Cardiology in Review最新文献

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Alternative Approaches to Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention, How Do They Compare?: A Systematic Review and Meta-Analysis. 冠状动脉旁路移植术的替代方法与经皮冠状动脉介入治疗的比较?系统回顾与元分析》。
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2023-01-23 DOI: 10.1097/CRD.0000000000000524
Ryaan El-Andari, Sabin J Bozso, Nicholas M Fialka, Jimmy J H Kang, Ali Fatehi Hassanabad, Jeevan Nagendran
{"title":"Alternative Approaches to Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention, How Do They Compare?: A Systematic Review and Meta-Analysis.","authors":"Ryaan El-Andari, Sabin J Bozso, Nicholas M Fialka, Jimmy J H Kang, Ali Fatehi Hassanabad, Jeevan Nagendran","doi":"10.1097/CRD.0000000000000524","DOIUrl":"10.1097/CRD.0000000000000524","url":null,"abstract":"<p><p>Coronary artery disease (CAD) is a leading cause of mortality worldwide. Severe symptomatic CAD is treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Alternative CABG (ACABG) approaches including thoracotomy, off-pump, total endoscopic, and robotic-assisted CABG are increasing in prevalence to address the increased early risk of CABG. This systematic review and meta-analysis aims to review the contemporary literature comparing outcomes after ACABG and PCI. Pubmed, Medline, and Embase were systematically searched by 2 authors for articles comparing the outcomes after ACABG and PCI. A total of 1154 articles were screened, and 11 were included in this review. The RevMan 5.4 software was used to perform a meta-analysis of the pooled data. Individual studies found rates of long-term survival, major adverse cardiovascular and cerebrovascular events (MACCE), myocardial infarction (MI), and repeat revascularization either favored ACABG or did not differ significantly. Pooled estimates of the compiled data identified rates of MACCE, MI, and repeat revascularization favored ACABG. The results of this review demonstrated the favorable rates of long-term mortality, MACCE, MI, and repeat revascularization for ACABG in addition to similar short-term mortality and stroke when compared with PCI. Advancement of both CABG and PCI continues to improve patient outcomes. With the increasing prevalence of ACABG, similar studies will need to be undertaken with further direct comparisons between ACABG and PCI. Finally, hybrid revascularization should continue to be explored for its combined benefits of long-term outcomes, short-term safety, and ability to achieve complete revascularization.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9113050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDY-5301: An Innovative Approach to The Treatment of Revascularization Coronary Injury. FDY-5301:治疗血管再通冠状动脉损伤的创新方法。
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2023-03-08 DOI: 10.1097/CRD.0000000000000517
Lauren E Williams, William H Frishman
{"title":"FDY-5301: An Innovative Approach to The Treatment of Revascularization Coronary Injury.","authors":"Lauren E Williams, William H Frishman","doi":"10.1097/CRD.0000000000000517","DOIUrl":"10.1097/CRD.0000000000000517","url":null,"abstract":"<p><p>After experiencing an acute ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) is a preferred method of restoring blood flow to the heart. While this reperfusion has long-term benefits, it can result in reperfusion injury in the short term, which involves the formation of reactive oxygen species (ROS) and neutrophil recruitment. FDY-5301 is a sodium iodide-based drug that acts as a catalyst in the conversion of hydrogen peroxide to water and oxygen. FDY-5301 is designed to be administered as an intravenous bolus following a STEMI, before reperfusion with PCI, to reduce the damage associated with reperfusion injury. Clinical trials have shown FDY-5301 administration to be safe, feasible, and fast-acting in its ability to increase plasma iodide concentration, and the results are favorable in demonstrating potential efficacy. FDY-5301 shows potential in its use to reduce the effects of reperfusion injury, and ongoing Phase 3 trials will allow for continued evaluation of its performance.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10861190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogenicity of Homologous Heart Valves: Mechanisms and Future Considerations. 同源心脏瓣膜的免疫原性:机制与未来考虑
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2023-01-23 DOI: 10.1097/CRD.0000000000000519
Andrew D Vogel, Jennie H Kwon, Alekhya Mitta, Curry Sherard, Kelvin G M Brockbank, Taufiek Konrad Rajab
{"title":"Immunogenicity of Homologous Heart Valves: Mechanisms and Future Considerations.","authors":"Andrew D Vogel, Jennie H Kwon, Alekhya Mitta, Curry Sherard, Kelvin G M Brockbank, Taufiek Konrad Rajab","doi":"10.1097/CRD.0000000000000519","DOIUrl":"10.1097/CRD.0000000000000519","url":null,"abstract":"<p><p>Pediatric valvar heart disease continues to be a topic of interest due to the common and severe clinical manifestations. Problems with heart valve replacement, including lack of adaptive valve growth and accelerated structural valve degeneration, mandate morbid reoperations to serially replace valve implants. Homologous or homograft heart valves are a compelling option for valve replacement in the pediatric population but are susceptible to structural valve degeneration. The immunogenicity of homologous heart valves is not fully understood, and mechanisms explaining how implanted heart valves are attacked are unclear. It has been demonstrated that preservation methods determine homograft cell viability and there may be a direct correlation between increased cellular viability and a higher immune response. This consists of an early increase in human leukocyte antigen (HLA)-class I and II antibodies over days to months posthomograft implantation, followed by the sustained increase in HLA-class II antibodies for years after implantation. Cytotoxic T lymphocytes and T-helper lymphocytes specific to both HLA classes can infiltrate tissue almost immediately after implantation. Furthermore, increased HLA-class II mismatches result in an increased cell-mediated response and an accelerated rate of structural valve degeneration especially in younger patients. Further long-term clinical studies should be completed investigating the immunological mechanisms of heart valve rejection and their relation to structural valve degeneration as well as testing of immunosuppressant therapies to determine the needed immunosuppression for homologous heart valve implantation.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9844540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Technologies in the Detection of Atrial Fibrillation: Review of Literature and Comparison of Different Novel Technologies for Screening of Atrial Fibrillation. 检测心房颤动的新技术:文献综述及用于筛查心房颤动的不同新型技术比较。
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2023-03-22 DOI: 10.1097/CRD.0000000000000526
Onni E Santala, Jukka A Lipponen, Helena Jäntti, Tuomas T Rissanen, Mika P Tarvainen, Eemu-Samuli Väliaho, Olli A Rantula, Noora S Naukkarinen, Juha E K Hartikainen, Tero J Martikainen, Jari Halonen
{"title":"Novel Technologies in the Detection of Atrial Fibrillation: Review of Literature and Comparison of Different Novel Technologies for Screening of Atrial Fibrillation.","authors":"Onni E Santala, Jukka A Lipponen, Helena Jäntti, Tuomas T Rissanen, Mika P Tarvainen, Eemu-Samuli Väliaho, Olli A Rantula, Noora S Naukkarinen, Juha E K Hartikainen, Tero J Martikainen, Jari Halonen","doi":"10.1097/CRD.0000000000000526","DOIUrl":"10.1097/CRD.0000000000000526","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is globally the most common arrhythmia associated with significant morbidity and mortality. It impairs the quality of the patient's life, imposing a remarkable burden on public health, and the healthcare budget. The detection of AF is important in the decision to initiate anticoagulation therapy to prevent thromboembolic events. Nonetheless, AF detection is still a major clinical challenge as AF is often paroxysmal and asymptomatic. AF screening recommendations include opportunistic or systematic screening in patients ≥65 years of age or in those individuals with other characteristics pointing to an increased risk of stroke. The popularities of well-being and taking personal responsibility for one's own health are reflected in the continuous development and growth of mobile health technologies. These novel mobile health technologies could provide a cost-effective solution for AF screening and an additional opportunity to detect AF, particularly its paroxysmal and asymptomatic forms.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11296284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9509798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Coronary Sinus Reducer Stent for the Treatment of Refractory Angina Pectoris: From the Conception of Innovation to Clinical Application. 用于治疗难治性心绞痛的冠状动脉窦减压支架:从创新构想到临床应用。
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2022-12-28 DOI: 10.1097/CRD.0000000000000516
Yoav Paz, Liza Grosman-Rimon, Yair Levy, Amihay Shinfeld
{"title":"The Coronary Sinus Reducer Stent for the Treatment of Refractory Angina Pectoris: From the Conception of Innovation to Clinical Application.","authors":"Yoav Paz, Liza Grosman-Rimon, Yair Levy, Amihay Shinfeld","doi":"10.1097/CRD.0000000000000516","DOIUrl":"10.1097/CRD.0000000000000516","url":null,"abstract":"<p><p>The Neovasc Coronary Sinus Reducer Stent (CSRS) was developed for the treatment of patients who continue to suffer from disabling symptoms despite optimal medical therapy. This patient population with refractory angina symptoms is expected to grow, since life expectancy of individuals with atherosclerotic coronary artery disease is increasing. In this paper, we discussed the development of a novel device the CSRS and the upside-down strategy to rebuild a retrograde coronary pressure that was attenuated by the atherosclerotic disease.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10600451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Landiolol: An Ultra-Short-Acting β-Blocker. 兰地洛尔超短效β受体阻滞剂
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2023-04-25 DOI: 10.1097/CRD.0000000000000555
Shiavax J Rao, Arjun Kanwal, Amreen Kanwal, Alexandrina Danilov, William H Frishman
{"title":"Landiolol: An Ultra-Short-Acting β-Blocker.","authors":"Shiavax J Rao, Arjun Kanwal, Amreen Kanwal, Alexandrina Danilov, William H Frishman","doi":"10.1097/CRD.0000000000000555","DOIUrl":"10.1097/CRD.0000000000000555","url":null,"abstract":"<p><p>Landiolol is an ultra-short-acting, highly cardio-selective, β-blocker, that is currently approved for clinical use in Japan and the European Union, for the treatment of tachyarrhythmias. Landiolol is highly cardio-selective with high β1 selectivity and receptor affinity, resulting in a more potent chronotropic effect and less potent hypotensive effect compared with other β-blockers such as esmolol and propranolol. Based on the recent randomized controlled trials, low-dose landiolol may have a beneficial role in the prevention and management of postoperative atrial fibrillation following noncardiac and cardiac surgeries, including on-pump and off-pump coronary artery bypass grafting and valve surgery. Additionally, landiolol may have potential utility for myocardial salvage and prevention of postpercutaneous coronary intervention myocardial infarction. Furthermore, the use of landiolol may also have a therapeutic effect for rate control of sepsis-related tachyarrhythmias. Positive results of recent randomized controlled trials should continue to inspire clinicians to conduct further, larger studies, to find new potential clinical applications for this novel drug.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9462961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cosmic Radiations and the Cardiovascular System: A Narrative Review. 宇宙辐射与心血管系统:叙述性综述。
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2022-12-28 DOI: 10.1097/CRD.0000000000000521
Omar Giacinto, Francesco Pelliccia, Alessandro Minati, Federica De Crescenzo, Maria Luisa Garo, Massimo Chello, Mario Lusini
{"title":"Cosmic Radiations and the Cardiovascular System: A Narrative Review.","authors":"Omar Giacinto, Francesco Pelliccia, Alessandro Minati, Federica De Crescenzo, Maria Luisa Garo, Massimo Chello, Mario Lusini","doi":"10.1097/CRD.0000000000000521","DOIUrl":"10.1097/CRD.0000000000000521","url":null,"abstract":"<p><p>In recent times, space flights receive continued interest. Humankind's next two goals are to return to the Moon and, a few years later, to land on the surface of Mars. Although technology will improve enough to enable long voyages, there are still some unresolved questions about the effects of the space environment on human health, including the effects of such long voyages on organs. Specifically, there is no information on the effects of radiation in space on the human cardiovascular system. To better understand the adaptation of the cardiovascular system to radiation exposure, the physical properties of radiation and the cellular and molecular mechanisms underlying tissue changes are essential. To this end, this article aims to provide an overview of the effects of radiation on the cardiovascular system by analyzing the physical properties of radiation and their relationship to cellular and molecular mechanisms and potential changes. Each type of radiation triggers different responses in the cardiovascular system. Radiation plays a relevant role in altering endothelial function and arterial wall stiffness by inducing vascular changes that accelerate atherosclerosis and affect endothelial adhesiveness. Clinical studies have shown that vascular changes due to radiation depend on the delayed manifestations of early radiation damage. To reduce the effects of radiation in space, some pharmacological treatments that seem to be able to counteract oxidative stress during flight are being used. At the same time, new shielding systems that can reduce or eliminate radiation exposure must be developed. Future studies should aim to replicate flights in the deep space environment to study in more detail the harmful effects of radiation on the whole cardiovascular system.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10590775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Influenza Vaccination in Cardiovascular Disease: Systematic Review and Meta-Analysis. 流感疫苗接种在心血管疾病中的作用:系统回顾与元分析》。
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2023-05-09 DOI: 10.1097/CRD.0000000000000533
Rahul Gupta, Ray Quy, Muling Lin, Pranav Mahajan, Aaqib Malik, Aayushi Sood, Jayakumar Sreenivasan, Dhrubajyoti Bandyopadhyay, Akshay Goel, Ankit Agrawal, Apurva V Vyas, Nainesh C Patel, William H Frishman, Wilbert S Aronow
{"title":"Role of Influenza Vaccination in Cardiovascular Disease: Systematic Review and Meta-Analysis.","authors":"Rahul Gupta, Ray Quy, Muling Lin, Pranav Mahajan, Aaqib Malik, Aayushi Sood, Jayakumar Sreenivasan, Dhrubajyoti Bandyopadhyay, Akshay Goel, Ankit Agrawal, Apurva V Vyas, Nainesh C Patel, William H Frishman, Wilbert S Aronow","doi":"10.1097/CRD.0000000000000533","DOIUrl":"10.1097/CRD.0000000000000533","url":null,"abstract":"<p><p>Influenza vaccination has shown great promise in terms of its cardioprotective effects. The aim of our analysis is to provide evidence regarding the protective effects of influenza vaccination in patients with cardiovascular disease. We conducted a systematic literature search to identify trials assessing the cardiovascular outcomes of influenza vaccination. Summary effects were calculated using a DerSimonian and Laird fixed effects and random effects model as odds ratio with 95% confidence intervals (CIs) for all the clinical endpoints. Fifteen studies with a total of 745,001 patients were included in our analysis. There was lower rates of all-cause mortality [odds ratio (OR) = 0.74, 95% CI 0.64-0.86], cardiovascular death (OR = 0.73, 95% CI 0.59-0.92), and stroke (OR = 0.71, 95% CI 0.57-0.89) in patients who received the influenza vaccine compared to placebo. There was no significant statistical difference in rates of myocardial infarction (OR = 0.91, 95% CI 0.69-1.21) or heart failure hospitalizations (OR = 1.06, 95% CI 0.85-1.31) in the 2 cohorts. In patients with cardiovascular disease, influenza vaccination is associated with lower all-cause mortality, cardiovascular death, and stroke.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9785752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates on the Global Prevalence and Etiology of Constrictive Pericarditis: A Systematic Review. 关于缩窄性心包炎的全球发病率和病因的最新进展:系统综述。
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2023-03-08 DOI: 10.1097/CRD.0000000000000529
Marinos Kosmopoulos, Εfstathia Liatsou, Christina Theochari, Amalia Stavropoulos, Despoina Chatzopoulou, Konstantinos S Mylonas, Georgios Georgiopoulos, Dimitrios Schizas
{"title":"Updates on the Global Prevalence and Etiology of Constrictive Pericarditis: A Systematic Review.","authors":"Marinos Kosmopoulos, Εfstathia Liatsou, Christina Theochari, Amalia Stavropoulos, Despoina Chatzopoulou, Konstantinos S Mylonas, Georgios Georgiopoulos, Dimitrios Schizas","doi":"10.1097/CRD.0000000000000529","DOIUrl":"10.1097/CRD.0000000000000529","url":null,"abstract":"<p><p>Constrictive pericarditis is a rare disease with poorly understood epidemiology. A systematic literature search was adopted to assess the region- and period-specific traits of constrictive pericarditis through Pubmed, EMBASE, and Scopus. Case reports and studies including less than 20 patients were excluded. The risk of bias was assessed through the Study Quality Assessment Tools developed by the National Heart Lung Blood Institute by 4 reviewers. Patient demographics, disease etiology, and mortality were the primary assessed outcomes. One hundred thirty studies with 11,325 patients have been included in this systematic review and meta-analysis. The age at diagnosis of constrictive pericarditis has markedly increased after 1990. Patients from Africa and Asia are considerably younger compared with those from Europe and North America. Moreover, there are differences in etiology, as tuberculosis remains the dominant cause of constrictive pericarditis in Africa and Asia but has been surpassed by history of previous chest surgery in North America and Europe. The human immunodeficiency virus affects 29.1% of patients from Africa diagnosed with constrictive pericarditis, a feature that is not observed on any other continent. The early mortality rate after hospitalization has improved. The variances of age at diagnosis and etiology of constrictive pericarditis should be considered by the clinician during the work-up of cardiac and pericardial diseases. An underlying human immunodeficiency virus infection complicates a significant portion of constrictive pericarditis cases in Africa. Early mortality has improved across the world but remains high.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10850036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recovery From Left Ventricular Dysfunction. 从左心室功能障碍中恢复。
IF 2 4区 医学
Cardiology in Review Pub Date : 2024-09-01 Epub Date: 2022-06-07 DOI: 10.1097/CRD.0000000000000462
Basha Behrman, Wilbert S Aronow, William H Frishman
{"title":"Recovery From Left Ventricular Dysfunction.","authors":"Basha Behrman, Wilbert S Aronow, William H Frishman","doi":"10.1097/CRD.0000000000000462","DOIUrl":"10.1097/CRD.0000000000000462","url":null,"abstract":"<p><p>The treatment of heart failure is an evolving field of cardiology, with increasingly available therapeutics and significant disease burden. With the effective treatments available, we see a substantial patient population whose once reduced ejection fraction (EF) has normalized. Studies have assessed the natural history of these patients with improved EF and found improved mortality as compared with those patients with persistently reduced EF, with some evidence stating that each 5% increase in left ventricular EF correlates with a 4.9-fold decrease in the odds of mortality. This prognostic divergence has led to the recognition of this subset of patients as having a unique heart failure diagnosis, distinct from heart failure with reduced EF (HFrEF) or heart failure with preserved EF and to the adoption of the term heart failure with recovered EF. These patients, despite having improved mortality, do retain some of the molecular and histologic changes seen in HFrEF and are still at risk for decline in left ventricular function and adverse cardiac events, particularly when medical therapy is stopped. This distinction between recovery of EF and true myocardial recovery led to recent guidelines recommending continuation of guideline-directed medical therapy indefinitely, as well as surveillance echocardiography.</p>","PeriodicalId":9549,"journal":{"name":"Cardiology in Review","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44587457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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