Case Reports in Nephrology and Dialysis最新文献_第6页

Low-Density Lipoprotein Adsorption by Centrifugal Plasma Separation Can Shorten Treatment Time. 离心等离子体吸附低密度脂蛋白可缩短处理时间。

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Case Reports in Nephrology and Dialysis Pub Date : 2023-01-01 DOI: 10.1159/000531097

Atsushi Ohkubo, Takatoshi Sakurasawa, Shotaro Naito

{"title":"Low-Density Lipoprotein Adsorption by Centrifugal Plasma Separation Can Shorten Treatment Time.","authors":"Atsushi Ohkubo, Takatoshi Sakurasawa, Shotaro Naito","doi":"10.1159/000531097","DOIUrl":"https://doi.org/10.1159/000531097","url":null,"abstract":"Low-density lipoprotein (LDL) apheresis is effective for nephrotic syndrome in drug-resistant focal segmental glomerulosclerosis (FSGS). Dextran sulfate adsorption of LDL (DSAL) is widely used for this purpose. The Liposorber LA-15 system performs DSAL by membrane plasma separation (mDSAL) using an MA-03 plasma purification device. However, sufficient blood flow (Qb) frequently cannot be obtained from a peripheral vein with mDSAL. The recommended plasma filtration flow rate (Qf) when using the OP-05W membrane plasma separator is no more than 1/3 of Qb, giving plasma removal efficiency (PRE) of about 30%. In contrast, the centrifugal blood component separator Spectra Optia has PRE of 87-92.5% because centrifugal separation enables effective separation of plasma components even at low Qb. Here, we present the case of a man in his 40s with FSGS, for whom we began treatment with mDSAL with the intention of completing a 12-session cycle, but extended treatment times were required due to low Qb. Therefore, we switched to DSAL by centrifugation (cDSAL) using the Liposorber LA-40 system from the 6th session onward. Treatment time decreased from 190 min for the fifth session using mDSAL to 140 min for the sixth session using cDSAL. Mean treatment time also decreased from 155 ± 9 min for mDSAL (5 sessions) to 119 ± 20 min for cDSAL (7 sessions). Moreover, the LDL removal rate at a processed plasma volume was similar for both modalities. In conclusion, cDSAL can enable efficient plasma separation even with low Qb, with a comparable LDL removal rate and shorter treatment time relative to mDSAL.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/73/cnd-2023-0013-0001-531097.PMC10359670.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10221935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgement to Reviewers 审稿人致谢

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Case Reports in Nephrology and Dialysis Pub Date : 2022-12-16 DOI: 10.1159/000528549

引用次数: 0

Anti-GBM Disease after Oxford-AstraZeneca ChAdOx1 nCoV-19 Vaccination: A Report of Two Cases. 牛津-阿斯利康ChAdOx1 nCoV-19疫苗接种后的抗gbm疾病:附2例报告

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Case Reports in Nephrology and Dialysis Pub Date : 2022-11-22 eCollection Date: 2022-09-01 DOI: 10.1159/000525737

Craig Peter Coorey, Elaine Phua, Angela Chou, Yvonne Shen, Amanda Mather

{"title":"Anti-GBM Disease after Oxford-AstraZeneca ChAdOx1 nCoV-19 Vaccination: A Report of Two Cases.","authors":"Craig Peter Coorey, Elaine Phua, Angela Chou, Yvonne Shen, Amanda Mather","doi":"10.1159/000525737","DOIUrl":"https://doi.org/10.1159/000525737","url":null,"abstract":"There have been reports of rare de novo glomerular diseases following vaccination for coronavirus disease 2019 (COVID-19). We report two cases of anti-glomerular basement membrane (GBM) disease in previously healthy females after Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19). The first case was a 69-year-old female who developed lethargy and anuria approximately 8 weeks after her first dose of Oxford-AstraZeneca COVID-19 vaccine. The second case was a 72-year-old female who developed malaise and diarrhoea approximately 3 weeks after her second dose of Oxford-AstraZeneca COVID-19 vaccine. Both cases had severe acute kidney injury, raised anti-GBM antibody titres, and renal biopsies consistent with anti-GBM disease. Both cases were commenced on haemodialysis and treated with high dose glucocorticoids, cyclophosphamide, and plasmapheresis. Neither patient had recovery of renal function, and both remain dialysis dependent. These cases add to the previously reported cases of anti-GBM disease after mRNA COVID-19 vaccination. As more COVID-19 vaccinations are administered worldwide, it would be important for clinicians to be aware of this possible association, and continued surveillance is warranted.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/10/9e/cnd-0012-0234.PMC9710461.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35343448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Efficacy and Safety of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist in Real-Life: A Case Series of Patients in Maintenance Incremental Hemodialysis. 胰高血糖素样肽-1受体激动剂Semaglutide在现实生活中的有效性和安全性:维护性渐进式血液透析患者的病例系列。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-11-22 eCollection Date: 2022-09-01 DOI: 10.1159/000527919

José C De la Flor, Javier Deira Lorenzo, Alexander Marschall, Francisco Valga, Tania Monzón Vázquez, Elisa Ruiz Cícero

{"title":"Efficacy and Safety of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist in Real-Life: A Case Series of Patients in Maintenance Incremental Hemodialysis.","authors":"José C De la Flor, Javier Deira Lorenzo, Alexander Marschall, Francisco Valga, Tania Monzón Vázquez, Elisa Ruiz Cícero","doi":"10.1159/000527919","DOIUrl":"https://doi.org/10.1159/000527919","url":null,"abstract":"The glucagon-like peptide-1 receptor agonists (GLP-1RA) are among the newest treatment options available for managing of type 2 diabetes mellitus and slowing the progression of diabetes kidney disease (DKD). Subcutaneous (SC) semaglutide (Ozempic®) is a GLP-1RA with an extended half-life of approximately 1 week. GLP-1RA are highly effective in improving glycemic control and also show other beneficial effects such as increased natriuresis; decreased blood pressure and albuminuria; reduction of oxidative stress and inflammation; delay of gastric emptying and suppress appetite; the latter may result in significant weight loss. GLP-1RA can be used in patients with advanced-stage CKD; the European Medicines Agency has approved the use of all commercially available human GLP-1 analogs up to a minimal eGFR of 15 mL/min/1.73 m2. However, studies of safety and use of these agents in renal replacement therapy are scarce. Therefore, herein we present 3 cases of patients with advanced DKD in maintenance incremental hemodialysis with 1 session per week to describe the efficacy and safety of the SC semaglutide treatment and the favorable effects on glycemic control, lowering HbA1c, albuminuria, weight, blood pressure control, and preservation of residual kidney function (RKF) during a 6-month follow-up in a hospital hemodialysis unit in Spain. These effects could produce an improvement in morbidity and mortality and could also prevent albuminuria and preserve the RKF. This may allow our patients to maintain a weekly hemodialysis session and could facilitate their inclusion in the kidney transplant waiting lists.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/21/cnd-0012-0238.PMC9710441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35253168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Triosephosphate-Isomerase Deficiency: Epiphenomenon or Cause of Loin Pain Haematuria Syndrome? 三磷酸异构体酶缺乏:腰痛血尿综合征的附带现象还是原因?

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Case Reports in Nephrology and Dialysis Pub Date : 2022-11-11 eCollection Date: 2022-09-01 DOI: 10.1159/000527330

Hans-Joachim Schurek, Peter Maisel, Udo Helmchen, Björn Reusch, Arnulf Pekrun

{"title":"Triosephosphate-Isomerase Deficiency: Epiphenomenon or Cause of Loin Pain Haematuria Syndrome?","authors":"Hans-Joachim Schurek, Peter Maisel, Udo Helmchen, Björn Reusch, Arnulf Pekrun","doi":"10.1159/000527330","DOIUrl":"https://doi.org/10.1159/000527330","url":null,"abstract":"A 32-year-old male patient presented the clinical picture of loin pain haematuria syndrome with pain attacks accompanied by macrohaematuria. In renal biopsy, the preglomerular vessels showed segmental wall hyalinosis in the sense of low-grade nephrosclerosis, and glomerular capillaries with slightly but diffusely thickened, non-split basal membranes on electron microscopy. Notable were irregularly deformed, different dense erythrocytes in the glomerular capillaries, and several tubular lumina. The suspicion of erythrocytic enzyme deficiency could be confirmed. The enzyme activities of the erythrocytes were predominantly normal or slightly increased; only the activity of triosephosphate isomerase, a critical key enzyme of glycolysis, was reduced to 71% (resp. 57%) of the normal level, compatible with a heterozygous carrier status that could not be found. Patients with genomic triosephosphate-isomerase deficiency have degraded enzyme activities in virtually all tissues, such as leucocytes, platelets, and muscle cells. An association with neuromuscular symptoms is also known. Thus, it is possible that smooth muscle and intrarenal vascular spasms trigger clinical symptoms consisting of flank pain and phases of macrohaematuria. An aspirin-like defect (thrombocytopathy) had previously been found in connection with epistaxis (also due to TPI deficiency?). Enalapril treatment drastically reduced the frequency of macrohaematuria and pain attacks decreased to a lesser extent.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ad/f8/cnd-0012-0226.PMC9710468.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35253171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis. 生酮饮食奶昔含毛囊钩蚴相关急性间质性肾炎。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-27 eCollection Date: 2022-09-01 DOI: 10.1159/000526391

Gilda Portalatin, Shruti Shettigar, Astrid Carrion-Rodriguez, Sushma Medikayala, Leal Herlitz, Dianne Sandy, Surafel K Gebreselassie, Shane A Bobart

{"title":"Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis.","authors":"Gilda Portalatin, Shruti Shettigar, Astrid Carrion-Rodriguez, Sushma Medikayala, Leal Herlitz, Dianne Sandy, Surafel K Gebreselassie, Shane A Bobart","doi":"10.1159/000526391","DOIUrl":"https://doi.org/10.1159/000526391","url":null,"abstract":"Uncaria tomentosa is a plant that has been used in traditional medicine for its anti-inflammatory, immunomodulatory, and immunostimulant properties. As a result, it can be found in several over-the-counter supplements worldwide. Acute interstitial nephritis (AIN) can be due to an offending medication, infection, or autoimmunity. We present a case of a patient who was on a strict ketogenic diet, utilizing over-the-counter diet shakes containing the herbal supplement Uncaria tomentosa who developed acute kidney injury with a serum creatinine of 3.6 mg/dL up from a baseline of 0.7 mg/dL. Serological evaluation was negative, and kidney biopsy revealed interstitial inflammatory infiltrates including focally prominent eosinophils and multifocal tubulitis. Stopping the keto-diet shake containing Uncaria tomentosa and concomitant corticosteroid therapy resulted in improvement in kidney function to near baseline. To our knowledge, this is the only biopsy-proven case of AIN in the setting of Uncaria tomentosa use.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/a6/cnd-0012-0219.PMC9710449.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35252868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undetected Iatrogenic Drug-Induced Complications in a Hemodialyzed Anuric Patient: A Case Report and Review of the Literature. 无尿血液透析患者未被发现的医源性药物引起的并发症:1例报告及文献复习。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-27 eCollection Date: 2022-09-01 DOI: 10.1159/000527197

Edouard Cubilier, Mohamed Tayeb Salaouatchi, Maxime Taghavi, Saleh Kaysi, Joëlle Nortier, Maria do Carmo Filomena Mesquita

{"title":"Undetected Iatrogenic Drug-Induced Complications in a Hemodialyzed Anuric Patient: A Case Report and Review of the Literature.","authors":"Edouard Cubilier, Mohamed Tayeb Salaouatchi, Maxime Taghavi, Saleh Kaysi, Joëlle Nortier, Maria do Carmo Filomena Mesquita","doi":"10.1159/000527197","DOIUrl":"https://doi.org/10.1159/000527197","url":null,"abstract":"Anuric hemodialyzed end-stage renal disease patients are prone to multiple complications and comorbidities and are therefore often treated with various medications. Adverse drug reactions and risk factors leading to them can be difficult to discern in such polymedicated patients. Most problems regarding low phosphate levels are frequently underdiagnosed in clinical practice and sometimes overlooked in these regularly hyperphosphatemic patients. Hemodialysis vascular accesses are frequently subject to infections and therefore require adapted antibiotic treatments. We report a case of an occult severe multifactorial hypophosphatemia in an anuric hemodialyzed patient with multiple comorbidities who required two hospitalizations for encephalopathy, seizures, and cardiac failure. Retrospective analysis of the medical record revealed several underlying causes of hypophosphatemia, as well as undetected risk factors for adverse drug reactions related to cephalosporins. A global approach to these concerns in routine clinical practice would raise awareness of often disregarded issues related to hypophosphatemia and drug prescription in these patients.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/a4/cnd-0012-0212.PMC9710459.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35252875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Friend or a Foe? Bariatric Surgery in Chronic Kidney Disease: A Case Report. 朋友还是敌人?慢性肾脏疾病的减肥手术一例报告

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-24 eCollection Date: 2022-09-01 DOI: 10.1159/000525736

Sahil Bagai, Bhavna Bansal, Vipra Malik, Pallavi Prasad, Dinesh Khullar

引用次数: 0

An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report. 运动后横纹肌溶解和急性肾损伤的不寻常表现:1例报告。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-20 eCollection Date: 2022-09-01 DOI: 10.1159/000527194

Luiz Henrique Lélis Miranda, Débora Nóbrega de Lima, Marclébio Manuel Coêlho Dourado

{"title":"An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report.","authors":"Luiz Henrique Lélis Miranda, Débora Nóbrega de Lima, Marclébio Manuel Coêlho Dourado","doi":"10.1159/000527194","DOIUrl":"https://doi.org/10.1159/000527194","url":null,"abstract":"Exercise-induced rhabdomyolysis refers to the breakdown of striated muscle, which releases intracellular elements into the bloodstream due to heavy physical activity. In rare instances, this condition may be the first clinical manifestation of sickle cell trait (SCT). We report on a 31-year-old woman with post-infectious fatigue who, after suffering mild COVID-19 symptoms 3 weeks prior, presented with intense muscle pain in the ankles, dyspnea, and choluria hours after strenuous physical exercise during a practical test. She sought emergent care the next day, where serum creatinine was measured at 2.4 mg/dL (baseline 1.0 mg/dL) and creatine phosphokinase at 118,000 U/L. She was previously healthy, without regular use of any medication, and habitually sedentary except in training, with no personal or family history of blood or muscle diseases. She was admitted without hemodialysis and discharged after 2 weeks. At 3 months, she had normalization of creatine phosphokinase and creatinine. As an outpatient, other tests were requested. Hemoglobin (Hb) electrophoresis revealed HbA1 of 57.8%, HbA2 of 3.1%, HbF of 0.3%, and HbS of 38.8%, which were compatible with SCT. Evaluation for SCT should be considered in cases of exercise-induced rhabdomyolysis, especially in young, healthy patients.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2a/6c/cnd-0012-0193.PMC9710430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35252869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antineutrophil Cytoplasmic Autoantibody-Negative Pauci-Immune Crescentic Glomerulonephritis in a Patient with Systemic Lupus Erythematosus. 系统性红斑狼疮患者的抗中性粒细胞胞浆自身抗体阴性的包囊免疫新月形肾小球肾炎1例。

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Case Reports in Nephrology and Dialysis Pub Date : 2022-10-20 eCollection Date: 2022-09-01 DOI: 10.1159/000527248

Chee Eng Chan, Tze Jian Ng, Mohd Kamil Ahmad, Fariz Safhan Mohamad Nor

{"title":"Antineutrophil Cytoplasmic Autoantibody-Negative Pauci-Immune Crescentic Glomerulonephritis in a Patient with Systemic Lupus Erythematosus.","authors":"Chee Eng Chan, Tze Jian Ng, Mohd Kamil Ahmad, Fariz Safhan Mohamad Nor","doi":"10.1159/000527248","DOIUrl":"https://doi.org/10.1159/000527248","url":null,"abstract":"Renal involvement in systemic lupus erythematosus is usually exhibited as lupus nephritis, which is a form of immune complex-mediated glomerulonephritis and one of the most severe organ manifestations of systemic lupus erythematosus. The pathogenesis involved glomerular immune complex deposition, which leads to glomerular inflammation and typically shows a \"full-house\" pattern on immunofluorescence microscopy. Other forms of glomerulonephritis are rarely observed in patients with systemic lupus erythematosus. Pauci-immune crescentic glomerulonephritis is the pattern of injury most commonly observed in patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. The characteristic histological feature of pauci-immune crescentic glomerulonephritis is focal necrotizing and crescentic glomerulonephritis with little or no glomerular staining for immunoglobulin by immunofluorescence microscopy. We report a rare case of antineutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus.","PeriodicalId":9599,"journal":{"name":"Case Reports in Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/fe/cnd-0012-0201.PMC9710425.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35252872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0