Canadian Journal of Cardiology最新文献

Beyond the Skinfolds: Diagnostic and Therapeutic Hope for the Obese & Formerly Obese. 超越皮肤褶皱：肥胖和曾经肥胖的诊断和治疗的希望。

IF 5.3 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-29 DOI: 10.1016/j.cjca.2025.07.014

D Douglas Miller

引用次数: 0

Predictors of cardiovascular events in patients with Takayasu arteritis: A real-world Study. 高须动脉炎患者心血管事件的预测因素：一项真实世界的研究。

IF 5.3 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-29 DOI: 10.1016/j.cjca.2025.07.028

Shiping He, Jing Li, Xiaofeng Zeng

引用次数: 0

Carbon and Travel Cost Reduction from Remote Medication Titration for Advanced Heart Failure: A Secondary Analysis of a Randomized Controlled Trial. 晚期心力衰竭远程药物滴定降低碳排放和旅行成本：一项随机对照试验的二次分析。

IF 5.3 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-29 DOI: 10.1016/j.cjca.2025.07.026

Michael D Elfassy, Kyle Runeckles, Nicole Simms, Geoffrey M Anderson, Anne Simard, Darshan H Brahmbhatt, Emily Seto, Augusta Lipscombe, Farid Faroutan, Fiona A Miller, Heather J Ross

{"title":"Carbon and Travel Cost Reduction from Remote Medication Titration for Advanced Heart Failure: A Secondary Analysis of a Randomized Controlled Trial.","authors":"Michael D Elfassy, Kyle Runeckles, Nicole Simms, Geoffrey M Anderson, Anne Simard, Darshan H Brahmbhatt, Emily Seto, Augusta Lipscombe, Farid Faroutan, Fiona A Miller, Heather J Ross","doi":"10.1016/j.cjca.2025.07.026","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.07.026","url":null,"abstract":"Background: Optimization of guideline-directed medical therapy (GDMT) in heart failure with reduced ejection fraction (HFrEF) often requires frequent in-person visits, contributing to patient burden and healthcare-related carbon emissions. Remote patient management (RPM) may offer a lower-carbon and cost alternative while maintaining care quality.Methods: This is a secondary analysis of the Medly Titrate randomized controlled trial comparing RPM-based remote GDMT titration with usual care. Carbon emissions and patient travel costs were estimated using the CASCADES Virtual Care Carbon Accounting Tool. A 1:1 nearest-neighbor matching analysis based on median one-way travel distance was conducted to mitigate geographic confounding. Bootstrap analyses were used to estimate confidence intervals for group differences.Results: Remote optimization resulted in more patients reaching GDMT targets (98% vs. 85%) and 62-day faster titration. Patients in the remote arm traveled a median of 140 km versus 213 km in usual care. Matched analysis showed significant reductions in total carbon emissions (-8.50 tonnes; 95% CI -34.58 to -1.84), travel distance (-41,923.53 km; 95% CI -170,491.85 to -9,064.21), and travel costs (-$12,258.78 CAD; 95% CI -49,806.33 to -2,661.51). A folded F test confirmed greater variance in one-way trip distances (P < 0.001).Conclusions: Remote GDMT titration reduced travel, carbon emissions, and costs while maintaining care quality. This study is the first to quantify environmental and financial savings from remote HF medication titration using an integrated carbon calculator.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could Mineralocorticoid Receptor Antagonists Restore Myocardial Iron Homeostasis in Heart Failure? 矿化皮质激素受体拮抗剂能否恢复心力衰竭患者心肌铁稳态？

IF 5.3 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-26 DOI: 10.1016/j.cjca.2025.07.025

Aleksandar Cirovic

引用次数: 0

De Winter pattern and transient prominent anterior forces in a patient with left anterior descending coronary artery stenosis. 左冠状动脉前降支狭窄患者的De Winter模式和短暂性突出的前力。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-24 DOI: 10.1016/j.cjca.2025.07.022

Jani Rankinen, Andrés Ricardo Pérez-Riera, Raimundo Barbosa-Barros, Kjell Nikus

引用次数: 0

Predicting Pacing After Transcatheter Aortic Valve Replacement: Cracking the Right Bundle Code. 预测经导管主动脉瓣置换术后的起搏：破解右束密码。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-22 DOI: 10.1016/j.cjca.2025.07.023

Mattia Pagnoni, Stephane Fournier, David Meier

引用次数: 0

Aortic Valve Replacement in Women with Reduced Ejection Fraction: Still Left Behind? 射血分数降低的女性主动脉瓣置换术：仍然落后吗？

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-22 DOI: 10.1016/j.cjca.2025.07.024

Aurelia Zimmerli, David Meier, Baris Gencer

引用次数: 0

Pulmonary Artery Intramural Hematoma Associated with Type B Aortic Dissection and Ductus Diverticulum. 肺动脉壁内血肿与B型主动脉夹层和憩室导管相关。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-21 DOI: 10.1016/j.cjca.2025.06.073

Zhongze Cao, Kun Fang, Mingyao Luo, Chang Shu

引用次数: 0

Left atrial myopathy and atrial arrhythmia recurrence following pulmonary vein isolation in patients with minimal left atrial low voltage areas. 最小左房低压区肺静脉隔离后左房肌病和心房心律失常复发。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-21 DOI: 10.1016/j.cjca.2025.07.020

Sophia Z Massin, Adrian Suszko, Stephen P Wright, Filo Billia, Andrew C T Ha, Sheldon M Singh, Patrick R Lawler, Susanna Mak, Vijay S Chauhan

{"title":"Left atrial myopathy and atrial arrhythmia recurrence following pulmonary vein isolation in patients with minimal left atrial low voltage areas.","authors":"Sophia Z Massin, Adrian Suszko, Stephen P Wright, Filo Billia, Andrew C T Ha, Sheldon M Singh, Patrick R Lawler, Susanna Mak, Vijay S Chauhan","doi":"10.1016/j.cjca.2025.07.020","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.07.020","url":null,"abstract":"Background: Atrial low-voltage areas (LVA) provide the substrate for AF. In AF patients with minimal left atrial (LA) LVA, this substrate has not been well characterized. We determined whether LA myopathy is present in AF patients with minimal LA LVA (mLVA) by evaluating LA mechanical function and blood biomarkers of structural remodeling.Methods: AF patients undergoing pulmonary vein isolation (PVI) and controls without AF were prospectively enrolled. In AF patients, mLVA was defined by LA LVA cutpoints <1% to <5% (<0.5 mV), while the remaining patients at each cutpoint were +LVA. LA systolic function was evaluated from dP/dtmax of LA pressure. LA diastolic function was assessed from LA wall compliance. Blood biomarkers were assayed using immune-sorbent techniques. Atrial arrhythmia (AA) recurrence was assessed 12-months after PVI.Results: Among 36 controls and 60 AF patients, LA dP/dtmax was lower in mLVA than controls (p<0.001), while +LVA and mLVA had similar dP/dtmax. LA compliance was lower in mLVA compared to controls (p<0.001), and lower in +LVA vs. mLVA (p<0.05). Patient groups were associated with mechanical function after adjusting for LVA risk factors. NT-proANP was abnormally elevated in 32% of mLVA patients, and the levels were higher in +LVA than mLVA (p<0.001). mLVA patients with AA recurrence had lower LA dP/dtmax than those without AA recurrence (p=0.012).Conclusions: mLVA have LA mechanical dysfunction and abnormal NT-proANP levels, not present in controls. AA recurrence in mLVA is associated with LA systolic dysfunction. These findings support the presence of early, diffuse LA myopathy in mLVA.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life's Crucial 9, Genetic Susceptibility, and the Risk of Atrial Fibrillation: A Prospective Study in the UK Biobank Cohort. 生命至关重要，遗传易感性和房颤风险：英国生物库队列的前瞻性研究

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2025-07-19 DOI: 10.1016/j.cjca.2025.07.021

Jianing Li, Guoxian Li, Ze Ma, Ziqing Sun, Yujie Shi, Zexin Lou, Hanqing Zhao, Mengtong Sun, Yu Wang, Qiang Han, Miao Jiang, Yueping Shen

{"title":"Life's Crucial 9, Genetic Susceptibility, and the Risk of Atrial Fibrillation: A Prospective Study in the UK Biobank Cohort.","authors":"Jianing Li, Guoxian Li, Ze Ma, Ziqing Sun, Yujie Shi, Zexin Lou, Hanqing Zhao, Mengtong Sun, Yu Wang, Qiang Han, Miao Jiang, Yueping Shen","doi":"10.1016/j.cjca.2025.07.021","DOIUrl":"https://doi.org/10.1016/j.cjca.2025.07.021","url":null,"abstract":"Background: To date, the association between Life's Crucial 9 (LC9) and atrial fibrillation (AF) incidence has not been explored. This study aimed to investigate the association between LC9 and the incidence of AF and evaluate the potential role of genetic risk.Methods: LC9 consists of nine elements categorized as low, medium, and high cardiovascular health (CVH). Polygenic risk scores (PRS) were categorized as low, medium, or high. A Cox proportional hazards regression model was used to determine the association between LC9 and AF incidence. The combined effects and interactions between LC9 and AF PRS on AF incidence were also examined.Results: During the median follow-up of 12.87 years, 11,141 patients developed AF. Moderate CVH (hazard ratio [HR]: 0.75; 95% confidence interval [CI]: 0.70, 0.79) and high CVH (HR: 0.66; 95% CI: 0.62, 0.71) were associated with a reduced risk of AF, respectively, compared to those with low CVH. Individuals with a high CVH and low PRS exhibited the lowest risk of AF compared to those with a low CVH and high PRS (HR: 0.55; 95% CI: 0.47, 0.64). Additive interactions between low/moderate CVH and high PRS were found [relative excess risk due to interaction (95% CI): 1.45 (0.75, 2.15) and 0.60 (0.28, 0.92); attributable proportion due to interaction (95% CI): 0.25 (0.15, 0.35) and 0.14 (0.06, 0.21), respectively].Conclusions: Higher LC9 scores were associated with a decreased risk of AF. Adherence to the LC9 guidelines may help reduce the incidence of AF, regardless of genetic risk.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0