Canadian Journal of Cardiology最新文献

{"title":"Outcomes and Patterns Related to Magnesium in Acute Heart Failure: A Population-Based Study","authors":"Robert Margaryan MSc,&nbsp;Sunjidatul Islam MBBS, MSc,&nbsp;Douglas Dover PhD,&nbsp;Finlay A. McAlister MD, MSc,&nbsp;Padma Kaul PhD,&nbsp;Justin A. Ezekowitz MBBCh, MSc","doi":"10.1016/j.cjca.2026.03.037","DOIUrl":"10.1016/j.cjca.2026.03.037","url":null,"abstract":"<div><h3>Background</h3><div>The significance of magnesium as a treatment or prognostic factor in heart failure (HF) remains uncertain despite frequent use. We evaluated the frequency and outcomes of magnesium testing, hypomagnesemia, and intravenous (IV) replacement in a large population-based cohort.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used linked administrative data (April 2012 to March 2020). Patients with a primary diagnosis of HF in the emergency department (ED) or hospital were included. Outcomes included all-cause and cause-specific death and hospitalisation. Secondary outcomes included ED visits and physicians claims. We also examined rates of serum magnesium testing and hypomagnesemia.</div></div><div><h3>Results</h3><div>Among 78,957 acute HF episodes (in 42,763 patients), 58.7% included serum magnesium testing. Of those tested, serum magnesium levels were &lt; 0.75 mmol/L in 31.7%, 0.75-0.95 mmol/L in 56.8% and &gt; 0.95 mmol/L in 11.5%. Magnesium levels (per 0.02 mmol/L increase) were independently associated with mortality when &lt; 0.70 mmol/L (hazard ratio [HR] 0.99, 95% confidence interval [CI] 0.98-0.99; <em>P</em> &lt; 0.001) or &gt; 0.86 mmol/L (HR 1.04, 95% CI 1.03-1.04; <em>P</em> &lt; 0.001). IV magnesium was administered to 13.7% (n = 6333) of tested patients, including 29.7% without hypomagnesemia. After multivariable adjustment, IV magnesium was associated with a higher short-term mortality (HR 1.66, 95% CI 1.4-1.96; <em>P</em> &lt; 0.0001) and hospitalisation risk (HR 1.36, 95% CI 1.13-1.63; <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Serum magnesium testing is common in patients presenting to the ED or hospital with HF, and low or high magnesium is associated with worse outcomes. Replacement with IV magnesium was associated with worse outcomes even after adjustment, warranting further study.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2442-2452"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated Aortic Root Thrombosis During Mechanical Left Ventricular Support After Bentall Procedure in a Marfan Patient","authors":"Yoshiyuki Takami MD, PhD,&nbsp;Shin-ichi Tanida NP,&nbsp;Masanobu Yanase MD, PhD","doi":"10.1016/j.cjca.2026.03.042","DOIUrl":"10.1016/j.cjca.2026.03.042","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2477-2478"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular Imaging–guided Percutaneous Coronary Intervention in Patients With and Without Diabetes: A Meta-analysis of Randomized Trials","authors":"Hendrianus Hendrianus MD,&nbsp;Sang Yeub Lee MD, PhD,&nbsp;Hoyoun Won MD, PhD,&nbsp;Young-Hoon Jeong MD, PhD,&nbsp;Jun Hwan Cho MD,&nbsp;Ki-Bum Won MD, PhD,&nbsp;Jinhwan Jo MD,&nbsp;Kyung Taek Park MD,&nbsp;Gyu Tae Park MD,&nbsp;Woo Jin Jang MD, PhD,&nbsp;Wang-Soo Lee MD, PhD,&nbsp;Sang-Wook Kim MD, PhD","doi":"10.1016/j.cjca.2026.03.012","DOIUrl":"10.1016/j.cjca.2026.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Intravascular imaging improves percutaneous coronary intervention (PCI) outcomes, but its effect according to diabetes status remains insufficiently defined.</div></div><div><h3>Methods</h3><div>PubMed, Embase, and CENTRAL were systematically searched for randomized trials comparing intravascular imaging–guided vs angiography-guided PCI, or optical coherence tomography (OCT) vs intravascular ultrasound (IVUS), reporting outcomes by diabetes status. The primary outcome was target vessel failure (TVF) at ≥ 1 year. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were estimated from event counts using a random-effects model.</div></div><div><h3>Results</h3><div>Eleven randomized controlled trials (n = 17,692) were included. Intravascular imaging–guided PCI reduces TVF compared with angiography guidance, with consistent effects in patients with diabetes (risk ratio [RR] 0.69, 95% confidence interval [CI] 0.53-0.90; <em>P</em> = 0.006) and without diabetes (RR 0.65, 95% CI 0.55-0.77; <em>P</em> &lt; 0.001, <em>P</em>_interaction = 0.72). Similar reductions were observed in complex PCI populations and with both IVUS and OCT guidance. In diabetes patients undergoing complex PCI, intravascular imaging likely reduces TVF (RR 0.74, 95% CI 0.53-1.04), whereas OCT guidance may reduce TVF (RR 0.70, 95% CI 0.42-1.16). In exploratory head-to-head analyses, OCT showed no difference in TVF risk compared with IVUS, with consistent findings across diabetes status. Meta-regression identified age and follow-up duration as potential effect modifiers in patients with diabetes.</div></div><div><h3>Conclusions</h3><div>Intravascular imaging–guided PCI reduces TVF compared with angiography guidance in both patients with and without diabetes. In some diabetic subgroups, intravascular imaging may reduce TVF, although estimates were imprecise. These findings support intravascular imaging to optimize PCI outcomes regardless of diabetes status.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2344-2355"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P102 LEFT ATRIAL RESERVOIR STRAIN OUTPERFORMS LEFT ATRIAL VOLUME IN ASSESSING HEMODYNAMIC STRESS IN SEVERE AORTIC STENOSIS","authors":"Z. Zhu,&nbsp;N. Pandith,&nbsp;A. Roshan,&nbsp;C.M. Thorson,&nbsp;M.E. Barnes,&nbsp;W.T.C. Wong,&nbsp;I. Korchinski,&nbsp;T.S.M. Tsang","doi":"10.1016/j.cjca.2026.07.106","DOIUrl":"10.1016/j.cjca.2026.07.106","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S68"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P090 ASSOCIATION BETWEEN ISCHEMIC STROKE AND SUBSEQUENT OAC ADHERENCE IN PATIENTS WITH ATRIAL FIBRILLATION – A RETROSPECTIVE OBSERVATIONAL COHORT STUDY","authors":"A.A. Shukkoor,&nbsp;R. Turgeon,&nbsp;M.A. De Vera,&nbsp;M. Harrison,&nbsp;H. Helisaz,&nbsp;P. Loewen","doi":"10.1016/j.cjca.2026.07.100","DOIUrl":"10.1016/j.cjca.2026.07.100","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S64"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P024 LONG-TERM PATENCY AND GRAFT FAILURE MODES AFTER ROBOTIC-ASSISTED MINIMALLY INVASIVE DIRECT CORONARY ARTERY BYPASS: A 15-YEAR SINGLE-CENTRE EXPERIENCE","authors":"D. Al-Hakim,&nbsp;A. Sharma,&nbsp;K. Stefanyk,&nbsp;R. Cook","doi":"10.1016/j.cjca.2026.07.033","DOIUrl":"10.1016/j.cjca.2026.07.033","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S19-S20"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P074 THE CHANGING PREVALENCE OF COMPLEX CONGENITAL HEART DISEASE CAUSED BY TERMINATIONS OF PREGNANCY","authors":"C. Dufour,&nbsp;L.O. Roy,&nbsp;S. Blais,&nbsp;L. Watelle,&nbsp;C. Drolet,&nbsp;A. Dancea,&nbsp;N. Dahdah,&nbsp;M.È. Roy-Lacroix,&nbsp;L. Vauhois,&nbsp;J.L. Bigras,&nbsp;T. Cavallé-Garrido,&nbsp;F. Dallaire","doi":"10.1016/j.cjca.2026.07.367","DOIUrl":"10.1016/j.cjca.2026.07.367","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S52-S53"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P011 CLINICAL AND ECHOCARDIOGRAPHIC OUTCOMES FOLLOWING MITRAL VALVE REPLACEMENT USING NOVEL BOVINE PERICARDIAL VALVE BIOPROSTHESIS IN REAL-WORLD SETTING","authors":"M. Côté,&nbsp;A. Abo Dan,&nbsp;A. Chabane,&nbsp;P.E. Noly,&nbsp;P. Borchiellini,&nbsp;P. Demers,&nbsp;M. Pellerin,&nbsp;D. Bouchard","doi":"10.1016/j.cjca.2026.07.022","DOIUrl":"10.1016/j.cjca.2026.07.022","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S11-S12"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P056 A SYSTEMATIC REVIEW AND META-ANALYSIS OF INFLAMMATORY AND OXIDATIVE STRESS BIOMARKERS ASSOCIATED WITH E-CIGARETTE USAGE","authors":"Z. Li,&nbsp;J. Heshmati,&nbsp;H. Thode,&nbsp;M. Yamani,&nbsp;T. Gelibo,&nbsp;S. Mahmoodianfard,&nbsp;H. Mir","doi":"10.1016/j.cjca.2026.07.065","DOIUrl":"10.1016/j.cjca.2026.07.065","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S40"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P089 ARTIFICIAL INTELLIGENCE REVEALS DIASTOLIC DYSFUNCTION AND HFPEF FROM ROUTINE ECG TRACINGS","authors":"D. Shirvani,&nbsp;A. Shokravi,&nbsp;P. Nelson,&nbsp;N. Nasibi,&nbsp;C. Luong","doi":"10.1016/j.cjca.2026.07.099","DOIUrl":"10.1016/j.cjca.2026.07.099","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S63-S64"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}