal ANCA positive-associated vasculitis (AAV) after nivolumab therapy. Three weeks after the last nivolumab injection, the patient presented with proteinuria at 1.73 g/g of creatininuria, hematuria, and acute kidney injury needing dialysis associated with lung hemorrhage; anti-neutrophil cytoplasmic antibody (ANCA titer ≥1,280 with myeloperoxidase specificity of 780 U/mL) was positive, and kidney biopsy confirmed glomerular injury with crescents. The patient underwent treatment with steroid pulses, rituximab, and plasmapheresis, resulting in an improvement of the renal function and lung hemorrhage and produced a negative ANCA titer. Despite the results of the PEXIVAS study and the absence of clear benefit of plasmapheresis demonstrated in idiopathic AAV, we suggest that drug-induced AAV may be effectively treated by plasmapheresis, steroids, and rituximab.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"11 3","pages":"376-383"},"PeriodicalIF":0.7,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/61/84/cnd-0011-0376.PMC8787507.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39883056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Acknowledgement to the Reviewers 对评审员的确认

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Case Reports in Nephrology and Dialysis Pub Date : 2021-12-21 DOI: 10.1159/000520195

引用次数: 0

Severe Acute Respiratory Syndrome Corona Virus-2 Infection in a Pediatric Kidney Transplant Recipient: A Case Report from India. 小儿肾移植受者的严重急性呼吸综合征冠状病毒2感染:来自印度的一例报告

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Case Reports in Nephrology and Dialysis Pub Date : 2021-12-07 eCollection Date: 2021-09-01 DOI: 10.1159/000520558

Ravi Raju Tatapudi, Venkateswara Rao Kopparti, Anusha Poosapati, Srinivas Metta, Vedita Palli, Balakrishna Vedulla

{"title":"Severe Acute Respiratory Syndrome Corona Virus-2 Infection in a Pediatric Kidney Transplant Recipient: A Case Report from India.","authors":"Ravi Raju Tatapudi, Venkateswara Rao Kopparti, Anusha Poosapati, Srinivas Metta, Vedita Palli, Balakrishna Vedulla","doi":"10.1159/000520558","DOIUrl":"https://doi.org/10.1159/000520558","url":null,"abstract":"COVID-19 pandemic affected millions of people across India. COVID-19 cases are fewer in children with less severity and better outcomes than in adults. However, a small proportion develop severe illness and succumb to the disease. Clinical manifestations and optimal management of COVID-19 in immunocompromised children are not clearly known. Remdesivir was shown to be efficient in reducing the recovery time in COVID-19 patients requiring supplemental oxygen. Remdesivir is approved for use in children with severe COVID-19, but there are no guidelines in patients with risk factors like recent solid organ transplantation. We report a case of a 10-year-old kidney transplant recipient (KTR) infected with severe acute respiratory syndrome corona virus-2, 2.5 months after the transplantation. Unlike most children, he presented with high fever, cough, and vomiting. His inflammatory markers were elevated. In this case report, we discussed management and clinical outcomes of this patient. In view of recent kidney transplantation and the severity of infection with emergent oxygen requirement, we gave him remdesivir. We continued prednisolone and tacrolimus and stopped mycophenolate. He recovered completely in 7 days. We feel that severely immunosuppressed KTR children with COVID-19 will benefit with remdesivir administration. Monitoring tacrolimus trough levels is essential for maintaining adequate immunosuppression.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"11 3","pages":"367-373"},"PeriodicalIF":0.7,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/b1/cnd-0011-0367.PMC8738907.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39724783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Successful Kidney Transplant for Nephropathic Cystinosis in a Patient with Von Willebrand Disease Type III: The First Case Report. 血管性血友病III型肾病型胱氨酸病患者肾移植成功1例

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Case Reports in Nephrology and Dialysis Pub Date : 2021-11-30 eCollection Date: 2021-09-01 DOI: 10.1159/000520794

Mohammad Khaled Alsultan, Zeina Nizar Bdeir, Qussai Hassan, Tahani Ali

{"title":"Successful Kidney Transplant for Nephropathic Cystinosis in a Patient with Von Willebrand Disease Type III: The First Case Report.","authors":"Mohammad Khaled Alsultan, Zeina Nizar Bdeir, Qussai Hassan, Tahani Ali","doi":"10.1159/000520794","DOIUrl":"https://doi.org/10.1159/000520794","url":null,"abstract":"Nephropathic cystinosis (NC) is a rare autosomal recessive disease, which causes cysteine-crystals accumulation with progression to end-stage renal disease (ESRD). Von willebrand disease (VWD) type III is a rare subtype of von willebrand factor (VWF) abnormality, which is characterized by severe reduction of VWF and factor VIII activity. A 16-year-old patient with NC and VWD type III presented with uremic symptoms due to ESRD. Dialysis access was inserted and followed by hemodialysis (HD) for 4 months with a proper infusion of blood products. While renal transplant remains the treatment of choice of NC and superior to chronic HD, bleeding complications were a major concern in this case with coexisting VWD type III. However, with the meticulous implementation of the Hematology team's daily recommendations, renal transplantation was successfully performed. This is the first case that mentions a new association between two inherited rare disorders, NC and VWD type III, and this entity has not been reported before. Moreover, successful kidney transplantation in our patient supports the possibility of these procedures in hereditary clotting disorders.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"11 3","pages":"362-366"},"PeriodicalIF":0.7,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/14/cnd-0011-0362.PMC8739642.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39724784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabry Nephropathy in a Young Female Patient Presenting with Only Urinary Mulberry Bodies Treated with Chaperone Therapy. 法布里肾病的年轻女性患者在只有尿桑体与伴侣治疗。

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Case Reports in Nephrology and Dialysis Pub Date : 2021-11-29 eCollection Date: 2021-09-01 DOI: 10.1159/000520157

Tsugumi Fukunaga, Shingo Nakayama, Takuo Hirose, Kishin Muramatsu, Akari Endo, Yuka Miyake, Go Anan, Ikuko Oba-Yabana, Atsuhiro Kanno, Hannah Nakamura, Junichi Tani, Kimitoshi Nakamura, Kazuhiro Sumitomo, Wako Yumura, Katsutoshi Furukawa, Takefumi Mori

{"title":"Fabry Nephropathy in a Young Female Patient Presenting with Only Urinary Mulberry Bodies Treated with Chaperone Therapy.","authors":"Tsugumi Fukunaga, Shingo Nakayama, Takuo Hirose, Kishin Muramatsu, Akari Endo, Yuka Miyake, Go Anan, Ikuko Oba-Yabana, Atsuhiro Kanno, Hannah Nakamura, Junichi Tani, Kimitoshi Nakamura, Kazuhiro Sumitomo, Wako Yumura, Katsutoshi Furukawa, Takefumi Mori","doi":"10.1159/000520157","DOIUrl":"https://doi.org/10.1159/000520157","url":null,"abstract":"Fabry disease (FD) is an X-linked disorder of the sphingolipid metabolism, caused by deficiency or decreased activity of α-galactosidase A. We report a rare case of Fabry nephropathy (FN) in a 21-year-old Japanese female patient presenting with only urinary mulberry bodies; she was treated with pharmacological chaperone therapy (PCT) after renal biopsy. The patient underwent a detailed examination because her mother was diagnosed with FD in the Division of Community Medicine of our hospital. She did not have renal dysfunction or proteinuria, and only mulberry bodies were detected in the urine. The activity of α-galactosidase A was low, and genetic analysis revealed the R301Q mutation. A percutaneous renal biopsy was performed, and the findings revealed enlargement and vacuolation of glomerular podocytes by light microscopy, and myelin and zebra bodies were detected in podocytes by electron microscopy. She was diagnosed with FN by renal biopsy and gene analysis. PCT was selected as the treatment to prevent cardiac events and renal dysfunction. The present case suggests that renal biopsy may be necessary even for young women with only mulberry bodies for the diagnosis of FN. It could be useful to evaluate the effect of treatment using the counts of mulberry bodies in the urine. In addition, due to its oral administration, PCT may be suitable for patients who are unable to visit the hospital frequently.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"11 3","pages":"355-361"},"PeriodicalIF":0.7,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/ba/cnd-0011-0355.PMC8739663.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemolysis in a Patient during Hemodialysis. 一例血液透析患者的溶血。

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Case Reports in Nephrology and Dialysis Pub Date : 2021-11-23 eCollection Date: 2021-09-01 DOI: 10.1159/000520559

Maxime Taghavi, Lucas Jacobs, Saleh Kaysi, Maria do Carmo Filomena Mesquita

{"title":"Hemolysis in a Patient during Hemodialysis.","authors":"Maxime Taghavi, Lucas Jacobs, Saleh Kaysi, Maria do Carmo Filomena Mesquita","doi":"10.1159/000520559","DOIUrl":"https://doi.org/10.1159/000520559","url":null,"abstract":"We report a case of hemolysis during a hemodialysis (HD) session in a 71-year-old man. His end-stage kidney disease is secondary to light-chain amyloidosis with renal involvement. Despite immunosuppressive treatment, his renal function continued to decline, and dialysis had to be initiated. Peritoneal dialysis (PD) was started but that had to be converted to HD because of pleural effusion due to PD fluid leakage. On the event day, the patient presented a respiratory distress 2 h after the initiation of HD. He developed a sudden onset of dyspnea with hypoxemia, associated with abdominal pain, nausea, and vomiting. He also presented chest pain with arterial hypertension. The pre-pump arterial and post-pump pressures were, respectively, 40 and 100 mm Hg, with no machine alarm. The blood color in the circuit changed and became darker, so HD was stopped immediately without blood restitution, and then a blood workup was obtained, and the patient was treated with oxygen therapy, IV methylprednisolone 40 mg, and IV furosemide 100 mg. Tubing checkup performed after the incident showed a kinked arterial tube which led to the suspicion of acute hemolysis. Blood transfusion was therefore urgently ordered, and the patient was immediately transferred to the intensive care unit (ICU). Artificial ventilation was required for 4 days, with initial massive blood transfusion. A 24-h treatment with extracorporeal cytokine adsorber CytoSorb® was also performed, followed by the regular HD sessions thrice weekly. Evolution was favorable, and the patient was discharged from the ICU 18 days later.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"11 3","pages":"348-354"},"PeriodicalIF":0.7,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/67/cnd-0011-0348.PMC8740279.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection. 恶性相关膜性肾病伴抗pla2r自身抗体阳性:巧合或联系。

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Case Reports in Nephrology and Dialysis Pub Date : 2021-11-18 eCollection Date: 2021-09-01 DOI: 10.1159/000520399

Lyle W Baker, Jaime Jimenez-Lopez, Xochiquetzal J Geiger, Nabeel Aslam

{"title":"Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection.","authors":"Lyle W Baker, Jaime Jimenez-Lopez, Xochiquetzal J Geiger, Nabeel Aslam","doi":"10.1159/000520399","DOIUrl":"https://doi.org/10.1159/000520399","url":null,"abstract":"Membranous nephropathy (MN) is currently classified as either primary - often associated with positive anti-phospholipase-A2 receptor (PLA2R) autoantibodies - or as secondary - associated with malignancy, infection, medications, or autoimmune disease. We present a case of biopsy-proven MN with very high serum titer of anti-PLA2R autoantibodies in a patient with a synchronous diagnosis of poorly differentiated esophageal adenocarcinoma and renal cell carcinoma who presented with nephrotic syndrome. Based on the current classification, MN in the presence of active malignancy is diagnosed as secondary and unlikely to have positive anti-PLA2R autoantibodies. This raises several questions: whether this patient has secondary MN associated with malignancy and coincidentally discovered anti-PLA2R autoantibodies, primary MN due to anti-PLA2R autoantibodies with coincidentally discovered malignancy, or whether malignancy can induce the formation of anti-PLA2R autoantibodies that result in MN. This case report highlights the importance of age-appropriate cancer screening, even in patients with presumed primary MN and positive anti-PLA2R autoantibodies.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":"11 3","pages":"334-339"},"PeriodicalIF":0.7,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/d0/cnd-0011-0334.PMC8738902.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4