Canadian Journal of Cardiology最新文献

{"title":"Perpsectives on Mini-Invasive Left Atrial Appendage Closure: Preliminary Clinical Outcomes and Cost Data","authors":"Romain Eschalier MD, PhD, Clément Riocreux MD, Bruno Pereira PhD, Simon Berger MD, Aurélie Chalard MD, Catherine Denis MD, Pierre-Antoine Catalan MD, Matthieu Jabaudon MD, PhD, Emmanuel Futier MD, PhD, Grégoire Massoullie MD, Guillaume Clerfond MD","doi":"10.1016/j.cjca.2025.01.013","DOIUrl":"10.1016/j.cjca.2025.01.013","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Page 898"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Axonal Guidance Cue Semaphorin 3A in Innervation of the Postnatal Heart in Health and Disease","authors":"Claire J. Koppel MD ,&nbsp;Charlotte M.S. De Henau MSc ,&nbsp;Dianne Vreeken PhD ,&nbsp;Marco C. DeRuiter PhD ,&nbsp;Monique R.M. Jongbloed MD, PhD ,&nbsp;Janine M. van Gils PhD","doi":"10.1016/j.cjca.2024.12.030","DOIUrl":"10.1016/j.cjca.2024.12.030","url":null,"abstract":"<div><div>During cardiac development, the heart is innervated by the autonomous nervous system. After development, neurons of the autonomic nervous system have limited capacity for growth and regeneration. However, in recent decades, it has become clear that cardiac nerves can regenerate after cardiac damage. Excessive reinnervation, so-called sympathetic hyperinnervation, may render patients vulnerable to ventricular arrhythmias and heart failure. Several studies have investigated axonal guidance cues as mediators of cardiac innervation. Axonal guidance cues direct neuronal growth of the axon and play a significant role in the regeneration and remodelling of cardiac autonomic innervation after cardiac damage. This review focusses on the current literature regarding the axonal guidance cue group of semaphorins and their function in the healthy and diseased postnatal heart. In view of cardiac innervation, most studies have focussed on semaphorin 3A (SEMA3A), whereas less is known about the function of the other semaphorin classes. SEMA3A is a neuronal repellent and is associated with a decrease in the density of sympathetic neurons in the heart. Its decline in expression after myocardial infarction plays a role in the development of sympathetic hyperinnervation and the subsequent increased risk of ventricular arrhythmias. In congestive heart failure, the opposite occurs: an increase in SEMA3A expression underlies decreased nerve density that may also serve as a substrate for ventricular arrhythmias. Although the literature on their role in cardiac innervation is still relatively scarce, semaphorins, especially SEMA3A, seem worthwhile to consider when exploring options to modulate pathologic innervation patterns in cardiovascular disease.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 899-910"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-term Outcomes of Frozen Elephant Trunk for Chronic Aortic Dissection","authors":"Dmitri S. Panfilov MD, PhD,&nbsp;Boris N. Kozlov MD, PhD","doi":"10.1016/j.cjca.2025.01.003","DOIUrl":"10.1016/j.cjca.2025.01.003","url":null,"abstract":"<div><h3>Background</h3><div>The aim of the study was to analyse the mid-term outcomes of the frozen elephant trunk (FET) procedure for chronic aortic dissection (СAD).</div></div><div><h3>Methods</h3><div>From March 2012 to December 2022, 123 FET procedures were performed in patients with acute and chronic aortic dissection (CAD) as well as aortic aneurysm. Fifty-eight patients with CAD were eligible for study. CAD patients were divided into 2 groups: type A (n = 32) and type B (n = 26). Pre-, intra-, and postoperative data were collected retrospectively from electronic patient records, with a median follow-up period of 21.5 months (range 1-96 months).</div></div><div><h3>Results</h3><div>The overall 30-day mortality in CAD patients was 10.3%. The overall survival rate for the entire cohort was 66.5 ± 7.9%, and for type A and type B patients, respectively, it was 77.6 ± 8.1% and 53 ± 1.3% (<em>P</em> = 0.229). Distal stent graft–induced new entry developed in 2 (3.4%) patients. Freedom from composite outcome (death or/and distal aortic re-intervention) for the entire cohort was 56.8 ± 9.8%, and for type A and type B patients was 66.5 ± 1.2% and 44.8 ± 1.4%, respectively (<em>P</em> = 0.181). The incidence of stroke was 1.7%. Two patients (3.4%) had signs of spinal cord ischemia. Respiratory failure occurred in 14 patients (23.1%). The rate of dialysis was 15.5% (n = 9). The chest re-exploration for bleeding rate was 5.2% (n = 3).</div></div><div><h3>Conclusions</h3><div>Early and late outcomes (death and/or distal aortic re-intervention) after the FET in CAD are tolerable without difference between type A and type B.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 989-995"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The New Niche: Transcatheter Aortic Valve Explantation and the Key Issues Concerning the Heart Team","authors":"Asher Frydman MD,&nbsp;Maria Servito MD,&nbsp;Hellmuth R. Muller Moran MD, MSc, FRCSC","doi":"10.1016/j.cjca.2025.01.011","DOIUrl":"10.1016/j.cjca.2025.01.011","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 843-847"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitral Valve-in-Valve Transcatheter Mitral Valve Replacement Using a Novel Snaring Technique","authors":"Hussein Sliman MD,&nbsp;Amnon Eitan MD,&nbsp;Danny Dvir MD,&nbsp;Avinoam Shiran MD,&nbsp;Salim Adawi MD,&nbsp;Ronen Jaffe MD","doi":"10.1016/j.cjca.2025.01.010","DOIUrl":"10.1016/j.cjca.2025.01.010","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 891-892"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitral Valve Prolapse Caused by TLL1 Gain-of-Function Mutation","authors":"Nadav Agam BMedSc ,&nbsp;Vadim Dolgin PhD ,&nbsp;Artyom Star MD ,&nbsp;Ofek Freund BMedSc ,&nbsp;Matan M. Jean BMedSc ,&nbsp;Amit Safran MMedSc ,&nbsp;Tomer Poleg BMedSc ,&nbsp;Doron Zahger MD ,&nbsp;Ohad S. Birk MD, PhD","doi":"10.1016/j.cjca.2025.01.018","DOIUrl":"10.1016/j.cjca.2025.01.018","url":null,"abstract":"<div><h3>Background</h3><div>Mitral valve prolapse (MVP) is a common cardiac valvular anomaly that can be caused by mutations in genes of various biologic pathways. Individuals of 3 generations of a kindred presented with an apparently dominant heredity of isolated MVP.</div></div><div><h3>Methods</h3><div>Clinical evaluation and echocardiography were performed for all complying members of a family (n = 13). Whole exome and genome sequencing data of 2 affected individuals were analyzed, delineating shared heterozygous variants, and then further tested for segregation within the kindred (Sanger sequencing). Tolloid-like 1 (TLL1) enzymatic activity was assayed in media of HEK293 cells transfected with wild-type vs mutant TLL1.</div></div><div><h3>Results</h3><div>The only heterozygous variant segregating in the affected kindred as expected for dominant heredity of MVP was p.T253A, within the catalytic domain of TLL1. Of 8 heterozygotes, 6 had MVP and 2 had trivial mitral regurgitation. An activity assay in the extracellular media of the HEK293-transfected cells showed that, over time (12 hours), the enzymatic activity of the mutated TLL1 protein was 3.4-fold higher than that of the wild-type.</div></div><div><h3>Conclusions</h3><div>Our genetic and biochemical studies show that a TLL1 gain-of-function mutation, prolonging the half-life of TLL1 active protein in the extracellular matrix, causes autosomal dominant MVP with variable expressivity. TLL1 encodes an extracellular metalloprotease regulating extracellular matrix composition and maintenance. In previous work, heterozygous loss-of-function TLL1 mutations have been shown to cause autosomal dominant atrial septal defects. Our findings enable novel insights into the molecular pathways of valvular physiology and disease, the role of TLL1 in human development, and the differing phenotypes in loss-of-function and gain-of-function mutations of the same gene.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 928-935"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking Down Bias: A Methodological Primer on Identifying, Evaluating, and Mitigating Bias in Cardiovascular Research","authors":"Nicholas Grubic MSc ,&nbsp;Amy Johnston PhD ,&nbsp;Varinder K. Randhawa MD, PhD ,&nbsp;Karin H. Humphries DSc ,&nbsp;Laura C. Rosella PhD ,&nbsp;Katerina Maximova PhD","doi":"10.1016/j.cjca.2024.12.022","DOIUrl":"10.1016/j.cjca.2024.12.022","url":null,"abstract":"<div><div>Systematic error, often referred to as bias is an inherent challenge in observational cardiovascular research, and has the potential to profoundly influence the design, conduct, and interpretation of study results. If not carefully considered and managed, bias can lead to spurious results, which can misinform clinical practice or public health initiatives and compromise patient outcomes. This methodological primer offers a concise introduction to identifying, evaluating, and mitigating bias in observational cardiovascular research studies that examine the causal association between an exposure (or treatment) and an outcome. Using high-profile examples from the cardiovascular literature, this review provides a theoretical overview of 3 main types of bias—selection bias, information bias, and confounding—and discusses the implications of specialized types of biases commonly encountered in longitudinal cardiovascular research studies, namely, competing risks, immortal time bias, and confounding by indication. Furthermore, strategies and tools that can be used to minimize and assess the influence of bias are highlighted, with a specific focus on using the target trial framework, directed acyclic graphs, quantitative bias analysis, and formal risk of bias assessments. This review aims to assist researchers and health care professionals in designing observational studies and selecting appropriate methodologies to reduce bias, ultimately enhancing the estimation of causal associations in cardiovascular research.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 996-1009"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interatrial Shunt Therapy: A Rescue Option for Nonoperable Mitral Valve Disease Patients","authors":"Eduard Solé-González MD, PhD ,&nbsp;Marta Farrero MD, PhD ,&nbsp;Xavier Freixa MD, PhD ,&nbsp;Estefanía Torrecilla ,&nbsp;Laura Sanchís MD, PhD ,&nbsp;Pedro Caravaca-Pérez MD ,&nbsp;Ana García-Álvarez MD, PhD ,&nbsp;Marta Sitges MD, PhD ,&nbsp;Willliam T. Abraham MD ,&nbsp;Josep Rodés-Cabau MD ,&nbsp;Omar Abdul-Jawad Altisent MD, PhD","doi":"10.1016/j.cjca.2025.01.009","DOIUrl":"10.1016/j.cjca.2025.01.009","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 888-890"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-in-Canada Use of Novel Heart Preservation System","authors":"Lebei Pi MD ,&nbsp;Vivek Rao MD, PhD ,&nbsp;Filio Billia MD, PhD ,&nbsp;Diego Delgado MD, MSc ,&nbsp;Michael McDonald MD ,&nbsp;Yas Moayedi MD, MHSc ,&nbsp;Juglans Alvarez MD, MSc","doi":"10.1016/j.cjca.2024.12.019","DOIUrl":"10.1016/j.cjca.2024.12.019","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 1010-1012"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefit of Systematic “Jailed Wire” Technique for Bifurcation Provisional Stenting. A CABRIOLET Substudy","authors":"François Dérimay MD, PhD ,&nbsp;Aurélien Mercier MD ,&nbsp;Adel Aminian MD ,&nbsp;Luc Maillard MD, PhD ,&nbsp;Géraud Souteyrand MD, PhD ,&nbsp;Pascal Motreff MD, PhD ,&nbsp;Benoit Lattuca MD, PhD ,&nbsp;Guillaume Cayla MD, PhD ,&nbsp;Gilles Rioufol MD, PhD ,&nbsp;Gérard Finet MD, PhD","doi":"10.1016/j.cjca.2024.12.021","DOIUrl":"10.1016/j.cjca.2024.12.021","url":null,"abstract":"<div><h3>Background</h3><div>Jailed wire (JW) in the side branch (SB) is recommended during coronary bifurcation provisional stenting, but there is uncertainty about the real benefit. Our objective was to evaluate the benefit of a JW technique in the <strong>C</strong>oronary <strong>A</strong>rtery <strong>B</strong>ifurcation <strong>R</strong>evascularization Without k<strong>I</strong>ssing ball<strong>O</strong>on inf<strong>L</strong>ation by r<strong>E</strong>po<strong>T</strong> (CABRIOLET) registry.</div></div><div><h3>Methods</h3><div>In CABRIOLET, which included 500 patients, we compared the primary composite end point of a poor final SB angiographic result (of <strong>T</strong>hrombolysis <strong>i</strong>n <strong>M</strong>yocardial <strong>I</strong>nfarction (TIMI) flow &lt; III, dissection grade &gt; B, thrombosis, residual stenosis &gt; 70%, or additional SB stenting) whether JW was performed or not. On the basis of the usual operator practice, we also compared a systematic JW strategy: operators known to place JW frequently (&gt; 75% performed), to a conditional strategy: selective JW practices (&lt; 20% of JW).</div></div><div><h3>Results</h3><div>JW was performed in 251 patients (50.2%), without significant baseline clinical and angiographic differences compared with those who received no JW. JW was associated with higher primary end point (15.1% vs 8.4%; <em>P</em> &lt; 0.05), and increased fluoroscopy time and contrast volume (15.9 ± 7.3 minutes and 181 ± 62 mL vs 13.3 ± 6.5 minutes and 161 ± 74 mL; <em>P</em> &lt; 0.05). JW was performed in 12.1% of patients (26 of 214) in the conditional JW group and 78.7% (225 of 286) in systematic group. The primary end point was similar in both strategies (11.2% and 12.2%; <em>P</em> = 0.78), although with greater fluoroscopy time and contrast volume for systematic JW (180 ± 57 mL and 15.3 ± 7.5 minutes vs 162 ± 79 mL and 13.7 ± 6.1 minutes; <em>P</em> &lt; 0.05). There was no difference in 1-year major adverse cardiovascular events depending on whether JW was performed or not and between conditional or systematic strategies.</div></div><div><h3>Conclusions</h3><div>In a large registry, JW was associated with poorer final SB angiographic results than no JW. Final SB angiographic results were similar between conditional or systematic JW strategies.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 871-877"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}