Canadian Journal of Cardiology最新文献

{"title":"P078 EXTRACORPOREAL LIFE SUPPORT FOR RIGHT VENTRICULAR FAILURE FOLLOWING PERICARDIECTOMY FOR PATIENTS WITH CONSTRICTIVE PERICARDITIS","authors":"A. Tago, M. Dahrab, J. Chow, E. Belley-Côté, F. Amin, J. Young, R. Fournier","doi":"10.1016/j.cjca.2026.07.088","DOIUrl":"10.1016/j.cjca.2026.07.088","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S56"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P002 5 YEAR EXPERIENCE WITH MINIMALLY INVASIVE MITRAL VALVE REPAIR WITH COMPLEX NEOCHORDAL RECONSTRUCTION","authors":"R. El-Andari, M. Machhiwala, E. Nurmambetova, M. Buchko, M. Moon, J. Nagendran","doi":"10.1016/j.cjca.2026.07.013","DOIUrl":"10.1016/j.cjca.2026.07.013","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S5"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P029 OPEN AORTIC REPAIR USING LEFT HEART BYPASS VERSUS VENO-ARTERIAL EXTRACORPEAL MEMBRANE OXYGENATION","authors":"M. King, J. Faulds, Y. Voloshyn, R. Groenewoud, D. Peng, J.M. Kim, M. Janusz, J. Price","doi":"10.1016/j.cjca.2026.07.037","DOIUrl":"10.1016/j.cjca.2026.07.037","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S23-S24"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P031 PRACTICAL LESSONS FROM OUR ISOLATED MINI THORACOTOMY AVR JOURNEY: FROM SUTURELESS VALVES TO SUTURE-FASTENING TECHNOLOGY","authors":"A. Abo Dan, N. Ajmi, A. Sarshoghi, A. Aljuayli, P. Demers, D. Bouchard","doi":"10.1016/j.cjca.2026.07.039","DOIUrl":"10.1016/j.cjca.2026.07.039","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S24-S25"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P081 IVABRADINE IN CARDIOGENIC SHOCK: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"L. Al-Duaij, R. Fournier, K. Sayer, K. Um, P. Bhatt, D. Al Faraj, M. Shen, C. Ainsworth, F. Amin, E. Belley-Cote","doi":"10.1016/j.cjca.2026.07.091","DOIUrl":"10.1016/j.cjca.2026.07.091","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S58"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dealing With Irregular Monitoring Frequency When Creating Dynamic Prediction Models With Real-World Clinical Data","authors":"Liping Wang MS","doi":"10.1016/j.cjca.2026.02.019","DOIUrl":"10.1016/j.cjca.2026.02.019","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page 2410"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Baseline Smoking Status on Intensive Blood Pressure Control: Results From the STEP Randomized Trial","authors":"Sifei Chen PhD,&nbsp;Yufei Ji PhD,&nbsp;Ruixue Yang PhD,&nbsp;Xinyi Peng MD, PhD,&nbsp;Jingjing Bai Msc,&nbsp;Xiaohan Fan MD, PhD,&nbsp;Qirui Song MD, PhD,&nbsp;Jun Cai MD, PhD","doi":"10.1016/j.cjca.2026.04.005","DOIUrl":"10.1016/j.cjca.2026.04.005","url":null,"abstract":"<div><h3>Background</h3><div>The <strong>St</strong>rategy of Blood Pressure Intervention in the <strong>E</strong>lderly Hypertensive <strong>P</strong>atients (STEP) trial has proven that intensive systolic blood pressure (SBP) lowering reduces cardiovascular events. However, the cardiovascular risks posed by smoking have caused uncertainty regarding the effects of intensive SBP control in smokers.</div></div><div><h3>Methods</h3><div>In this secondary subgroup analysis of the STEP trial, the participants were categorized into nonsmokers and current smokers on the basis of their baseline smoking status. The primary outcome was a composite of cardiovascular outcomes, including stroke, acute coronary syndrome, acute decompensated heart failure, coronary revascularization, atrial fibrillation, and death from cardiovascular causes. Cox proportional hazards regression and interaction analysis were used to assess the effects of baseline smoking status on intensive SBP control.</div></div><div><h3>Results</h3><div>A total of 8489 patients were included in this analysis. The proportion of patients who reached the intensive SBP target was smaller in current smokers during the first 9 months. Compared with nonsmokers, current smokers had a higher adjusted risk of primary outcome (hazard ratio, 1.39; 95% confidence interval, 1.03-1.88; <em>P</em> = 0.03) and stroke (hazard ratio, 1.66; 95% confidence interval, 1.03-2.67; <em>P</em> = 0.04). The interactions between baseline smoking status and SBP treatment were not statistically significant for all outcomes. Findings were similar in sensitivity analyses using 4 smoking categories and in analyses including only never and often smokers.</div></div><div><h3>Conclusions</h3><div>Smoking was associated with a higher risk of primary outcome and stroke. We observed no statistical evidence of heterogeneity in the treatment effect of intensive SBP control according to smoking status.</div></div><div><h3>Clinical Trial Registration</h3><div>NCT03015311.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2464-2472"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Predictive Value of Baseline Concordant Left Bundle Branch Block Morphology for Success Rate and Clinic Outcomes in Left Bundle Branch Pacing","authors":"Dingkun Lu MD,&nbsp;Xiaofei Li MD,&nbsp;Haojie Zhu MD,&nbsp;Kailun Zhu MD,&nbsp;Zhimin Liu MD,&nbsp;Yan Yao MD, FHRS,&nbsp;Xiaohan Fan MD, PhD, FHRS","doi":"10.1016/j.cjca.2026.03.043","DOIUrl":"10.1016/j.cjca.2026.03.043","url":null,"abstract":"<div><h3>Background</h3><div>The left bundle branch block (LBBB) morphology could be divided into concordant LBBB (con-LBBB; T waves concordant with QRS) or discordant LBBB (dis-LBBB; T waves discordant with QRS) types on the basis of the direction of T and QRS main waves except for true or non-true LBBB (non-tLBBB). In this study we aimed to investigate the influence of baseline LBBB morphology on success rate of left bundle branch pacing (LBBP), echocardiographic response, and clinical outcomes in patients who received LBBP-delivered cardiac resynchronization therapy.</div></div><div><h3>Methods</h3><div>Consecutive patients with heart failure (HF) and LBBB who attempted to receive LBBP-delivered cardiac resynchronization therapy were prospectively enrolled from 2019 to 2024. Baseline LBBB morphology was identified as con-LBBB, dis-LBBB, and non-tLBBB types. The primary end point was echocardiographic response at 6-month follow-up. Secondary end points included: (1) LBBP success; (2) echocardiographic super-response; (3) all-cause mortality and/or HF hospitalization.</div></div><div><h3>Results</h3><div>A total of 110 patients (32 with con-LBBB, 31 with dis-LBBB, and 47 with non-tLBBB) post cardiac resynchronization therapy were included. The LBBP success rate was highest in the con-LBBB group, followed by the dis-LBBB, and non-tLBBB group (84.4% vs 71.0% vs 51.1%; <em>P</em> = 0.007). After adjusting for confounders, con-LBBB was an independent predictor for LBBP success (odds ratio [OR], 3.90 [95% confidence interval (CI), 1.21-12.51]; <em>P</em> = 0.022), echocardiographic response (OR, 4.88 [95% CI, 1.26-18.81]; <em>P</em> = 0.021), and super-response (OR, 3.87 [95% CI, 1.40-10.69]; <em>P</em> = 0.009). During a mean follow-up of 20.2 ± 12.9 months, con-LBBB was associated with decreased all-cause mortality or HF hospitalization (hazard ratio, 0.08 [95% CI, 0.01-0.62]; <em>P</em> = 0.015).</div></div><div><h3>Conclusions</h3><div>Baseline con-LBBB might be a useful predictor for LBBP success and favourable clinical outcomes.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2393-2406"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Outcomes of Operated Versus Nonoperated Patients With Infective Endocarditis and Cerebral Complications: The COOPER Study","authors":"Olivia Graveleau MD,&nbsp;Johann Cattan MD,&nbsp;Gaultier Marnat MD,&nbsp;Melchior Jonveaux MD,&nbsp;Marina Dijos MD,&nbsp;Marine Bouchat MD,&nbsp;Guillaume Bonnet MD, PhD,&nbsp;Lionel Leroux MD, PhD,&nbsp;Mathieu Pernot MD, PhD,&nbsp;Julien Peltan MD,&nbsp;Georgios Nesseris MD,&nbsp;Louis Labrousse MD, PhD,&nbsp;Benjamin Seguy MD,&nbsp;Edouard Gerbaud MD, PhD,&nbsp;Soumaya Sridi-Cheniti MD,&nbsp;Hélène Chaussade MD,&nbsp;Carine Greib MD,&nbsp;Fabrice Camou MD,&nbsp;Olivia Peuchant PharmD, PhD,&nbsp;Gaetane Wirth MD,&nbsp;Julien Ternacle MD, PhD","doi":"10.1016/j.cjca.2026.03.022","DOIUrl":"10.1016/j.cjca.2026.03.022","url":null,"abstract":"<div><h3>Background</h3><div>Cerebral complications in patients with infective endocarditis (IE) are common and worsen prognosis. Determining the optimal timing for cardiac surgery in this context remains challenging. In this study we describe the characteristics and outcomes of IE patients with cerebral complications who were managed either surgically or medically.</div></div><div><h3>Methods</h3><div>We analyzed all consecutive patients with IE-related cerebral complications enrolled in a prospective cohort study in Aquitaine, France (2013-2021). Patients were classified as operated or nonoperated. The primary outcome was all-cause mortality at 1 month; secondary outcomes included all-cause mortality up to 1 year and the impact of cerebral lesion type and surgical timing.</div></div><div><h3>Results</h3><div>Among 1230 IE patients, 288 had cerebral complications (age 65 ± 14 years, 74% male). Ischemic and hemorrhagic cerebral lesions occurred in 76% and 19% of patients, respectively. Severe valvular damages were present in 43% and cardiac surgery was indicated in 86% of cases. One-month mortality was significantly higher among nonoperated vs operated patients (27% vs 5.9%, <em>P</em> &lt; 0.001). Multivariate analysis identified heart failure, coma, and cardiac surgery (odds ratio 0.24, 95% confidence interval 0.10-0.56, <em>P</em> &lt; 0.001) as independent predictors of mortality. Neither the type of cerebral lesion nor surgical timing appeared to affect prognosis.</div></div><div><h3>Conclusions</h3><div>When indicated, cardiac surgery should be systematically discussed in IE patients with cerebral complications. Early intervention guided by a multidisciplinary endocarditis team with neurology expertise may improve outcomes.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2501-2510"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Sirolimus-Coated Balloons for the Treatment of Coronary Disease. The Metal-Free Registry","authors":"Giuseppe Di Gioia MD, PhD,&nbsp;Marco Ferrone MD, PhD,&nbsp;Danilo Franco MD, PhD,&nbsp;Massimo Russo MD, MD,&nbsp;Michele Franzese MD,&nbsp;Angelo Cioppa MD,&nbsp;Grigore Popusoi MD,&nbsp;Sebastiano Verdoliva MD,&nbsp;Armando Pucciarelli MD,&nbsp;Giuseppe Ciliberti MD,&nbsp;Antonio Colombo MD, PhD,&nbsp;Tullio Tesorio MD,&nbsp;Luigi Salemme MD","doi":"10.1016/j.cjca.2026.04.006","DOIUrl":"10.1016/j.cjca.2026.04.006","url":null,"abstract":"<div><h3>Background</h3><div>Long-term clinical outcomes are lacking for patients treated with sirolimus-eluting balloons (SEBs). We sought to evaluate long-term clinical outcomes of the SELUTION SLR (Selution; MedAlliance; Nyon, Switzerland) SEB in various clinical settings.</div></div><div><h3>Methods</h3><div>From 2021 to 2025, we included patients treated with the Selution SEB. Patients were divided into 3 groups: drug-eluting stent in-stent restenosis (DES-ISR), small vessel (SV; diameter &lt; 3 mm) and big vessel (BV). Inverse probability of treatment weighting analysis was used to account for baseline differences. The primary end point was target lesion failure, defined as the composite of cardiovascular death, target vessel myocardial infarction, and target lesion revascularization.</div></div><div><h3>Results</h3><div>A total of 495 patients were included in the study. Of these, 33.1% were included for DES-ISR, 40.4% for <em>de novo</em> SV lesions, and 26.5% for <em>de novo</em> BV lesions. In patients treated for <em>de novo</em> lesions, bail out stenting occurred in 16.6% of patients. Up to 3 years, there were no significant differences in any end points between DES-ISR and SV, nor between DES-ISR and BV. A significantly lower bail out rate was observed in the second half of patients included in the registry (12.6%) compared with the early inclusion group (20.5%; <em>P</em> = 0.049), without an increase in clinical events.</div></div><div><h3>Conclusions</h3><div>Patients treated with the Selution SEB were associated with favourable clinical outcomes at mid- and long-term follow-up. There were no significant differences in any end points between DES-ISR and SV, nor between DES-ISR and BV.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2320-2328"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}