Canadian Journal of Cardiology最新文献

Risk Factors for Reduced Long-term Survival Following Isolated Surgical Aortic Valve Replacement in Different Age Groups. 不同年龄组的孤立手术主动脉瓣置换术后长期存活率降低的风险因素。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-11-02 DOI: 10.1016/j.cjca.2024.10.023

Rosalind Groenewoud, Defen Peng, Byron H Gottschalk, Sorush Rokui, Catherine Gauthier, Jian Ye

{"title":"Risk Factors for Reduced Long-term Survival Following Isolated Surgical Aortic Valve Replacement in Different Age Groups.","authors":"Rosalind Groenewoud, Defen Peng, Byron H Gottschalk, Sorush Rokui, Catherine Gauthier, Jian Ye","doi":"10.1016/j.cjca.2024.10.023","DOIUrl":"https://doi.org/10.1016/j.cjca.2024.10.023","url":null,"abstract":"Background: According to recent guidelines, the selection of transcatheter vs. surgical aortic valve replacement (TAVR vs SAVR) in low-risk patients depends on age and life expectancy. Our objective was to understand independent risk factors for reduced life expectancy following isolated SAVR and the rate of re-do aortic valve (AV) intervention in different age groups, to delineate optimal intervention depending on patient characteristics.Methods: Between 2000-2015, 2026 patients underwent isolated SAVR with Edwards pericardial tissue valves. Multivariable models were conducted to determine independent risk factors for long-term survival in three age groups.Results: The 10-year survival rates were 83.4±2.3%, 72.7± 2.6% and 39.8±3.0% in Group I (age <65 years, n=577), II (age 65 - <75 years, n=693) and III (age ≥75 years, n=756), respectively. Independent factors for the reduced long-term survival were pulmonary hypertension (PH), renal failure, peripheral vascular disease, diabetes, and NYHA class IV in Group I; PH, diabetes, current smoking, and atrial arrhythmia in Group II; and PH, anemia, and NYHA class IV in Group III. The re-do AV intervention rate at 10 years was much higher in Group I than in Groups II and III (14.7±2.5% vs. 3.4±1.1% and 0.8±0.4%, P<0.001).Conclusions: We identified risk factors for reduced long-term survival following isolated SAVR in different age groups and PH being the only risk factor across all ages, which should assist in decision-making for SAVR vs. TAVR. Our results also support the current recommendation of bioprostheses in patients aged >65 years given extremely low rate of re-do AV intervention.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined annuloplasty and transcatheter edge-to-edge repair for tricuspid regurgitation: simultaneous or staged? 三尖瓣反流的联合瓣环成形术和经导管边缘到边缘修补术：同时进行还是分阶段进行？

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-29 DOI: 10.1016/j.cjca.2024.10.022

Andrea Ruberti, Laura Sanchis, Marta Sitges, Eduardo Flores-Umanzor, Omar Abdul-Jawad Altisent, Xavier Freixa

引用次数: 0

A Novel Therapy for the Failing Right Ventricle in Acute Myocardial Infarction: The First Reported Cases. 急性心肌梗死右心室衰竭的新疗法：首例报道

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-29 DOI: 10.1016/j.cjca.2024.09.036

Cui Zhao, Pengju Lu, Jixiang Wang, Yin Liu

引用次数: 0

Vascular Health in Congenital Heart Disease: A Systematic Review and Meta-Analysis. 先天性心脏病患者的血管健康：系统回顾与元分析》。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-26 DOI: 10.1016/j.cjca.2024.10.021

Juliana Lasso-Mendez, Christopher Spence, Lisa K Hornberger, Allison Sivak, Margie H Davenport

{"title":"Vascular Health in Congenital Heart Disease: A Systematic Review and Meta-Analysis.","authors":"Juliana Lasso-Mendez, Christopher Spence, Lisa K Hornberger, Allison Sivak, Margie H Davenport","doi":"10.1016/j.cjca.2024.10.021","DOIUrl":"https://doi.org/10.1016/j.cjca.2024.10.021","url":null,"abstract":"Background: Congenital heart disease (CHD) affects 1% of live births and is a risk factors for cardiovascular disease and reduced life expectancy. Previous studies have suggested CHD is associated with impaired vascular health, but this has not been established. Therefore, the objective of this study was to examine the impact of congenital heart disease (CHD) on vascular health.Methods: Eight electronic databases were searched through April 12, 2024. Studies of all designs (except case studies and reviews) which reported on the population (individuals with CHD of any age), comparator (individuals without CHD), and outcomes of interest: endothelial dependent (flow-mediated vasodilation [FMD%], reactive hyperemia index [RHI]) and independent (nitroglycerine mediated dilation [NMD%]) vascular function, arterial stiffness (pulse-wave velocity [PWV], stiffness index [SI], augmentation index [AIx], distensibility and compliance), and carotid intima-media thickness (cIMT) were included. Results are presented as standardized mean differences and 95% confidence intervals and by effect size.Results: 138 studies (N=16,115) were included in the meta-analysis. Individuals with CHD exhibited decreased vascular function compared to those without including decreased FMD% -0.96, 95% CI: -1.22, -0.70, I2= 85%, large effect size), RHI by ultrasound -2.88, 95% CI: -4.85, -0.90, I2 =96%, large effect size), and NMD% -0.98; 95% CI: -1.35, -0.61, I2= 87%, large effect size). Various CHD subtypes including, coarctation of the aorta, transposition of the great arteries, tetralogy of Fallot, post-Fontan showed significant vascular dysfunction. Shunt lesions did not show significant vascular dysfunction.Conclusion: CHD is associated with vascular dysfunction, increased arterial stiffness and greater cIMT in both pediatric and adult patients. PROSPERO registration number: CRD42022369180.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of High-Sensitivity Cardiac Troponin I Elevation after On- and Off-pump Coronary Artery Bypass Grafting on Long-term Prognosis. 冠状动脉旁路移植术后高敏心肌肌钙蛋白 I 升高对长期预后的影响

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-25 DOI: 10.1016/j.cjca.2024.10.018

Juncheng Wang, Peng Wang, Hanning Liu, Yan Zhao, Wei Feng, Sheng Liu, Zhe Zheng

{"title":"Impact of High-Sensitivity Cardiac Troponin I Elevation after On- and Off-pump Coronary Artery Bypass Grafting on Long-term Prognosis.","authors":"Juncheng Wang, Peng Wang, Hanning Liu, Yan Zhao, Wei Feng, Sheng Liu, Zhe Zheng","doi":"10.1016/j.cjca.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.cjca.2024.10.018","url":null,"abstract":"Background: Postoperative myocardial injury is correlated with long-term prognosis after coronary artery bypass grafting (CABG) and is diagnosed with troponin levels, which vary substantially upon surgical strategies. We aimed to explore the troponin I cut-off values for prognostically significant myocardial injury separately in on-pump and off-pump procedures with a high-sensitivity assay (hs-cTnI).Methods: Patients who underwent isolated CABG from 2018 to 2020 with available perioperative hs-cTnI measurements were included in the current study and followed up. We explored the relationships between hs-cTnI levels and different outcomes. To identify hs-cTnI threshold levels indicative of higher risks, restrictive spline regressions were performed for on-pump and off-pump procedures.Results: A total of 7813 patients were included with a median follow-up of 2.7 years (interquartile range [IQR]: 1.7-3.3 years) years, 218 (2.8%) of whom experienced death. Upon adjusting for clinical variables, the study found a significant association between peak hs-cTnI levels within the first 48 hours after surgery and all endpoints. The spline regressions demonstrated that the hs-cTnI levels measured within 48 hours after surgery, which were associated with a hazard ratio of more than 1.00 for all-cause death, were 1,446ng/L (55.6×upper reference limit [URL], 95% CI: 45.0-106.5) for on-pump and 564ng/L (21.7×URL, 95% CI: 21.0-30.2) for off-pump.Conclusions: Elevated hs-cTnI levels after CABG were associated with poorer longer-term outcomes. A prognosis relevant hs-cTnI cut-off value within 48 hours post-CABG for on-pump is significantly higher than that for off-pump.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ushering in a New Era of Hypertension Canada Guidelines: A Roadmap of What Lies Ahead. 开创加拿大高血压指南新纪元：未来路线图。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-24 DOI: 10.1016/j.cjca.2024.10.020

Rémi Goupil, Ross T Tsuyuki, Kristin A Terenzi, Nancy Santesso, Gregory L Hundemer

引用次数: 0

Remodeling of T-Tubules and Associated Calcium Handling Dysfunction in Heart Failure: Mechanisms and Therapeutic Insights. 心力衰竭中 T 型微管的重塑及相关的钙处理功能障碍：机制与治疗启示

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-23 DOI: 10.1016/j.cjca.2024.10.017

Yi Hao Loh, Jingyi Lv, Yenfang Goh, Xiangjie Sun, Xianfeng Zhu, Muergen Muheyati, Yi Luan

{"title":"Remodeling of T-Tubules and Associated Calcium Handling Dysfunction in Heart Failure: Mechanisms and Therapeutic Insights.","authors":"Yi Hao Loh, Jingyi Lv, Yenfang Goh, Xiangjie Sun, Xianfeng Zhu, Muergen Muheyati, Yi Luan","doi":"10.1016/j.cjca.2024.10.017","DOIUrl":"https://doi.org/10.1016/j.cjca.2024.10.017","url":null,"abstract":"In cardiomyocytes, transverse tubules (T-tubules) are sarcolemmal invaginations that facilitate excitation-contraction coupling (ECC) and diastolic function. The clinical significance of T-tubules has become evident as their remodeling is recognized as a hallmark feature of heart failure (HF) and a key contributor to disrupted Ca2+ homeostasis, compromised cardiac function, and arrhythmogenesis. Further investigations have revealed that T-tubule remodeling is particularly pronounced in HF with reduced ejection fraction (HFrEF), but not in HF with preserved ejection fraction (HFpEF), implying that T-tubule remodeling may play a crucial pathophysiological role in HFrEF. While research on the functional importance of T-tubules is ongoing due to their complexity, T-tubule remodeling has been found to be reversible. Such finding has triggered a surge in studies aimed at identifying specific therapeutic approaches for HFrEF. This review discusses the functional importance of T-tubules and their microdomains, the pathophysiology of T-tubule remodeling, and the potential mechanisms of current HFrEF therapeutic approaches in reversing T-tubule alterations. We also highlight discrepancies regarding the roles of T-tubule proteins in the recovery process across studies to offer valuable insights for future research.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Translational Perspective on the Interplay Between Hypertension, Inflammation and Cognitive Impairment. 从转化角度看高血压、炎症和认知障碍之间的相互作用。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-23 DOI: 10.1016/j.cjca.2024.10.015

Jacopo Pacella, Giuseppe Lembo, Lorenzo Carnevale

{"title":"A Translational Perspective on the Interplay Between Hypertension, Inflammation and Cognitive Impairment.","authors":"Jacopo Pacella, Giuseppe Lembo, Lorenzo Carnevale","doi":"10.1016/j.cjca.2024.10.015","DOIUrl":"10.1016/j.cjca.2024.10.015","url":null,"abstract":"Hypertension represents the major risk factor in the onset of cardiovascular disease worldwide. Preclinically, several mouse models of hypertension have been developed to investigate the pathophysiological link between hypertension and vascular impairment. Specifically, angiotensin-II infusion, transverse aortic constriction, deoxycorticosterone acetate salt, and L-NAME administration as hypertensive stimuli at the preclinical level permit the unveiling of a proinflammatory response driven by the innate and adaptive immune system and leads to vascular injury in terms of structural and functional alterations. Vascular impairment seems to be particularly critical at the cerebral level wherein arterioles, venules, and capillaries finely tune blood supply across the whole brain leading to the onset of a well known clinical condition named cerebral small vessel disease (cSVD) characterized by extensive brain injury, which culminates in the decline of cognitive functions. Advances in magnetic resonance imaging permit identification and accurate diagnosis of specific cSVD biomarkers including white matter hyperintensities, lacunar strokes, cerebral microbleeds, and enlarged perivascular spaces, each of which proved to be associated with a specific cognitive domain impairment. Such an approach in combination with pharmacological interventions targeted to the lowering of blood pressure and the prevention of vascular thrombosis formation represents a solid strategy in the prevention and the management of cSVD cognitive decay.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining Our Understanding of Prenatal Risk Factors Associated With Congenital Heart Disease. 进一步了解与先天性心脏病相关的产前风险因素。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-23 DOI: 10.1016/j.cjca.2024.10.016

Karen Ho, Lisa K Hornberger, Isabelle Vonder Muhll

引用次数: 0

Cardiac Rehabilitation in Heart Failure with Reduced Ejection Fraction: Pathophysiology, Benefits and Precautions. 射血分数减低性心力衰竭的心脏康复：病理生理学、益处和注意事项。

IF 5.8 2区医学

Canadian Journal of Cardiology Pub Date : 2024-10-19 DOI: 10.1016/j.cjca.2024.10.014

Alexandra Barriault, Umair Iftikhar, James A Stone

{"title":"Cardiac Rehabilitation in Heart Failure with Reduced Ejection Fraction: Pathophysiology, Benefits and Precautions.","authors":"Alexandra Barriault, Umair Iftikhar, James A Stone","doi":"10.1016/j.cjca.2024.10.014","DOIUrl":"https://doi.org/10.1016/j.cjca.2024.10.014","url":null,"abstract":"Heart failure (HF) is a highly comorbid condition associated with significant mortality, despite advances in current medical management. Patients suffering from HF represent a high needs disease care population in whom structured, long-term chronic disease care delivery models, such as cardiac rehabilitation (CR), have been shown to be highly cost effective in reducing hospitalizations and improving quality of life. Heart failure with reduced ejection fraction (HFrEF) is affecting a growing number of Canadians and health care costs secondary to this condition are rising, with further increases over the next decade to be expected. Cardiac rehabilitation is a guideline-directed medical therapy for patients living with HFrEF, and with increasing numbers of HF patients across the World, there is a prescient need to revisit the benefits, safety, and the prescription of this intervention for the health care professionals treating this condition. Certainly, there is a clinical need for HF practitioners to better understand the pathophysiological benefits of CR with respect to exercise training, as well as the prudent precautions required to facilitate the safe delivery of this highly cost-effective patient intervention.","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0