Cardiovascular diagnosis and therapy最新文献

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The best devices for superficial femoral artery, with "limited" cases and vessel preparations. 最佳装置用于股浅动脉,“有限”病例和血管准备。
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-19 DOI: 10.21037/cdt-24-418
Norihito Nakamura, Manabu Shiozaki, Sho Torii
{"title":"The best devices for superficial femoral artery, with \"limited\" cases and vessel preparations.","authors":"Norihito Nakamura, Manabu Shiozaki, Sho Torii","doi":"10.21037/cdt-24-418","DOIUrl":"10.21037/cdt-24-418","url":null,"abstract":"","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1003-1006"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A computer vision model for the identification and scoring of calcium in aortic valve stenosis: a single-center experience. 主动脉瓣狭窄中钙的识别和评分的计算机视觉模型:单中心体验。
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-16 DOI: 10.21037/cdt-24-179
Tibor Poruban, Dominik Pella, Ingrid Schusterova, Marta Jakubova, Karolina Angela Sieradzka Uchnar, Marianna Barbierik Vachalcova
{"title":"A computer vision model for the identification and scoring of calcium in aortic valve stenosis: a single-center experience.","authors":"Tibor Poruban, Dominik Pella, Ingrid Schusterova, Marta Jakubova, Karolina Angela Sieradzka Uchnar, Marianna Barbierik Vachalcova","doi":"10.21037/cdt-24-179","DOIUrl":"10.21037/cdt-24-179","url":null,"abstract":"<p><strong>Background: </strong>Echocardiography is widely used to assess aortic stenosis (AS) but can yield inconsistent results, leading to uncertainty about AS severity and the need for further diagnostics. This retrospective study aimed to evaluate a novel echocardiography-based marker, the signal intensity coefficient (SIC), for its potential in accurately identifying and quantifying calcium in AS, enhancing noninvasive diagnostic methods.</p><p><strong>Methods: </strong>Between May 2022 and October 2023, 112 cases of AS that were previously considered severe by echocardiography were retrospectively evaluated, as well as a group of 50 cases of mild or moderate AS, both at the Eastern Slovak Institute of Cardiovascular Diseases in Kosice, Slovakia. Utilizing ImageJ software, we quantified the SIC based on ultrasonic signal intensity distribution at the aortic valve's interface. Pixel intensity histograms were generated to measure the SIC, and it was compared with echocardiographic variables. To account for variations in brightness due to differing acquisition settings in echocardiography images (where the highest intensity corresponds to calcium), adaptive image binarization has been implemented. Subsequently, the region of interest (ROI) containing calcium was interactively selected and extracted. This process enables the calculation of a calcium pixel count, representing the spatial quantity of calcium. This study employed multivariate logistic regression using backward elimination and stepwise techniques. Receiver operating characteristic (ROC) curves were utilized to assess the model's performance in predicting AS severity and to determine the optimal cut-off point.</p><p><strong>Results: </strong>The SIC emerged as a significant predictor of AS severity, with an odds ratio (OR) of 0.021 [95% confidence interval (CI): 0.004-0.295, P=0.008]. Incorporating SIC into a model alongside standard echocardiographic parameters notably enhanced the C-statistic/ROC area from 0.7023 to 0.8083 (P=0.01).</p><p><strong>Conclusions: </strong>The SIC, serving as an additional echocardiography-based marker, shows promise in enhancing AS severity detection.</p>","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1029-1037"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the impact of evolocumab on thin-cap fibroatheroma and endothelial function in patients with very high-risk atherosclerotic cardiovascular disease: a study protocol for a randomized controlled trial. 评估evolocumab对高危动脉粥样硬化性心血管疾病患者薄帽纤维粥样硬化瘤和内皮功能的影响:一项随机对照试验的研究方案
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-19 DOI: 10.21037/cdt-24-336
Bingyu Gao, Nan Nan, Mingduo Zhang, Jinfan Tian, Yanlong Ren, Yuguo Xue, Min Zhang, Xiantao Song, Changjiang Ge
{"title":"Assessing the impact of evolocumab on thin-cap fibroatheroma and endothelial function in patients with very high-risk atherosclerotic cardiovascular disease: a study protocol for a randomized controlled trial.","authors":"Bingyu Gao, Nan Nan, Mingduo Zhang, Jinfan Tian, Yanlong Ren, Yuguo Xue, Min Zhang, Xiantao Song, Changjiang Ge","doi":"10.21037/cdt-24-336","DOIUrl":"10.21037/cdt-24-336","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of very high-risk atherosclerotic cardiovascular disease (ASCVD) is significant in China, with suboptimal rates of low-density lipoprotein cholesterol (LDL-C) compliance exacerbating plaque instability and causing a higher incidence of major adverse cardiac events (MACEs). Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are effective in reducing LDL-C levels, increase the stability of vulnerable plaque, and influence the progression of atherosclerosis through multiple mechanisms as demonstrated in animal studies. However, there is currently a lack of <i>in vivo</i> evidence regarding the efficacy and safety of high-intensity statin therapy combined with PCSK9i in the secondary prevention of ASCVD in the Chinese population. This study aims to demonstrate the efficacy of high-intensity statins combined with PCSK9i on vulnerable plaques in very high-risk ASCVD patients through intravascular imaging and non-invasive endothelial function test.</p><p><strong>Methods: </strong>This randomized, open-label, prospective clinical study involves 240 patients with very high-risk ASCVD who meet the criteria outlined in the 2023 Chinese lipid management guidelines. Patients recruitment will be processed in Beijing Anzhen Hospital from January 2021 to December 2024. Patients with thin-cap fibroatheroma (TCFA) detected by optical coherence tomography (OCT) are randomly assigned in a 1:1 ratio to the evolocumab group (evolocumab 140 mg every 2 weeks plus atorvastatin 40 mg nightly) or the standard treatment group (atorvastatin 40 mg nightly). The primary endpoint is the absolute change of the minimum fibrous cap thickness (FCT) at a median follow-up of 1 year. The secondary endpoints are other OCT metrics, assessment of MACE rates, alterations in serum lipid profiles and markers of inflammation, endothelial function, and adverse drug reactions. Logistic regression, analysis of covariance (ANCOVA), Kaplan-Meier curve survival analysis, and Cox regression will be used to investigate the relationship between variables and endpoints.</p><p><strong>Discussion: </strong>The purpose of this study is to evaluate the efficacy of high-intensity statin therapy combined to PCSK9i for the secondary prevention of coronary artery disease in Chinese patients with very high-risk ASCVD. The results will provide evidence to optimize the management of this high-risk population.</p><p><strong>Trial registration: </strong>This study was registered on chictr.org.cn (ChiCTR2000032570).</p>","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1236-1246"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Energy loss and adults with congenital heart disease: a novel marker of cardiac workload beyond right ventricular size. 能量损失和成人先天性心脏病:一种新的心脏负荷超过右心室大小的标记。
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-18 DOI: 10.21037/cdt-24-296
Yumi Shiina, Keiichi Itatani, Kei Inai, Koichiro Niwa
{"title":"Energy loss and adults with congenital heart disease: a novel marker of cardiac workload beyond right ventricular size.","authors":"Yumi Shiina, Keiichi Itatani, Kei Inai, Koichiro Niwa","doi":"10.21037/cdt-24-296","DOIUrl":"10.21037/cdt-24-296","url":null,"abstract":"<p><p>Right ventricular (RV) dysfunction after biventricular repair is critical in most adults with congenital heart disease (ACHD). Conventional 2D magnetic resonance imaging (MRI) measurement is considered as a 'gold standard' for RV evaluation; however, addition information on ACHD after biventricular repair is sometimes required. The reasons why adjunctive information is required is as follows: (I) to evaluate the severity of cardiac burden in symptomatic patients with normal RV size and ejection fraction (EF), (II) to determine the optimal timing of invasive treatments in asymptomatic ones, and (III) to detect proactively a potential cardiac burden leading to ventricular deterioration, from a fluid dynamics perspective. Energy loss (EL) using 4D flow MRI is a novel non-invasive flow visualisation method, and EL using 4D flow MRI can be a potential marker of cardiac burden. EL is the energy dissipated by blood viscosity, and evaluates the cardiac workload related to the prognosis of heart failure. The advantages are as follows: EL can detect cardiac overload which integrates both afterload and preload. EL is an independent parameter of current heart failure or cardiac remodeling state, such as chamber size or ventricular wall motion. This parameter is based on intuitive and clear physiological concepts, suitable for <i>in vivo</i> flow measurements using inner velocity profiles without a pressure-volume loop. The possible clinical applications of EL are as follows: (I) to follow the temporal changes in each patient and (II) to calculate the percentage of cardiac burden by combining pressure data from catheterisation. Although EL appears to be an ideal marker of haemodynamics from a fluid dynamics perspective, EL measurement using 4D flow MRI has some limitations. Flow dynamics software is still being developed, both technically and methodologically, and its clinical impact on long-term outcomes remains unknown. Therefore, further studies are warranted.</p>","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1202-1209"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of cardiovascular magnetic resonance in single ventricle physiology: a narrative review. 心血管磁共振对单心室生理学的影响:一个叙述性的回顾。
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-19 DOI: 10.21037/cdt-24-409
Inga Voges, Dominik Daniel Gabbert, Daniela Panakova, Sylvia Krupickova
{"title":"Impact of cardiovascular magnetic resonance in single ventricle physiology: a narrative review.","authors":"Inga Voges, Dominik Daniel Gabbert, Daniela Panakova, Sylvia Krupickova","doi":"10.21037/cdt-24-409","DOIUrl":"10.21037/cdt-24-409","url":null,"abstract":"<p><strong>Background and objective: </strong>Cardiovascular magnetic resonance (CMR) is a routine cross-sectional imaging modality in adults with congenital heart disease. Developing CMR techniques and the knowledge that CMR is well suited to assess long-term complications and to provide prognostic information for single ventricle (SV) patients makes CMR the ideal assessment tool for this patient cohort. Nevertheless, many of the techniques have not yet been incorporated into day-to-day practice. The aim of this review is to provide a comprehensive overview of CMR applications in SV patients together with recent scientific findings.</p><p><strong>Methods: </strong>Articles from 2009 to August 2024 retrieved from PubMed on CMR in SV patients were included. Case reports and non-English literature were excluded.</p><p><strong>Key content and findings: </strong>CMR is essential for serial follow-up of SV patients and CMR-derived standard markers can improve patient management and prognosis assessment. Advanced CMR techniques likely will enhance our understanding of Fontan hemodynamics and are promising tools for a comprehensive patient evaluation and care.</p><p><strong>Conclusions: </strong>There is increasing research that shows the advantages of CMR in Fontan patients. However, further research about the prognostic role of CMR in older Fontan patients and how new methods such as modeling and deep learning pipelines can be clinically implemented is warranted.</p>","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1161-1175"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twins with at least one with CHD and their immunisation status in direct comparison-are both twins complying with the German immunisation recommendations? 至少有一个患有冠心病的双胞胎及其免疫状况的直接比较-双胞胎是否都符合德国的免疫建议?
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-09 DOI: 10.21037/cdt-24-302
Julia Remmele, Paul C Helm, Jia Li, Renate Oberhoffer-Fritz, Ulrike M M Bauer, Peter Ewert
{"title":"Twins with at least one with CHD and their immunisation status in direct comparison-are both twins complying with the German immunisation recommendations?","authors":"Julia Remmele, Paul C Helm, Jia Li, Renate Oberhoffer-Fritz, Ulrike M M Bauer, Peter Ewert","doi":"10.21037/cdt-24-302","DOIUrl":"10.21037/cdt-24-302","url":null,"abstract":"<p><strong>Background: </strong>Patients with congenital heart defects (CHDs) are at higher risk for infectious diseases. This may partly be due to frequent hospital stays and the associated exposure to pathogens. This study aims to provide a comprehensive overview of immunisation coverage among twins in which at least one twin has CHD. Confounding factors from shared environments and genetic components can be controlled through co-twin control analysis, thus minimising confounding effects.</p><p><strong>Methods: </strong>In the framework of the cross-sectional twin study \"Same Same, but different?\" twins, with at least one of them having CHD aged 3 to 99 years, were recruited nationwide in Germany between August 2019 and December 2022. Their primary immunisation status based on the German Standing Committee on Vaccination (STIKO) and immunisation against respiratory diseases, including influenza, respiratory syncytial virus (RSV), pneumococci, and coronavirus disease 2019 (COVID-19), were assessed and compared between the twins.</p><p><strong>Results: </strong>In total, 64 twins (128 individuals) were included for direct twin comparison. Overall, 56.3% of the twins reached complete primary immunisation status, negatively influenced by hospitalisation duration [odds ratio (OR): 0.98; 95% confidence interval (CI): 0.96-0.99; P=0.01]. Compared to their healthy twin, twins with CHD received their rotavirus vaccine significantly later (P=0.04). Only 3.1% of the twins with CHD received the pneumococcal vaccine recommended for high-risk patients. A higher number of catheter interventions can lead to a higher number of patients receiving the pneumococcal vaccine (OR: 1.79; 95% CI: 1.16-2.76; P=0.009). The direct twin comparison showed a significant difference between the twins in vaccination against influenza (P=0.007), although it is recommended for CHD patients and their household contacts-including their twin. A higher number of surgeries (OR: 1.51; 95% CI: 1.12-2.05; P=0.007) and catheter interventions (OR: 1.49; 95% CI: 1.00-2.21; P=0.049) increase the probability of influenza vaccination in CHD patients.</p><p><strong>Conclusions: </strong>In the direct twin comparison, twins are similarly vaccinated except for RSV and influenza. Immunisation against influenza in twins should be improved. With new upcoming RSV vaccines, existing recommendations must be reconsidered and adapted. Another disturbing fact is that only 30% of infants are vaccinated against pertussis and pneumococcus within the primary recommended timeframe, even though they are exposed at high risk during infancy. Further education of parents, patients, and medical staff might lead to higher vaccination coverage, especially in pneumococcal vaccines recommended for high-risk patients. We must provide sufficient information on the importance of vaccinations and their side effects for parents' and patients' decision-making.</p>","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1108-1121"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in clinical translation of cardiac magnetic resonance imaging radiomics in non-ischemic cardiomyopathy: a narrative review. 心脏磁共振成像放射组学在非缺血性心肌病临床翻译中的挑战:叙述性回顾。
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-11-12 DOI: 10.21037/cdt-24-138
Jia Deng, Langtao Zhou, Bihong Liao, Qinxi Cai, Guanghua Luo, Hong Zhou, Huifang Tang
{"title":"Challenges in clinical translation of cardiac magnetic resonance imaging radiomics in non-ischemic cardiomyopathy: a narrative review.","authors":"Jia Deng, Langtao Zhou, Bihong Liao, Qinxi Cai, Guanghua Luo, Hong Zhou, Huifang Tang","doi":"10.21037/cdt-24-138","DOIUrl":"10.21037/cdt-24-138","url":null,"abstract":"<p><strong>Background and objective: </strong>Radiomics is an emerging technology that facilitates the quantitative analysis of multi-modal cardiac magnetic resonance imaging (MRI). This study aims to introduce a standardized workflow for applying radiomics to non-ischemic cardiomyopathies, enabling clinicians to comprehensively understand and implement this technology in clinical practice.</p><p><strong>Methods: </strong>A computerized literature search (up to August 1, 2024) was conducted using PubMed to identify relevant studies on the roles and workflows of radiomics in non-ischemic cardiomyopathy. Expert discussions were also held to ensure the accuracy and relevance of the findings. Only English-language publications were reviewed.</p><p><strong>Key content and findings: </strong>The paper details the essential processes of radiomics, including feature extraction, feature engineering, model construction, and data analysis. It emphasizes the role of MRI in assessing cardiac structure and function and demonstrates how MRI-based radiomics can aid in diagnosing and differentiating non-ischemic cardiomyopathies such as hypertrophic cardiomyopathy, dilated cardiomyopathy, and myocarditis. The study also investigates various cardiac MRI sequences to enhance the clinical application of radiomics.</p><p><strong>Conclusions: </strong>The standardized radiomics workflow presented in this study aims to assist clinicians in effectively utilizing MRI-based radiomics for the diagnosis and management of non-ischemic cardiomyopathies, thereby improving clinical decision-making.</p>","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1210-1227"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy & cardiovascular disease: the PREG-CVD-HH registry. 妊娠与心血管疾病:PREG-CVD-HH登记。
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-19 DOI: 10.21037/cdt-24-248
Dora Csengeri, Elisabeth Unger, Jessica Weimann, Michael Huntgeburth, Yskert von Kodolitsch, Tanja Zeller, Stefan Blankenberg, Paulus Kirchhof, Anke Diemert, Renate B Schnabel, Christoph R Sinning, Elvin Zengin-Sahm
{"title":"Pregnancy & cardiovascular disease: the PREG-CVD-HH registry.","authors":"Dora Csengeri, Elisabeth Unger, Jessica Weimann, Michael Huntgeburth, Yskert von Kodolitsch, Tanja Zeller, Stefan Blankenberg, Paulus Kirchhof, Anke Diemert, Renate B Schnabel, Christoph R Sinning, Elvin Zengin-Sahm","doi":"10.21037/cdt-24-248","DOIUrl":"10.21037/cdt-24-248","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cardiovascular disease (CVD) remains the leading cause of death in pregnant and peripartal women in western countries. Physiological changes during pregnancy can lead to cardiovascular complications in the mother; women with pre-existing heart disease may not tolerate these changes well, increasing their susceptibility to adverse cardiovascular outcomes during pregnancy. The aim of this study is to characterize pregnancy-induced changes in cardiac function, biomarker concentrations and cardiovascular outcomes in women with CVD during pregnancy at a tertiary care hospital in Germany.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The PREG-CVD-HH study is a prospective single-center observational study of pregnant women with prevalent CVD treated at the University Medical Center Hamburg, Germany and currently includes 63 women with congenital or acquired heart disease and ten women from the general population included as controls. Participants underwent baseline assessment and dedicated comprehensive echocardiography. Biomarkers N-terminal pro B-type natriuretic peptide (NT-proBNP), MR-proadrenomedullin (MRproADM) and high-sensitivity cardiac troponin I (hs-cTnI) were measured serially throughout pregnancy and until 6 and 12 months postpartum. A maternal cardiac event was defined as death due to cardiovascular cause, arrhythmia, heart failure or hospitalization for other cardiac intervention.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Mean maternal age was 34 years. A majority had a congenital heart disease (N=41), 10 patients developed pregnancy-associated CVD (e.g., preeclampsia, peripartum cardiomyopathy) and 12 women had known acquired heart disease (e.g., valvular disease, arrhythmia, cardiomyopathy). New-onset heart failure was observed in 14.1% of patients (N=9). Five patients developed arrhythmia and three patients developed preeclampsia. About 21.2% of patients were hospitalized due to cardiovascular events. Death from any or cardiovascular cause did not occur over the study period. Left and right ventricular global longitudinal strain (LV GLS, RV GLS) showed a transient worsening in the third trimester and peripartum period. NT-proBNP ranges broadened during the pregnancy and tended to progressively decrease postpartum in women with CVD. Hs-cTnI levels tended to trend upwards during pregnancy in patients with CVD, however, the hs-cTnI levels remained consistently low throughout pregnancy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;In our cohort, pregnancy was associated with a transient increase in cardiac biomarkers and worsening of cardiac function during the third trimester and peripartum. These temporal changes reversed at 6-12 months postpartum, potentially due to decreased cardiac load, fluid shifts and hormonal changes. Overall, data on reference ranges in echocardiographic and biomarker measurements in the pregnant cardiac population are limited and require further investigation. Albeit one third of our cohort was deemed at high an","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1058-1069"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Procedural success prediction in chronic total occlusion percutaneous coronary intervention (CTO-PCI)-the rise of the machines? 慢性全闭塞经皮冠状动脉介入治疗(CTO-PCI)的手术成功率预测——机器的兴起?
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-17 DOI: 10.21037/cdt-24-392
Claudiu Ungureanu, Gregor Leibundgut
{"title":"Procedural success prediction in chronic total occlusion percutaneous coronary intervention (CTO-PCI)-the rise of the machines?","authors":"Claudiu Ungureanu, Gregor Leibundgut","doi":"10.21037/cdt-24-392","DOIUrl":"10.21037/cdt-24-392","url":null,"abstract":"","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"994-997"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized trial comparing a stent-avoiding with a stent-preferred strategy in complex femoropopliteal lesions. 比较复杂股腘动脉病变避免支架与首选支架策略的随机试验。
IF 2.1 3区 医学
Cardiovascular diagnosis and therapy Pub Date : 2024-12-31 Epub Date: 2024-12-12 DOI: 10.21037/cdt-24-384
Gemmi Sufali, Martin Teraa
{"title":"Randomized trial comparing a stent-avoiding with a stent-preferred strategy in complex femoropopliteal lesions.","authors":"Gemmi Sufali, Martin Teraa","doi":"10.21037/cdt-24-384","DOIUrl":"10.21037/cdt-24-384","url":null,"abstract":"","PeriodicalId":9592,"journal":{"name":"Cardiovascular diagnosis and therapy","volume":"14 6","pages":"1011-1014"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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