{"title":"One-year Clinical Outcomes and Predictors of Distal Embolization After JETSTREAM™ Atherectomy for Calcified Femoropopliteal Artery Lesions: Results From the JET-FORWARD Study.","authors":"Shunsuke Kojima, Takahiro Tokuda, Akiko Tanaka, Naoki Yoshioka, Kohei Yamaguchi, Takashi Yanagiuchi, Kenji Ogata, Tatsuro Takei, Tatsuya Nakama","doi":"10.1007/s00270-025-04063-1","DOIUrl":"10.1007/s00270-025-04063-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to identify predictors of distal embolization following JETSTREAM™ atherectomy for calcified femoropopliteal lesions and evaluate 1-year clinical outcomes in a real-world setting.</p><p><strong>Materials and methods: </strong>We analyzed data from 109 patients with 121 calcified femoropopliteal lesions who underwent JETSTREAM™ atherectomy therapy between October 2022 and December 2023 as part of the JET-FORWARD study, a retrospective, single-arm, multicenter study. Distal embolization incidence and risk factors were the primary focus, while 1-year primary patency served as efficacy outcome measures. Safety outcomes also included mortality and major target limb amputation.</p><p><strong>Results: </strong>The mean lesion length was 15.5 ± 9.4 cm, and the technical success rate-defined as residual stenosis less than 30% and absence of grade C or higher dissection post-procedure-was 93.4%. Angiographically significant distal embolization occurred in 35.5% of cases during the index procedure. On multivariate analysis, poor tibial runoff (≤ 1 tibial artery), severe small artery disease, nodular calcification, and debulking lengths > 10 cm were independent predictors of distal embolization. The 1-month mortality and 1-year limb salvage rates were 2.8% and 98.9%, respectively. The 1-year primary patency rate was 88.9%.</p><p><strong>Conclusion: </strong>Angiographically significant distal embolization occurred in 35.5% of cases with JETSTREAM atherectomy, while 1-year outcomes remained favorable in treating femoropopliteal lesions. This study also identified four predictors of distal embolization. Thus, careful risk factor evaluation and patient selection are essential during atherectomy.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"760-768"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierre-Olivier Comby, Kévin Guillen, Olivier Chevallier, Emilie Couloumy, Anne Dencausse, Philippe Robert, Sarah Catoen, Anne-Virginie Salsac, Serge Ludwig Aho-Glele, Romaric Loffroy
{"title":"Embolic Effect of Different Cyanoacrylates: Radiological and Histological Comparison in an In Vivo Rabbit Renal-Artery Model.","authors":"Pierre-Olivier Comby, Kévin Guillen, Olivier Chevallier, Emilie Couloumy, Anne Dencausse, Philippe Robert, Sarah Catoen, Anne-Virginie Salsac, Serge Ludwig Aho-Glele, Romaric Loffroy","doi":"10.1007/s00270-025-03997-w","DOIUrl":"10.1007/s00270-025-03997-w","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the radiological and histological effects of three different cyanoacrylate glues used for in vivo renal artery embolization in rabbits.</p><p><strong>Materials and methods: </strong>N-butyl cyanoacrylate (NBCA), NBCA-methacryloxysulfolane (NBCA-MS), and α-hexyl-cyanoacrylate (AHCA) were each used to embolize five renal arteries under free-flow conditions with a 1:3 glue/ethiodized oil ratio. The rabbits were euthanized 30 min after embolization. Micro-computed tomography (CT) was used to assess glue cast distribution (extent of penetration into the vascular tree), fragmentation (presence of discontinuities within the cast), and heterogeneity (variability in cast density). Histological slides were analyzed for lumen dilatation, intimal arteritis, necrosis, and peri-arterial edema. Statistical analyses were performed using the Kruskal-Wallis test.</p><p><strong>Results: </strong>Glue penetration into interlobar and corticomedullary arteries was observed consistently in all three groups. Fragmentation scores showed no significant differences between glue types, but AHCA demonstrated significantly lower heterogeneity in proximal arteries compared to NBCA-MS (P = 0.019). Severe lumen dilatation and intimal necrosis were observed in all samples, whereas intimal arteritis was significantly less severe with AHCA compared to NBCA-MS (P < 0.001). No significant differences in peri-arterial edema were found between groups.</p><p><strong>Conclusion: </strong>Micro-CT features were similar with all three glues. AHCA produced greater cast uniformity and less intimal arteritis, suggesting a role in endovascular embolization.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"823-833"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David-Dimitris Chlorogiannis, Bedros Taslakian, Osman Ahmed, Attur Mukundan, Ali Guermazi, Anish Ghodadra, Venkatesh P Krishnasamy, Wali Badar, Yan Epelboym
{"title":"Key Osteoarthritis Biomarkers: What Interventional Radiologists Performing Genicular Artery Embolization Need to Know.","authors":"David-Dimitris Chlorogiannis, Bedros Taslakian, Osman Ahmed, Attur Mukundan, Ali Guermazi, Anish Ghodadra, Venkatesh P Krishnasamy, Wali Badar, Yan Epelboym","doi":"10.1007/s00270-025-04045-3","DOIUrl":"10.1007/s00270-025-04045-3","url":null,"abstract":"<p><p>Knee osteoarthritis (OA) is a major cause of pain and disability. Genicular artery embolization (GAE) is a promising alternative for patients unresponsive to conservative treatment or unsuitable for total knee replacement. GAE may alleviate knee pain by reducing synovitis and by causing ischemia to pathologic knee nerves. However, outcomes vary based on baseline MRI and radiographic findings, making patient selection challenging. Recently, reduction in synovitis on contrast-enhanced MRI has been associated with pain relief post-GAE. Novel OA phenotypes (inflammatory, cartilage, bone, and atrophic) can aid in patient selection by using imaging and molecular biomarkers. Moreover, imaging features such as cartilage defects, bone marrow lesions, and synovitis may predict symptomatic outcomes. This review explores OA pathophysiology, focusing on radiographic, biochemical, and imaging biomarkers in evaluating GAE for knee OA treatment.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"729-738"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of Primary Solid Renal Tumours Using Histotripsy: Study Protocol for the CAIN Feasibility Trial.","authors":"Tze Min Wah, Joseph F Amaral, Paul F Laeseke","doi":"10.1007/s00270-025-04035-5","DOIUrl":"10.1007/s00270-025-04035-5","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this prospective, multi-centre, single-arm feasibility trial is to evaluate the technical success and safety profile of the HistoSonics System for the treatment of primary solid renal tumours using histotripsy.</p><p><strong>Methods/design: </strong>The CAIN trial will enrol up to 20 patients with a non-metastatic solid renal tumour ≤ 3 cm treated with histotripsy. Histotripsy is a non-thermal and non-ionizing mechanical process of tissue destruction resulting from the targeted delivery of focused ultrasound pulses. The primary endpoints are technical success and freedom from index procedure related major complications. Technical success is defined as complete coverage of the tumour as determined ≤ 36 h post-index procedure by contrast-enhanced magnetic resonance imaging (MRI) or computerized tomography (CT). An index procedure related major complication is defined as Clavien-Dindo Classification Grade 3 or higher up to 30 days after the last histotripsy procedure. Treated patients will have a follow-up visit performed at 14 days, 30 days, 90 days, and 180 days post-procedure.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov identifier NCT05432232 & NIHR CRN CPMS 53429.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"857-865"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lohith Karigowda, Simon Wong, Jimmy Chien, Peter Emerson, Kush Deshpande, Luke Baker
{"title":"Correction to: Pacemaker Lead Displacement After Mechanical Thrombectomy for Acute Pulmonary Embolism.","authors":"Lohith Karigowda, Simon Wong, Jimmy Chien, Peter Emerson, Kush Deshpande, Luke Baker","doi":"10.1007/s00270-025-04037-3","DOIUrl":"10.1007/s00270-025-04037-3","url":null,"abstract":"","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"896"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiation Use in Image-Guided Interventions: Think Differently-Image Utility Over Image Quality.","authors":"James R Duncan, M Allan Thomas, Alex M Barnacle","doi":"10.1007/s00270-025-04027-5","DOIUrl":"10.1007/s00270-025-04027-5","url":null,"abstract":"<p><p>When attempting to optimize radiation use during a fluoroscopic procedure, the aim is to acquire images that adequately address the needs of the different tasks which together comprise the procedure. Naturally, each procedure and its different segments may yield a variety of needs and related images. Ideally, these images should possess just enough information to adequately address the uncertainties of the task at hand. While complex tasks might justify acquiring high quality images with their minimal uncertainty, low quality images with their higher uncertainty, are often sufficient for simple tasks. This shift in perspective indicates a need to focus on the factors that govern the clinical utility of images rather than the more traditional concept of image quality.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"846-850"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association Between Geriatric Nutritional Risk Index and Discharge Outcome after Elective Thoracic Endovascular Aortic Repair.","authors":"Takafumi Ouchi, Noriyuki Kato, Hiroaki Kato, Takatoshi Higashigawa, Hisato Ito, Ken Nakajima, Shuji Chino, Toshiya Tokui, Kensuke Oue, Toru Mizumoto, Yasutaka Ichikawa, Hajime Sakuma","doi":"10.1007/s00270-025-04066-y","DOIUrl":"10.1007/s00270-025-04066-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the utility of the Geriatric Nutritional Risk Index (GNRI) in predicting nonhome discharge (NHD) and delayed discharge after elective thoracic endovascular aortic repair (TEVAR).</p><p><strong>Methods: </strong>The study population included patients undergoing elective simple TEVAR for intact thoracic aortic aneurysm or subacute or chronic aortic dissection between January 2009 and December 2022 and not experiencing neurological complications or re-interventions during hospitalization. The primary outcome measure was NHD and significantly delayed discharge. GNRI was calculated using the following equation: GNRI = 14.89 × serum albumin (g/dL) + 41.7 × (body mass index [kg/m<sup>2</sup>] / 22). A univariable logistic regression model was used to determine the odds ratio for GNRI. The predictive performance of GNRI was evaluated using the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>A total of 229 patients were analyzed and the overall rate of the primary outcome was 5.7% (NHD, n = 6; delayed discharge, n = 10; both, n = 3). Patients with the primary outcome were more likely to have a lower GNRI (98 vs 103; P = .01) than those without. The logistic regression model showed that a high GNRI was protective against NHD (odds ratio, 0.38; 95% confidence interval, 0.18-0.76; P = .008). The AUC for GNRI was 0.710 (95% confidence interval, 0.602-0.821). The sensitivity, specificity, positive predictive value, and negative predictive value of GNRI < 92 were 23%, 89%, 11%, and 95%, respectively.</p><p><strong>Conclusions: </strong>Preoperative evaluation of GNRI may be useful in predicting NHD and delayed discharge.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"807-814"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invited Commentary on the Embolic Effect of Different Cyanoacrylates: Radiological and Histological Comparison in an in vivo Rabbit Renal-Artery Model.","authors":"Atsushi Saiga","doi":"10.1007/s00270-025-04047-1","DOIUrl":"10.1007/s00270-025-04047-1","url":null,"abstract":"","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"834-835"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}