Canadian Journal of Cardiology最新文献

Who should be referred for tricuspid valve intervention?

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-28 DOI: 10.1016/j.cjca.2025.03.025

Géraldine Ong, Thomas Attumalil, Alexandru Patrascu, Amr Gamal, Yazeed Almalki, Michael Ruiz, Sami Alnasser, Neil Fam

引用次数: 0

Echocardiographic assessment of Right Ventricular Diastolic Function in Children and Adults: Present State and Future Directions.

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-28 DOI: 10.1016/j.cjca.2025.03.024

Matthew Henry, Luc Mertens

{"title":"Echocardiographic assessment of Right Ventricular Diastolic Function in Children and Adults: Present State and Future Directions.","authors":"Matthew Henry, Luc Mertens","doi":"10.1016/j.cjca.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.024","url":null,"abstract":"Diastolic function plays an important but often overlooked role in overall ventricular performance and is comprised of sequence of events which together result in adequate filling at low filling pressures. From a physiologic point of view there are two distinct, yet related periods that drive diastole: active relaxation and late filling. Much of the literature on diastolic function is based on the left ventricle however there are significant differences in morphology, physiology and adaptation between ventricles. Echocardiographic assessment of RV diastolic function is challenging due to our imperfect understanding in RV physiology, suboptimal imaging tools and the use of models that have been built using the left ventricle. Conventional assessment includes IVC size, RA volume and the use of Doppler to quantify tissue and blood velocity (TV E/A, e', a', E/e', IVRT, hepatic vein and pulmonary artery). In adults, TV E/A used in combination with e', IVC size, may be used to classify diastolic impairment however in children this is dependent to a greater degree on age and pathology. Right atrial and ventricular strain suffers from fewer limitations and may show incremental benefit however remains understudied, particularly in children. Novel methods made possible with ultrafast ultrasound provide a means to non-invasively assess intraventricular pressure differences as a measure of active relaxation, and shear wave velocity to directly assess myocardial stiffness, however these remain in pre-clinical stages. This review discusses right ventricular diastolic physiology, the current state and limitations of echocardiographic evaluation and explores promising new methods for its assessment.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potent P2Y12 Inhibitors in Patients with Cancer Undergoing Percutaneous Coronary Intervention.

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-28 DOI: 10.1016/j.cjca.2025.03.026

Francesco Costa, Jose Ignacio Larrubia Valle, Maria Victoria Garcia Ruiz

引用次数: 0

Sex-Specific Associations of Cardiovascular Risk Factors with Subclinical Cardiac Remodeling: A Magnetic Resonance Imaging Study.

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-28 DOI: 10.1016/j.cjca.2025.03.023

Maya S Verma, Kate Lindsay, Jiayi Ni, Matthias G Friedrich, Judy M Luu

{"title":"Sex-Specific Associations of Cardiovascular Risk Factors with Subclinical Cardiac Remodeling: A Magnetic Resonance Imaging Study.","authors":"Maya S Verma, Kate Lindsay, Jiayi Ni, Matthias G Friedrich, Judy M Luu","doi":"10.1016/j.cjca.2025.03.023","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.023","url":null,"abstract":"Background: Cardiovascular disease (CVD) is the leading cause of death in women, yet sex-specific risk factor influences remain understudied. Cardiac magnetic resonance imaging (CMR) detects early remodeling via left ventricular mass-to-volume ratio (LVMV), a validated concentricity marker. This study examines sex differences in the association of CV risk factors, diet, and cardiac remodeling.Methods: We analyzed 622 age-matched adults (51% female, mean age 50.8 ± 9.5) from the Courtois Cardiovascular Signature Program. LVMV was defined as LV systolic mass divided by end-diastolic volume. Alcohol and sugar intake was self-rated on a Likert scale. Mann-Whitney U and regression analyses assessed sex-specific associations between CV risk factors and LVMV.Results: Hypertension was present in 20.6% of males and 17.4% of females; diabetes in 9.8% and 6.0%. Males had higher triglycerides, alcohol/sugar intake, and LVMV (0.92 ± 0.20 vs. 0.77 ± 0.18 g/ml). Hypertension correlated with higher LVMV in both sexes (males: ß=0.099, p<0.001; females: ß=0.078, p<0.05), while triglycerides (ß=0.032, p<0.05) and alcohol intake (H=19.41, p<0.0001) were male-specific predictors. In females, diabetes and sugar intake were significantly associated with LVMV (ß=0.102, ß=0.062, p<0.05).Conclusions: CV risk factors impact cardiac remodeling differently by sex. In males, LVMV was linked to triglycerides and alcohol intake, while in females, diabetes and sugar intake showed stronger associations. These results underscore the need for tailored cardiovascular prevention strategies that account for sex differences in metabolic and lifestyle risk factors.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of cardiovascular events in patients with Takayasu arteritis.

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-27 DOI: 10.1016/j.cjca.2025.03.022

Shiping He, Zhan Rong, Yanhong Wang, Zhenbiao Wu, Hongbin Li, Lili Pan, Xinwang Duan, Lijun Wu, Hongfeng Zhang, Yunjiao Yang, Jing Li, Xiaofeng Zeng

{"title":"Predictors of cardiovascular events in patients with Takayasu arteritis.","authors":"Shiping He, Zhan Rong, Yanhong Wang, Zhenbiao Wu, Hongbin Li, Lili Pan, Xinwang Duan, Lijun Wu, Hongfeng Zhang, Yunjiao Yang, Jing Li, Xiaofeng Zeng","doi":"10.1016/j.cjca.2025.03.022","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.03.022","url":null,"abstract":"Background: This study was aimed to analyze the factors associated with cardiovascular events and develop a prediction model to predict 10-year cardiovascular events probability in patients with Takayasu arteritis (TAK).Methods: Patients with TAK were prospectively enrolled from seven clinical centers between July 2013 and March 2021. The Cox proportional hazard regression was used to assess factors associated with cardiovascular events and develop a prediction model. The model performance was measured by Harrell's concordance index (C-index), Brier score and calibration plots. The nomogram was used to calculate the 10-year cardiovascular events probability.Results: A total of 702 patients (aged 29.2 ± 9.9 years; 623 [88.7%] women) were included. Cardiovascular events were observed in 94 patients (13.4%) after a median follow-up of 67 months (IQR 46-99). Elevated erythrocyte sedimentation rate (ESR) at disease onset (HR 2.30 [1.47-3.60]), pulmonary hypertension (HR 1.87 [0.93-3.77]), pulselessness (HR 1.73 [1.14-2.63]), diagnostic delay ≥ 3 years (HR 1.63 [1.01-2.65]), aortic regurgitation (HR 1.61 [1.01-2.56]), and age at diagnosis (HR 1.05 [1.02-1.07]) independently increased cardiovascular events and were included in the final model. The optimism-corrected C-index and Brier score of prediction model were 0.71 (0.66-0.76) and 0.072, respectively, and the calibration plots suggested good agreement between the observed and predicted probability of cardiovascular events.Conclusion: Patients with TAK were at high risk of cardiovascular events. Advanced age at diagnosis, diagnosis delayed over 3 years, pulselessness, pulmonary hypertension, aortic regurgitation, and elevated ESR at disease onset were risk factors for cardiovascular events.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Estrogen's Protective Power in Women's Cardiovascular Health.

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-27 DOI: 10.1016/j.cjca.2025.03.020

Amélie Paquin, Ana C Iribarren

引用次数: 0

When Nothing Goes Right, Go Left! Predicting the Origin of Outflow Tract Premature Ventricular Contractions to Guide Catheter Ablation.

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-27 DOI: 10.1016/j.cjca.2025.03.021

Girish M Nair, Pablo B Nery

引用次数: 0

Pulmonary ridge coverage in left atrial appendage closure: maximizing benefits with minimal risk.

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-24 DOI: 10.1016/j.cjca.2025.03.018

Pedro Cepas-Guillén, Andrea Ruberti, Eduardo Flores-Umanzor, Ander Regueiro, Laura Sanchis, Xavier Freixa

引用次数: 0

Educating Athletes on Cardiovascular Pre-Participation Screening: A Quick Reference Infographic.

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-23 DOI: 10.1016/j.cjca.2025.03.017

Nicholas Grubic, John McCleary, Nima Vasingh, Matthew Fraser, Meghan K Ford, Braeden Hill, Valentina Mihajlovic, Ryan Bennett, Jane S Thornton, Amer M Johri

引用次数: 0

Author Corrections to "Optimal Timing of Pulmonary Valve Replacement - The Holy Grail in Tetralogy of Fallot [Canadian Journal of Cardiology 40 (2024) 2473-2475]".

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-03-22 DOI: 10.1016/j.cjca.2025.03.012

Giulia Pula, Kevin C Harris

引用次数: 0