Canadian Journal of Cardiology最新文献

{"title":"P110 TRANSVALVULAR FLOW AND AORTIC VALVE CALCIFICATION IN DISCORDANT SEVERE AORTIC STENOSIS","authors":"T. Grinberg, G. Prosperi-Porta, M.R.R. Durr, A. Tavoosi, L. Beauchesne, L. Lau, A. Mulloy, M. Rashid, H. Alfraidi, I.G. Burwash, D. Messika-Zeitoun","doi":"10.1016/j.cjca.2026.07.113","DOIUrl":"10.1016/j.cjca.2026.07.113","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S73"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P042 THE \"INFECTION TAX\" IN CARDIAC SURGERY: NURSE-LED NASAL PHOTODISINFECTION AS A CRITICAL CAPACITY-BUILDING MEASURE","authors":"T. Williams, J. Hockok, C. Cross","doi":"10.1016/j.cjca.2026.07.048","DOIUrl":"10.1016/j.cjca.2026.07.048","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S31-S32"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P068 MULTIDOMAIN PROFILING IDENTIFIES CORRELATES OF HEART FAILURE, ARRHYTHMIA, AND DEVICE BURDEN IN ADULTS WITH COMPLEX CONGENITAL HEART DISEASE","authors":"J. Sait, N. Kara, A. Dore, F.P. Mongeon, B. Mondésert, V. Roy, J. Brouillette, P. Khairy, M. Ruiz, M.A. Chaix","doi":"10.1016/j.cjca.2026.07.078","DOIUrl":"10.1016/j.cjca.2026.07.078","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S48-S49"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Storm Clouds Coming: Red-Flag Warning for Hypertension Prevalence and Control in the Post-COVID-19 Era","authors":"Ross D. Feldman MD, Raj S. Padwal MD, MSc, Sheldon W. Tobe MD, MScCH","doi":"10.1016/j.cjca.2026.06.026","DOIUrl":"10.1016/j.cjca.2026.06.026","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2296-2298"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign Hysterectomy and Risk of Cardiometabolic Disease: A Population-based Cohort Study","authors":"Natalie V. Scime PhD,&nbsp;Beili Huang MSc,&nbsp;Amity Quinn PhD,&nbsp;Marcello Tonelli MD,&nbsp;Maria C. Cusimano MD,&nbsp;Hilary K. Brown PhD,&nbsp;Michael D. Hill MD,&nbsp;Derek S. Chew MD,&nbsp;Jamie L. Benham MD,&nbsp;Erin A. Brennand MD","doi":"10.1016/j.cjca.2026.06.003","DOIUrl":"10.1016/j.cjca.2026.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Hysterectomy is the most frequently performed surgery in nonpregnant women yet might have underappreciated implications for long-term chronic disease risk. In this study we investigated the association between benign hysterectomy with ovarian conservation and future risk of cardiometabolic disease.</div></div><div><h3>Methods</h3><div>This was a population-based cohort study of women aged 20-39 years in Alberta (1997-2021) and included: (1) an overall cohort with all eligible women (n = 1,191,263); and (2) a matched subcohort of exposed women (n = 45,331) age-matched with 6 unexposed women (n = 271,986). The primary outcome was first diagnosis of cardiometabolic disease and secondary outcomes were 10 cardiometabolic diseases. We used Cox proportional hazards regression modelling with age as the time scale (median follow-up, 13.3 years) in the overall cohort, and Royston-Parmar models with time since surgery as the time scale (median follow-up, 10.3 years) in the age-matched subcohort. Models were adjusted for birth year or year of hysterectomy, and time-varying rural residence, material deprivation quintile, continuity of primary care, and comorbidities.</div></div><div><h3>Results</h3><div>In the overall cohort, hysterectomy was associated with accelerated time to first diagnosis of cardiometabolic disease (adjusted hazard ratio [aHR], 1.33; 95% confidence interval [CI], 1.30-1.36) and with incidence of 7/10 cardiometabolic diseases; the strongest associations were chronic kidney disease (aHR, 1.29; 95% CI, 1.23-1.35), ischemic heart disease (aHR, 1.31; 95% CI, 1.25-1.38), metabolic dysfunction-associated steatotic liver disease (aHR, 1.43; 95% CI, 1.32-1.55), and stroke (aHR, 1.33; 95% CI, 1.23-1.45). Results were similar in the age-matched subcohort.</div></div><div><h3>Conclusions</h3><div>Benign hysterectomy with ovarian conservation might be an important female-specific risk factor for cardiometabolic disease, warranting judicious use and expanded patient counselling on potential long-term health risks.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2411-2420"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Kidney Function in Myocardial Infarction Patients Who Underwent Coronary Intervention: Acute Kidney Injury Risk and Long-term Prognosis","authors":"Shuo Wu MD,&nbsp;Shikun Wang MD, PhD,&nbsp;Feng Xu MD, PhD,&nbsp;Jiaojiao Pang MD, PhD,&nbsp;Yuguo Chen MD, PhD","doi":"10.1016/j.cjca.2026.04.001","DOIUrl":"10.1016/j.cjca.2026.04.001","url":null,"abstract":"<div><h3>Background</h3><div>Acute kidney injury (AKI) is a critical complication in ST-segment elevation myocardial infarction (STEMI) patients who undergo percutaneous coronary intervention (PCI). The effect of high preoperative estimated glomerular filtration rate (eGFR; ≥ 105 mL/min/1.73 m²) on AKI and long-term adverse outcomes remains poorly understood.</div></div><div><h3>Methods</h3><div>In this multicentre, prospective cohort study we enrolled 4536 STEMI consecutive patients who underwent emergency PCI in China. Logistic regression was used to assess the association between preoperative eGFR and AKI, and Cox regression was used to evaluate the effect of preoperative eGFR and AKI on 2-year adverse outcomes.</div></div><div><h3>Results</h3><div>Among 4536 patients, 820 (18.1%) had high eGFR, 1806 (39.8%) normal eGFR (90-105 mL/min/1.73 m²), 1547 (34.1%) mild reduction of eGFR (60-90 mL/min/1.73 m²), and 363 (8.0%) had low eGFR (&lt; 60 mL/min/1.73 m²). Mean age was 62 years; 23.2% were female. Low and high eGFR levels were independently associated with increased AKI risk (adjusted odds ratio, 1.818 [95% confidence interval (CI), 1.268-2.608] and 2.143 [95% CI, 1.517-3.025]). Two-year major adverse cardiovascular events incidence increased progressively with declining eGFR: 4.0% (high), 5.5% (normal), 11.3% (mild), and 22.3% (low). Among patients with normal-to-high eGFR, those with AKI had higher risks of major adverse cardiovascular events (hazard ratio, 2.418 [95% CI, 1.579-3.704]) and all-cause mortality (hazard ratio, 2.380 [95% CI, 1.407-4.025]).</div></div><div><h3>Conclusions</h3><div>This study confirmed a U-shaped relationship between preoperative eGFR and AKI, highlighting that high eGFR is an under-recognized risk factor for AKI and long-term adverse outcomes in STEMI patients. These findings underscore the need for enhanced clinical vigilance and tailored management strategies for PCI patients with high preoperative eGFR.</div></div><div><h3>Clinical Trial Registration</h3><div>NCT03510832.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2372-2379"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Year Outcomes of Optical Coherence Tomography–Guided Percutaneous Coronary Intervention Stratified by Underlying Causes of Acute Coronary Syndrome","authors":"Myong Hwa Yamamoto MD, PhD,&nbsp;Takuya Mizukami MD, PhD,&nbsp;Hiroyoshi Mori MD, PhD,&nbsp;Nobuaki Kobayashi MD, PhD,&nbsp;Masamichi Takano MD, PhD,&nbsp;Seita Kondo MD, PhD,&nbsp;Tomoyo Sugiyama MD, PhD,&nbsp;Tsunekazu Kakuta MD, PhD,&nbsp;Kohei Wakabayashi MD, PhD,&nbsp;Satoru Suwa MD,&nbsp;Tomotaka Dohi MD, PhD,&nbsp;Hiroshi Suzuki MD, PhD,&nbsp;Shigeki Kimura MD, PhD,&nbsp;Masao Yamaguchi MD, PhD,&nbsp;Sunao Nakamura MD, PhD,&nbsp;Toru Naganuma MD, PhD,&nbsp;Takumi Higuma MD, PhD,&nbsp;Junichi Yamaguchi MD, PhD,&nbsp;Taishi Yonetsu MD, PhD,&nbsp;Yuji Ikari MD, PhD,&nbsp;Toshiro Shinke MD, PhD","doi":"10.1016/j.cjca.2026.05.017","DOIUrl":"10.1016/j.cjca.2026.05.017","url":null,"abstract":"<div><h3>Background</h3><div>Optical coherence tomography (OCT) can identify the underlying causes of acute coronary syndrome (ACS), including plaque rupture (PR), plaque erosion (PE), and eruptive calcified nodule (CN), which may have prognostic implications. However, the duration and extent of their impacts remain unclear.</div></div><div><h3>Methods</h3><div>The multicentre prospective TACTICS registry enrolled patients with ACS undergoing OCT-guided percutaneous coronary intervention within 24 hours of symptom onset. Two-year clinical outcomes were assessed in 617 patients with OCT-diagnosed PR, PE, or CN (n = 411, 178, and 28, respectively). Major adverse cardiac events (MACE), a composite of cardiovascular death, myocardial infarction, heart failure, or ischemia-driven revascularisation, were independently adjudicated.</div></div><div><h3>Results</h3><div>During a median follow-up of 736 days, MACE occurred most frequently in CN (46.4%), primarily driven by cardiovascular death and ischemia-driven revascularisation, followed by PR (13.9%) and PE (8.4%) (log-rank <em>P</em> &lt; 0.001). Landmark Cox analysis demonstrated that within 180 days, CN and PR carried substantially higher MACE risk than PE (CN: HR 9.77, 95% CI 2.96-35.29 [<em>P</em> &lt; 0.001]; PR: HR 3.19, 95% CI 1.32-9.94 [<em>P</em> = 0.008]). Beyond 180 days, CN continued to exhibit significantly elevated risk (HR 6.30, 95% CI 2.39-15.60; <em>P</em> &lt; 0.001), whereas PR did not differ from PE (HR 1.04, 95% CI 0.53-2.17; <em>P</em> = 0.915).</div></div><div><h3>Conclusions</h3><div>Compared with PE, CN was associated with persistently adverse outcomes, whereas PR conferred elevated risk primarily in the early phase. OCT-defined underlying causes of ACS may help to identify high risk phenotypes and provide prognostic insight into temporal risk profiles.</div></div><div><h3>Clinical Trial Registration</h3><div>UMIN000039050.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2310-2319"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Foundation Models in Cardiology","authors":"Dor Hadida Barzilai MD,&nbsp;Alon Gorenshtein MD,&nbsp;Yiftach Barash MD,&nbsp;Mahmud Omar MD,&nbsp;Daor Hayu,&nbsp;Eyal Klang MD","doi":"10.1016/j.cjca.2026.04.030","DOIUrl":"10.1016/j.cjca.2026.04.030","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2407-2408"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P055 MODERATE OR GREATER TRICUSPID REGURGITATION INDEPENDENTLY PREDICTS MORTALITY AND HEART FAILURE HOSPITALIZATION IN LIGHT CHAIN CARDIAC AMYLOIDOSIS","authors":"D.Y. Wang,&nbsp;N. Yoosefi,&nbsp;P. Makedonski,&nbsp;A. Starovoytov,&nbsp;M. Kang,&nbsp;B. Zaidel,&nbsp;S. Ho,&nbsp;S. Virani,&nbsp;M. Davis","doi":"10.1016/j.cjca.2026.07.064","DOIUrl":"10.1016/j.cjca.2026.07.064","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S39"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P050 CARDIOVASCULAR RISK OF BURTON’S TYROSINE KINASE INHIBITORS: AN UPDATED SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS","authors":"H. Bhatt,&nbsp;I. Alqassas,&nbsp;F. Foroutan,&nbsp;R. Lu,&nbsp;M. Dryburgh,&nbsp;N. Butani,&nbsp;J.G. Lee,&nbsp;A. Orchanian-Cheff,&nbsp;D.P. Leong,&nbsp;A. Prica,&nbsp;D. Addison,&nbsp;L. Mozessohn,&nbsp;M. Fradley,&nbsp;A. Vijenthira,&nbsp;P. Chakraborty,&nbsp;K. Nanthakumar,&nbsp;P. Thavendiranathan,&nbsp;H. Abdel-Qadir","doi":"10.1016/j.cjca.2026.07.060","DOIUrl":"10.1016/j.cjca.2026.07.060","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S36-S37"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}