{"title":"P065 INFECTIVE ENDOCARDITIS IN ADULTS WITH CONGENITAL HEART DISEASE: A NORTH AMERICAN REGISTRY","authors":"M. Janzen, J. Grewal","doi":"10.1016/j.cjca.2026.07.075","DOIUrl":"10.1016/j.cjca.2026.07.075","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page S46"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Baskaran, J. Pinthus, A. Benz, C. Higano, C.C. Garcia, J. Lopez-Lopez, F. Cirne, R. Mian, B. Shayegan, P. Violette, V. Fradet, A. Kann, D. Xavier, J. Selvanayagam, D. Leong
{"title":"P047 ASSOCIATION BETWEEN HEMOGLOBIN AND CARDIOVASCULAR OUTCOMES IN PATIENTS WITH PROSTATE CANCER: A RADICAL-PC ANALYSIS","authors":"G. Baskaran, J. Pinthus, A. Benz, C. Higano, C.C. Garcia, J. Lopez-Lopez, F. Cirne, R. Mian, B. Shayegan, P. Violette, V. Fradet, A. Kann, D. Xavier, J. Selvanayagam, D. Leong","doi":"10.1016/j.cjca.2026.07.058","DOIUrl":"10.1016/j.cjca.2026.07.058","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages S34-S35"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When “Absence” Itself Becomes a Signal: The Impact of Monitoring Density on Dynamic Prediction Models for Acute Kidney Injury","authors":"Ao Wang MMed, Ran Li MMed, Yong Sun PhD","doi":"10.1016/j.cjca.2026.02.003","DOIUrl":"10.1016/j.cjca.2026.02.003","url":null,"abstract":"","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Page 2409"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angela Ambrosio MSc, Chai-Ann Ng PhD, Lindsay Burnell MSc, Emma Redpath MSc, Laura Arbour MSc, MD, Jamie I. Vandenberg MBBS, PhD, Emilie Theberge MSc, Michael J. Thibert MD, Markus B. Sikkel MBBS, PhD, Andrew D. Krahn MD, Richard Leather MD, Martin van Zyl MD
{"title":"KCNH2 Duplication Variant (c.2164_2181dup) Associated With Sudden Cardiac Death in a Family With Congenital Long QT Syndrome","authors":"Angela Ambrosio MSc, Chai-Ann Ng PhD, Lindsay Burnell MSc, Emma Redpath MSc, Laura Arbour MSc, MD, Jamie I. Vandenberg MBBS, PhD, Emilie Theberge MSc, Michael J. Thibert MD, Markus B. Sikkel MBBS, PhD, Andrew D. Krahn MD, Richard Leather MD, Martin van Zyl MD","doi":"10.1016/j.cjca.2026.03.020","DOIUrl":"10.1016/j.cjca.2026.03.020","url":null,"abstract":"<div><h3>Background</h3><div>Congenital long QT syndrome (LQTS) is an inherited arrhythmogenic disorder characterised by prolonged QTc intervals and T-wave abnormalities on electrocardiography (ECG). Prolonged QT intervals can lead to syncope, seizures, <em>torsades de pointes</em>, and sudden cardiac death. There are several genes, including <em>KCNH2</em>, known to be associated with congenital LQTS, and genetic variations in <em>KCNH2</em> are known to cause a reduction in the delayed rectifier potassium current (<em>I</em><sub>Kr</sub>).</div></div><div><h3>Methods</h3><div>Clinical genetic testing and variant reclassification were performed by Blueprint Genetics. The functional effect of the <em>KCNH2</em> variant was quantified with the use of a calibrated automated patch clamp electrophysiology assay.</div></div><div><h3>Results</h3><div>We discuss a case in which postmortem genetic testing of a 34-year-old woman revealed a variant of uncertain significance (VUS) (c.2164_2181dup) in <em>KCNH2</em>. Subsequent cascade genetic testing in her father and brother identified the same VUS, and both showed evidence of clinical LQTS. Patch clamp analysis shows that c.2164_2181dup causes a severe loss-of-function phenotype and can be assigned with a strong level of functional evidence (PS3) for VUS reclassification.</div></div><div><h3>Conclusions</h3><div>With previous reports of LQTS associated with c.2164_2181dup, the phenotypes observed in this family, and the strong level of functional evidence obtained from patch clamp analysis, c.2164_2181dup has been clinically reclassified as likely pathogenic.</div></div>","PeriodicalId":9555,"journal":{"name":"Canadian Journal of Cardiology","volume":"42 10","pages":"Pages 2431-2438"},"PeriodicalIF":5.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}