Grace S. Lee MD , Stephen E. Fremes MD, MSc , Derrick Y. Tam MD, PhD
{"title":"Invited Commentary: The Need for Nuance: High-Sensitivity Troponin Levels in ONCAB vs OPCAB Patients","authors":"Grace S. Lee MD , Stephen E. Fremes MD, MSc , Derrick Y. Tam MD, PhD","doi":"10.1016/j.cjca.2024.12.003","DOIUrl":"10.1016/j.cjca.2024.12.003","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 2","pages":"Pages 306-308"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Information for Readers","authors":"","doi":"10.1016/S0828-282X(25)00027-3","DOIUrl":"10.1016/S0828-282X(25)00027-3","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 2","pages":"Page A8"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ran Li MD, PhD , Xiaohan Li MD, PhD , Xi Zhang MD, PhD , Jizhang Yu MD, PhD , Yuan Li MD, PhD , Shuan Ran MD, PhD , Song Wang MD, PhD , Zilong Luo MD , Jiulu Zhao MD, PhD , Yanglin Hao MD, PhD , Junjie Zong MD, PhD , Kexiao Zheng MD , Longyong Lai MD , Han Zhang MD , Pinyan Huang MD, PhD , Cheng Zhou MD, PhD , Jie Wu MD, PhD , Weicong Ye MD, PhD , Jiahong Xia MD, PhD
{"title":"Macrophages in Cardiovascular Fibrosis: Novel Subpopulations, Molecular Mechanisms, and Therapeutic Targets","authors":"Ran Li MD, PhD , Xiaohan Li MD, PhD , Xi Zhang MD, PhD , Jizhang Yu MD, PhD , Yuan Li MD, PhD , Shuan Ran MD, PhD , Song Wang MD, PhD , Zilong Luo MD , Jiulu Zhao MD, PhD , Yanglin Hao MD, PhD , Junjie Zong MD, PhD , Kexiao Zheng MD , Longyong Lai MD , Han Zhang MD , Pinyan Huang MD, PhD , Cheng Zhou MD, PhD , Jie Wu MD, PhD , Weicong Ye MD, PhD , Jiahong Xia MD, PhD","doi":"10.1016/j.cjca.2024.11.018","DOIUrl":"10.1016/j.cjca.2024.11.018","url":null,"abstract":"<div><div>Cardiovascular fibrosis is a common pathological process that contributes to the development and progression of various cardiovascular diseases. Despite being widely believed to be an irreversible and relentless process, preclinical models and clinical trials have shown that cardiovascular fibrosis is an extremely dynamic process. Additionally, as part of the innate immune system, macrophages are heterogeneous cells that are pivotal in tissue regeneration and fibrosis. They participate in fibroblast activation, extracellular matrix remodelling, and the regression of fibrosis. Although we have made some advances in understanding macrophages in cardiovascular fibrosis, a gap still remains between their identification and conversion into effective treatments. Moreover, the traditional M1-M2 paradigm faces many challenges because it does not sufficiently clarify macrophage diversity and their functions. Exploring novel macrophage-based therapies is urgent for cardiovascular fibrosis treatment. Single-cell techniques have shed light on identifying novel subpopulations that differ in function and molecular signature under steady-state and pathological conditions. In this review, we outline the developmental origins of macrophages, which underlie their functions; and recent technology development in the single-cell era. In addition, we describe the markers and mediators of the newly defined macrophage subpopulations and the molecular mechanisms involved to elucidate potential approaches for targeting macrophages in cardiovascular fibrosis.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 2","pages":"Pages 309-322"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invited Commentary: What Is the Link Between Ferroptosis and Cardiac Hypertrophy?","authors":"Qiuyu Sun BSc , Gary D. Lopaschuk PhD","doi":"10.1016/j.cjca.2024.11.028","DOIUrl":"10.1016/j.cjca.2024.11.028","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 2","pages":"Pages 241-243"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invited Commentary: Do Patients With Acute Myocardial Ischemia Need to Be Transfused With a Higher Hemoglobin Threshold?","authors":"Paul C. Hébert MD, MHSc , Jeffrey L. Carson MD","doi":"10.1016/j.cjca.2024.11.033","DOIUrl":"10.1016/j.cjca.2024.11.033","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 2","pages":"Pages 323-325"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel A.N. Mascarenhas MD , Bharat K. Kantharia MD
{"title":"Dofetilide and Flecainide Combination: The Serendipity of Successful Treatment of Atrial Fibrillation After Failed Ablation","authors":"Daniel A.N. Mascarenhas MD , Bharat K. Kantharia MD","doi":"10.1016/j.cjca.2024.11.015","DOIUrl":"10.1016/j.cjca.2024.11.015","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 2","pages":"Pages 212-214"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}