Pierre-Olivier Comby, Kévin Guillen, Olivier Chevallier, Emilie Couloumy, Anne Dencausse, Philippe Robert, Sarah Catoen, Anne-Virginie Salsac, Serge Ludwig Aho-Glele, Romaric Loffroy
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引用次数: 0
Abstract
Purpose: To compare the radiological and histological effects of three different cyanoacrylate glues used for in vivo renal artery embolization in rabbits.
Materials and methods: N-butyl cyanoacrylate (NBCA), NBCA-methacryloxysulfolane (NBCA-MS), and α-hexyl-cyanoacrylate (AHCA) were each used to embolize five renal arteries under free-flow conditions with a 1:3 glue/ethiodized oil ratio. The rabbits were euthanized 30 min after embolization. Micro-computed tomography (CT) was used to assess glue cast distribution (extent of penetration into the vascular tree), fragmentation (presence of discontinuities within the cast), and heterogeneity (variability in cast density). Histological slides were analyzed for lumen dilatation, intimal arteritis, necrosis, and peri-arterial edema. Statistical analyses were performed using the Kruskal-Wallis test.
Results: Glue penetration into interlobar and corticomedullary arteries was observed consistently in all three groups. Fragmentation scores showed no significant differences between glue types, but AHCA demonstrated significantly lower heterogeneity in proximal arteries compared to NBCA-MS (P = 0.019). Severe lumen dilatation and intimal necrosis were observed in all samples, whereas intimal arteritis was significantly less severe with AHCA compared to NBCA-MS (P < 0.001). No significant differences in peri-arterial edema were found between groups.
Conclusion: Micro-CT features were similar with all three glues. AHCA produced greater cast uniformity and less intimal arteritis, suggesting a role in endovascular embolization.
期刊介绍：
CardioVascular and Interventional Radiology (CVIR) is the official journal of the Cardiovascular and Interventional Radiological Society of Europe, and is also the official organ of a number of additional distinguished national and international interventional radiological societies. CVIR publishes double blinded peer-reviewed original research work including clinical and laboratory investigations, technical notes, case reports, works in progress, and letters to the editor, as well as review articles, pictorial essays, editorials, and special invited submissions in the field of vascular and interventional radiology. Beside the communication of the latest research results in this field, it is also the aim of CVIR to support continuous medical education. Articles that are accepted for publication are done so with the understanding that they, or their substantive contents, have not been and will not be submitted to any other publication.
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