Canadian Journal of Cardiology最新文献

{"title":"Editorial Commentary to Mapping the Monogenic and Polygenic Architecture of Mitral Valve Prolapse","authors":"Yohan Bossé PhD , Sébastien Thériault MD, MSc , Patrick Mathieu MD, MSc","doi":"10.1016/j.cjca.2025.01.022","DOIUrl":"10.1016/j.cjca.2025.01.022","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 936-938"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Link Between Mobile Phone Use and Cardiovascular Disease: A Call for Greater Attention","authors":"Yanjun Zhang MD, Xianhui Qin MD","doi":"10.1016/j.cjca.2025.02.024","DOIUrl":"10.1016/j.cjca.2025.02.024","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Page 958"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitral Valve Surgery After Failed Transcatheter Edge-to-Edge Repair: A Meta-Analysis","authors":"Francesco Cabrucci MD ,&nbsp;Massimo Baudo MD ,&nbsp;Dimitrios E. Magouliotis MD, MSc, PhD ,&nbsp;Yoshiyuki Yamashita MD, PhD ,&nbsp;Stephanie Kjelstrom MPH ,&nbsp;Beatrice Bacchi MD ,&nbsp;Massimo Bonacchi MD ,&nbsp;Aleksander Dokollari MD, PhD ,&nbsp;Serge Sicouri MD ,&nbsp;Basel Ramlawi MD","doi":"10.1016/j.cjca.2025.02.010","DOIUrl":"10.1016/j.cjca.2025.02.010","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter edge-to-edge repair (TEER) is increasingly used for mitral regurgitation (MR), particularly in high-risk patients. However, when TEER fails, patients often require mitral valve surgery, which remains challenging because of patients' compromised condition. This study aims to evaluate short- and long-term surgical outcomes following failed TEER.</div></div><div><h3>Methods</h3><div>This meta-analysis included observational studies with reported outcomes of mitral valve surgery after failed TEER published until September 2024. Multivariable meta-regressions were performed to predict short- and long-term mortality. Kaplan-Meier function was reconstructed from individual studies.</div></div><div><h3>Results</h3><div>Sixteen studies were included with a total sample of 892 patients. The mean age was 74.8 years (55% males), with most patients (87.8%) in New York Heart Association class III or IV before surgery. Pooled mean Society of Thoracic Surgeons (STS) predicted risk of mortality score before index TEER was 6.3%. Surgical indications were recurrent MR ≥3+ (93%), mitral stenosis (17%), and endocarditis (2.7%). The average time between TEER and surgery was 6.4 months. Mitral valve replacement was performed in 83.8% of cases. Thirty-day all-cause mortality was 12.2% but significantly lower for elective cases (2.5%). At a mean follow-up of 14.7 months, mortality was 28.3%. Preoperative incidence of coronary artery disease, lower left ventricle ejection fraction (LVEF), rate of concomitant procedures, and functional mitral regurgitation were predictors of short- and long-term outcomes.</div></div><div><h3>Conclusion</h3><div>Mitral valve surgery after failed TEER presents significant challenges, yet acceptable outcomes are achievable, particularly in elective cases. Complete treatment of concomitant lesions may improve outcomes in patients with preserved LVEF. Future research should stratify outcomes based on emergent vs elective surgery and MR etiology to guide tailored surgical strategies.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 813-828"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canadian Cardiovascular Society Clinical Practice Update on Contemporary Approaches to Smoking Cessation","authors":"Hassan Mir MD, MHI, MPH (Co-chair) ,&nbsp;Mark J. Eisenberg MD, MPH (Co-chair) ,&nbsp;Neal L. Benowitz MD ,&nbsp;Emily Cowley PharmD ,&nbsp;Javad Heshmati PhD ,&nbsp;Prabhat Jha MD, DPhil ,&nbsp;Milan Khara MBChB ,&nbsp;Kerri-Anne Mullen PhD ,&nbsp;Sandra N. Ofori MBBS, MSc, PhD ,&nbsp;Nancy A. Rigotti MD ,&nbsp;Richard San Cartier NP","doi":"10.1016/j.cjca.2024.12.037","DOIUrl":"10.1016/j.cjca.2024.12.037","url":null,"abstract":"<div><div>Smoking tobacco is the leading cause of preventable disease and death in Canada. Life expectancy of those who smoke is on average 10 years shorter than those who do not smoke. It is the most important modifiable risk factor for cardiovascular disease (CVD), doubling the risk of abdominal aortic aneurysm, coronary artery disease, ischemic stroke, and peripheral arterial disease. Smoking cessation is the single most powerful preventative intervention in clinical practice. Within 1 year of smoking cessation, the risk of CVD events decreases by 50%; after 15 years, the risk is the same as that of someone who has never smoked. Those who quit by age 40 have a life expectancy similar to that of people who have never smoked. Smoking cessation is a fundamental responsibility of every health care provider and must be a priority in all clinical settings. All patients must be systematically identified, treated, and have sufficient follow-up arranged. Advice should be brief, clear, and unambiguous to inform people who smoke about the harms of smoking and the benefits of cessation, in a personalized and nonjudgemental manner. It should be combined with pharmacotherapy because this can increase the likelihood of success by almost threefold. Health care practitioners should be as comfortable managing smoking cessation and initiating pharmacotherapy as they would be managing other CVD risk factors like hypertension or dyslipidemia.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 797-812"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commentary to Accurate Sizing in Bicuspid Aortic Stenosis in Transcatheter Aortic Valve Implantation—The “Level of Implantation at the Raphe” Method","authors":"Jakob J. Reichl MD,&nbsp;Thorald Stolte MD,&nbsp;Thomas Nestelberger MD","doi":"10.1016/j.cjca.2025.02.005","DOIUrl":"10.1016/j.cjca.2025.02.005","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 840-842"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commentary to Prenatal Adaptation of the Functionally Single Ventricle and Its Impact on the Fetal Circulation","authors":"Lisa K. Hornberger MD","doi":"10.1016/j.cjca.2025.01.016","DOIUrl":"10.1016/j.cjca.2025.01.016","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 986-988"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commentary to Transcatheter Aortic Valve Replacement in Low-Risk Patients With Prolonged Life Expectancy: All That Glitters Is Not Gold","authors":"Harold L. Lazar MD","doi":"10.1016/j.cjca.2024.12.034","DOIUrl":"10.1016/j.cjca.2024.12.034","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 848-849"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four-dimensional Cardiac Modelling of Multiphase Computed Tomography for Predicting Outcomes After Transcatheter Aortic Valve Replacement","authors":"Mohamad Rabbani MDCM, MSc ,&nbsp;Ali Fatehi Hassanabad MD, MSc ,&nbsp;Alessandro Satriano PhD ,&nbsp;Dina Labib MD, PhD ,&nbsp;Carmen P. Lydell MD ,&nbsp;Michael Bristow MD ,&nbsp;Anna Bizios MD ,&nbsp;Corey Adams MD ,&nbsp;Muhammad Mustafa Alhussein MD ,&nbsp;Steven Dykstra MSc ,&nbsp;Jacqueline Flewitt MSc ,&nbsp;Sandra Rivest RN ,&nbsp;William Kent MD ,&nbsp;Zhiying Liang MSc ,&nbsp;Tianqi Tao BSc ,&nbsp;Andrew G. Howarth MD, PhD ,&nbsp;Elena Di Martino PhD ,&nbsp;Nowell M. Fine MD, MPH ,&nbsp;Michael W.A. Chu MD ,&nbsp;James A. White MD","doi":"10.1016/j.cjca.2024.12.008","DOIUrl":"10.1016/j.cjca.2024.12.008","url":null,"abstract":"<div><h3>Background</h3><div>Multiphase computed tomography angiography (mpCTA) is routinely performed prior to transcatheter aortic valve replacement (TAVR) to determine eligibility and enable preprocedural planning. Incremental prognostic value may be realized from full-cycle, multiphase reconstructions to assess the contractile health of the cardiac chambers. In this study we assessed the feasibility of 4-dimensional chamber modelling of the left ventricle (LV) to support 3-dimensional minimum principal strain (3DminPS)-based predictions of clinical outcomes after TAVR.</div></div><div><h3>Methods</h3><div>Two hundred five patients undergoing pre-TAVR mpCTA were studied. UNet-based 3D chamber segmentation was followed by mesh modelling and 3D feature tracking–based deformation to determine global 3DminPS for endocardial, epicardial, and transmural layers. Independent associations of 3DminPS with the primary outcome of heart failure hospitalization or death are described.</div></div><div><h3>Results</h3><div>Of the 205 patients studied, 196 (96%) had analyzable mpCTAs (median age, 85 years; 55% male; Society of Thoracic Surgeons Predicted Risk of Mortality score = 3.10; 60.0% echocardiographic LV ejection fraction). At a median of 25 months after TAVR, 55 patients (28%) experienced the primary outcome. After adjustment for baseline variables, patients with an endocardial 3DminPS amplitude worse than −23.7% experienced a 2.7-fold higher risk of the outcome (adjusted hazard ratio, 2.7; 95% confidence interval, 1.4-5.1; <em>P</em> = 0.001), with this high-risk cohort having 1- and 3-year event rates of 32% and 49%, respectively.</div></div><div><h3>Conclusions</h3><div>Four-dimensional chamber modelling of mpCTA using UNet-based segmentation and standardized mesh deformation is feasible and enables delivery of 3D deformation markers with strong prognostic value for the prediction of outcomes after TAVR. Prospective validation in a multicentre setting is currently being undertaken.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 959-969"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commentary to Transcatheter Edge-to-Edge Repair in Intermediate Risk Patients With Degenerative Mitral Regurgitation: A Word of Caution","authors":"Harold L. Lazar MD","doi":"10.1016/j.cjca.2025.01.020","DOIUrl":"10.1016/j.cjca.2025.01.020","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 829-830"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Patients With Bicuspid Aortic Valve Undergoing a Targeted Transcatheter Aortic Valve Replacement Approach: The LIRA Method","authors":"Barbara Bellini MD ,&nbsp;Vittorio Romano RT ,&nbsp;Greca Zanda MD ,&nbsp;Gianmarco Iannopollo MD ,&nbsp;Tommaso De Ferrari MD ,&nbsp;Eva Bijlsma MD ,&nbsp;Francesca Napoli MD ,&nbsp;Ciro Vella MD ,&nbsp;Domitilla Gentile MD ,&nbsp;Giulia Ghizzoni MD ,&nbsp;Luca Angelo Ferri MD ,&nbsp;Filippo Russo MD ,&nbsp;Marco Bruno Ancona MD ,&nbsp;Francesco Ancona MD ,&nbsp;Eustachio Agricola MD ,&nbsp;Anna Palmisano MD ,&nbsp;Antonio Esposito MD ,&nbsp;Matteo Montorfano MD","doi":"10.1016/j.cjca.2024.12.006","DOIUrl":"10.1016/j.cjca.2024.12.006","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve (BAV) disease is still burdened by a non-negligible rate of stroke and permanent pacemaker implantation (PPI). These suboptimal results, possibly related to the unique BAV anatomy, may suggest the use of a different sizing method in this setting. The aim of our study is to evaluate whether the application of the supra-annular LIRA method may improve clinical outcomes in this population.</div></div><div><h3>Methods</h3><div>In this single-center retrospective study, we enrolled consecutive patients with severe aortic stenosis and raphe-type BAV undergone TAVR with the implantation of supra-annular self-expanding prostheses sized according to the LIRA method. The primary endpoint was the device success. Secondary endpoints were in-hospital and 30-day safety outcomes and 1-year clinical efficacy. All study endpoints were adjudicated according to the Valve Academic Research Consortium 3 criteria.</div></div><div><h3>Results</h3><div>A total of 104 patients (mean age, 79.8 ± 5.83 years) were enrolled in our study. The mean Society of Thoracic Surgeons score was 4.96 ± 4.73%. Use of the LIRA method led to prosthesis downsizing in 85.6% of patients. Device success was 94.2%. All-cause death was 0%, conversion to surgery was 0%, and an extremely low rate of stroke (1.9%) and PPI (9.6%) was observed. The intended performance of the valve was attained in 96.1% of patients and it was maintained at 1-year follow-up. Clinical efficacy at 1 year was reached in 90.6% of patients.</div></div><div><h3>Conclusions</h3><div>The LIRA method represents an alternative option for prosthesis sizing in patients with type 1 and type 2 BAV undergoing TAVR with promising early and midterm outcomes.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"41 5","pages":"Pages 831-839"},"PeriodicalIF":5.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}