Canadian Journal of Cardiology最新文献

{"title":"Reticulocyte production index in heart failure: refining prognosis beyond current risk markers?","authors":"Alejandro Godoy, Noel C Chan","doi":"10.1016/j.cjca.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.010","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Hypoxemia Following Re-do Tricuspid Valve Surgery: A Vicious Cycle of Shunting.","authors":"Nadhem Abdallah, Marcel Rivard, Robert Shapiro, Mengistu Simegn, Andrew Shaffer, Gautam R Shroff","doi":"10.1016/j.cjca.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.009","url":null,"abstract":"<p><p>Acquired systemic-to-pulmonary venous shunts are rare, occurring when collateral vessels form between systemic and pulmonary veins, bypassing the right heart and alveolar spaces. We present the case of a 29-year-old male with recurrent prosthetic tricuspid valve (TV) endocarditis. Following redo TV surgery, he developed refractory hypoxemia, resistant to diuresis and supplemental oxygen. Dedicated imaging, including bubble study, computed tomography, and technetium-99m macroaggregated albumin scan, confirmed extensive systemic-to-pulmonary venous shunting. The patient underwent collateral vein embolization procedures, resulting in significant clinical improvement. This case emphasizes the importance of multimodal imaging and multidisciplinary management in the diagnosis and treatment of rare shunts.</p>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valvular Heart Disease: Be Prepared for the Next Epidemic.","authors":"Michael-Roy Raphael Durr, Ian G Burwash, Lawrence Lau, Hassan Alfraidi, Anahita Tavosi, Alwaleed Aljamaan, Graeme Prosperi-Porta, Maria Agustina Lopez Laporte, Roja Gauda, Luc Beauchesne, Vincent Chan, Michael Froeschl, Thierry Mesana, David Messika-Zeitoun","doi":"10.1016/j.cjca.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.008","url":null,"abstract":"<p><p>Valvular heart disease (VHD) remains an underrecognized cause of morbidity and mortality, with many cases unappreciated, diagnosed late, or undertreated. Its prevalence increases with age, and as Canada's population continues to age, the burden on the healthcare system will inevitably escalate. In this article, we examine the current and future outlook of VHD in Canada and propose strategies to improve the healthcare system in preparation for the challenges ahead.</p>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Public Health - Dare We Have Hope?","authors":"Yoni Freedhoff","doi":"10.1016/j.cjca.2025.02.037","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.02.037","url":null,"abstract":"<p><p>For decades, the world has faced growing floods of lifestyle-responsive, chronic, non-communicable diseases (cNCDs). Though obesity is certainly the most discussed flood, there are more - prominently including type 2 diabetes, hypertension, and metabolic dysfunction-associated fatty liver disease. Unfortunately, public health has yet to solve the riddle as to how to effectively mitigate these floods' currents or consequences despite in some cases successfully effecting behaviour changes through interventions.</p>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming Inertia in Cardiogenic Shock: Bridging Gaps and Advancing Care.","authors":"Christopher B Fordyce, Filio Bilia, Warwick Butt, Ren Jie Robert Yao, Yoan Lamarche, Varinder K Randhawa, Sean van Diepen","doi":"10.1016/j.cjca.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.007","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial Functional Mitral Regurgitation: from Echo to the surgical view.","authors":"Michele Galeazzi, Marco Rolando, Paolo Berretta, Olimpia Bifulco, Marco Di Eusanio","doi":"10.1016/j.cjca.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.006","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients at lower surgical risk: meta-analysis of randomized trials.","authors":"Tsahi T Lerman, Noam Greenberg, Mark Kheifets, Yeela Talmor-Barkan, Pablo Codner, Leor Perl, Guy Witberg, Katia Orvin, Alon Eisen, Tzlil Grinberg, Keren Skalsky, Yaron Shapira, David Belkin, Troels Højsgaard Jørgensen, Hans Gustav Hørsted Thyregod, Ole De Backer, Boris Fishman, Ran Kornowski, Amos Levi","doi":"10.1016/j.cjca.2025.02.036","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.02.036","url":null,"abstract":"<p><strong>Background: </strong>The use of transcatheter aortic valve implantation (TAVI) for severe aortic stenosis is expanding to patients across the entire spectrum of surgical risk. We aimed to perform a meta-analysis comparing TAVI and surgical aortic valve replacement (SAVR) in trials enrolling lower risk patients.</p><p><strong>Methods: </strong>We conducted a meta-analysis of randomized controlled trials (RCTs) comparing safety and efficacy outcomes between TAVI and SAVR among lower risk patients (mean/median STS score <4). Point-estimate meta-analysis and reconstructed individual patient data (RIPD) survival analysis were conducted. Primary outcomes included all-cause mortality, stroke, and a composite of all-cause mortality or disabling stroke (PROSPERO CRD42024541837).</p><p><strong>Results: </strong>The analysis included six RCTs, totaling 2668 TAVI and 2573 SAVR patients, mean follow-up time of 3.02 years. TAVI was associated with lower risk of all-cause mortality (RR 0.68 [95%CI 0.52-0.88]) and a composite of all-cause mortality or disabling stroke (RR 0.69 [95%CI 0.55-0.86]) without a significant difference in stroke up to 2 years. Longer-term point-estimate analysis showed no difference. In RIPD, TAVI was associated with a lower risk of all-cause mortality, driven by an early advantage. Restricted mean survival time (RMST) differences for primary outcomes were <2.5 months and ≤1 month for all-cause mortality. TAVI was associated with a lower risk of bleeding, kidney injury and atrial fibrillation, but a higher risk of pacemaker implantation and moderate-severe aortic regurgitation.</p><p><strong>Conclusion: </strong>In patients at lower surgical risk, TAVI was associated with improved short-term mortality. More data from long-term studies are needed.</p>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Treatment of Severe Obstructive Hypertrophic Cardiomyopathy: Combining Septal Reduction Therapy and Myosin Inhibitors.","authors":"Josef Veselka, Ladislav Dusek, Klara Hulikova Tesarkova","doi":"10.1016/j.cjca.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.003","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Prognostication and Therapeutic Guidance through Advances in Right Heart Imaging Approaches.","authors":"Hoda Mombeini, Valentina Mercurio, Ryan Osgueritchian, Julia Grapsa, Jiwon Kim, Monica Mukherjee","doi":"10.1016/j.cjca.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.002","url":null,"abstract":"<p><p>There is growing consensus on the importance of accurately assessing right heart size and function due to its critical relationship with cardiac outcomes across a wide range of cardiovascular diseases. The right heart plays a central role in maintaining cardiac performance, making its assessment essential for diagnosis, management, and prognostication. The need for precise and reliable assessment tools has led to substantial advancements in imaging technology, which have successfully addressed many of the challenges posed by the unique and complex anatomy of the right heart chambers. The present review underscores the evolving role of multimodality imaging in risk stratification, therapeutic guidance, and outcome prediction. Further advancements in technology and clinical integration are essential to optimizing care and improving outcomes for patients with cardiovascular disease. We will delve into the strengths and limitations of multimodality techniques and their applicability in different clinical scenarios to equip clinicians with insights into selecting the most appropriate modality for specific cardiac conditions. Additionally, we will underscore the practical implications of these imaging modalities in guiding clinical decisions and improving patient outcomes.</p>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Potentially Irreversible Cardiac Damage in Fabry Disease Precedes Gb3 Inclusion Body Formation.","authors":"Chung-Lin Lee, Pei-Sin Chen, Yu-Ying Lu, Yu-Ting Chiang, Ching-Tzu Yen, Chun-Ying Huang, Yen-Fu Cheng, Hsiang-Yu Lin, Yun-Ru Chen, Dau-Ming Niu","doi":"10.1016/j.cjca.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.001","url":null,"abstract":"<p><strong>Background: </strong>Fabry disease (FD) is a lysosomal storage disorder impacting multiple organs, including the heart. We investigated whether early-stage globotriaosylceramide (Gb3) accumulation, occurring before the formation of inclusion bodies, could cause significant stress and potentially irreversible damages of the cardiac tissue in FD patients.</p><p><strong>Methods: </strong>Immunofluorescent (IF) staining and Western blotting were performed on fibroblasts from FD IVS4 patients and myocardial biopsies from G3Stg/GLAko mice as well as three IVS4 patients (aged 44, 37, and 41 years). Notably, all biopsies showed detectable Gb3 accumulation under IF but lacked the typical pathology of FD (Gb3 inclusion bodies). Staining targeted nuclear factor-κB (NF-κB), interleukin-18 (IL-18), phospho-p42/44 mitogen-activated protein kinase (MAPK), and inducible nitric oxide synthase (iNOS) as markers of inflammation and oxidative stress. Additionally, alpha-smooth muscle actin (α-SMA) IF staining was conducted to identify myofibroblasts.</p><p><strong>Results: </strong>Fibroblasts from FD patients, along with cardiac tissues from both G3Stg/GLAko mice and FD patients, exhibited significant accumulation of inflammatory markers such as NF-κB IL-18 and phospho-p42/44 MAPK, as well as the oxidative stress marker iNOS. Despite the absence of typical FD pathology, the presence of fibrogenesis was confirmed in myocardial biopsies from these patients through strong positive staining of α-SMA.</p><p><strong>Conclusions: </strong>Significant cellular stress and potential irreversible damage may occur before the onset of typical pathological changes in the cardiac tissues of FD. Our findings raise an intriguing question: should ERT be initiated much earlier than currently recommended? However, this hypothesis requires validation through rigorous randomized controlled trials (RCTs) to draw definitive conclusions.</p>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}