Cardiology journal最新文献

{"title":"Intravascular ultrasound imaging in evaluation of aortic stiffness: A proof-of-concept study.","authors":"Niya Boykova Mileva,&nbsp;Dobrin Iotkov Vassilev","doi":"10.5603/CJ.a2021.0003","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0003","url":null,"abstract":"<p><strong>Background: </strong>Aortic stiffness is a well-known cardio-vascular risk factor. For years, different methods have been studied in the assessment of aortic elastic properties and large arterial stiffness for risk stratification. Herein is an assessment of the role of intravascular ultrasound (IVUS) imaging for the evaluation of aortic elastic properties.</p><p><strong>Methods: </strong>Intravascular ultrasound imaging of the aorta was performed in 12 patients with transthoracic echocardiography (TTE) and computed tomography (CT) evidence for enlargement of the ascending aorta - diameter ≥ 40.0 mm. Mechanical properties of the aorta were derived from the measured diameters and intra-aortic pressure. Paired samples T-test analyses were performed to determine differences between measurements derived by TTE, CT and IVUS.</p><p><strong>Results: </strong>Mean values of the calculated elastic properties via IVUS of the ascending aorta were as follows: compliance 0.021 ± 0.02; strain 205 ± 4.3; aortic stiffness index 4.3 ± 0.75; elastic modulus 0.31 ± 0.05. On paired T-test analysis maximum ascending aortic diameter measured by CT aortography and IVUS did not differ significantly (t = -0.19, p = 0.985), but a significant difference between IVUS measurements and TTE derived diameters was found (t = 13.118, p = 0.034). On average, IVUS diameters were 2.3 mm larger than the results acquired by TTE (95% confidence interval: 14.21-17.13).</p><p><strong>Conclusions: </strong>Intravascular ultrasound examination of the ascending aorta provided larger diameters than the ones collected by means of TTE. However, IVUS measurements did not differ significantly from diameters derived by CT aortography.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"221-227"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/da/cardj-30-2-221.PMC10129260.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9400946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of point-of-use ultrasound of resuscitation outcomes: A systematic review and meta-analysis of 3265 patients.","authors":"Maciej Dudek,&nbsp;Lukasz Szarpak,&nbsp;Frank W Peacock,&nbsp;Aleksandra Gasecka,&nbsp;Tomasz Michalski,&nbsp;Pawel Wroblewski,&nbsp;Halla Kaminska,&nbsp;Gabriela Borkowska,&nbsp;Ewa Skrzypek,&nbsp;Adam Smereka,&nbsp;Jaroslaw Meyer-Szary,&nbsp;Sylwia Marciniak,&nbsp;Mariola Malecka","doi":"10.5603/CJ.a2021.0044","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0044","url":null,"abstract":"<p><strong>Background: </strong>Echocardiography in the setting of resuscitation can provide information as to the cause of the cardiac arrest, as well as indicators of futility. This systematic review and meta-analysis were performed to determine the value of point-of-care ultrasonography (PoCUS) in the assessment of survival for adult patients with cardiac arrest.</p><p><strong>Methods: </strong>This meta-analysis was performed in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE, Web of Science, Cochrane have been searched from databases inception until March 2nd 2021. The search was limited to adult patients with cardiac arrest and without publication dates or country restrictions. Papers were chosen if they met the required criteria relating to the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of this diagnostic technique concerning resuscitation outcomes.</p><p><strong>Results: </strong>This systematic review identified 20 studies. Overall, for survival to hospital discharge, PoCUS was 6.2% sensitivity (95% confidence interval [CI] 4.7-8.0%) and 2.1% specific (95% CI 0.8-4.2%). PoCUS sensitivity and specificity for return of spontaneous circulation were 23.8% (95% CI 21.4-26.4%) and 50.7% (95% CI 45.8-55.7%) respectively, and for survival to admission 13.8% (95% CI 12.2-15.5%) and 20.1% (95% CI 16.2-24.3%), respectively.</p><p><strong>Conclusions: </strong>The results do not allow unambiguous recommendation of PoCUS as a predictor of resuscitation outcomes and further studies based on a large number of patients with full standardization of operators, their training and procedures performed were necessary.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"237-246"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/20/cardj-30-2-237.PMC10129265.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9406806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type II Kounis syndrome diagnosed by optical coherence tomography and coronary angioscopy.","authors":"Yuhei Nojima,&nbsp;Hidenori Adachi,&nbsp;Madoka Ihara,&nbsp;Shinsuke Nanto","doi":"10.5603/CJ.2023.0010","DOIUrl":"https://doi.org/10.5603/CJ.2023.0010","url":null,"abstract":"Kounis syndrome (KS), an allergen-induced coronary artery disorder, is classified as type I, causing vasospastic allergic angina; type II, causing allergic acute coronary syndrome (ACS) contrib-uted to vulnerable plaque; and type III, causing coronary artery stent thrombosis. Herein, we report the first documented type II KS case diag - nosed using optical coherence tomography (OCT) and coronary angioscopy (CAS). An 80-year-old man underwent resection for bladder cancer. One gram of cefazolin was administered at the beginning of surgery, and rocuronium and propofol were administered before intubation. A few minutes later, the patient’s blood pressure dropped suddenly from 120/80 mmHg to 70/40 mmHg, and","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"157-158"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/96/cardj-30-1-157.PMC9987555.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9407500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomics analysis of coronary blood microparticles in patients with acute myocardial infarction.","authors":"Yiping Ma,&nbsp;Yujuan Yuan,&nbsp;Zulipiya Aili,&nbsp;Miribani Maitusong,&nbsp;Hao Li,&nbsp;Muyesai Nijiati","doi":"10.5603/CJ.a2022.0081","DOIUrl":"https://doi.org/10.5603/CJ.a2022.0081","url":null,"abstract":"<p><strong>Background: </strong>Acute myocardial infarction (AMI) is the leading cause of death for patients with cardiovascular disease (CVD). Although researchers have made substantial efforts to elucidate its pathogenesis, the molecular mechanisms underlying AMI remain unknown. The aim of this study was to use proteomics to identify differentially expressed proteins (DEPs) and the possible biological functions and metabolic pathways related to coronary blood microparticles (MPs) in patients with AMI and stable coronary artery disease (SCAD); this study will allow for the identification of individuals at risk of acute thrombosis.</p><p><strong>Methods: </strong>The study was performed on 5 AMI patients and 5 SCAD patients. DEPs were identified, and Gene Ontology (GO) enrichment and KEGG pathway enrichment analyzes were performed to determine the relative abundance and biological function of the significant DEPs that were identified in the present study.</p><p><strong>Results: </strong>The current analysis identified 198 DEPs in the coronary blood of AMI patients and SCAD patients, including 85 proteins that were significantly upregulated and 113 proteins that were significantly downregulated. GO enrichment analysis demonstrated that GDP binding and GTP binding were enriched in molecular function. Similarly, KEGG pathway enrichment analysis revealed that the identified proteins were involved in pantothenate and coenzyme A biosynthesis, starch and sucrose metabolism, and the AMPK signalling pathway.</p><p><strong>Conclusions: </strong>The proteome of coronary MPs differs between patients with AMI and patients with SCAD. In summary, the GO terms and KEGG pathways enriched by the DEPs may reflect the possible molecular mechanisms underlying the pathogenesis of acute thrombosis in patients with AMI.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"286-296"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/20/cardj-30-2-286.PMC10129261.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9407800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications following transcatheter edge-to-edge mitral valve repair: Personal experience and review of the literature.","authors":"Dominik Maj, Karolina Jasińska-Gniadzik, Tomasz Kopiec, Małgorzata Wieteska, Aleksandra Gąsecka, Adam Rdzanek, Adriaan O Kraaijeveld, Krzysztof Pujdak, Marcin Grabowski, Arkadiusz Pietrasik","doi":"10.5603/CJ.a2023.0029","DOIUrl":"10.5603/CJ.a2023.0029","url":null,"abstract":"<p><p>Mitral valve dysfunction affects around 2% of the population and its incidence is still increasing, making it the second most common valvular heart disease, after aortic stenosis. Depending on the etiology of the disease, it can be classified into primary or secondary mitral regurgitation. The first line of treatment is optimal medical therapy. If ineffective, mitral valve intervention can be considered. For patients disqualified from surgical treatment, transcatheter edge-to-edge repair with the use of MitraClip may be considered. Over 100,000 MitraClip procedures have been performed which makes this the most established transcatheter technique for the treatment of severe mitral regurgitation. The aim of this review is to discuss the technical details of the MitraClip procedure, clinical evidence regarding the efficacy of MitraClip, complications related to the clip implantation alongside with acute complications based on the currently available evidence and clinical experience.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":" ","pages":"832-842"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flecainide in clinical practice.","authors":"Mikołaj Basza,&nbsp;Cezary Maciejewski,&nbsp;Wojciech Bojanowicz,&nbsp;Paweł Balsam,&nbsp;Marcin Grabowski,&nbsp;Przemysław Mitkowski,&nbsp;Maciej Kempa,&nbsp;Oskar Kowalski,&nbsp;Zbigniew Kalarus,&nbsp;Miłosz Jaguszewski,&nbsp;Andrzej Lubiński,&nbsp;Ludmiła Daniłowicz-Szymanowicz,&nbsp;Łukasz Szumowski,&nbsp;Maciej Sterliński,&nbsp;Łukasz Kołtowski","doi":"10.5603/CJ.a2023.0018","DOIUrl":"https://doi.org/10.5603/CJ.a2023.0018","url":null,"abstract":"<p><p>Flecainide, similar to encainide and propafenone, is IC class antiarrhythmic, inhibiting Nav1.5 sodium channels in heart muscle cells and modulates cardiac conduction. Despite its over 40-year presence in clinical practice, strong evidence and well-known safety profile, flecainide distribution in Europe has not always been equal. In Poland, the drug has been available in pharmacies only since October this year, and previously it had to be imported on request. Flecainide can be used successfully in both the acute and chronic treatment of cardiac arrhythmias. The main indication for flecainide is the treatment of paroxysmal supraventricular tachycardias, including atrial fibrillation, atrioventricular nodal re-entrant tachycardia, atrioventricular re-entrant tachycardia and ventricular arrhythmias in patients without structural heart disease. Beyond that, it may be used in some supraventricular tachycardia in children and for sustained fetal tachycardia. Many studies indicate its efficacy comparable to or better than previously used drugs such as propafenone and amiodarone, depending on the indication. This review aims to highlight the most important clinical uses of flecainide in the light of the latest scientific evidence and to provide an overview of the practical aspects of treatment, including indications, off-label use, contraindications, areas of use, monitoring of treatment and most common complications, taking into account special populations: children and pregnant women.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 3","pages":"473-482"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/f6/cardj-30-3-473.PMC10287070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The head-up cardiopulmonary resuscitation method: Improving neurological outcomes.","authors":"Anastasiia Bondarenko,&nbsp;Alla Navolokina,&nbsp;Marko Kozyk","doi":"10.5603/CJ.a2023.0034","DOIUrl":"https://doi.org/10.5603/CJ.a2023.0034","url":null,"abstract":"This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. Cardiology Journal 2023, Vol. 30, No. 3, 497–498 DOI: 10.5603/CJ.a2023.0034 Copyright © 2023 Via Medica ISSN 1897–5593 eISSN 1898–018X LETTER TO THE EDITOR CLINICAL CARDIOLOGY","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 3","pages":"497-498"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/93/cardj-30-3-497.PMC10287069.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10083806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of D-dimer level and neutrophil to lymphocyte ratio predicts long-term clinical outcomes in acute coronary syndrome after percutaneous coronary intervention.","authors":"Ling-Feng Gu,&nbsp;Jie Gu,&nbsp;Si-Bo Wang,&nbsp;Hao Wang,&nbsp;Ya-Xin Wang,&nbsp;Yuan Xue,&nbsp;Tian-Wen Wei,&nbsp;Jia-Teng Sun,&nbsp;Xiao-Qing Lian,&nbsp;Jia-Bao Liu,&nbsp;En-Zhi Jia,&nbsp;Lian-Sheng Wang","doi":"10.5603/CJ.a2021.0097","DOIUrl":"10.5603/CJ.a2021.0097","url":null,"abstract":"<p><strong>Background: </strong>High D-dimer (DD) is associated with short-term adverse outcomes in patients with acute coronary syndrome (ACS). In ACS patients who underwent percutaneous coronary intervention (PCI), however, the value of DD (or combined with neutrophil to lymphocyte ratio [NLR]) to predict long-term major adverse cardiovascular events (MACEs) has not been fully evaluated.</p><p><strong>Methods: </strong>Patients diagnosed with ACS and receiving PCI were included. The primary outcome was MACEs. Cox proportional hazards regression and logistic regression were used to illustrate the relationship between clinical risk factors, biomarkers and MACEs. Survival models were developed based on significant factors and evaluated by the Concordance-index (C-index).</p><p><strong>Results: </strong>The final study cohort was comprised of 650 patients (median age, 64 years; 474 males), including 98 (15%) with MACEs during a median follow-up period of 40 months. According to the cut-off value of DD and NLR, the patients were separated into four groups: high DD or nonhigh DD with high or nonhigh NLR. After adjusting for confounding variables, DD (adjusted hazard ratio [aHR]: 2.39, 95% confidence interval [CI]: 1.52-3.76) and NLR (aHR: 2.71, 95% CI: 1.78-4.11) were independently associated with long-term MACEs. Moreover, patients with both high DD and NLR had a significantly higher risk in MACEs when considering patients with nonhigh DD and NLR as reference (aHR: 6.19, 95% CI: 3.30-11.61). The area under curve increased and reached 0.70 in differentiating long-term MACEs when DD and NLR were combined, and survival models incorporating the two exhibited a stronger predictive power (C-index: 0.75).</p><p><strong>Conclusions: </strong>D-dimer (or combined with NLR) can be used to predict long-term MACEs in ACS patients undergoing PCI.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 4","pages":"576-586"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/42/cardj-30-4-576.PMC10508083.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10207520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the course of SARS-CoV-2 infection in left ventricular assist device recipients implanted before and during COVID-19 pandemic.","authors":"Sylwia Wiśniowska-Śmiałek,&nbsp;Paweł Rubiś,&nbsp;Grzegorz Wasilewski,&nbsp;Izabela Górkiewicz-Kot,&nbsp;Michał Kaleta,&nbsp;Liza Vashchelina,&nbsp;Irena Milaniak,&nbsp;Ewa Dziewięcka,&nbsp;Ferdynanda Krupa-Hubner,&nbsp;Paulina Tomsia,&nbsp;Rafał Drwiła,&nbsp;Hubert Hymczak,&nbsp;Dorota Sobczyk,&nbsp;Bogusław Kapelak,&nbsp;Karol Wierzbicki","doi":"10.5603/CJ.a2023.0044","DOIUrl":"10.5603/CJ.a2023.0044","url":null,"abstract":"This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. Cardiology Journal 2023, Vol. 30, No. 4, 668–670 DOI: 10.5603/CJ.a2023.0044 Copyright © 2023 Via Medica ISSN 1897–5593 eISSN 1898–018X RESEARCH LETTER COVID-19","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 4","pages":"668-670"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/90/cardj-30-4-668.PMC10508076.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10208143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of quantitative flow ratio-guided complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease: A pilot randomized controlled trial.","authors":"Jing Zhang,&nbsp;Mingyan Yao,&nbsp;Xinwei Jia,&nbsp;Huiping Feng,&nbsp;Jingjing Fu,&nbsp;Wei Tang,&nbsp;Hongliang Cong","doi":"10.5603/CJ.a2021.0111","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0111","url":null,"abstract":"<p><strong>Background: </strong>In patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD), the treatment strategy for non-infarct-related artery (non-IRA) remains controversial. Quantitative flow ratio (QFR) is a new angiography-based physiological assessment index. However, there is little evidence on the practical clinical application of QFR.</p><p><strong>Methods: </strong>Two hundred and twenty-nine patients with STEMI and MVD were recruited for this study. Patients were randomly assigned to either receive QFR-guided complete revascularization (QFR-G-CR) of non-IRA or receive no further invasive treatment. The primary (1°) endpoint analyzed included death due to all causes, non-fatal myocardial infarction (MI), and ischemia-induced revascularization at 12 months post-surgery. Secondary (2°) endpoints included cardiovascular death, unstable angina, stent thrombosis, New York Heart Association (NYHA) class IV heart failure, and stroke at 1 year post surgery. Massive bleeding and contrast-associated acute kidney injury (CAKI) were used as safety endpoints.</p><p><strong>Results: </strong>Around the 12 month follow up, the 1o outcome was recorded in 11/115 patients (9.6%) in the QFR-G-CR population, relative to 23/114 patients (20.1%) in the IRA-only PCI population (hazard ratio [HR]: 0.45; 95% confidence interval [CI]: 0.22-0.92; p = 0.025). Unstable angina in 6 (5.2%) and 16 (14.0%) patients (HR: 0.36; 95% CI: 0.14-0.92; p = 0.026), respectively. No marked alterations were found in the massive bleeding and CAKI categories.</p><p><strong>Conclusions: </strong>In conclusion, STEMI and MVD patients can benefit from QFR-G-CR of non-IRA lesions in the initial stages of acute MI. This can help reduce incidences of major adverse cardiovascular events and unstable angina, relative to IRA treatment only. Chinese Clinical Trial Registration number: ChiCTR2100044120.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"178-187"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/3d/cardj-30-2-178.PMC10129263.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}