Cardiology journal最新文献

{"title":"Measurement of vegetations in infective endocarditis: An inaccurate method to decide the therapeutical approach.","authors":"Gonzalo Cabezón Villalba,&nbsp;Javier López,&nbsp;Pablo Elpidio Garcia-Granja,&nbsp;Teresa Sevilla,&nbsp;Ana Revilla,&nbsp;Maria de Miguel,&nbsp;Paloma Pulido,&nbsp;Itziar Gómez,&nbsp;J Alberto San Román","doi":"10.5603/CJ.a2022.0119","DOIUrl":"https://doi.org/10.5603/CJ.a2022.0119","url":null,"abstract":"<p><strong>Background: </strong>The European Society of Cardiology and American Heart Association guidelines give a central role to the maximal vegetation diameter in the indication for surgery to prevent embolism in left sided infective endocarditis. Vegetation measuring is likely to be inaccurate. The hypothesis herein, is that the vegetation diameter is not an appropriate surgical criterion given the variability of its measurement.</p><p><strong>Methods: </strong>Two trained echocardiographers independently measured the maximal vegetation diameter by transesophageal echocardiogram of 76 vegetations in 67 consecutive patients with definite infective endocarditis in an off-line workstation. The interobserver variability was calculated by the interclass correlation coefficient. The relationship between the strength of agreement for the cut-off points of 10 and 15 mm was also calculated. Finally, the number of patients whose surgical indication would have changed depending on which operator measured the vegetation was evaluated.</p><p><strong>Results: </strong>Interobserver interclass correlation coefficient in the measurement of the maximal longitudinal diameter of the vegetations was 0.757 (0.642-0.839). The strength of agreement of the interobserver analysis for the cut-off point of 10 mm was 0.533 (0.327-0.759). For the cut-off point of 15 mm it was 0.475 (0.270-0.679). If heart failure or uncontrolled infections had been absent, the surgical indication would have changed in a total of 33 patients (33/76; 43%) depending on which operator measured the vegetation.</p><p><strong>Conclusions: </strong>The variability in the measurements of the maximal longitudinal diameter by transesophageal echocardiogram is high. Surgical indications based on the cut-off points recommended by the international guidelines should be revised.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"68-72"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/77/cardj-30-1-68.PMC9987538.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10861879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patient with heart failure, who is frail: How does this affect therapeutic decisions?","authors":"Marta Wleklik, Quin Denfeld, Michal Czapla, Ewa A Jankowska, Massimo Francesco Piepoli, Izabella Uchmanowicz","doi":"10.5603/CJ.a2023.0027","DOIUrl":"10.5603/CJ.a2023.0027","url":null,"abstract":"<p><p>Patients with heart failure (HF) are heterogeneous, not only related to comorbidities but also in the presentation of frailty syndrome. Frailty syndrome also affects patients with HF across the lifespan. Frailty in patients with HF has a significant impact on clinical features, diagnosis, management, adverse medical outcomes and costs. In everyday clinical practice, frail patients with HF require an individualized approach, often imposing the need to modify therapeutic decisions. The aim of this review is to illustrate how frailty and multimorbidity in HF can affect therapeutic decisions. The scientific evidence underlying this publication was obtained from an analysis of papers indexed in the PubMed database. The search was limited to articles published between 1990 and July 2022. The search was limited to full-text papers published in English. The database was searched for relevant MeSH phrases and their combinations and keywords including: \"elderly, frail\"; \"frailty, elderly\"; \"frail older adults\"; \"frailty, older adults\"; \"adult, frail older\"; \"frailty, heart failure\"; \"frailty, multimorbidity\"; \"multimorbidity, heart failure\"; \"multimorbidity, elderly\"; \"older adults, cardiovascular diseases\". In therapeutic decisions regarding patients with HF, additionally burdened with multimorbidity and frailty, it becomes necessary to individualize the approach in relation to optimization and treatment of coexisting diseases, frailty assessment, pharmacological and non-pharmacological treatment and in the implementation of invasive procedures in the form of implantable devices or cardiac surgery.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":" ","pages":"825-831"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9310619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actual status and future directions of cardiac telerehabilitation.","authors":"Krzysztof Milewski,&nbsp;Pawel Balsam,&nbsp;Mateusz Kachel,&nbsp;Bronislaw Sitek,&nbsp;Aleksandra Kolarczyk-Haczyk,&nbsp;Szymon Skoczyński,&nbsp;Piotr Hirnle,&nbsp;Monika Gawałko,&nbsp;Łukasz Kołtowski,&nbsp;Renata Główczynska,&nbsp;Tomasz Zając,&nbsp;Andrzej Małecki,&nbsp;Agata Nowak,&nbsp;Paweł Kaźmierczak,&nbsp;Ewa Piotrowicz,&nbsp;Ryszard Piotrowicz,&nbsp;Miłosz Jaguszewski,&nbsp;Grzegorz Opolski,&nbsp;Marcin Grabowski","doi":"10.5603/CJ.a2022.0104","DOIUrl":"https://doi.org/10.5603/CJ.a2022.0104","url":null,"abstract":"Telerehabilitation (TR) was developed to achieve the same results as would be achieved by the standard rehabilitation process and to overcome potential geographical barriers and staff deficiencies. This is especially relevant in periodic crisis situations, including the recent COVID-19 pandemic. Proper execution of TR strategy requires both well-educated staff and dedicated equipment. Various studies have shown that TR may have similar effects to traditional rehabilitation in terms of clinical outcomes and may also reduce total healthcare costs per participant, including rehospitalization costs. However, as with any method, TR has its advantages and disadvantages, including a lack of direct contact or prerequisite, rudimentary ability of the patients to handle mobile devices, among other competencies. Herein, is a discussion of the current status of TR, focusing primarily on cardiac TR, describing some technical/organizational and legal aspects, highlighting the indications, examining cost-effectiveness, as well as outlining possible future directions.","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"12-23"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/fd/cardj-30-1-12.PMC9987557.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9400279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical valve replacement in a case of idiopathic dilated cardiomyopathy with massive left atrial dilatation and secondary mitral regurgitation.","authors":"Stephane Noble,&nbsp;Sarah Mauler-Wittwer,&nbsp;Philippe Meyer,&nbsp;Georgios Giannakopoulos","doi":"10.5603/CJ.2023.0023","DOIUrl":"https://doi.org/10.5603/CJ.2023.0023","url":null,"abstract":"56-year-old patient, known for having idiopathic dilated cardiomyopathy for more than 30 years with chronic atrial fibrillation under","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"333-334"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/4a/cardj-30-2-333.PMC10129252.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9403597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical therapy with flecainide and propafenone in atrial fibrillation: Long-term clinical experience in the tertiary care setting.","authors":"Boldizsar Kovacs,&nbsp;Haci Yakup Yakupoglu,&nbsp;Urs Eriksson,&nbsp;Nazmi Krasniqi,&nbsp;Firat Duru","doi":"10.5603/CJ.a2022.0116","DOIUrl":"https://doi.org/10.5603/CJ.a2022.0116","url":null,"abstract":"<p><strong>Background: </strong>Flecainide and propafenone are Class Ic antiarrhythmic drugs that block the cardiac fast inwards Na+ current and are used for rhythm control in patients with atrial fibrillation (AF). However, data on long-term clinical efficacy and safety of these drugs in a real-world setting are scarce.</p><p><strong>Methods: </strong>Patients with AF who received chronic flecainide or propafenone therapy were retrospectively studied from the database of a tertiary care center. The primary outcome of the study was clinical efficacy of Class Ic antiarrhythmics, which was assessed based on the improvement of arrhythmia-related symptoms at the time of last follow-up.</p><p><strong>Results: </strong>Among the 361 patients (261 males, 72.3%) with a mean age of 56 ± 12 years, 287 (79.5%) were using long-term flecainide, and 74 (20.5%) patients propafenone. The majority of the patients had paroxysmal AF (n = 331, 91.7%) and had an atrioventricular-nodal blocking co-medication (n = 287, 79.5%). A total of 117 (32%) patients discontinued therapy after a median of 210 days (interquartile range 62-855 days). Clinical efficacy was observed in 188 (52%) patients. The most common reason for therapy discontinuation was adverse drug effects, particularly proarrhythmic effects (48% for flecainide and 33% for propafenone). Patients who did not clinically benefit from Class Ic antiarrhythmics more often underwent pulmonary vein isolation (p = 0.02).</p><p><strong>Conclusions: </strong>Long-term therapy with Class Ic antiarrhythmics showed clinical efficacy in approximately half of the patients with paroxysmal or persistent AF. However, these drugs were also associated with a relatively high rate of adverse events, and in particular proarrhythmic effects, which often resulted in therapy discontinuation rendering appropriate patient selection and therapy surveillance essential.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 1","pages":"82-90"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/4f/cardj-30-1-82.PMC9987554.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9418584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin converting enzyme inhibitors versus angiotensin II type 1 receptor blockers in patients with acute myocardial infarction and prediabetes after successful implantation of newer-generation drug-eluting stents.","authors":"Yong Hoon Kim,&nbsp;Ae-Young Her,&nbsp;Myung Ho Jeong,&nbsp;Byeong-Keuk Kim,&nbsp;Sung-Jin Hong,&nbsp;Sang-Ho Park,&nbsp;Seunghwan Kim,&nbsp;Chul-Min Ahn,&nbsp;Jung-Sun Kim,&nbsp;Young-Guk Ko,&nbsp;Donghoon Choi,&nbsp;Myeong-Ki Hong,&nbsp;Yangsoo Jang","doi":"10.5603/CJ.a2021.0116","DOIUrl":"10.5603/CJ.a2021.0116","url":null,"abstract":"BACKGROUND Because limited data are available, the present study investigated 2-year major clinical outcomes after angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) therapy in patients with acute myocardial infarction (AMI) and prediabetes after successful implantation of newer-generation drug-eluting stents (DESs). METHODS Overall, 2932 patients with AMI and prediabetes were classified into two groups - the ACEIs group (n = 2059) and the ARBs group (n = 873). The primary endpoint was the occurrence of patient-oriented composite outcome (POCO), defined as all-cause death, recurrent myocardial infarction (Re-MI), or any repeat revascularization. The secondary endpoint was definite or probable stent thrombosis (ST). RESULTS The cumulative incidences of POCO (adjusted hazard ratio [aHR]: 1.020; 95% confidence interval [CI]: 0.740-1.404; p = 0.906), all-cause death (aHR: 1.394; 95% CI: 0.803-2.419; p = 0.238), Re-MI (aHR: 1.210; 95% CI: 0.626-2.340; p = 0.570), any repeat revascularization (aHR: 1.150; 95% CI: 0.713-1.855; p = 0.568), and ST (aHR: 1.736; 95% CI: 0.445-6.766; p = 0.427) were similar between the groups. These results were confirmed after propensity score-adjusted analysis. CONCLUSIONS In this study, patients with AMI and prediabetes who received ACEIs or ARBs showed comparable clinical outcomes during the 2-year follow-up period.","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 4","pages":"614-626"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/09/cardj-30-4-614.PMC10508070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10259308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simplified coronary flow reserve calculations based on three-dimensional coronary reconstruction and intracoronary pressure data.","authors":"Benjamin Csippa, Áron Üveges, Dániel Gyürki, Csaba Jenei, Balázs Tar, Balázs Bugarin-Horváth, Gábor Tamás Szabó, András Komócsi, György Paál, Zsolt Kőszegi","doi":"10.5603/CJ.a2021.0117","DOIUrl":"10.5603/CJ.a2021.0117","url":null,"abstract":"<p><strong>Background: </strong>Measurements of fractional flow reserve (FFR) and/or coronary flow reserve (CFR) are widely used for hemodynamic characterization of coronary lesions. The frequent combination of the epicardial and microvascular disease may indicate a need for complex hemodynamic evaluation of coronary lesions. This study aims at validating the calculation of CFR based on a simple hemodynamic model to detailed computational fluid dynamics (CFD) analysis.</p><p><strong>Methods: </strong>Three-dimensional (3D) morphological data and pressure values from FFR measurements were used to calculate the target vessel. Nine patients with one intermediate stenosis each, measured by pressure wire, were included in this study.</p><p><strong>Results: </strong>A correlation was found between the determined CFR from simple equations and from a steady flow simulation (r = 0.984, p < 10-5). There was a significant correlation between the CFR values calculated by transient and steady flow simulations (r = 0.94, p < 10-3).</p><p><strong>Conclusions: </strong>Feasibility was demonstrated of a simple hemodynamic calculation of CFR based on 3D-angiography and intracoronary pressure measurements. A simultaneous determination of both the FFR and CFR values provides the capability to diagnose microvascular dysfunction: the CFR/FFR ratio characterizes the microvascular reserve.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 4","pages":"516-525"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ce/3f/cardj-30-4-516.PMC10508073.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10259766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudo-discordance mimicking low-flow low-gradient aortic stenosis in transcatheter aortic valve replacement patients with severe symptomatic aortic stenosis.","authors":"Rafael Kuperstein, Michael Michlin, Israel Barbash, Israel Mazin, Yafim Brodov, Paul Fefer, Amit Segev, Victor Guetta, Elad Maor, Orly Goiten, Michael Arad, Micha S Feinberg, Ehud Schwammenthal","doi":"10.5603/CJ.a2021.0106","DOIUrl":"10.5603/CJ.a2021.0106","url":null,"abstract":"<p><strong>Background: </strong>While the combination of a small aortic valve area (AVA) and low mean gradient is frequently labeled 'low-flow low-gradient aortic stenosis (AS)', there are two potential causes for this finding: underestimation of mean gradient and underestimation of AVA.</p><p><strong>Methods: </strong>In order to investigate the prevalence and causes of discordant echocardiographic findings in symptomatic patients with AS and normal left ventricular (LV) function, we evaluated 72 symptomatic patients with AS and normal LV function by comparing Doppler, invasive, computed tomography (CT) LV outflow tract (LVOT) area, and calcium score (CaSc).</p><p><strong>Results: </strong>Thirty-six patients had discordant echocardiographic findings (mean gradient < 40 mmHg, AVA ≤ 1 cm²). Of those, 19 had discordant invasive measurements (true discordant [TD]) and 17 concordant (false discordant [FD]): In 12 of the FD the mean gradient was > 30 mmHg; technical pitfalls were found in 10 patients (no reliable right parasternal Doppler in 6). LVOT area by echocardiography or CT could not differentiate between concordants and discordants nor between TD and FD (p = NS). CaSc was similar in concordants and FD (p = 0.3), and it was higher in true concordants than in TD (p = 0.005). CaSc positive predictive value for the correct diagnosis of severe AS was 95% for concordants and 93% for discordants.</p><p><strong>Conclusions: </strong>Discordant echocardiographic findings are commonly found in patients with symptomatic AS. Underestimation of the true mean gradient due to technical difficulties is an important cause of these discrepant findings. LVOT area by echocardiography or CT cannot differentiate between TD and FD. In the absence of a reliable and compete multi-window Doppler evaluation, patients should undergo CaSc assessment.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 3","pages":"422-430"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/98/cardj-30-3-422.PMC10287073.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9704772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angio-computed tomography reveals differences in the anatomy of renal arteries in resistant hypertension patients qualified for renal denervation versus pseudo-resistant hypertensive subjects.","authors":"Tomasz Skowerski,&nbsp;Mariusz Skowerski,&nbsp;Andrzej Kułach,&nbsp;Tomasz Roleder,&nbsp;Andrzej Ochała,&nbsp;Zbigniew Gąsior","doi":"10.5603/CJ.a2021.0026","DOIUrl":"https://doi.org/10.5603/CJ.a2021.0026","url":null,"abstract":"<p><strong>Background: </strong>Renal denervation is a novel therapeutic option in resistant hypertension (RHT). The anatomy of renal arteries and the presence of additional renal arteries are important determinants of the effect of the procedure. The aim of this study was to assess the anatomy of renal arteries using angio- -computed tomography in patients with RHT, who were qualified for renal denervation.</p><p><strong>Methods: </strong>We analyzed angio-computed tomography scans of the renal arteries of 72 patients qualified for renal denervation. We divided the study population into two groups: a resistant hypertension group (RHT) and a pseudo-resistant hypertension group (NRHT). The biochemical and endocrine diagnostic procedures were performed to rule out secondary hypertension. We analyzed the morphology, the diameters, and the number of additional renal arteries.</p><p><strong>Results: </strong>In both groups, we found additional renal arteries (ARN). ARN were more frequent in RHT than in patients with non-resistant hypertension (48.4% vs. 24.3%; p < 0.05). They were present more often on the left side (18 left side vs. 7 right side). The ARNs were longer than main renal artery - left side 41.7 ± 12.1 mm vs. 51.1 ± 11.8 mm, right side 49.2 ± 14.5 mm vs. 60 ± ± 8.6 mm, respectively (p < 0.05). The diameters of ARN were similar in both groups. In the group of patients with RHT the number of ARN was significantly higher (p < 0.04).</p><p><strong>Conclusions: </strong>The ARNs occur more often in patients with RHT. It seems that there is no connection between the resistance of hypertension and the diameters of renal arteries.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 3","pages":"379-384"},"PeriodicalIF":2.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/ed/cardj-30-3-379.PMC10287086.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9754411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between mitral annulus calcification and subtypes of heart failure rehospitalization.","authors":"Yuta Kato, Tadaaki Arimura, Yuhei Shiga, Takashi Kuwano, Makoto Sugihara, Shin-Ichiro Miura","doi":"10.5603/CJ.a2021.0076","DOIUrl":"10.5603/CJ.a2021.0076","url":null,"abstract":"<p><strong>Background: </strong>Mitral annulus calcification (MAC) has been associated with cardiovascular diseases, including heart failure (HF); however, the associations between MAC and both the category and etiology of HF have not been fully elucidated. The aim of this study was to investigate the relationship between MAC and three types of HF rehospitalization: HF with preserved ejection fraction (HFpEF), HF with mid-range EF (HFmrEF), and HF with reduced EF (HFrEF).</p><p><strong>Methods: </strong>We enrolled consecutive patients undergoing echocardiography, who were admitted to our hospital for clinically indicated congestive HF between April 2014 and March 2018. Cox proportionalhazards models were used after adjusting for age, gender, and hypertension.</p><p><strong>Results: </strong>Of 353 patients, 40 (11.3%) had MAC. With a median follow-up of 2.8 years, 100 (28%) patients were rehospitalized for congestive HF (HFpEF 40%, HFmrEF 16%, HFrEF 44%, respectively). According to the Kaplan-Meier method, the estimated incidence of HFpEF rehospitalization in the MAC group was significantly greater than that in the non-MAC group (p < 0.001) whereas the incidences of HFmrEF and HFrEF rehospitalization were comparable between the groups (p = 0.101 and p = 0.291, respectively). In a multivariate analysis, MAC remained significantly associated with HFpEF rehospitalization (hazard ratio: 3.379; 95% confidence interval: 1.651-6.597). At initial HF hospitalization, E/e' was significantly higher in the MAC group (both septum and lateral, p < 0.05), suggesting a possible relationship between MAC and left ventricular diastolic function.</p><p><strong>Conclusions: </strong>Mitral annulus calcification was associated with increased HFpEF rehospitalization and might be a cause of left ventricular diastolic dysfunction.</p>","PeriodicalId":9492,"journal":{"name":"Cardiology journal","volume":"30 2","pages":"256-265"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/54/db/cardj-30-2-256.PMC10129255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}