CardioVascular and Interventional Radiology最新文献

{"title":"Benign Soft Tissue Lesions Responsible for Pain: When and How Should the IR Intervene.","authors":"Dimitrios Filippiadis, Evangelos Petsatodis, Georgios Charalampopoulos, Athanasios Giannakis, David Dimitrios Chlorogiannis, Georgios Velonakis, Francois Cornelis","doi":"10.1007/s00270-024-03940-5","DOIUrl":"https://doi.org/10.1007/s00270-024-03940-5","url":null,"abstract":"<p><p>In most of the cases Interventional Radiology techniques and therapies are proposed for the management of symptomatic soft tissue benign tumors responsible for pain and/or compression symptoms aiming to offer a curative intent by means of tumor necrosis with subsequent symptoms' management and improvement of life quality. The ablative therapies include chemical, thermal and non-thermal approaches while, trans-arterial (chemo)embolization also has a distinct role. Adjunct ancillary techniques should be performed whenever necessary to increase efficacy and safety and avoid or reduce complications. The purpose of the current review is to identify the basis for treating soft tissue benign tumors with Interventional Radiology therapies, to offer a detailed review of them, to explain the expected outcomes and describe techniques for avoiding complications. Furthermore, a reflection upon future directions will be suggested.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-Month Outcomes from the Prospective, Multi-Center, Non-Randomized Clinical Study of the COVERA⁽™⁾ Arterio VeNous (AV) Stent Graft in the Treatment of Stenosis in the VEnous OutfloW of AV Fistula Access Circuits (AVeNEW PAS).","authors":"Bart Dolmatch, Talar Saber, Margo Underwood","doi":"10.1007/s00270-024-03930-7","DOIUrl":"10.1007/s00270-024-03930-7","url":null,"abstract":"<p><strong>Purpose: </strong>The AVeNEW Post-Approval Study (AVeNEW PAS) follows upon results from the AVeNEW IDE clinical trial and was designed to provide additional clinical evidence of safety and effectiveness using the Covera™ Vascular Covered Stent to treat arteriovenous fistula (AVF) stenoses in a real-world hemodialysis patient population.</p><p><strong>Materials and methods: </strong>One hundred AVF patients were prospectively enrolled at 11 clinical trial sites in the USA and treated with the covered stent after angioplasty of a clinically significant target stenosis. The primary safety outcome was freedom from any adverse event that suggests the involvement of the AV access circuit evaluated at 30 days. The primary efficacy outcome was Target Lesion Primary Patency (TLPP) at six months, determined by an independent core laboratory. Secondary outcome measures included technical success defined as successful deployment to the intended location and access circuit primary patency (ACPP).</p><p><strong>Results: </strong>Safety was 94.9% with no device-related deaths nor in-patient hospitalization. Technical success was 100%. TLPP rates at 1, 3, and 6 months were 100, 89.7, and 82.2%. ACPP rates at 1, 3, and 6 months were 98, 76.3, and 60.0%. Target stenoses were 81% restenotic, and 75% located in the cephalic vein arch. There were 35% non-target stenoses treated with angioplasty during the index procedure.</p><p><strong>Conclusion: </strong>The 6-month results of the AVeNEW PAS confirm results from the AVeNEW IDE clinical trial and demonstrate safety and efficacy using the Covera⁽™⁾ Covered Stent in a real-world US hemodialysis patient population.</p><p><strong>Trial registration: </strong>NCT04261686.</p><p><strong>Level of evidence: </strong>3 - prospective, multicenter.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided Transperineal Prostate Thermal Ablation (TPTA) for Benign Prostatic Hyperplasia: Feasibility of an Outpatient Procedure using Radiofrequency Ablation.","authors":"Thiago Franchi Nunes, Rafael Dahmer Rocha, Bibiana Ruiz Wehling Ilgenfritz, Flávio Scavone Stefanini, Vinicius Adami Vayego Fornazari, Guilherme Cayres Mariotti, Publio Cesar Cavalcante Viana, Rodrigo Gobbo Garcia, Hugo Alexandre Socrates de Castro, Denis Szejnfeld","doi":"10.1007/s00270-024-03958-9","DOIUrl":"https://doi.org/10.1007/s00270-024-03958-9","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the feasibility, safety, and short-term (3-month) results of transperineal prostate thermal ablation (TPTA) as a minimally invasive outpatient treatment for benign prostatic hyperplasia (BPH).</p><p><strong>Materials and methods: </strong>A prospective nonrandomized study of 25 patients with lower urinary tract symptoms secondary to BPH seeking care at 2 interventional radiology centers between March and July 2024. TPTA was performed using a 17G radiofrequency needle with a 10-mm active tip under unconscious sedation combined with bilateral perineal and periprostatic nerve blocks. The primary outcome measure was technical success, defined as successful bilateral ablation of the prostate transition zone. Secondary outcome measures included changes of international prostate symptom score (IPSS), quality of life (QoL), prostate volume, intravesical prostatic protrusion (IPP), prostate-specific antigen (PSA), post-void residual volume (PVR), maximum urinary flow rate (Qmax), and need for BPH medical therapy at 3 months relative to baseline.</p><p><strong>Results: </strong>All procedures were technically successful (100%). The median patient age was 69.4 years (IQR 54-74), and all were discharged within 3 h of the end of the procedure. Sixteen patients (64.0%) were discharged without a urinary catheter, and 6 patients (24.0%) reported mild complications. At 3-month follow-up, there were significant reductions in IPSS (79.1%), QoL score (70.3%), prostate volume (36.9%), IPP (70.8%), PSA (54.7%), and PVR (51.1%), whereas Qmax increased significantly (102.3%). Twenty-four patients (96.0%) reported discontinuation of medical therapy after TPTA.</p><p><strong>Conclusion: </strong>Ultrasound-guided TPTA using radiofrequency ablation is feasible and safe in the outpatient setting, with significant clinical improvements after 3 months of the procedure.</p><p><strong>Level of evidence: </strong>Level 3 [non-randomized prospective cohort study].</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Physiopathology of Pain Pathways for a Practical Approach of Cancer Pain Management.","authors":"Y Bohren, M Cachemaille, I D Timbolschi, C Perruchoud","doi":"10.1007/s00270-024-03920-9","DOIUrl":"10.1007/s00270-024-03920-9","url":null,"abstract":"<p><p>Pain associated with cancer is often the first symptom reported with major repercussions on patient's quality of life. Mechanical compression, release of algogenic substances by the tumor or the complications of oncologic treatment represent the major causes. Nociceptive and neuropathic pain are both induced by different mediators that give rise to a neuroinflammation creating a peripheral and central sensitization responsible of chronic pain. Understanding the pain pathway may orientate to the most appropriate treatment. Oral medication should be often reevaluated to consider multimodal analgesia including interventional pain procedures with intrathecal therapy and neuromodulation.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Stent Restenosis in Peripheral Arterial Disease: Ultra-High-Resolution Photon-Counting Versus Third-Generation Dual-Source Energy-Integrating Detector CT Phantom Study in Seven Different Stent Types.","authors":"Theresa-Marie Dachs, Sven R Hauck, Maximilian Kern, Catharina Klausenitz, Maximilian Hoffner, Melanie Schernthaner, Hanaa Abdel-Rahman, Albert Hannover, Andreas Strassl, Irene Steiner, Christian Loewe, Martin A Funovics","doi":"10.1007/s00270-024-03874-y","DOIUrl":"10.1007/s00270-024-03874-y","url":null,"abstract":"<p><strong>Purpose: </strong>The visualization of peripheral in-stent restenosis using energy-integrating detector CT is challenging due to deficient spatial resolution and artifact formation. This study compares the first clinically available photon-counting detector CT to third-generation dual-source energy-integrating detector CT.</p><p><strong>Materials and methods: </strong>Nylon cylinders with central bores (4 mm, 2 mm), mimicking 75% and 95% stenoses, were placed inside seven different 8-mm diameter stents and filled with diluted contrast medium. Phantoms were scanned with photon-counting detector CT at slice thicknesses of 0.2 mm (available only in this scanner type), 0.5 mm, and 1.0 mm versus 0.5 mm and 1.0 mm in energy-integrating detector CT at matched CT dose indices. Contrast-to-noise ratios were calculated from attenuation rates. Residual lumen size was measured as full width at half-maximum. Subjective image quality was assessed by two independent blinded raters.</p><p><strong>Results: </strong>Mean contrast-to-noise ratio was lowest in photon-counting detector CT at 0.2 mm slice thickness (0%, 75%, and 95% in-stent restenosis: 6.11 ± 0.6, 5.27 ± 0.54, and 5.02 ± 0.66) and highest at 1.0 mm slice thicknesses with similar measurements in photon-counting detector CT and energy-integrating detector CT (11.46 ± 1.08, 9.94 ± 1.01, 8.26 ± 1.0 vs. 3.34 ± 1.0, 9.92 ± 0.38, 7.94 ± 1.07). Mean full width at half-maximum measurements in photon-counting detector CT at 0.2 mm slice thickness for 0%, 75%, and 95% in-stent restenosis were 8.00 ± 0.37, 3.98 ± 0.34, and 1.92 ± 0.16 mm. Full width at half-maximum was least precise in 95% in-stent restenosis at 1.0 mm slice thickness with similar measurements between scanners (1.57 ± 0.33 vs. 1.71 ± 0.15 mm). Interrater correlation coefficient was 0.75 [95% CI: [0.53; 0.86]; subjective scores were best at 0.2 mm slice thickness in photon-counting detector CT (19.43 ± 0.51 and 19.00 ± 0.68).</p><p><strong>Conclusion: </strong>In phantom in-stent restenosis in 8 mm stents, we observed similar full width at half-maximum for photon-counting detector CT and energy-integrating detector CT in 0% and 75% in-stent restenosis, but at 95% in-stent restenosis, FWHM tended to be more accurate in smaller slice thicknesses in both scanners. Subjective image assessment yielded best results at 0.2 mm slice thickness in photon-counting detector CT despite lower contrast-to-noise ratio.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"65-74"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Image-Guided Percutaneous Irreversible Electroporation of Adrenal Metastases.","authors":"Govindarajan Narayanan, Nicole T Gentile, Khloe Gu, Brian J Schiro, Ripal T Gandhi, Costantino S Peña, Madelon Dijkstra","doi":"10.1007/s00270-024-03893-9","DOIUrl":"10.1007/s00270-024-03893-9","url":null,"abstract":"<p><strong>Purpose: </strong>A single-center retrospective study was performed to evaluate the safety and efficacy of minimally invasive irreversible electroporation (IRE) to treat metastatic adrenal tumors.</p><p><strong>Materials and methods: </strong>This single-center study, approved by the Institutional Review Board, retrospectively analyzed six patients who underwent image-guided percutaneous IRE for adrenal metastases. Pre-procedural imaging included CT, MRI and/or ¹⁸F-FDG PET-CT scans. Primary outcomes measures included technical success, efficacy and safety, while secondary outcome measures were local progression-free survival (LPFS), distant progression-free survival (DPFS) and overall survival (OS). Follow-up scans were scheduled post-procedure, and data analysis employed Excel, SPSS and R.</p><p><strong>Results: </strong>Patients had diverse primary tumor origins including renal cell carcinoma (2/6), colorectal carcinoma (1/6), non-small cell lung carcinoma (1/6), leiomyosarcoma (1/6) and urothelial carcinoma (1/6). Adverse events were minimal, with only one grade 1 complication reported. Tumor characteristics revealed tumors close to critical structures, with a median pre-ablation size of 23 mm. Technical success was achieved in all procedures. At first follow-up, one patient had complete response, one patient had partial response of the right adrenal gland and complete response of the left adrenal gland, two patients had partial response and two patients had stable disease. Local tumor progression occurred in two out of seven tumors with a median LPFS of 10.9 months, and distant progression was observed in four out of six patients.</p><p><strong>Conclusion: </strong>Percutaneous, minimally invasive IRE shows promise as a safe treatment option for unresectable metastatic adrenal tumors, demonstrating potential effectiveness. However, further studies with larger patient cohorts are needed to confirm its safety and efficacy.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"77-83"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Mechanical Thrombectomy for Acute Ischemic Stroke Following Cardiac Interventions: A Systematic Review and Meta-Analysis.","authors":"Seyed Behnam Jazayeri, Omar M Al-Janabi, Sherief Ghozy, Alejandro A Rabinstein, Ramanathan Kadirvel, David F Kallmes","doi":"10.1007/s00270-024-03890-y","DOIUrl":"10.1007/s00270-024-03890-y","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to pool the evidence on the safety and efficacy of mechanical thrombectomy (MT) in patients who develop acute ischemic stroke (AIS) due to large vessel occlusion (LVO) following recent cardiac interventions.</p><p><strong>Methods: </strong>PubMed, Embase and Scopus were searched from inception up to February 2024 using a combination of \"cardiac interventions\" and \"mechanical thrombectomy\" as keywords. Studies that evaluated AIS within 30 days of a recent cardiac intervention who underwent MT were included. The proportion of mortality, favorable functional outcome (modified Rankin Scale (mRS) 0-2), successful reperfusion (TICI ≥ 2b or TIMI ≥ 2) and symptomatic intracranial hemorrhage (sICH) were pooled using generalized linear mixed model.</p><p><strong>Results: </strong>Thirty-one case reports/series and 11 observational studies including 195 MT procedures were included. The patients' mean age was 72 years. The most common cardiac intervention associated with AIS was transcatheter aortic valve replacement/implantation in 96/192 cases (50%). The median onset of stoke was 0 (IQR 0-3) days after cardiac intervention. Rate of successful reperfusion was 79.4% [95%confidence interval (CI) 66.7-88.1%], rate of mRS 0-2 after 90 days was 42.7% [95%CI 32.5-53.6%], and rate of mortality at 90 days was 30.3% [95%CI 21.7-40.6%]. The rate of sICH was 11.6% [95%CI 5.9-21.5%].</p><p><strong>Conclusion: </strong>MT to treat AIS due to LVO after cardiac interventions may result in good rates of functional recovery, though mortality and sICH may be higher. Regular and repeated neurological examinations should be performed following cardiac interventions, with special attention to stroke. If stroke is detected, MT should be considered as a viable option.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"45-58"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Survival and Recurrence of Lung Ablation Patients Using Deep Learning-Based Automatic Segmentation and Radiomics Analysis.","authors":"Hossam A Zaki, Karim Oueidat, Celina Hsieh, Helen Zhang, Scott Collins, Zhicheng Jiao, Aaron W P Maxwell","doi":"10.1007/s00270-024-03912-9","DOIUrl":"10.1007/s00270-024-03912-9","url":null,"abstract":"<p><strong>Purpose: </strong>To predict survival and tumor recurrence following image-guided thermal ablation (IGTA) of lung tumors segmented using a deep learning approach.</p><p><strong>Methods and materials: </strong>A total of 113 patients who underwent IGTA for primary and metastatic lung tumors at a single institution between January 1, 2004 and July 14, 2022 were retrospectively identified. A pretrained U-Net model was applied to the dataset of pre- and post-procedure CT scans to segment lung zones. Following lung segmentation, a U-shaped encoder-decoder transformer architecture (UNETR) was trained to segment lung tumors from pre- and post-procedure CT scans, and radiomic features were automatically extracted. These features were input into a support vector machine (SVM)-based survival prediction model trained to assign rank scores to samples based on binary survival or recurrence label and follow-up time. C-index and time-dependent AUC were subsequently calculated to evaluate model performance.</p><p><strong>Results: </strong>Initial tumor segmentation using UNETR achieved a Dice score of 0.75. Applying a radiomics-based survivability prediction model to the post-procedure scans resulted in a c-index of 0.71 and a time-dependent AUC of 0.75. In contrast, when this model was applied to pre-procedure scans, it achieved a 0.56 for both metrics. For predicting time to recurrence, the radiomics-based model achieved a c-index of 0.65 and a time-dependent AUC of 0.72 on post-procedure imaging. In contrast, when this model was applied to pre-procedure scans, it achieved a 0.54 for both metrics.</p><p><strong>Conclusion: </strong>Radiomic feature analysis of lung tumors following automatic segmentation by a state-of-the-art transformer-based U-NET may predict survival and recurrence following image-guided thermal ablation of pulmonary malignancies.</p><p><strong>Level of evidence: </strong>Level 3, Retrospective cohort study.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"16-25"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"In-Stent Restenosis in Peripheral Arterial Disease: Ultra-High-Resolution Photon-Counting Versus Third-Generation Dual-Source Energy-Integrating Detector CT Phantom Study in Seven Different Stent Types\" Dachs TM, et al. CVIR 2024.","authors":"Josua A Decker, Thomas Kroencke","doi":"10.1007/s00270-024-03929-0","DOIUrl":"10.1007/s00270-024-03929-0","url":null,"abstract":"","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"75-76"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC.","authors":"Jan Zavadil, Jaroslav Juracek, Barbora Cechova, Tomas Rohan, Jakub Husty, Ondrej Slaby, Martina Litschmannova, Michal Uher, S Nahum Goldberg, Tomas Andrasina","doi":"10.1007/s00270-024-03908-5","DOIUrl":"10.1007/s00270-024-03908-5","url":null,"abstract":"<p><strong>Purpose: </strong>TACE induces variable systemic effects by producing factors that promote inflammation, oncogenesis, and angiogenesis. Here we compare concentrations of microRNAs (miR-21, miR-210 and miR-34a) and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) patients undergoing TACE with degradable (DSM) and nondegradable (DEB) particles and potential use of these biomarker changes for prediction of patient outcomes.</p><p><strong>Materials and methods: </strong>Overall, 52 patients with HCC treated with DSM TACE (24 patients) and DEB TACE (28 patients) were included in this prospective study. Concentrations of studied biomarkers were measured from blood plasma preprocedurally, immediately (< 90 min) postprocedurally, and 24-h after TACE. Levels were compared between DSM and DEB TACE and correlated with treatment response six and 12 months after the first TACE.</p><p><strong>Results: </strong>Both DSM and DEB TACE elevated plasma levels of miR-21, miR-34a, and miR-210 at 24 h post-procedure compared to baseline levels (FC 1.25-4.0). MiR-34a elevation immediately after TACE was significantly associated with nonprogressive disease compared to those with progressive disease at both six months (FC_a: p = 0.014) and 12 months (FC_a: p = 0.029) post-TACE. No significant biomarker changes were found between the embolization particle groups. However, VEGF levels showed a decrease only in the DSM TACE group (FC₂₄: p =  < 0.001).</p><p><strong>Conclusion: </strong>Embolization particle type did not significantly impact miRNA or VEGF changes post-TACE. However, miR-34a elevation immediately after the procedure predicts better patient outcome and may prove useful as a biomarkers for the monitoring of clinical outcomes.</p><p><strong>Level of evidence: </strong>Level 3 Prospective cohort study.</p>","PeriodicalId":9591,"journal":{"name":"CardioVascular and Interventional Radiology","volume":" ","pages":"26-37"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}